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P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating
Open accessAbstract
Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the relationship between tau pathology and behavioral impairments, we comprehensively assessed behavioral abnormalities in a mouse tauopathy model expressing the human P301S mutant tau protein in the early stage of disease to detect its initial neurological manifestations. Behavioral abnormalities, shown by open field test, elevated plus-maze test, hot plate test, Y-maze test, Barnes maze test, Morris water maze test, and/or contextual fear conditioning test, recapitulated the neurological deficits of human tauopathies with dementia. Furthermore, we discovered that prepulse inhibition (PPI), a marker of sensorimotor gating, was enhanced in these animals concomitantly with initial neuropathological changes in associated brain regions. This finding provides evidence that our tauopathy mouse model displays neurofunctional abnormalities in prodromal stages of disease, since enhancement of PPI is characteristic of amnestic mild cognitive impairment, a transitional stage between normal aging and dementia such as Alzheimer's disease (AD), in contrast with attenuated PPI in AD patients. Therefore, assessment of sensorimotor gating could be used to detect the earliest manifestations of tauopathies exemplified by prodromal AD, in which abnormal tau protein may play critical roles in the onset of neuronal dysfunctions.
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“The presence of spatial memory deficits in the PS19 line is controversial, with some studies pointing towards the development of deficits in the MWM test from a relatively young age of 5 [28] or 6.5 months [41], while others report initial deficits in spatial memory at 10 [42] or even 12 months of age [29], respectively.”
From Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau (2021) · cites this paper as [28]
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“This is consistent with a hyperactivity phenotype in 6-month-old PS19 mice, presenting with better, albeit not statistically significant, performance on the rotarod compared to WT control animals [28].”
From Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau (2021) · cites this paper as [28]
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“Both models rely on transgene overexpression and familial mutations (such as ADAD mutations in 5xFAD mice and frontotemporal dementia mutations in PS19 mice) and are not well suited for studying the causative events that lead to the development of pathology in sporadic AD [44–47].”
From APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology (2025) · cites this paper as [46]
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“Although behavioral and electrophysiological deficits have been reported in the PS19 line at the ages assessed in our study (Yoshiyama et al., 2007, Takeuchi et al., 2011, Briggs et al., 2017, Chalermpalanupap et al., 2018), we did not observe robust differences in spine density when PS19 mice were compared to NTG littermates.”
From Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice (2021) · cites this paper as Takeuchi et al., 2011
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Cites
The tail suspension test: A new method for screening antidepressants in mice
Steru, L., Chermat, R., Thierry, B., & Simon, P. (1985) · Psychopharmacology · doi:10.1007/bf00428203 · Cited by 3,534
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208
Self-citationTau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174
Self-citationTransmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,522 · cited 1×
“Crawley's three-chamber social approach test consists of a sociability test and a social novelty preference test. These tests assess social interaction that is relatively independent of locomotor activity compared to other social interaction tests, because the preference of the mice can be quantified based on the time…”
BackgroundMemory and Executive Function in Aging and AD
Buckner, R. L. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.006 · Cited by 1,508
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Sensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312
Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125
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Items 201–246 of 246
