The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice
Open accessAbstract
Neutrophils have been implicated in both protective and pathological responses following influenza virus infections. We have used mAb 1A8 (anti-Ly6G) to specifically deplete LyG6(high) neutrophils and induce neutropenia in mice infected with virus strains known to differ in virulence. Mice were also treated with mAb RB6-8C5 (anti-Ly6C/G or anti-Gr-1), a mAb widely used to investigate the role of neutrophils in mice that has been shown to bind and deplete additional leukocyte subsets. Using mAb 1A8, we confirm the beneficial role of neutrophils in mice infected with virus strains of intermediate (HKx31; H3N2) or high (PR8; H1N1) virulence whereas treatment of mice infected with an avirulent strain (BJx109; H3N2) did not affect disease or virus replication. Treatment of BJx109-infected mice with mAb RB6-8C5 was, however, associated with significant weight loss and enhanced virus replication indicating that other Gr-1(+) cells, not neutrophils, limit disease severity during mild influenza infections.
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STUDIES ON INFLUENZA IN THE PANDEMIC OF 1957-1958. II. PULMONARY COMPLICATIONS OF INFLUENZA*†
Louria, D. B., Blumenfeld, H. L., Ellis, J. T., Kilbourne, E. D., & Rogers, D. E. (1959) · Journal of Clinical Investigation · doi:10.1172/jci103791 · Cited by 479
Cited by
Influenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
Brandes, M., Klauschen, F., Kuchen, S., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.06.013 · Cited by 381
Dienz, O., Rud, J. G., Eaton, S. M., Lanthier, P. A., Burg, E., Drew, A., Bunn, J., Suratt, B. T., Haynes, L., & Rincon, M. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.2 · Cited by 275
Metadata
- Authors
- Tate, M. D., Ioannidis, L. J., Croker, B., Brown, L. E., Brooks, A. G., & Reading, P. C.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-03-14
- Volume
- 6
- Issue
- 3
- Pages
- e17618
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2083944844
- Cited by
- 185
- References
- 1
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tate, M. D., Ioannidis, L. J., Croker, B., Brown, L. E., Brooks, A. G., & Reading, P. C. (2011). The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice. PLoS ONE. https://doi.org/10.1371/journal.pone.0017618
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
