The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease
Open accessAbstract
Chemokine (C-C motif) receptor 2 (CCR2)-signaling can mediate accumulation of microglia at sites affected by neuroinflammation. CCR2 and its main ligand CCL2 (MCP-1) might also be involved in the altered metabolism of beta-amyloid (Aβ) underlying Alzheimer's disease (AD). We therefore measured the levels of CCL2 and three other CCR2 ligands, i.e. CCL11 (eotaxin), CCL13 (MCP-4) and CCL26 (eotaxin-3), in the cerebrospinal fluid (CSF) and plasma of 30 controls and 119 patients with mild cognitive impairment (MCI) at baseline. During clinical follow-up 52 MCI patients were clinically stable for five years, 47 developed AD (i.e. cases with prodromal AD at baseline) and 20 developed other dementias. Only CSF CCL26 was statistically significantly elevated in patients with prodromal AD when compared to controls (p = 0.002). However, in patients with prodromal AD, the CCL2 levels in CSF at baseline correlated with a faster cognitive decline during follow-up (r(s) = 0.42, p = 0.004). Furthermore, prodromal AD patients in the highest tertile of CSF CCL2 exhibited a significantly faster cognitive decline (p<0.001) and developed AD dementia within a shorter time period (p<0.003) compared to those in the lowest tertile. Finally, in the entire MCI cohort, CSF CCL2 could be combined with CSF Tau, P-tau and Aβ42 to predict both future conversion to AD and the rate of cognitive decline. If these results are corroborated in future studies, CCL2 in CSF could be a candidate biomarker for prediction of future disease progression rate in prodromal AD. Moreover, CCR2-related signaling pathways might be new therapeutic targets for therapies aiming at slowing down the disease progression rate of AD.
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“In particular, CCL2, a proinflammatory chemokine, is implicated in the chronic neuroinflammation accompanying AD,18 and its cerebrospinal fluid levels predict a faster rate of cognitive decline in AD.19”
From Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease (2015) · cites this paper as [19]
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“Importantly, the increase of these markers seems to be correlated with the cognitive impairment occurring in AD (Solfrizzi et al., 2006; Westin et al., 2012).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Westin et al., 2012
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,467
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
Shaw, L. M., Vanderstichele, H., Knapik‐Czajka, M., Clark, C. M., Aisen, P. S., Petersen, R. C., Blennow, K., Soares, H., Simon, A., Lewczuk, P., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21610 · Cited by 2,065
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Blennow, K., Hampel, H., Weiner, M., & Zetterberg, H. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.4 · Cited by 1,863
Hansson, O., Zetterberg, H., Buchhave, P., Londos, E., Blennow, K., & Minthon, L. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70355-6 · Cited by 1,700
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Items 201–279 of 279
Sabirov, D., Ogurcov, S., Shulman, I., Kabdesh, I. M., Garanina, E. E., Sufianov, A. A., Rizvanov, A. A., & Mukhamedshina, Y. O. (2023) · Biomedicines · doi:10.3390/biomedicines11102641 · Cited by 7
Novel plasma protein biomarkers: A time-dependent predictive model for Alzheimer's disease
Zhuang, T., Yang, Y., Ren, H., Zhang, H., Gao, C. Q., Chen, S., Shen, J., Ji, M., & Cui, Y. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105650 · Cited by 7
Bartolini, L., Moran, M. P., Norato, G., Thomas, B., Dick, A., Wells, E. M., Suslovic, W., Bumbut, A., Chamberlain, J. M., Theodore, W. H., et al. (2021) · Seizure · doi:10.1016/j.seizure.2021.05.022 · Cited by 7
Hoozemans, J. J. M. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000243 · Cited by 8
Alcohol-Induced Activation of Chemokine System and Neuroinflammation Development
Викторовна, М. Е., Vyalova, N. M., Bokhan, N. A., & Ivanova, S. А. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924110038 · Cited by 7
Yang, J., Bernard, L., Chen, J., Sullivan, V. K., Deal, J. A., Kim, H., Yu, B., Steffen, L. M., & Rebholz, C. M. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.03.015 · Cited by 8
Peripheral Inflammatory Biomarkers of Alzheimer’s Disease
Hao, J., Guo, Y., Guo, K., & Yang, Q. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215422 · Cited by 5
Noda, M., & Verkhratsky, A. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199794591.003.0019 · Cited by 4
A deep belief network-based method to identify proteomic risk markers for Alzheimer diseasePreprint
An, N., Jin, L., Ding, H., Yang, J., & Yuan, J. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2003.05776 · Cited by 6
From Organotypic Mouse Brain Slices to Human Alzheimer Plasma Biomarkers: A Focus on Microglia
Steiner, K., Yılmaz, N., Gern, A., Marksteiner, J., Faserl, K., Villunger, M., Sarg, B., & Humpel, C. (2024) · Biomolecules · doi:10.3390/biom14091109 · Cited by 6
Alzheimer’s Pathology: Should Peripheral Monocytes and CCR2 Take Center stage?