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Parekh, P. A., Badachhape, A., Mu, Q., Bhavane, R. C., Srivastava, M., Stupin, I. V., Bhandari, P., Devkota, L., Eriksen, J. L., Tanifum, E. A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.14.444233 · Cited by 1
Takahashi, H., Bhagwagar, S. Z., Nies, S. H., Chiasseu, M., Wang, G., Mackenzie, I. R., & Strittmatter, S. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.25.521308 · Cited by 1
Essepian, N., Yuan, S., Roberts, R., Sherman, E., Gniadzik, W., Wang, Q., Erişir, A., & Jiang, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.21.655370 · Cited by 1
Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentPreprint
Malone, T. J., Cekada, K., Tyan, J., Chen, L., Wang, G., & Gu, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.30.696887 · Cited by 1
ASSESSING MEMORY IN AN ALDEHYDE DEHYDROGENASE 2 KNOCKOUT MODEL OF ALZHEIMER'S DISEASE
Elharram, A. (2013) · QSpace (Queen's University Library)
大西, 智., & Onishi, T. (2016) · Terrestrial Environment Research Center (University of Tsukuba)
Lawn, T., Aman, Y., Rukavina, K., Sideris-Lampretsas, G., Howard, M. A., Ballard, C. G., Chaudhuri, К. R., & Malcangio, M. (2021) · Ból · doi:10.5604/01.3001.0014.9017
Zampar, S. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9004
Chung, D. C., Stankowski, J. N., & Petrucelli, L. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0056
Rocha, C. M. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.23.2022.tde-30012023-111435
Arutjunyan, A. V., Milyutina, Y. P., Shcherbitskaia, A. D., Kerkeshko, G. O., & Zalozniaia, I. V. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523040012
Yang, Z., & Lei, P. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0201
OTULIN Interactome Reveals Immune Response and Autophagy Associated with Tauopathy in a Mouse ModelPreprint
Li, L., Li, M., Zhou, Y., Kakhniashvili, D. G., Wang, X., & Liao, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.07.636114
Protein kinase CK2α’ as a dual modulator of immune signaling and synaptic dysfunction in TauopathyPreprint
White, A., Gavrilyuk, P., Gu, P., Moya, R. F., Thurston, R., Fickak, A., Rozema, N. B., Keshavaram, P., Vermilyea, S., Schlichte, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.24.661391
Kron, J. O.-Z. J., Daykin, H. J., Metha, J. A., Potts, Y., Walker, L. C., Allocca, G., Keenan, R. J., Hoyer, D., & Jacobson, L. H. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5374075
Tian, X., Le, N. N., Zhao, Y., Alawamleh, D., Schwartz, A. M., Meyer, L. F., Helm, E., & Wu, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157524
White, A., Gavrilyuk, P., Gu, P., Moya, R. F., Thurston, R. H., Fickak, A., Rozema, N. B., Keshavaram, P., Vermilyea, S., Schlichte, R., et al. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00563-3
Kweon, S. H., Lee, J., Han, B.-C., & Ko, H. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.04.674314
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Zhao, S., Jiang, X., Jiang, Y., Meng, J., Han, L., Cao, J., Zhu, M. T., Zhou, Y., Zhang, X., Luo, H., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107145
Yang, T., Liu, H., Tran, K. C., Leng, A., Massa, S. M., & Longo, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12923390
Brody, A. H., Nies, S. H., Guan, F., Smith, L. M., Mukherjee, B., Salazar, S. A., Lee, S., Lam, T. K. T., & Strittmatter, S. M. (2022) · Figshare · doi:10.6084/m9.figshare.19695711
Yang, T., Liu, H., Tran, K. C., Leng, A., Massa, S. M., & Longo, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12923387
Yang, T., Liu, H., Tran, K. C., Leng, A., Massa, S. M., & Longo, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12923381
Yang, T., Liu, H., Tran, K. C., Leng, A., Massa, S. M., & Longo, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12923384
Tag, S. H., Kim, B. S., Bae, J., Chang, K.-A., & Im, H.-I. (2022) · Figshare · doi:10.6084/m9.figshare.20035812
Yang, T., Liu, H., Tran, K. C., Leng, A., Massa, S. M., & Longo, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12923378
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Kim, S., & Gray, N. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00004-0
Jia, N., Guan, H., Zuo, Y., Jeong, Y. Y., Amireddy, N., Rajapaksha, G., Gonzalez, C. U., Jaber, N., Lee, Y.-K., Nissenbaum, M., et al. (2026) · bioRxiv · doi:10.64898/2026.03.23.713823
Altered neuronal activity in the hippocampal CA3 region in an in vitro model of tauopathy
Goncalves, A. (2020) · theses.fr (ABES) · doi:10.70675/b42db6dez88a0z4a14z93eez8f51d19d46f5
