The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders
Open accessAbstract
BACKGROUND: Accumulating evidence suggests that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD. METHODOLOGY/PRINCIPAL FINDINGS: A multiplex assay for cytokines and chemokines was applied to plasma samples from male subjects with high-functioning ASD (n = 28) and matched controls (n = 28). Among a total of 48 analytes examined, the plasma concentrations of IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 and GRO-α were significantly higher in subjects with ASD compared with the corresponding values of matched controls after correction for multiple comparisons. CONCLUSION/SIGNIFICANCE: The results suggest that abnormal immune responses as assessed by multiplex analysis of cytokines may serve as one of the biological trait markers for ASD.
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Citations
Cites
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 1×
“For instance, postmortem studies have shown that the protein levels of tumor necrosis factor a (TNF-a) and interleukin (IL)-6 [5], as well as the number of activated microglia [6], are significantly increased in the brains of subjects with ASD compared to controls.”
BackgroundAshwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood
Lichtenstein, P., Carlström, E., Råstam, M., Gillberg, C., & Anckarsäter, H. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10020223 · Cited by 738
The immune response in autism: a new frontier for autism research
Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528
Elevated cytokine levels in children with autism spectrum disorder
Molloy, C. A., Morrow, A. L., Meinzen-Derr, J., Schleifer, K., Dienger, K., Manning-Courtney, P., Altaye, M., & Wills-Karp, M. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.11.007 · Cited by 386
Cerebrospinal Fluid and Serum Markers of Inflammation in Autism
Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300
Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism
Gupta, S., Aggarwal, S., Rashanravan, B., & Lee, T. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00021-6 · Cited by 250
Low-grade endotoxemia in patients with severe autism
Emanuele, E., Orsi, P., Boso, M., Broglia, D., Brondino, N., Barale, F., di Nemi, S. U., & Politi, P. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.033 · Cited by 225
Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001943 · Cited by 197 · cited 1×
“. And increased levels of inflammatory cytokines have been detected even in peripheral samples such as serum”
Background
Cited by
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
“For example, elevated levels of IL-17a, the predominant TH17 cytokine, have been detected in the serum of a subset of autistic children (14, 15).”
BackgroundThe Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder
Vuong, H. E., & Hsiao, E. Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.024 · Cited by 595
Microglial Activation in Young Adults With Autism Spectrum Disorder
Suzuki, K., Sugihara, G., Ouchi, Y., Nakamura, K., Futatsubashi, M., Takebayashi, K., Yoshihara, Y., Omata, K., Matsumoto, K., Tsuchiya, K. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.272 · Cited by 523
Self-citationCytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis
Masi, A., Quintana, D. S., Glozier, N., Lloyd, A. R., Hickie, I. B., & Guastella, A. J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.59 · Cited by 466
Metadata
- Authors
- Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Wakuda, T., Takebayashi, K., Takagai, S., Matsumoto, K., Tsuchiya, K. J., Iwata, Y., Nakamura, K., Tsujii, M., Sugiyama, T., & Mori, N.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-05-27
- Volume
- 6
- Issue
- 5
- Pages
- e20470
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2023766860
- Cited by
- 252
- References
- 11
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Wakuda, T., Takebayashi, K., Takagai, S., Matsumoto, K., Tsuchiya, K. J., Iwata, Y., Nakamura, K., Tsujii, M., Sugiyama, T., & Mori, N. (2011). Plasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders. PLoS ONE. https://doi.org/10.1371/journal.pone.0020470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
