The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Genetic and Environmental Contributions to Weight, Height, and BMI from Birth to 19 Years of Age: An International Study of Over 12,000 Twin Pairs
Open accessAbstract
OBJECTIVE: To examine the genetic and environmental influences on variances in weight, height, and BMI, from birth through 19 years of age, in boys and girls from three continents. DESIGN AND SETTINGS: Cross-sectional twin study. Data obtained from a total of 23 twin birth-cohorts from four countries: Canada, Sweden, Denmark, and Australia. Participants were Monozygotic (MZ) and dizygotic (DZ) (same- and opposite-sex) twin pairs with data available for both height and weight at a given age, from birth through 19 years of age. Approximately 24,036 children were included in the analyses. RESULTS: Heritability for body weight, height, and BMI was low at birth (between 6.4 and 8.7% for boys, and between 4.8 and 7.9% for girls) but increased over time, accounting for close to half or more of the variance in body weight and BMI after 5 months of age in both sexes. Common environmental influences on all body measures were high at birth (between 74.1-85.9% in all measures for boys, and between 74.2 and 87.3% in all measures for girls) and markedly reduced over time. For body height, the effect of the common environment remained significant for a longer period during early childhood (up through 12 years of age). Sex-limitation of genetic and shared environmental effects was observed. CONCLUSION: Genetics appear to play an increasingly important role in explaining the variation in weight, height, and BMI from early childhood to late adolescence, particularly in boys. Common environmental factors exert their strongest and most independent influence specifically in pre-adolescent years and more significantly in girls. These findings emphasize the need to target family and social environmental interventions in early childhood years, especially for females. As gene-environment correlation and interaction is likely, it is also necessary to identify the genetic variants that may predispose individuals to obesity.
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Cites
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Methodology for Genetic Studies of Twins and Families
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“Several publications have discussed these two assumptions [32–34].”
BackgroundGenetic and Environmental Factors in Relative Body Weight and Human Adiposity
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The Body-Mass Index of Twins Who Have Been Reared Apart
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Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105 · cited 1×
“Several publications have discussed these two assumptions [32–34].”
BackgroundSocioeconomic status and obesity in adult populations of developing countries: A review
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Variance Components Models for Gene–Environment Interaction in Twin Analysis
Purcell, S. (2002) · Twin Research · doi:10.1375/136905202762342026 · Cited by 924 · cited 2×
“Increasing heritability estimates have also been observed in other traits over childhood, such as in cognitive development [48], and this is generally attributed in part to changing gene expression, but also to gene-environment interaction (G6E) [19,49] and geneenvironment correlations [50–52].”
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Rodriguez-Martinez, A., Zhou, B., Sophiea, M. K., Bentham, J., Paciorek, C. J., Iurilli, M. L., Carrillo-Larco, R. M., Bennett, J. E., Di Cesare, M., Taddei, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31859-6 · Cited by 417
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Mosing, M. A., Madison, G., Pedersen, N. L., Kuja-Halkola, R., & Ullén, F. (2014) · Psychological Science · doi:10.1177/0956797614541990 · Cited by 237
A review of current guidelines for the treatment of obesity
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Jelenkovic, A., Sund, R., Hur, Y.-M., Yokoyama, Y., Hjelmborg, J. V. B., Möller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., et al. (2016) · Scientific Reports · doi:10.1038/srep28496 · Cited by 202
Self-citation
Metadata
- Authors
- Dubois, L., Ohm Kyvik, K., Girard, M., Tatone-Tokuda, F., Pérusse, D., Hjelmborg, J., Skytthe, A., Rasmussen, F., Wright, M. J., Lichtenstein, P., & Martin, N. G.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-02-08
- Volume
- 7
- Issue
- 2
- Pages
- e30153
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2088712214
- Cited by
- 261
- References
- 78
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dubois, L., Ohm Kyvik, K., Girard, M., Tatone-Tokuda, F., Pérusse, D., Hjelmborg, J., Skytthe, A., Rasmussen, F., Wright, M. J., Lichtenstein, P., & Martin, N. G. (2012). Genetic and Environmental Contributions to Weight, Height, and BMI from Birth to 19 Years of Age: An International Study of Over 12,000 Twin Pairs. PLoS ONE. https://doi.org/10.1371/journal.pone.0030153
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