The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors
Open accessAbstract
BACKGROUND: Platelets are involved in the thromboses that are central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks in the morning (~9 AM), potentially related to endogenous circadian clock control of platelet activation. The objective was to test if the human endogenous circadian system influences (1) platelet function and (2) platelet response to standardized behavioral stressors. We also aimed to compare the magnitude of any effects on platelet function caused by the circadian system with that caused by varied standardized behavioral stressors, including mental arithmetic, passive postural tilt and mild cycling exercise. METHODOLOGY/PRINCIPAL FINDINGS: We studied 12 healthy adults (6 female) who lived in individual laboratory suites in dim light for 240 h, with all behaviors scheduled on a 20-h recurring cycle to permit assessment of endogenous circadian function independent from environmental and behavioral effects including the sleep/wake cycle. Circadian phase was assessed from core body temperature. There were highly significant endogenous circadian rhythms in platelet surface activated glycoprotein (GP) IIb-IIIa, GPIb and P-selectin (6-17% peak-trough amplitudes; p ≤ 0.01). These circadian peaks occurred at a circadian phase corresponding to 8-9 AM. Platelet count, ATP release, aggregability, and plasma epinephrine also had significant circadian rhythms but with later peaks (corresponding to 3-8 PM). The circadian effects on the platelet activation markers were always larger than that of any of the three behavioral stressors. CONCLUSIONS/SIGNIFICANCE: These data demonstrate robust effects of the endogenous circadian system on platelet activation in humans--independent of the sleep/wake cycle, other behavioral influences and the environment. The 9 AM timing of the circadian peaks of the three platelet surface markers, including platelet surface activated GPIIb-IIIa, the final common pathway of platelet aggregation, suggests that endogenous circadian influences on platelet function could contribute to the morning peak in adverse cardiovascular events as seen in many epidemiological studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There are also effects of the circadian system on platelet activation, with a morning peak in platelet surface-activated GPIIb-IIIa, the final part of the platelet aggregation pathway (115).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [115]
In the citing paper
“Platelet count and aggregability peaked at a circadian phase equivalent to 3–8 PM”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Scheer et al., 2011
In the citing paper
“platelet size and surface expressions of activated GPIIb-IIIa, P-selectin, and GP1b were all greatest during the biological morning, corresponding to 6 AM to noon”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Scheer et al., 2011
In the citing paper
“The reactivity of the above platelet measures to mental, postural, and physical stress was not significantly influenced by the circadian timing system, and thus, the influence of the circadian timing system and that of behavioral stressors appear to be additive”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Scheer et al., 2011
In the citing paper
“Recent work has demonstrated in healthy humans that platelet size, count, aggregability, and platelet surface expression of activated GPIIb-IIIa, P-selectin, and GP1b—factors involved in the pathway of platelet aggregation and adhesion to subendothelial tissue (Merten et al., 2000; Phillips et al., 1988; Sadler, 1998)—are influenced by the circadian timing system”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Scheer et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Self-citationResetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
Ruggeri, Z. M. (2002) · Nature Medicine · doi:10.1038/nm1102-1227 · Cited by 1,605
Circadian variation in the frequency of sudden cardiac death.
Muller, J. E., Ludmer, P. L., Willich, S. N., Tofler, G. H., Aylmer, G., Klangos, I., & Stone, P. H. (1987) · Circulation · doi:10.1161/01.cir.75.1.131 · Cited by 1,083
Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler, C. A., Rutherford, J. D., Willich, S. N., Gleason, R. E., Williams, G. H., & Muller, J. E. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706113162405 · Cited by 1,072
Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.
