The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase
Open accessAbstract
Microbial biofilms are composed of a hydrated matrix of biopolymers including polypeptides, polysaccharides and nucleic acids and act as a protective barrier and microenvironment for the inhabiting microbes. While studying marine biofilms, we observed that supernatant produced by a marine isolate of Bacillus licheniformis was capable of dispersing bacterial biofilms. We investigated the source of this activity and identified the active compound as an extracellular DNase (NucB). We have shown that this enzyme rapidly breaks up the biofilms of both Gram-positive and Gram-negative bacteria. We demonstrate that bacteria can use secreted nucleases as an elegant strategy to disperse established biofilms and to prevent de novo formation of biofilms of competitors. DNA therefore plays an important dynamic role as a reversible structural adhesin within the biofilm.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
NETs: a new strategy for using old weapons
Papayannopoulos, V., & Zychlinsky, A. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.011 · Cited by 634 · cited 1×
“These are thought to play an important role in capturing invasive pathogens [29].”
Background
Cited by
Microbial Biofilms in the Food Industry—A Comprehensive Review
Carrascosa, C., Raheem, D., Ramos, F., Saraiva, A., & Raposo, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18042014 · Cited by 459
Extracellular DNA as a target for biofilm control
Okshevsky, M., Regina, V. R., & Meyer, R. L. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.12.002 · Cited by 299
Baker, P., Hill, P. J., Snarr, B. D., Alnabelseya, N., Pestrak, M. J., Lee, M. J., Jennings, L. K., Tam, J., Melnyk, R. A., Parsek, M. R., et al. (2016) · Science Advances · doi:10.1126/sciadv.1501632 · Cited by 284
Chen, Z., Ji, H., Liu, C., Bing, W., Wang, Z., & Qu, X. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201605296 · Cited by 266
A Critical Role for Extracellular DNA in Dental Plaque Formation
Rostami, N., Shields, R. C., Yassin, S. A., Hawkins, A. R., Bowen, L., Luo, T. L., Rickard, A. H., Holliday, R., Preshaw, P. M., & Jakubovics, N. S. (2017) · Journal of Dental Research · doi:10.1177/0022034516675849 · Cited by 56
Metadata
- Authors
- Nijland, R., Hall, M. J., & Burgess, J. G.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-12-14
- Volume
- 5
- Issue
- 12
- Pages
- e15668
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2090267699
- Cited by
- 207
- References
- 2
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nijland, R., Hall, M. J., & Burgess, J. G. (2010). Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase. PLoS ONE. https://doi.org/10.1371/journal.pone.0015668
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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