The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Hepatocyte Growth Factor Modulates Interleukin-6 Production in Bone Marrow Derived Macrophages: Implications for Inflammatory Mediated Diseases
Open accessAbstract
The generation of the pro-inflammatory cytokines IL-6, TNF-α, and IL-1β fuel the acute phase response (APR). To maintain body homeostasis, the increase of inflammatory proteins is resolved by acute phase proteins via presently unknown mechanisms. Hepatocyte growth factor (HGF) is transcribed in response to IL-6. Since IL-6 production promotes the generation of HGF and induces the APR, we posited that accumulating HGF might be a likely candidate for quelling excess inflammation under non-pathological conditions. We sought to assess the role of HGF and how it influences the regulation of inflammation utilizing a well-defined model of inflammatory activation, lipopolysaccharide (LPS)-stimulation of bone marrow derived macrophages (BMM). BMM were isolated from C57BL6 mice and were stimulated with LPS in the presence or absence of HGF. When HGF was present, there was a decrease in production of the pro-inflammatory cytokine IL-6, along with an increase in the anti-inflammatory cytokine IL-10. Altered cytokine production correlated with an increase in phosphorylated GSK3β, increased retention of the phosphorylated NFκB p65 subunit in the cytoplasm, and an enhanced interaction between CBP and phospho-CREB. These changes were a direct result of signaling through the HGF receptor, MET, as effects were reversed in the presence of a selective inhibitor of MET (SU11274) or when using BMM from macrophage-specific conditional MET knockout mice. Combined, these data provide compelling evidence that under normal circumstances, HGF acts to suppress the inflammatory response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“in cultured macrophages HGF suppresses production of IL-6”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“As we have previously shown HGF suppresses LPS-induced production of IL-6 in cultured macrophages via the MET receptor [10]”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“hepatocellular IL-6 induction in response to HGF is exactly the opposite of what we recently observed with regard to HGF and IL-6 in cultured macrophages [10]”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“As we have previously shown that HGF can suppress IL-6 production in LPS-stimulated macrophages [10]”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“In a recent publication we demonstrated that unlike what we now see with hepatocytes, HGF instead suppresses IL-6 production in macrophages via signaling through the MET receptor [10].”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578
The glamour and gloom of glycogen synthase kinase-3
Jope, R. S., & Johnson, G. V. W. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.12.004 · Cited by 1,535
Interleukin-6 and chronic inflammation
Gabay, C. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1917 · Cited by 1,468
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210
Martin, M., Rehani, K., Jope, R. S., & Michalek, S. M. (2005) · Nature Immunology · doi:10.1038/ni1221 · Cited by 1,099
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–156 of 156
Aguilar‐Valenzuela, R., Carlsen, E. D., Liang, Y., Soong, L., & Sun, J. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12456 · Cited by 8
Park, H.-T., Park, H.-E., Cho, Y.-I., Kim, E.-H., Jung, M., Shin, S., Lee, S., Kim, D.-Y., & Yoo, H. S. (2017) · Journal of Veterinary Science · doi:10.4142/jvs.2017.18.s1.343 · Cited by 8
Santiuste, M. S., Vaquerizo, V., Esteban, J.-A., do Prado, R. C. P., Padilla, S., & Anitua, E. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14228075 · Cited by 8
Elchaninov, A. V., Fatkhudinov, T., Arutyunyan, I. V., Макаров, А. В., Usman, N. Y., Михайлова, Л. П., Lokhonina, А. V., Botchey, V. M., Glinkina, V. V., & Bolshakova, G. B. (2018) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-018-4115-9 · Cited by 7
Prezoto, B. C., Kato, E. E., Gonçalves, L. R. C., Sampaio, S. C., & Sano-Martins, I. S. (2019) · Toxicon · doi:10.1016/j.toxicon.2019.03.003 · Cited by 7
Chalenko, Y. M., Slonova, D., Kechko, O. I., Kalinin, E. V., Mitkevich, V. A., & Ermolaeva, S. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087256 · Cited by 6