Shattil, S. J., Hoxie, J. A., Cunningham, M. C., & Brass, L. F. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39154-8 · Cited by 942
Circadian clocks in human red blood cells
O'Neill, J. S., & Reddy, A. B. (2011) · Nature · doi:10.1038/nature09702 · Cited by 843
Increased risk of ischaemic heart disease in shift workers
Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91619-3 · Cited by 459
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 205
Freynhofer, M. K., Hein-Rothweiler, R., Haller, P. M., Aradi, D., Dézsi, D. A., Groß, L., Orban, M., Trenk, D., Geisler, T., Huczek, Z., et al. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1677549 · Cited by 16
Diurnal regulation of sphingolipids in blood
Brunkhorst, R., Pfeilschifter, W., Rajkovic, N., Pfeffer, M., Fischer, C., Korf, H., Christoffersen, C., Trautmann, S., Thomas, D., Pfeilschifter, J. M., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.12.001 · Cited by 17
Delisle, B. P., George, A. L., Nerbonne, J. M., Bass, J. T., Ripplinger, C. M., Jain, M. K., Hermanstyne, T. O., Young, M. E., Kannankeril, P. J., Duffy, J. F., et al. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.010190 · Cited by 16
Self-citationThe Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective
Huang, W., Zong, J., Zhang, Y. L., Zhou, Y., Zhang, L., Wang, Y., Shan, Z., Xie, Q., Li, M., Pan, S., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0921 · Cited by 16
Development of circadian neurovascular function and its implications
Mitchell, J. W., & Gillette, M. U. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1196606 · Cited by 13
DeVaughn, H., Rich, H. E., Shadid, A., Vaidya, P. K., Doursout, M., & Shivshankar, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312823 · Cited by 14
du Pré, B. C., van Veen, T. A. B., Crnko, S., Vos, M. A., Deddens, J. C., Doevendans, P. A., & Laake, L. W. V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081670 · Cited by 13
Traverse, J. H. (2013) · Circulation Research · doi:10.1161/circresaha.113.301079 · Cited by 13
Song, Z., Yan, M., Zhang, S., Hu, B., Qing, X., Shao, Z., Chen, S., Lv, X., & Liu, H. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102633 · Cited by 12
Abuelazm, M. T., Saleh, O. M., AlBarakat, M. M., Katamesh, B. E., Abdalshafy, H., Mahmoud, A., & Abdelazeem, B. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003508 · Cited by 11
Tian, H., Zhao, X., Zhang, Y., & Xia, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28738 · Cited by 11
Downregulation of platelet activation markers during long-term immobilization
Arinell, K., Fröbert, O., Blanc, S., Larsson, A. O., & Christensen, K. (2012) · Platelets · doi:10.3109/09537104.2012.715215 · Cited by 11
Circadian-time dependent tolerance and haematological toxicity to isoniazid in murine
Souayed, N., Chennoufi, M., Boughattas, F., Hassine, M., Attia, M. B., Aouam, K., Reinberg, A., & Boughattas, N. A. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.02.026 · Cited by 11
on behalf on the AMIS Plus Investigators, Fournier, S., Müller, O., Benedetto, U., Roffi, M., Pilgrim, T., Eberli, F. R., Rickli, H., Radovanović, D., Erné, P., et al. (2017) · Clinical Research in Cardiology · doi:10.1007/s00392-017-1189-8 · Cited by 10
Erdoğdu, M., Yüksel, M. F., Işık, B., Boyalı, E., Erdağı, K., & Sevindi, T. (2021) · Journal of Men s Health · doi:10.31083/jomh.2021.106 · Cited by 10
Lo, M.-T., Bandín, C., Yang, H.-W., Scheer, F. A. J. L., Hu, K., & Garaulet, M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.168 · Cited by 10
Self-citationAntimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions
Pezzanite, L. M., Chow, L., DOW, S. W., Goodrich, L. R., Gilbertie, J. M., & Schnabel, L. V. (2023) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2023.06.005 · Cited by 9
Can we improve the efficacy of low-dose aspirin?