Cho, E., Lee, S., Lee, H., Kim, J., Kwon, Y. W., Hoe, H., Kim, D., & Yoon, J. H. (2026) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2026.101580
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Shee, S., Huang, M., Baghel, M. S., Zheng, Y., Lun, S., Yadav, S. K., Yadav, N. N., Ruiz-Gonzalez, C. E., Tyagi, S., Nuermberger, E. L., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.12.724591
Lucy, T. T., Mamun-Or-Rashid, A. N. M., Lee, D. C., Lefterov, I. M., Koldamova, R. P., & Fitz, N. F. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27115050
Targeted neuronal reprogramming rescues memory and neural synchrony in Alzheimer’s disease
Galán-Ganga, M., Rodríguez-Navarro, I., Zaballa, S., Ramón-Lainez, A., Gómez-Rivada, N., Peters, C., Fernández‐Irigoyen, J., Santamaría, E., Rabadán, M. A., Alberch, J., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00481-w
Chronic pain in Alzheimer disease and the role of neuroimmune interactions
Malcangio, M., & Sideris-Lampretsas, G. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100149
Suo, X., Wan, P., Yu, J., Zhu, X., Tian, C., Li, S., Sun, G., Liu, H., Liu, S., Geng, M., et al. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04834-3
Sun, X., Ramakrishnan, S., Ogbolu, V. C., Kanaan, N. M., Karch, C. M. M., Baas, P. W., & Liang, Q. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71565
Repeated mild spinal cord contusions exacerbate tauopathy development in PS19 mice
Halloin, N., Debortoli, N., Lopez‐Gutierrez, L., COLLIGNON, H., Marlier, Z., Ando, K., Suain, V., Conrard, L., Mignolet, M., Sprimont, L., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02378-9
Gene therapy in Alzheimer’s disease (AD)
Bemanalizadeh, M., Ashrafi, M., Eslami, M., Moein, S., Kazemi, A., & Mansouri, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40467-2.00014-2
Shokr, M. M., & Abdelaziz, A. M. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02393-1
Kokhan, V. S., Belokopytova, K. V., Pikalov, V. A., Федорова, Т. Н., Андреевич, А. Р., & Chaprov, K. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06283-z
Zadrożny, M., Zadrożna, P., Niewiadomski, W., Riedel, G., Harrington, C. R., Wischik, C. M., Niewiadomska, G., & Gąsiorowska, A. (2026) · Cells · doi:10.3390/cells15201908
Sex-divergent neurovascular and cognitive effects of chronic cerebral hypoperfusion.
Kirby, B. D., Clary, B. L., Burrage, E., Chantler, P. D., Dakhlallah, D., Karelina, K., Brown, C. M., & Simpkins, J. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116066
BCG vaccination mitigates tau pathology and restores cognitive function in PS19 mice
Shee, S., Huang, M., Baghel, M. S., Zheng, Y., Lun, S., Yadav, S. K., Yadav, N. N., Ruiz-Gonzalez, C. E., Tyagi, S. K., Nuermberger, E. L., et al. (2026) · Science Advances · doi:10.1126/sciadv.aej4603
α7 nicotinic acetylcholine receptors and memory processes: mechanistic and behavioral studies
van Goethem, N. P. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150625ng
Metadata
- Authors
- Takeuchi, H., Iba, M., Inoue, H., Higuchi, M., Takao, K., Tsukita, K., Karatsu, Y., Iwamoto, Y., Miyakawa, T., Suhara, T., Trojanowski, J. Q., Lee, V. M. Y., & Takahashi, R.
- Affiliations
- Kyoto University (JP)
- Hospital of the University of Pennsylvania (US)
- National Institute of Radiological Sciences (JP)
- National Institute for Physiological Sciences (JP)
- Fujita Health University (JP)
- Corresponding author
- Inoue, Haruhisa
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-06-15
- Volume
- 6
- Issue
- 6
- Pages
- e21050
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3115982
- OpenAlex
- W2158765009
- Cited by
- 247
- References
- 65
- Citations by year
- 2026: 27 · 2025: 36 · 2024: 24 · 2023: 18 · 2022: 24 · 2021: 24 · 2020: 21 · 2019: 13 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 5 · 2012: 3
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (AG 10 124)
- Japan Society for the Promotion of Science (22700338, 23390235, 21300121)
- Japan Science and Technology Agency
- RIKEN
- National Institute on Aging (P30AG010124, P01AG017586, AG17586, AG-10124)
- RIKEN Brain Science Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- tauopathy, transgenic mouse model, dementia, sensorimotor gating, prepulse inhibition, prodromal Alzheimer's disease, amnestic mild cognitive impairment, behavioral abnormalities, early disease detection, cognitive impairment
- MeSH terms
- Animals, Dementia, Disease Models, Animal, Humans, Mice, Transgenic, tau Proteins, Maze Learning, Mice, Sensory Gating
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