Harries, L. W., Pilling, L. C., Lampron, A., Rivest, S., & Melzer, D. R. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.12.72 · Cited by 4
Computer-Aided Drug Design Approaches to Study Key Therapeutic Targets in Alzheimer’s Disease
Lemos, A., Melo, R., Moreira, I. S., & Cordeiro, M. N. D. S. (2017) · Neuromethods · doi:10.1007/978-1-4939-7404-7_3 · Cited by 4
Huang, J., Wang, Y., Stein, T. D., Ang, T. F. A., Zhu, Y., Tao, Q., Lunetta, K. L., Mez, J. B., Au, R., Farrer, L. A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3376348/v1 · Cited by 4
Mathew, J., Maroky, A. S., SINDURAJ, S., & Chandrababu, A. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i5.54564 · Cited by 3
Hau, S. O., Svensson, M., Petersson, A., Eberhard, J., & Jirström, K. (2023) · BMC Cancer · doi:10.1186/s12885-023-11562-2 · Cited by 4
Höfling, C., Donkersloot, P., Ulrich, L., Burghardt, S., Opitz, M., Geißler, S., Schilling, S., Cynis, H., Michalski, D., & Roßner, S. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106671 · Cited by 3
Sheikh, M. A., Moon, M. P., Wright, C. B., Gutierrez, J., Liu, M., Rundek, T., Cheung, K., Hornig, M., & Elkind, M. S. V. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100937 · Cited by 3
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Li, X., Su, W., & Cai, L. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1508662 · Cited by 4
Anastasi, F., Genius, P., Rodríguez‐Fernández, B., Yang, C., Gorijala, P., Timsina, J., Hernández‐Villamizar, L. F., Lorenzini, L., del Campo, M., Sánchez‐Benavides, G., et al. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.10.003 · Cited by 5
Tavares-Júnior, J. W. L., Ciurleo, G. C. V., Feitosa, E. D. A. A. F., Oriá, R. B., & Braga‐Neto, P. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231368 · Cited by 3
An overview on the impact of viral pathogens on Alzheimer's disease
AmeliMojarad, M., AmeliMojarad, M., & Cui, X. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102615 · Cited by 4
Shi, X., Gong, X., Xiong, H., & Zhang, J. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00706-y · Cited by 3
Khoshneviszadeh, M., Jandke, S., Kaushik, R., Ulbrich, P., Norman, O., Jukkola, J., Heikkinen, A., Schreiber, S., & Dityatev, A. E. (2022) · Research Square · doi:10.21203/rs.3.rs-1980968/v1 · Cited by 3
Huang, J., Wang, Y., Stein, T. D., Ang, T. F. A., Zhu, Y., Tao, Q., Lunetta, K. L., Mez, J., Au, R., Farrer, L. A., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03542-w · Cited by 8
do Nascimento, N. B., Farias, H. R., Schons, T., Padilha, A. P. Z., da Costa, M. S., Peres, A. M., Santos¹, L. F. D. S., Dantas, R. M., Ramos, J. M. O., Rodrigues, M. S., et al. (2026) · Neurochemical Research · doi:10.1007/s11064-025-04658-7 · Cited by 2
Molecular etiopathogenesis of neurodegenerative diseases
Divya, D., Thekkekkara, D., Sai, T. E., Ramakrishna, D., Manjula, S. N., & Goswami, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00002-7 · Cited by 2
Najafi, M., Amini, R., Maghsood, A. H., Fallah, M., & Foroughi-Parvar, F. (2021) · Iranian Journal of Parasitology · doi:10.18502/ijpa.v16i3.7096 · Cited by 2
Therapeutic Potential of PPARs in Alzheimer’s Disease
Upaganlawar, A. B., Upasani, C. D., & Ihim, S. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_14 · Cited by 2
Cerebrospinal fluid biomarkers for neurodegenerative disorders
Videira, R. M. A. S. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 2
Khoshneviszadeh, M., Jandke, S., Morton, L., Kaushik, R., Arndt, P., Norman, O., Jukkola, J., Dunay, I. R., Seidenbecher, C. I., Heikkinen, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-1980968/v2 · Cited by 2
Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performancePreprint
Anastasi, F., Genius, P., Rodríguez‐Fernández, B., Yang, C., Gorijala, P., Timsina, J., Hernández‐Villamizar, L. F., Lorenzini, L., del Campo, M., Sánchez‐Benavides, G., et al. (2024) · medRxiv · doi:10.21203/rs.3.rs-5267673/v1 · Cited by 2
Han, L., Dong, M.-M., Ding, K., Sun, Q., Zhang, Z., Liu, H., Han, Y., & Cao, J.-L. (2025) · Perioperative Medicine · doi:10.1186/s13741-025-00523-x · Cited by 1