Storey, R. F., Kristensen, S., & Grove, E. L. (2014) · Thrombosis and Haemostasis · doi:10.1160/th14-08-0702 · Cited by 9
Aradi, D., Sibbing, D., & Groß, L. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-05-0430 · Cited by 9
Circadian Dysregulation in Mental and Physical Health
Abbott, S. M., Malkani, R. G., & Zee, P. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00039-8 · Cited by 9
Circadian variation of ticagrelor-induced platelet inhibition in healthy adulty
Fournier, S., Guenat, F., Fournier, A., Alberio, L., Bonny, O., Calderara, D. B., Bardy, D., Lauriers, N., Harbaoui, B., Monney, P. A., et al. (2018) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvy003 · Cited by 9
Analysis of the Redox Oscillations in the Circadian Clockwork
Milev, N. B., Rey, G., Valekunja, U. K., Edgar, R. S., O'Neill, J. S., & Reddy, A. B. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.10.007 · Cited by 9
Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers
van den Brink, W. J., Oosterman, J. E., Smid, D. J., de Vries, H., Atsma, D. E., Overeem, S., & Wopereis, S. (2025) · Digital Health · doi:10.1177/20552076241288724 · Cited by 8
Circadian Rhythms and Acute Coronary Syndrome in the Elderly
Rueda, C. D., Díez‐Villanueva, P., Bonanad, C., & Alfonso, F. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2703082 · Cited by 8
Böhm, A., Lauko, V., Dostalova, K., Balanova, I., Varga, I., Bezák, B., Jajcay, N., Moravčík, R., Lazurova, L., Slezak, P., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02102-7 · Cited by 8
Das, S., Khan, R., Banerjee, S., Ray, S., & Ray, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04178-5 · Cited by 9
Albackr, H. B., AlHabib, K. F., Alshamiri, M. Q., Ullah, A. A., Subaie, F. A. A., Alghamdi, A. G., AlFaleh, H., Kashour, T. S., Suwaidi, J. M. S. A., Alsheikh-Ali, A. A. A., et al. (2018) · Angiology · doi:10.1177/0003319718797470 · Cited by 8
van Diemen, J. J. K., Madsen, M. C., Vrancken, P. M.-J., de Bie, K. C. C., van der Bom, J. G., Veen, G., Bonten, T. N., Fuijkschot, W. W., Smulders, Y. M., & Thijs, A. (2020) · Platelets · doi:10.1080/09537104.2020.1809643 · Cited by 8
Kıvrak, A., & Yıldırım, A. (2023) · Kardiologia Polska · doi:10.33963/kp.a2023.0150 · Cited by 8
Clopidogrel: A multifaceted affair
Martínez‐Quintana, E., & Tugores, A. (2014) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.413 · Cited by 8
Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage
Benedusi, M., Frigato, E., Bertolucci, C., & Valacchi, G. (2021) · Atmosphere · doi:10.3390/atmos12010116 · Cited by 8
Acute Impact of Different Exercise Modalities on Arterial and Platelet Function
Haynes, A., Linden, M. D., Robey, E., Watts, G. F., Barrett, P. H. R., Naylor, L. H., & GREEN, D. J. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001505 · Cited by 10
Eveningness is associated with coronary artery calcification in a middle-aged Swedish population
Frisk, M. K., Fagman, E., Arvidsson, D., Ekblom, Ö. B., Börjesson, M., Bergström, G. M. L., & Zou, D. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.11.004 · Cited by 7
Wake-up stroke-Amendable for thrombolysis-like stroke with known onset time?
Kurz, M. W., Advani, R., Behzadi, G. I. N., Eldøen, G., Farbu, E., & Kurz, K. D. (2016) · Acta Neurologica Scandinavica · doi:10.1111/ane.12686 · Cited by 7
PAI at breakfast (whether you like it or not)
Young, M. E. (2014) · Blood · doi:10.1182/blood-2013-11-538330 · Cited by 7
Human circadian rhythms and exercise: Significance and application in real-life situations
Mizuno, K. (2014) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.3.307 · Cited by 5
Hearn, J. I., Alhilali, M., Kim, M., Kalev‐Zylinska, M. L., & Poulsen, R. C. (2023) · Platelets · doi:10.1080/09537104.2023.2206918 · Cited by 6
Features of Circadian Rhythms in Patients with Cerebrovascular Diseases
Kostenko, E. V., & Петрова, Л. В. (2018) · InTech eBooks · doi:10.5772/intechopen.75963 · Cited by 6
Sleep disorders and circadian rhythms in diseases of the cardiovascular system
Kostenko, E. V., Петрова, Л. В., Ахматовна, Э. М., & Kamchatnov, P. R. (2015) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20151153130-36 · Cited by 6
