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The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans
Open accessAbstract
Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.
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Cites
Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03295.2003 · Cited by 1,425
Life and Death of Neurons in the Aging Brain
Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344
The impact of aging and gender on brain viscoelasticity
Sack, I., Beierbach, B., Wuerfel, J., Klatt, D., Hamhaber, U., Papazoglou, S., Martus, P., & Braun, J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.040 · Cited by 423
Self-citationAge- and sex-related effects on the neuroanatomy of healthy elderly
Lemaître, H., Crivello, F., Grassiot, B., Alpérovitch, A., Tzourio, C., & Mazoyer, B. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.042 · Cited by 280
Cited by
Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
Budday, S., Ovaert, T. C., Holzapfel, G. A., Steinmann, P., & Kuhl, E. (2020) · Archives of Computational Methods in Engineering · doi:10.1007/s11831-019-09352-w · Cited by 469
The soft mechanical signature of glial scars in the central nervous system
Moeendarbary, E., Weber, I. P., Sheridan, G. K., Koser, D. E., Soleman, S., Haenzi, B., Bradbury, E. J., Fawcett, J., & Franze, K. (2017) · Nature Communications · doi:10.1038/ncomms14787 · Cited by 406
Arani, A., Murphy, M. C., Glaser, K. J., Manduca, A., Lake, D. S., Kruse, S. A., Jack, C. R., Ehman, R. L., & Huston, J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.016 · Cited by 236
General review of magnetic resonance elastography
Low, G. (2016) · World Journal of Radiology · doi:10.4329/wjr.v8.i1.59 · Cited by 123
Hiscox, L. V., Johnson, C. L., McGarry, M. D. J., Perrins, M., Littlejohn, A., van Beek, E. J. R., Roberts, N., & Starr, J. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.01.010 · Cited by 118
Metadata
- Authors
- Sack, I., Streitberger, K.-J., Krefting, D., Paul, F., & Braun, J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-09-12
- Volume
- 6
- Issue
- 9
- Pages
- e23451
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2054989377
- Cited by
- 189
- References
- 4
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sack, I., Streitberger, K.-J., Krefting, D., Paul, F., & Braun, J. (2011). The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans. PLoS ONE. https://doi.org/10.1371/journal.pone.0023451
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