STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

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Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

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Dextran Sodium Sulfate-induced Colitis as a Model for Sarcopenia in Mice

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Muscle allele-specific expression QTLs may affect meat quality traits in Bos indicus

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Nutritional Assessment in Cancer Patients

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Ectodysplasin A2 receptor signaling in skeletal muscle pathophysiology

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The Proteolytic Systems of Muscle Wasting

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Repeated eccentric contractions positively regulate muscle oxidative metabolism and protein synthesis during cancer cachexia in mice

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Mechanisms and pharmacotherapy of cancer cachexia‐associated anorexia

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Systemic Actions of Breast Cancer Facilitate Functional Limitations

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eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways

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Effect of Ninjin’yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice

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Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine

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Sosiho-tang ameliorates cachexia-related symptoms in mice bearing colon 26 adenocarcinoma by reducing systemic inflammation and muscle loss

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Effect of Changes in Skeletal Muscle Mass on Oncological Outcomes During First-Line Sunitinib Therapy for Metastatic Renal Cell Carcinoma

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Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise

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Caloric restriction is associated with preservation of muscle strength in experimental cancer cachexia

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Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia

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Distinct glycolytic pathway regulation in liver, tumour and skeletal muscle of mice with cancer cachexia

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Hepatic signal transducer and activator of transcription‐3 signalling drives early‐stage pancreatic cancer cachexia via suppressed ketogenesis

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Skeletal muscle omics signatures in cancer cachexia: perspectives and opportunities

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The relationship of nutritional status with anticancer immunity and its prognostic value for head and neck cancer

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Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death

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α-Hydroxyisocaproic Acid Decreases Protein Synthesis but Attenuates TNFα/IFNγ Co-Exposure-Induced Protein Degradation and Myotube Atrophy via Suppression of iNOS and IL-6 in Murine C2C12 Myotube

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Mechanisms of Ovarian Cancer-Associated Cachexia

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Cancer-associated muscle weakness - From triggers to molecular mechanisms

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Systemic inflammation in chronic obstructive pulmonary disease and lung cancer

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Metabolic regulation in adult and aging skeletal muscle stem cellsPreprint

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ADAR2 deficiency ameliorates non‐alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1

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An Analysis of Differentially Expressed Coding and Long Non-Coding RNAs in Multiple Models of Skeletal Muscle Atrophy

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Brucea javanicaoil emulsion alleviates cachexia induced by Lewis lung cancer cells in mice

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Variable inflammation and intramuscular STAT 3 phosphorylation and myeloperoxidase levels after downhill running

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Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic opportunities

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Skeletal Muscle Metrics on Clinical 18 F- FDG PET/CT Predict Health Outcomes in Patients with SarcomaPreprint

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Cancer cachexia: A tumor-driven disorder of whole-body homeostasis

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Activation of the β-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production

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Deliberation on debilitating condition of cancer cachexia: Skeletal muscle wasting

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FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy

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The response of muscle progenitor cells to cutaneous thermal injury

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Muscle protein kinetics in cancer cachexia

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New developments in investigational HDAC inhibitors for the potential multimodal treatment of cachexia

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Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting

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The Effect of Mechanical Stretch on Myotube Growth Suppression by Colon-26 Tumor-Derived Factors

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Muscle‐specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long‐term mechanical ventilation and immobilization in rats

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The Etiology and Impact of Muscle Wasting in Metastatic CancerPreprint

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Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential

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Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

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Tocilizumab in combination with corticosteroids: potential for managing cancer cachexia with systemic hyperinflammation

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Novel investigational drugs mimicking exercise for the treatment of cachexia

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IFIT2‐depleted metastatic oral squamous cell carcinoma cells induce muscle atrophy and cancer cachexia in mice

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Preclinical characterization of the JAK/STAT inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content

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Neuregulin-1β modulates myogenesis in septic mouse serum-treated C2C12 myotubes in vitro through PPARγ/NF-κB signaling

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Complement pathway activation mediates pancreatic cancer–induced muscle wasting and pathological remodeling

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Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia

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Surgical inflammatory stress: the embryo takes hold of the reins again

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Walker-256 Tumour-Induced Cachexia Altered Liver Metabolomic Profile and Function in Weanling and Adult Rats

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DPA shows comparable chemotherapy sensitizing effects as EPA upon cellular incorporation in tumor cells

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Role of Masticatory Force in Modulating Jawbone Immunity and Bone Homeostasis: A Review

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Mechanism-Based Therapeutic Approaches to Cachexia

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Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia

Aquila, G., Cecconi, A. D. R., Forti, M., Frapolli, R., Bello, E., Novelli, D., Russo, I., Licandro, S. A., Staszewsky, L. I., Martinelli, G. B., et al. (2020) · Cancers · doi:10.3390/cancers12082312 · Cited by 7

Inflammation and Wasting of Skeletal Muscles in Kras-p53-Mutant Mice with Intraepithelial Neoplasia and Pancreatic Cancer—When Does Cachexia Start?