Turton, H. A., Pickworth, J. A., Paterson, G. G., Lawrie, A., Baillie, J. K., & Thompson, A. A. R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.825819 · Cited by 6
Yoshizaki, T., Ishihara, J., Kotemori, A., Kokubo, Y., Saito, I., Yatsuya, H., Yamagishi, K., Sawada, N., Iwasaki, M., Iso, H., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20019-8 · Cited by 7
Ecin, S. M., & Gezer, D. (2023) · Medicine · doi:10.1097/md.0000000000036532 · Cited by 5
Improved implementation of aspirin in pregnancy among Dutch gynecologists: Surveys in 2016 and 2021
de Weg, J. M. B., Visser, L., Oudijk, M. A., de Vries, J. I. P., de Groot, C. J. M., & de Boer, M. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268673 · Cited by 5
Pires, C. M., Lamas, D., Gaspar, A., Lourenço, A. P., Antunes, N., Marques, J. H. S., & Leite-Moreira, A. F. (2023) · Heart and Vessels · doi:10.1007/s00380-023-02247-8 · Cited by 5
Circadian Rhythm of Deaths in a Cardiology Department: A Five-Year Analysis
Vicent, L., González‐Casal, D., Bruña, V., Devesa, C., García-Carreño, J., Sousa-Casasnovas, I., Juárez, M., Fernández‐Avilés, F., & Martínez‐Sellés, M. (2020) · Cardiology · doi:10.1159/000505682 · Cited by 5
Modeling Circadian Fluctuations of Pharmacokinetic Parameters
Véronneau‐Veilleux, F., & Bélair, J. (2017) · Mathematical Modelling of Natural Phenomena · doi:10.1051/mmnp/201712509 · Cited by 5
Baert, V., Vilhelm, C., Escutnaire, J., Marc, J.-B., Wiel, É., Tazarourte, K., Goldstein, P., Khoury, C. E., Hubert, H., Génin, M., et al. (2020) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.13390 · Cited by 5
Schoergenhofer, C., Schwameis, M., Brunner, M., Zeitlinger, M. A., Winkler, F., Jilma, B., & Brunner‐Ziegler, S. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2015.1057896 · Cited by 5
Effect of KLF15-Mediated Circadian Rhythm on Myocardial Infarction: A Narrative Review
Zhao, J., Chen, Z., Yang, J., Duan, L., Yang, H. Y., Cai, D., & Zhao, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104831 · Cited by 5
Diurnal rhythm of the human plasma proteome
Jóhönnuson, E. M. S., Sennels, H. P., Jørgensen, H. L., Hannibal, J., Yeung, C. C., Rasmussen, C. B., Pruś, G., Albrechtsen, N. J. W., & Nielsen, A. B. (2025) · Clinical Proteomics · doi:10.1186/s12014-025-09551-7 · Cited by 4
Mousavi, S. A., Hermundstad, B., Flesland, A., Llohn, A. H., & Saether, P. C. (2022) · Journal of Blood Medicine · doi:10.2147/jbm.s362461 · Cited by 4
Behnes, M., Lahu, S., Ndrepepa, G., Menichelli, M., Mayer, K., Wöhrle, J., Bernlochner, I., Gewalt, S., Witzenbichler, B., Hochholzer, W., et al. (2022) · Clinical Research in Cardiology · doi:10.1007/s00392-022-02040-z · Cited by 4
Sleep Impairments and Circadian Rhythms in Diseases of the Cardiovascular System
Kostenko, E. V., Петрова, Л. В., Ахматовна, Э. М., & Kamchatnov, P. R. (2016) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-016-0298-6 · Cited by 4
Factors Associated with Medicine Timing Effects: A Meta-analysisPreprint
Ruben, M. D., Francey, L. J., Wu, G., Smith, D. F., FitzGerald, G. A., Hughey, J., & Hogenesch, J. B. (2021) · medRxiv · doi:10.1101/2021.10.24.21265348 · Cited by 4
Aneurysmal subarachnoid hemorrhage occurring during sleep: Clinical characteristics and risk factors
Inamasu, J., Akiyama, T., Akaji, K., Inaba, M., Nishimoto, M., Kojima, A., Terao, S., Hayashi, T., Mizutani, K., & Toda, M. (2024) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2024.107591 · Cited by 3
Bailey, C. P., Elmi, A. F., Qian, J., DiPietro, L., Tackney, M. S., & Napolitano, M. A. (2024) · Annals of Behavioral Medicine · doi:10.1093/abm/kaae084 · Cited by 4
Panzer, B., Wadowski, P. P., Huber, K., Panzer, S., & Gremmel, T. (2022) · Vascular Pharmacology · doi:10.1016/j.vph.2022.107089 · Cited by 3
Ma, T., Sirard, J. R., & Jennings, L. (2023) · Journal of Physical Activity and Health · doi:10.1123/jpah.2022-0505 · Cited by 3
Complex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells
Sciarra, F., Franceschini, E., Palmieri, G., & Venneri, M. A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117803 · Cited by 3
