Detection of Campylobacter concisus and Other Campylobacter Species in Colonic Biopsies from Adults with Ulcerative Colitis

Mukhopadhya, Indrani; Thomson, John M.; Hansen, Richard; Berry, Susan H.; El-Omar, Emad M.; Hold, Georgina L.

doi:10.1371/journal.pone.0021490

Cited by 145Inflammatory Bowel DiseaseSalmonella and Campylobacter epidemiologyGut microbiota and health

Detection of Campylobacter concisus and Other Campylobacter Species in Colonic Biopsies from Adults with Ulcerative Colitis

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Mukhopadhya, Indrani, Thomson, John M., Hansen, Richard, Berry, Susan H., El-Omar, Emad M., Hold, Georgina L.·2011·PLoS ONE

DOI 10.1371/journal.pone.0021490PMC PMC3124515

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Abstract

INTRODUCTION: The critical role of bacteria in the pathogenesis of ulcerative colitis (UC) is well recognized, but an individual causative microorganism has not been singled out so far. Campylobacter concisus and other non-jejuni species of Campylobacter have been implicated as putative aetiological agents in inflammatory bowel disease in children, but such studies have not been addressed in adults. This study investigated the prevalence of Campylobacter species in colonic biopsy samples from adults with UC and healthy controls. METHODS: Adult patients who were undergoing diagnostic colonoscopy were recruited for the study, which included 69 patients with histologically proven UC and 65 healthy controls. DNA was extracted from the biopsy samples and subjected to Campylobacter genus specific and Campylobacter concisus specific polymerase chain reaction and sequencing. RESULTS: Detection of all Campylobacter DNA utilising genus specific primers was significantly higher in cases of UC, with a prevalence of 73.9% (51/69) compared to 23.1% (15/65) in controls (p = 0.0001). Nested PCR for C. concisus DNA was positive in 33.3% (23/69) of biopsy samples from subjects with UC, which was significantly higher than the prevalence rate of 10.8% (7/65) from controls (p = 0.0019). Sequencing of the remaining Campylobacter positive samples revealed that Campylobacter ureolyticus was positive in 21.7% (15/69) of samples from UC subjects as opposed to 3.1% (2/65) in controls (p = 0.0013). Mixed Campylobacter species were more common in UC patients, 20.3% (14/69) as compared to controls 4.6% (3/65) (p = 0.0084). CONCLUSION: The higher prevalence of Campylobacter genus and more specifically C. concisus and C. ureolyticus in biopsy samples from adults with UC suggests these genera of bacteria may be involved in the chronic inflammation that is characteristically seen in UC. To the best of our knowledge this is the first report of this association of C. concisus and C. ureolyticus with UC in adults.

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Changes in the two dominant phyla, Firmicutes and Bacteroidetes, are coupled with an increase in abundance of members of the Proteobacteria phylum, which have been increasingly found to have a key role in IBD.
“Changes in the two dominant phyla, Firmicutes and Bacteroidetes, are coupled with an increase in abundance of members of the Proteobacteria phylum, which have been increasingly found to have a key role in IBD.66”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [66]

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Detection of Campylobacter concisus and Other Campylobacter Species in Colonic Biopsies from Adults
Colitis, U., Mukhopadhya, I., Thomson, J. M., Hansen, R., Berry, S. H., El-omar, E. M., & Hold, G. L. (2013)
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Detection of campylobacter concisus in colonic biopsies from adult patients with ulcerative colitis
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Prevalence of Campylobacter Species in Adult Crohn's Disease and the Preferential Colonization Sites of Campylobacter Species in the Human Intestine
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Prevalence of Campylobacter species in adult Crohn’s disease and the preferential colonization sites of Campylobacter species in the human intestine. Plos One 6: e25417
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The possible relationship between Campylobacter spp./Arcobacter spp. and patients with ulcerative colitis
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Authors: Mukhopadhya, I., Thomson, J. M., Hansen, R., Berry, S. H., El-Omar, E. M., & Hold, G. L.
Affiliations: University of Aberdeen (GB)
Corresponding author: Hold, Georgina L.
ORCID: Mukhopadhya, Indrani
Hansen, Richard
El-Omar, Emad M.
Hold, Georgina L.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2011-06-27
Volume: 6
Issue: 6
Pages: e21490
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0021490
PMC: PMC3124515
OpenAlex: W2100955999
Cited by: 145
References: 42
Citations by year: 2026: 1 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 7 · 2016: 13 · 2015: 14 · 2014: 15 · 2013: 12 · 2012: 12
FWCI: 8.58
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion, other-oa)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Campylobacter concisus, Campylobacter ureolyticus, ulcerative colitis, colonic biopsy, inflammatory bowel disease, bacterial etiology, adults, chronic inflammation, prevalence, nested PCR, DNA detection
MeSH terms: Adult, Campylobacter, Campylobacter Infections, Colitis, Ulcerative, Colon, Humans, Molecular Sequence Data, Polymerase Chain Reaction

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Detection of Campylobacter concisus and Other Campylobacter Species in Colonic Biopsies from Adults with Ulcerative Colitis

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