Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis.
Open accessAbstract
We previously reported that Candida albicans cell surface protein Hyr1 encodes a phagocyte killing resistance factor and active vaccination with a recombinant N-terminus of Hyr1 protein (rHyr1p-N), significantly protects immunocompetent mice from disseminated candidiasis. Here we report the marked efficacy of rHyr1p-N vaccine on improving the survival and reducing the fungal burden of disseminated candidiasis in both immunocompetent and immunocompromised mice using the FDA-approved adjuvant, alum. Importantly, we also show that pooled rabbit anti-Hyr1p polyclonal antibodies raised against 8 different peptide regions of rHyr1p-N protected mice in a hematogenously disseminated candidiasis model, raising the possibility of developing a successful passive immunotherapy strategy to treat this disease. Our data suggest that the rabbit anti-Hyr1p antibodies directly neutralized the Hyr1p virulence function, rather than enhanced opsonophagocytosis for subsequent killing by neutrophil in vitro. Finally, the rHyr1p-N vaccine was protective against non-albicans Candida spp. These preclinical data demonstrate that rHyr1p-N is likely to be a novel target for developing both active and passive immunization strategies against Candida infections.
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Hyr1 is a promising vaccine target for prevention of both C. albicans and Acinetobacter baumanii infections.
“Previous studies by our group indicate that Hyr1 is a promising vaccine target for prevention of both C. albicans and Acinetobacter baumanii infections [42–44].”
From Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection (2023) · cites this paper as [42]
The Results report that rHyr1p-N vaccination reduced fungal burden in mice challenged with C. albicans and other Candida species, supporting Hyr1 as a promising Candida vaccine target. Our copy does not report protection against Acinetobacter baumannii, so this source supports only the Candida part of the claim. (LLM, conf=0.88)
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Kaushik, M., Sharma, A., Gupta, S., & Gulati, P. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815080056123020008
Comparative genomic analysis of clinically relevant human skin-associated fungi
Agerbæk, S., Nielsen, K. N., Sølberg, J., Zhang, Y., Al-badran, Z., Stegger, M., Kabatnik, S., Mann, M., Clark, R. A., Saunte, D. M. L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74431-z
- Authors
- Luo, G., Ibrahim, A. S., French, S. W., Edwards, J. E., & Fu, Y.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Fu, Yue
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-10-10
- Volume
- 6
- Issue
- 10
- Pages
- e25909
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3189951
- OpenAlex
- W2076492225
- Cited by
- 62
- References
- 33
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 5 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institute of Allergy and Infectious Diseases (R03AI083251, R01AI019990, AI-063382, R21AI082414, R01-AI19990, R21AI066010, R01AI063382, R01AI063503)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida albicans, systemic candidiasis, active immunization, passive immunization, alum adjuvant, immunodeficient mice, non-albicans Candida, antifungal vaccines
- MeSH terms
- Adjuvants, Immunologic, Alum Compounds, Amino Acid Sequence, Animals, Antibodies, Fungal, Candida albicans, Candidiasis, Cross Reactions, Female, Fungal Proteins, Fungal Vaccines, Immunization, Passive, Immunocompetence, Mice, Inbred BALB C, Molecular Sequence Data, Peptide Fragments, Recombinant Proteins, Vaccination, Survival Rate, Immunocompromised Host, Mice
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