Chen, J., Zhang, H., Zhang, R., Liu, Z., Wang, J., Xiao, M., Ba, M., Yao, F., Liu, J., Huang, S., et al. (2014) · Europe PMC (PubMed Central) · Cited by 6
Matsuda, S., Kotani, T., Saito, T., Suzuka, T., Mori, T., & Takeuchi, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.792739 · Cited by 5
Lunardon, T., Sumner, S. M., Mollabashi, M., Darzenta, N., Davis, E., & Naskou, M. C. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1408080 · Cited by 5
Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation
Dhakal, B., Li, C. M. Y., Ramezanpour, M., Houtak, G., Li, R., Bouras, G. S., Colella, A. D., Chegeni, N., Chataway, T., Drew, P. A., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1054588 · Cited by 5
Expression of Cytokine Genes and Growth Factors in Rat Lungs and Kidneys after Subtotal Hepatectomy
Elchaninov, A. V., Fatkhudinov, T., Usman, N. Y., Arutyunyan, I. V., Макаров, А. В., Kananykhina, E. Y., Glinkina, V. V., Bolshakova, G. B., & Sukhikh, G. T. (2016) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-016-3423-1 · Cited by 5
Mata, M. F., Lopes, J. P., Ishikawa, M., Alaiti, M. A., Cabral, J. M. S., da Silva, C. L., & Costa, M. A. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.09.003 · Cited by 5
Elchaninov, A. V., Vishnyakova, P., Kuznetsova, M., Lokhonina, А. V., Soboleva, A., Trofimov, D. Y., Fatkhudinov, T., & Sukhikh, G. T. (2024) · Immunology and Cell Biology · doi:10.1111/imcb.12746 · Cited by 4
Altaie, A., Baboolal, T. G., Wall, O., Pandit, H. G., Jones, E., & McGonagle, D. (2021) · The American Journal of Sports Medicine · doi:10.1177/03635465211055164 · Cited by 4
Анатольевич, Д. С., Malanin, D. A., Rogova, L. N., Леонидович, С. Г., Grigorieva, N. V., & Байдова, К. В. (2016) · Traumatology and Orthopedics of Russia · doi:10.21823/2311-2905-2016-22-4-76-87 · Cited by 4
Iwasaki, T., & Shibasaki, S. (2013) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.13-00212-3 · Cited by 4
Grothey, B., Lyu, S. I., Quaas, A., Simon, A. G., Jung, J., Schröder, W., Bruns, C. J., Schiffmann, L. M., Popp, F., Schmidt, T., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05635-7 · Cited by 3
Potential Links Between Tendon Pathology and Platelet Rich Plasma Biology
Andı́a, I., Rubio‐Azpeitia, E., & Maffulli, N. (2016) · Springer eBooks · doi:10.1007/978-1-4471-7271-0_10 · Cited by 3
Crosstalk Between Liver and Extra-Liver Organs During Liver Regeneration in Mammals
Elchaninov, A. V., Bykova, D., Gantsova, E. A., Vishnyakova, P., Fatkhudinov, T., & Sukhikh, G. T. (2025) · Cells · doi:10.3390/cells14211691 · Cited by 2
Effect of super activated platelet lysate on cell proliferation, repair and osteogenesis
Guo, X., Liu, C., Zhang, Y., & Bi, L. (2022) · Bio-Medical Materials and Engineering · doi:10.3233/bme-221426 · Cited by 2
Дергилев, К. В., Beloglazova, I. B., Цоколаева, З. И., Azimova, E., Dolgodvorova, A., Goltseva, Y., Boldyreva, M. A., Menshikov, M. Y., Penkov, D., & Parfyonova, Y. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157298 · Cited by 3
Ollewagen, T., Tarr, G. S., Myburgh, K. H., Reuter, H., & Smith, C. (2022) · International Journal of Inflammation · doi:10.1155/2022/1524913 · Cited by 2
Przywara, D., Babiuch, W., Kosteczko, P., Petniak, A., Kondracka, A., Krzyżanowski, A., Czuba, M., Szymanowski, R., Kocki, J., & Gil-Kulik, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188269 · Cited by 1
Platelet-Rich Plasma Augmentation in Rotator Cuff Surgery: State of Art
Longo, U. G., Loppini, M., Berton, A., Maffulli, N., & Denaro, V. (2012) · Operative Techniques in Orthopaedics · doi:10.1053/j.oto.2011.10.003 · Cited by 1
Dao, M. A., Nolta, J. A., & Case, C. C. (2013) · Advances in Neuroimmune Biology · doi:10.3233/nib-130064 · Cited by 1
Matti, B. F., Sabir, S. F., Khaleq, M. A. A., & kaabi, M. H. A. (2017) · International Research Journal of Pharmacy · doi:10.7897/2230-8407.08692 · Cited by 1
Bakhashab, S., Barber, R., O’Neill, J., Arden, C., & Weaver, J. U. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158087 · Cited by 1
Proto, J. D. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
Coudriet, G. M. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Self-citationOVERCOMING SELF-REACTIVITY THROUGH IMMUNOLOGICAL AND METABOLIC REDOX MODULATION
Delmastro-Greenwood, M. M. (2012) · D-Scholarship@Pitt (University of Pittsburgh)