Embolic stroke of undetermined source (ESUS) cohort of Brazilian patients in a university hospital
Módolo, G. P., de Souza, J. T., Winckler, F. C., Ferreira, N. C., Lange, M. C., Avelar, W. M., Minicucci, M. F., de Freitas, C. C. M., Azevedo, P. S., Luvizutto, G. J., et al. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190045 · Cited by 3
Zar, A., Ahmadi, F., Krustrup, P., & Fernandes, R. J. (2020) · Middle East Journal of Rehabilitation and Health Studies · doi:10.5812/mejrh.104417 · Cited by 3
Hemostatic abnormalities in diabetes mellitus
Ajjan, R., & Grant, P. J. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch72 · Cited by 3
Sim, J., Park, Y., Park, B., Choi, Y., Lim, J. S., Ha, S., & Kim, J. U. (2025) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2025.111879 · Cited by 2
Coşkun, A. B., Elibol, E., & Ozer, S. D. (2025) · Cureus · doi:10.7759/cureus.86751 · Cited by 2
Circadian clock regulation of hemostasis: a systematic review of molecular pathways
Ibrahim, Z., Murphy, R. P., Cornélissen, G., Arya, R., & Goswami, N. (2026) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2026.106642 · Cited by 5
Okeke Chizoba, O., Emmanuel, M., Akosile Christopher, O., & Ani, K. U. (2020) · International Journal of Sport Exercise and Health Research · doi:10.31254/sportmed.4209 · Cited by 2
Effects of environmental and social stressors on biological rhythms
Sakakibara, H., Yasuda, M. T., & Shimoi, K. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.143 · Cited by 2
Alibhai, F. J., Tsimakouridze, E. V., Reitz, C. J., Pyle, W. G., & Martino, T. A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3450-8_8 · Cited by 1
CIRCADIAN PATTERN OF DEEP VEIN THROMBOSIS - TRUE OR FALSE
Damnjanović, Z. (2018) · Acta Medica Medianae · doi:10.5633/amm.2018.0409 · Cited by 2
Masiewicz, S., Gutovitz, S., Hart, L. B., Leaman, S. M., & Jehle, D. V. K. (2020) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2020.01.002 · Cited by 2
Ekechukwu, E. N. D., Omotosho, I. O., & Hamzat, T. K. (1970) · African Journal of Physiotherapy and Rehabilitation Sciences · doi:10.4314/ajprs.v9i1-2.1 · Cited by 2
GLAUCOMA: SECRETS OF SILENT THIEF OF VISION – A REVIEW
Opeyemi, O. T. (2017) · Universal Journal of Pharmaceutical Research · doi:10.22270/ujpr.v2i3.rw3 · Cited by 1
Searching for Order in Body Clocks: Circadian Rhythms and Redox Balance
del Olmo, M. (2021) · Logos Verlag Berlin eBooks · doi:10.30819/5406 · Cited by 1
Abbott, S. M. (2026) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/cont.0000000000001727 · Cited by 1
Circadian rhythm in platelet: an emerging therapeutic target in human diseases
Wang, Z., Chen, Z., Li, F., Chen, L., & Xiong, G. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1795526 · Cited by 1
Treweeke, A. T., Maskrey, B. H., Hickson, K. A., Miller, J. H., Leslie, S. J., & Megson, I. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147196 · Cited by 1
Bouali, I., Dridi, I., Gadacha, W., Aouam, K., Hassine, M., El-Bok, S., Boughattas, N. A., Ben‐Attia, M., Zaeid, S., & Souli, A. (2023) · Biological Rhythm Research · doi:10.1080/09291016.2023.2206088 · Cited by 1
Fan, B. E., Pasalic, L., Lippi, G., & Favaloro, E. J. (2025) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2025.05.018 · Cited by 1
Circadian Influences on Brain Damage, Regeneration, and Neurogenesis
Rakai, B. D. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25329
Fernandez, J. I. A. (2012) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/1115
Tsimakouridze, E. V. (2017) · The Atrium (University of Guelph)
Shin, J. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13497
Ardina, R., & Purbayanti, D. (2020) · Jurnal Surya Medika · doi:10.33084/jsm.v5i2.1295
Through the multidimensional looking glass: Novel perspectives on heart failure
Crnko, S. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/919
Prediction and Prevention of Preeclampsia
Staff, A. C., Umans, J. G., & Jeyabalan, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818417-2.00013-0
The role of the circadian system in cardiovascular diseases and clinical implications
