The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β
Open accessAbstract
Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ-/- mice to study whether ERβ is involved in the rapid regulation of K(ATP) channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM). We also investigated these effects of BPA in β-cells and whole islets of Langerhans from humans. 1 nM BPA rapidly decreased K(ATP) channel activity, increased glucose-induced [Ca(2+)](i) signals and insulin release in β-cells from WT mice but not in cells from ERβ-/- mice. The rapid reduction in the K(ATP) channel activity and the insulinotropic effect was seen in human cells and islets. BPA actions were stronger in human islets compared to mouse islets when the same BPA concentration was used. Our findings suggest that BPA behaves as a strong estrogen via nuclear ERβ and indicate that results obtained with BPA in mouse β-cells may be extrapolated to humans. This supports that BPA should be considered as a risk factor for metabolic disorders in humans.
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Cites
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Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice
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Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
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Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
Self-citationParabens and their effects on the endocrine system
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Metadata
- Authors
- Soriano, S., Alonso-Magdalena, P., García-Arévalo, M., Novials, A., Muhammed, S. J., Salehi, A., Gustafsson, J.-A., Quesada, I., & Nadal, A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-02-08
- Volume
- 7
- Issue
- 2
- Pages
- e31109
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2054433134
- Cited by
- 208
- References
- 8
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Soriano, S., Alonso-Magdalena, P., García-Arévalo, M., Novials, A., Muhammed, S. J., Salehi, A., Gustafsson, J.-A., Quesada, I., & Nadal, A. (2012). Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β. PLoS ONE. https://doi.org/10.1371/journal.pone.0031109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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