Nature Reviews UNCORRECTED PROOF
Andı́a, I., & Maffulli, N. (2013)
Регенерация печени млекопитающих: межклеточные взаимодействия
Ельчанинов, А. В., & Fatkhudinov, T. (2020) · Наука eBooks · doi:10.7868/9785020407770
Hamed, G. M., Ali, R. H., El-Masry, M. M., & Abou-Bakr, D. A. (2023) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093023030110
Cytokines and growth factors genes expression after subtotal liver resection in rats
Elchaninov, A. V., Fatkhudinov, T., Usman, N. Y., Arutyunyan, I. V., Макаров, А. В., Kananykhina, E. Y., Raimova, E. S., Bolshakova, G. B., & Sukhikh, G. T. (2016) · Genes and Cells · doi:10.23868/gc120578
Taniyama, O., Kumagai, K., Kanmura, S., Nakamura, Y., Eguchi, H., Uehara, M., Meguro, K., Toyodome, A., Ijuin, S., Sakae, H., et al. (2025) · Hepatology Research · doi:10.1111/hepr.14227
Endothelial Cell Transition: Preliminary Data on Cross-Organ Shift from Brain to Liver
Larionov, A. A., Filgueira, L., & Hammer, C. M. (2025) · Cells · doi:10.3390/cells14191538
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692543
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692537
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692552
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692549
Bang, Y., Hwang, S., Kim, Y. E., Sung, D. K., Yang, M., Ahn, S. Y., Sung, S. I., Joo, K. M., & Chang, Y. S. (2024) · Figshare · doi:10.6084/m9.figshare.26517863
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692561
Bang, Y., Hwang, S., Kim, Y. E., Sung, D. K., Yang, M., Ahn, S. Y., Sung, S. I., Joo, K. M., & Chang, Y. S. (2024) · Figshare · doi:10.6084/m9.figshare.26758673
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692555
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692546
Suzuka, T., Kotani, T., Saito, T., Matsuda, S., Sato, T., & Takeuchi, T. (2022) · Figshare · doi:10.6084/m9.figshare.21299410
Suzuka, T., Kotani, T., Saito, T., Matsuda, S., Sato, T., & Takeuchi, T. (2022) · Figshare · doi:10.6084/m9.figshare.21299404
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692558
Bang, Y., Hwang, S., Kim, Y. E., Sung, D. K., Yang, M., Ahn, S. Y., Sung, S. I., Joo, K. M., & Chang, Y. S. (2024) · Figshare · doi:10.6084/m9.figshare.26517916
Suzuka, T., Kotani, T., Saito, T., Matsuda, S., Sato, T., & Takeuchi, T. (2022) · Figshare · doi:10.6084/m9.figshare.21299407
Gantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Figshare · doi:10.6084/m9.figshare.26692540
Singh, K., Ali, M., Krishna Kumar, G., Palmo, T., Kumari, S., Thinlas, T., Pasha, Q., Graham, B. B., Mishra, A., & Kumar, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177787
Metadata
- Authors
- Coudriet, G. M., He, J., Trucco, M., Mars, W. M., & Piganelli, J. D.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Piganelli, Jon D.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-11-02
- Volume
- 5
- Issue
- 11
- Pages
- e15384
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2970559
- OpenAlex
- W2164624420
- Cited by
- 155
- References
- 39
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 17 · 2023: 6 · 2022: 13 · 2021: 14 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 17 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 10
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- American Diabetes Association (CDA 7.07)
- American Heart Association
- University of Pittsburgh
- Medical Center, University of Pittsburgh
- Children's Hospital of Pittsburgh
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- hepatocyte growth factor, interleukin-6, bone marrow-derived macrophages, lipopolysaccharide stimulation, acute phase response, inflammation resolution, GSK3β, NF-κB p65, CREB, CBP, IL-10, anti-inflammatory cytokines
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Animals, Bone Marrow Cells, Cells, Cultured, Dose-Response Relationship, Drug, Female, Indoles, Inflammation, Lipopolysaccharides, Macrophages, Male, Membrane Proteins, Mice, Inbred C57BL, Phosphoproteins, Phosphorylation, Piperazines, Protein Binding, Sulfonamides, Blotting, Western, Interleukin-6, Hepatocyte Growth Factor, Cyclic AMP Response Element-Binding Protein, Mice, Knockout, Proto-Oncogene Proteins c-met, Glycogen Synthase Kinase 3, Immunoprecipitation, Mice, Transcription Factor RelA, Mice, 129 Strain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