Radomirović, M. (2022) · Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma · doi:10.5937/mgiszm2286007r
Joshi, K., Das, M., Sarma, A., Arora, M. K., Singhal, M., & Kumar, B. (2023) · Current Hypertension Reviews · doi:10.2174/1573402119666230109142156
Circadian Rhythms During the Hyperacute Phase of Wake-Up Stroke: An Exploratory StudyPreprint
Zhang, X., Chen, Z., Chen, Q., Yu, L., Cai, X., Zhao, H., Shi, H., Wang, H., & Fang, Q. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4631077
Bedeutung des circadianen Rhythmus für organisch bedingte Erkrankungen
Wiater, A. H. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-21054-9.00006-9
de Weg, J. M. B., van Doornik, R., Auweele, K. V., de Groot, C. J. M., de Boer, M. A., & de Vries, J. I. P. (2024) · European Journal of Midwifery · doi:10.18332/ejm/191161
Introduction to Circadian Rhythms
Rizvi, S. I., & Majumdar, G. (2024) · Springer eBooks · doi:10.1007/978-981-97-6695-6_1
Riaz, F. (2025) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.16265
Evaluation of Circadian Variation in Growth Factors of Platelet-Rich Fibrin: A Pilot Study
Özcan, M., Polat, G. A., Alkaya, B., Türer, O. U., Yilmaz, M. B., & Haytaç, M. C. (2025) · Journal of Visualized Experiments · doi:10.3791/68902
Louadi, Z., Elkjaer, M. L., Klug, M., Lio, C. T., Fenn, A. M., Illés, Z., Bongiovanni, D., Baumbach, J., Kacprowski, T., List, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17120378
Louadi, Z., Elkjaer, M. L., Klug, M., Lio, C. T., Fenn, A. M., Illés, Z., Bongiovanni, D., Baumbach, J., Kacprowski, T., List, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.17120420
Circadian troponin dynamics reveal sex-specific signals for acute coronary syndrome evaluation
Emakhu, J., Soman, S., Hawatian, K., Gill, J. K., Cook, B. C., McCord, J., & Miller, J. (2026) · Internal and Emergency Medicine · doi:10.1007/s11739-026-04341-x
Aydın, E., Sajedi, H., Erciş, S., Akpınar, S., Kaya, H. B., Khodadadi, D., & Babaei, M. (2026) · European Journal of Clinical Nutrition · doi:10.1038/s41430-026-01730-5
Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence
Belančić, A., Skelin, M., Lam, Y. W., Fajkić, A., Perkov-Stipičin, B., Roncato, R., Krečak, I., & Lucijanić, M. (2026) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70302
Lapiņa, L., Suhecka, K., Ziedone, G., & Kurjāne, N. (2026) · Biomedicines · doi:10.3390/biomedicines14081745
Metadata
- Authors
- Scheer, F. A. J. L., Michelson, A. D., Frelinger, A. L., Evoniuk, H., Kelly, E. E., McCarthy, M., Doamekpor, L. A., Barnard, M. R., & Shea, S. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Corresponding author
- Scheer, Frank A. J. L.
- Shea, Steven A.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-09-08
- Volume
- 6
- Issue
- 9
- Pages
- e24549
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3169622
- OpenAlex
- W2049166597
- Cited by
- 206
- References
- 36
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 16 · 2023: 18 · 2022: 19 · 2021: 16 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 13 · 2016: 8 · 2015: 18 · 2014: 14 · 2013: 7 · 2012: 5
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Brigham and Women's Hospital (M01 RR02635)
- Deutsches Krebsforschungszentrum
- National Institutes of Health (NIH-R01, NCRR-GCRC-M01-RR02635, RR‐02635)
- U.S. Public Health Service (NCRR-GCRC-M01-RR02635)
- National Heart, Lung, and Blood Institute (NIH-R01-HL76409, NIH-K24-HL076446, K24HL076446, NIH-P30-HL101299, R01HL076409, P30HL101299)
- National Center for Research Resources (RR02635, M01 RR 02635, GCRC-M01-RR02635, UL1RR025758, M01RR002635)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- circadian rhythm, platelet activation, morning surge, platelet membrane glycoproteins, GPIIb/IIIa, P-selectin, platelet aggregation, mental arithmetic, physical activity, epinephrine, ATP release, cardiovascular events
- MeSH terms
- Adult, Behavior, Blood Pressure, Body Temperature, Cardiovascular System, Circadian Rhythm, Female, Humans, Light, Male, Stress, Psychological, Temperature, Time Factors, Exercise, Platelet Activation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