Molecular pathways and biomarkers associated with age-related cognitive decline
Mitra, S., Pandey, S., Gill, A., Roy, A., Dutta, S., Kumar, A., Ali, M., & Chawla, G. (2025) · Academia Biology · doi:10.20935/acadbiol7909 · Cited by 2
A blood-based signature of cerebrospinal fluid A β 1–42 statusPreprint
Goudey, B., Fung, B. J., Schieber, C., Initiative, A. D. N., & Faux, N. G. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/190207 · Cited by 1
Fluid Biomarkers and Diagnostics
Zetterberg, H., & Blennow, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00021-6
Sogorb‐Esteve, A., Swift, I. J., Woollacott, I., Warren, J. D., Zetterberg, H., & Rohrer, J. D. (2021) · Research Square · doi:10.21203/rs.3.rs-386614/v1
Carrasquillo, M. M., Bu, G., & Nielsen, H. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7309-1_2
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Gu, H., Xu, Y., Du, N., Yu, Y., Zheng, W., & Du, Y. (2022) · Biology · doi:10.3390/biology11020308
Enteric glia adopt an activated pro-inflammatory state in response to human and bacterial amyloidsPreprint
Verstraelen, P., Remoortel, S. V., Loose, N. D., Verboven, R., Barriga, G. G.-D., Christmann, A., Gries, M., Tükel, Ç., Martínez, S. I., Schäfer, K., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.08.503156
Novel Plasma Protein Biomarkers: A Time-Dependent predictive model for Alzheimer's DiseasePreprint
Zhuang, T., Yang, Y., Ren, H., Gao, C. Q., Chen, S., Shen, J., Ji, M., & Cui, Y. (2023) · Research Square · doi:10.21203/rs.3.rs-3666285/v1
Strauss, A., Swann, P., Kigar, S. L., Christou, R., Yarkoni, N. S., Murley, A. G., Chouliaras, L., Savulich, G., Bevan-Jones, W. R., Surendranthan, A., et al. (2024) · medRxiv · doi:10.1101/2024.01.16.24301348
Lee, C., Whooley, M. A., Niitsu, K., & Kim, W. (2024) · Psychology International · doi:10.3390/psycholint6020027
Sogorb‐Esteve, A., Swift, I. J., Woollacott, I., Warren, J. D., Zetterberg, H., & Rohrer, J. D. (2021) · Figshare · doi:10.6084/m9.figshare.16727664
The Association between Obstructive Sleep Apnoea and Dementia in Men: A 2023 Systematic ReviewPreprint
Tabche, C., Pillay, N. C., Atwan, Z., Raheem, M., Dubois, E., & Rawaf, S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4880347
Höfling, C., Ulrich, L., Burghardt, S., Donkersloot, P., Opitz, M., Geißler, S., Schilling, S., Cynis, H., Michalski, D., & Roßner, S. (2024) · Cells · doi:10.3390/cells13171412 · Cited by 2
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Th, S., Sh, I., & Kismat, T. (2024) · Al-Turath Medical Journal · doi:10.63964/atmj.2024.1.1
Flores-Aguilar, L., Iulita, M. F., Orciani, C., Tanna, N., Yang, J., Bennett, D. A., & Cuello, A. C. (2021) · Figshare · doi:10.6084/m9.figshare.14908162
Additional file 2 of Neurofilament light chain in the vitreous humor of the eye
Subramanian, M. L., Vig, V., Chung, J., Fiorello, M. G., Xia, W., Zetterberg, H., Blennow, K., Zetterberg, M., Shareef, F., Siegel, N. H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12972148
Additional file 4 of Neurofilament light chain in the vitreous humor of the eye
Subramanian, M. L., Vig, V., Chung, J., Fiorello, M. G., Xia, W., Zetterberg, H., Blennow, K., Zetterberg, M., Shareef, F., Siegel, N. H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12972154
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Additional file 1 of Neurofilament light chain in the vitreous humor of the eye
Subramanian, M. L., Vig, V., Chung, J., Fiorello, M. G., Xia, W., Zetterberg, H., Blennow, K., Zetterberg, M., Shareef, F., Siegel, N. H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12972145
Additional file 5 of Neurofilament light chain in the vitreous humor of the eye
Subramanian, M. L., Vig, V., Chung, J., Fiorello, M. G., Xia, W., Zetterberg, H., Blennow, K., Zetterberg, M., Shareef, F., Siegel, N. H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12972157
Flores-Aguilar, L., Iulita, M. F., Orciani, C., Tanna, N., Yang, J., Bennett, D. A., & Cuello, A. C. (2021) · Figshare · doi:10.6084/m9.figshare.14908147
