Cited by 229Schizophrenia research and treatmentMicroRNA in disease regulationTryptophan and brain disorders

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MicroRNA Expression Aberration as Potential Peripheral Blood Biomarkers for Schizophrenia

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Lai, Chi-Yu, Yu, Sung-Liang, Hsieh, Ming H., Chen, Chun-Houh, Chen, Hsuan-Yu, Wen, Chun-Chiang, Huang, Yung-Hsiang, Hsiao, Po-Chang, Hsiao, Chuhsing Kate, Liu, Chih-Min, Yang, Pan-Chyr, Hwu, Hai-Gwo, Chen, Wei J.·2011·PLoS ONE

DOI 10.1371/journal.pone.0021635PMC PMC3126851

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Abstract

Since brain tissue is not readily accessible, a new focus in search of biomarkers for schizophrenia is blood-based expression profiling of non-protein coding genes such as microRNAs (miRNAs), which regulate gene expression by inhibiting the translation of messenger RNAs. This study aimed to identify potential miRNA signature for schizophrenia by comparing genome-wide miRNA expression profiles in patients with schizophrenia vs. healthy controls. A genome-wide miRNA expression profiling was performed using a Taqman array of 365 human miRNAs in the mononuclear leukocytes of a learning set of 30 cases and 30 controls. The discriminating performance of potential biomarkers was validated in an independent testing set of 60 cases and 30 controls. The expression levels of the miRNA signature were then evaluated for their correlation with the patients' clinical symptoms, neurocognitive performances, and neurophysiological functions. A seven-miRNA signature (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) was derived from a supervised classification with internal cross-validation, with an area under the curve (AUC) of receiver operating characteristics of 93%. The putative signature was then validated in the testing set, with an AUC of 85%. Among these miRNAs, miR-34a was differentially expressed between cases and controls in both the learning (P = 0.005) and the testing set (P = 0.002). These miRNAs were differentially correlated with patients' negative symptoms, neurocognitive performance scores, and event-related potentials. The results indicated that the mononuclear leukocyte-based miRNA profiling is a feasible way to identify biomarkers for schizophrenia, and the seven-miRNA signature warrants further investigation.

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Authors: Lai, C.-Y., Yu, S.-L., Hsieh, M. H., Chen, C.-H., Chen, H.-Y., Wen, C.-C., Huang, Y.-H., Hsiao, P.-C., Hsiao, C. K., Liu, C.-M., Yang, P.-C., Hwu, H.-G., & Chen, W. J.
Affiliations: National Taiwan University (TW)
Institute of Statistical Science, Academia Sinica (TW)
Corresponding author: Chen, Wei J.
ORCID: Lai, Chi-Yu
Yu, Sung-Liang
Hsieh, Ming H.
Chen, Chun-Houh
Chen, Hsuan-Yu
Huang, Yung-Hsiang
Hsiao, Po-Chang
Hsiao, Chuhsing Kate
Liu, Chih-Min
Yang, Pan-Chyr
Hwu, Hai-Gwo
Chen, Wei J.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2011-06-29
Volume: 6
Issue: 6
Pages: e21635
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0021635
PMC: PMC3126851
OpenAlex: W2065980876
Cited by: 228
References: 75
Citations by year: 2026: 6 · 2025: 7 · 2024: 13 · 2023: 6 · 2022: 8 · 2021: 18 · 2020: 10 · 2019: 13 · 2018: 18 · 2017: 20 · 2016: 25 · 2015: 18 · 2014: 29 · 2013: 20 · 2012: 12
FWCI: 14.31
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: National Science Council (NSC98-2314-B-002-125-MY3)
National Health Research Institutes (NHRI-EX99-9511PP)
National Taiwan University (97R0337, 97HP0071, 97HP0023)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: schizophrenia, microRNA expression, peripheral blood biomarkers, microRNA signature, mononuclear leukocytes, miR-34a, negative symptoms, neuropsychological performance, event-related potentials, blood-based diagnosis
MeSH terms: Humans, Schizophrenia, Biomarkers, Case-Control Studies, MicroRNAs

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MicroRNA Expression Aberration as Potential Peripheral Blood Biomarkers for Schizophrenia

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