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Muscle Homeostasis Is Disrupted in Burned Adults

Clark, A. T., Song, J., Xiao, Y., Carlson, D., Huebinger, R. M., Liu, M. M., Madni, T. D., Imran, J. B., Taveras, L. R., Weis, H. B., et al. (2019) · Journal of Burn Care & Research · doi:10.1093/jbcr/irz190 · Cited by 7

β‑carotene attenuates muscle wasting in cancer cachexia by regulating myogenesis and muscle atrophy

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Brassinin alleviates cancer cachexia by suppressing diverse inflammatory mechanisms in mice

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Pancreatic cancer cachexia: A systemic consequence of multi-organ interactions

Xiao, A., Feng, Y., Yin, B., Zhang, J., Cao, Z., Liu, X., Liang, Y., & Wu, W. (2025) · hLife · doi:10.1016/j.hlife.2025.05.002 · Cited by 6

Scutellarein attenuates cancer cachexia-induced muscle atrophy via targeted inhibition of the JAK/STAT pathway

Ahn, H., Kim, H., Yoon, Y., Jeong, M., Lee, S., Chen, P., Wang, K., Park, S., Kim, J. H., Ahn, J., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.001 · Cited by 5

Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia

Cabrera, A. R., Jones, R. G., Schrems, E. R., da Silva, F. M., Wen, Y., Washington, T. A., Murach, K. A., & Greene, N. P. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00751.2025 · Cited by 6

Single‐Cell RNA‐Sequencing Reveals Cachectic Satellite Cell Population in Muscle of Male Mice With Cancer Cachexia

Brown, A., Collao, N., Saleh, A., Strong, N., Lisio, M. D., & Wiper‐Bergeron, N. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70260 · Cited by 5

The Conjugated Bile Acids Profile Suggests a Novel Liver‐Muscle Axis Associated With Sarcopenia in Chronic Liver Disease

Iwasa, M., Eguchi, A., Kohjima, M., Miyazaki, T., Kitamura, H., Takami, Y., Yamashita, N., Tempaku, M., Izuoka, K., Kobayashi, Y., et al. (2026) · Liver International · doi:10.1111/liv.70612 · Cited by 5

EDA2R-NIK signaling in cancer cachexia

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Height‐adjusted lean body mass and its associations with physical activity and kidney function in pediatric kidney transplantation

Ahmed, A., Coté, A. T., Lui, S., & Blydt‐Hansen, T. D. (2021) · Pediatric Transplantation · doi:10.1111/petr.14128 · Cited by 5

Skeletal muscle proteome expression differentiates severity of cancer cachexia in mice and identifies loss of fragile X mental retardation syndrome‐related protein 1

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The Role of Interleukin-6/GP130 Cytokines in Cancer Cachexia

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Molecular Regulation and Rejuvenation of Muscle Stem (Satellite) Cell Aging

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Cellular mechanisms promoting cachexia and how they are opposed by sirtuins

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The Impact of Non-bone Metastatic Cancer on Musculoskeletal Health

Galiana-Melendez, F., & Huot, J. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00872-4 · Cited by 2

Nutritional Support for Patients with Pancreatic Cancer

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Dysphagia of cachexia and sarcopenia

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Diet-induced obesity does not exacerbate cachexia in male mice bearing Lewis-lung carcinoma tumors

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GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice

Huot, J. R., Jamnick, N. A., Pin, F., Livingston, P. D., Callaway, C. S., Morrow, S. K., & Bonetto, A. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00035.2025 · Cited by 4

Assessing Metabolic Dysregulation in Muscle During Cachexia

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Effects of whole-body vibration training in a cachectic C26 mouse model

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Resistance-Based Muscle Therapy, Frailty, and Muscle Biopsy Findings in Kidney Transplant Candidates: A Clinical Trial

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Liver metabolism in cardiac cachexia

Springer, J., von Haehling, S., & Anker, S. D. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.019 · Cited by 3

Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42Preprint

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Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia

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Increased Myocardial MAO-A, Atrogin-1, and IL-1β Expression in Transgenic Mice with Pancreatic Carcinoma—Benefit of MAO-A Inhibition for Cardiac Cachexia

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JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food IntakePreprint

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Coptis japonica Makino ethanol extracts attenuates cancer cachexia induced muscle and fat wasting through inhibition of the STAT3 signaling pathway

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Formation of Liver Metastases Is Accompanied by Accelerated Musculoskeletal Deficits in LLC Tumor Hosts

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MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia

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STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer

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JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

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STAT3 in the systemic inflammation of cancer cachexia

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Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

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IL-17A contributes to skeletal muscle atrophy in lung cancer-induced cachexia via JAK2/STAT3 pathway

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