Hau, S. O., Svensson, M., Petersson, A., Eberhard, J., & Jirström, K. (2024) · Figshare · doi:10.6084/m9.figshare.24522855
Hau, S. O., Svensson, M., Petersson, A., Eberhard, J., & Jirström, K. (2023) · Figshare · doi:10.6084/m9.figshare.24522646
Additional file 3 of Neurofilament light chain in the vitreous humor of the eye
Subramanian, M. L., Vig, V., Chung, J., Fiorello, M. G., Xia, W., Zetterberg, H., Blennow, K., Zetterberg, M., Shareef, F., Siegel, N. H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12972151
Sogorb‐Esteve, A., Swift, I. J., Woollacott, I., Warren, J. D., Zetterberg, H., & Rohrer, J. D. (2021) · Figshare · doi:10.6084/m9.figshare.16727667
Flores-Aguilar, L., Iulita, M. F., Orciani, C., Tanna, N., Yang, J., Bennett, D. A., & Cuello, A. C. (2021) · Figshare · doi:10.6084/m9.figshare.14908144
Additional file 6 of Neurofilament light chain in the vitreous humor of the eye
Subramanian, M. L., Vig, V., Chung, J., Fiorello, M. G., Xia, W., Zetterberg, H., Blennow, K., Zetterberg, M., Shareef, F., Siegel, N. H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12972160
Hau, S. O., Svensson, M., Petersson, A., Eberhard, J., & Jirström, K. (2024) · Figshare · doi:10.6084/m9.figshare.26636856
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Vautheny, A. (2019) · theses.fr (ABES) · doi:10.70675/1812d71aze8d9z48d6z87d1z5a23a4e81953
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Fattahi, F., Abed, S., Kouchakali, G., Derakhshan, S. M., Sadeh, R. N., & Khaniani, M. S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05821-z · Cited by 1
Li, X., Xu, J., Du, G., Jia, X., Zhao, D., Zhou, C., Xiao, K., Gu, J., Zhu, J., & Shang, X. (2026) · Advanced Science · doi:10.1002/advs.75969
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.05
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.references
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.07
Third Section: Design of a dimeric-nanobody specific for Aβ42 oligomers: the Dimeric-DesAb-O
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.06
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.03
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.04
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.02
Conclusion and Future Perspectives
Napolitano, L. (2026) · Firenze University Press eBooks · doi:10.36253/979-12-215-0993-9.08
Yasuno, F., Kimura, Y., Yamauchi, Y., Minami, H., Kasuga, K., Ikeuchi, T., Takeda, A., & Sakurai, T. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101333
Wasim, R. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02342-y
BindingDB (2024) · UC San Diego · doi:10.7270/q2sn0f5x
Metadata
- Authors
- Westin, K., Buchhave, P., Nielsen, H., Minthon, L., Janciauskiene, S., & Hansson, O.
- Affiliations
- Lund University (SE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Hansson, Oskar
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-01-30
- Volume
- 7
- Issue
- 1
- Pages
- e30525
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3268759
- OpenAlex
- W2135955660
- Cited by
- 277
- References
- 28
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 30 · 2023: 11 · 2022: 29 · 2021: 27 · 2020: 21 · 2019: 20 · 2018: 11 · 2017: 23 · 2016: 10 · 2015: 18 · 2014: 21 · 2013: 21 · 2012: 5
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- Skåne County Council's Research and Development Foundation
- Vetenskapsrådet
- Swedish Brain Power
- Socialstyrelsen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- MCP-1, CCR2, Alzheimer's disease, mild cognitive impairment, cognitive decline, cerebrospinal fluid biomarkers, CCL26, eotaxin, CCL13, conversion to Alzheimer's disease, tau protein, phosphorylated tau, amyloid-beta 42, disease progression prediction, chemokine signaling, neuroinflammation
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Demography, Female, Follow-Up Studies, Humans, Male, Cohort Studies, Biomarkers, Linear Models, Disease Progression, Chemokine CCL2, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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