The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
Open accessAbstract
Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also creates a gradient of lactate that mirrors the gradient of oxygen in tumors. More than a metabolic waste, the lactate anion is known to participate to cancer aggressiveness, in part through activation of the hypoxia-inducible factor-1 (HIF-1) pathway in tumor cells. Whether lactate may also directly favor HIF-1 activation in endothelial cells (ECs) thereby offering a new druggable option to block angiogenesis is however an unanswered question. In this study, we therefore focused on the role in ECs of monocarboxylate transporter 1 (MCT1) that we previously identified to be the main facilitator of lactate uptake in cancer cells. We found that blockade of lactate influx into ECs led to inhibition of HIF-1-dependent angiogenesis. Our demonstration is based on the unprecedented characterization of lactate-induced HIF-1 activation in normoxic ECs and the consecutive increase in vascular endothelial growth factor receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) expression. Furthermore, using a variety of functional assays including endothelial cell migration and tubulogenesis together with in vivo imaging of tumor angiogenesis through intravital microscopy and immunohistochemistry, we documented that MCT1 blockers could act as bona fide HIF-1 inhibitors leading to anti-angiogenic effects. Together with the previous demonstration of MCT1 being a key regulator of lactate exchange between tumor cells, the current study identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, lactate accumulation is instrumental for the promotion of angiogenesis.”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Sonveaux et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · cited 1×
“transporter 4 (MCT4) and key pro-angiogenic effectors such as vascular endothelial growth factor (VEGF) [11,12].”
BackgroundThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Regulation of angiogenesis by hypoxia: role of the HIF system
Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Kerbel, R. S. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0706596 · Cited by 2,011
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 541
Tang, J., Cheng, Y., Chuang, Y.-T., Yang, K., Chang, F., Liu, W., & Chang, H. (2022) · Cells · doi:10.3390/cells11060961 · Cited by 21
McGillen, J. B., Kelly, M., Martínez‐González, A., Martin, N. K., Gaffney, E. A., Maini, P. K., & Pérez‐García, V. M. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.09.018 · Cited by 21
Research progress on the regulatory role of lactate and lactylation in tumor microenvironment
Gao, C., Li, J., & Shan, B. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189339 · Cited by 22
Metabolomic Profiling in Renal Cell Carcinoma Patients: News and Views
Aurilio, G., Santoni, M., Massari, F., Cimadamore, A., Rizzo, A., Mollica, V., Verri, E., Battelli, N., & Montironi, R. (2021) · Cancers · doi:10.3390/cancers13205229 · Cited by 21
Yan, Y., Xiu, L., Yang, Q., Zhang, H., Hettinga, K. A., Li, H., & Chen, W. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200196 · Cited by 20
Importance of lactate dehydrogenase (LDH) and monocarboxylate transporters (MCTs) in cancer cells
Hatami, H., Sajedi, A., Mir, S. M., & Memar, M. Y. (2022) · Health Science Reports · doi:10.1002/hsr2.996 · Cited by 21
Endothelial cells and cancer cells
Zecchin, A., Borgers, G., & Carmeliet, P. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000138 · Cited by 20
α-Cyano-4-hydroxycinnamate induces apoptosis in Dalton’s lymphoma cells
Kumar, A., Kant, S., & Singh, S. M. (2012) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e3283586743 · Cited by 20
Metabolism in Immune Cell Differentiation and Function
Chapman, N. M., Shrestha, S., & Chi, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1170-6_1 · Cited by 22
Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?
Mendes, C., & Serpa, J. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01965-0 · Cited by 20
Sun, H., Zhang, X., Dai, J., Pan, Z., Wu, Y. R., Yu, D., Zhu, S., Chen, Y., Qin, T., & Ouyang, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.08.061 · Cited by 20
The Distinctive Serum Metabolomes of Gastric, Esophageal and Colorectal Cancers
Ren, Z., Rajani, C., & Jia, W. P. (2021) · Cancers · doi:10.3390/cancers13040720 · Cited by 21
Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications
Indini, A., Grossi, F., Mandalà, M., Taverna, D., & Audrito, V. (2021) · Biomedicines · doi:10.3390/biomedicines9060607 · Cited by 20
Zhao, L., Tang, X., Huang, R., Liu, Q., Liao, L., Hu, Y., He, K., Zhang, X., Guo, J., Chen, S., et al. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.08.007 · Cited by 19
Changes in Metabolism as a Diagnostic Tool for Lung Cancer: Systematic Review
Mariën, H., Derveaux, E., Vanhove, K., Adriaensens, P., Thomeer, M., & Mesotten, L. (2022) · Metabolites · doi:10.3390/metabo12060545 · Cited by 19
Deng, Q., Wu, C., Liu, T. C., Duan, R., & Yang, L. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114450 · Cited by 18
Lactate shuttling drives the browning of white adipose tissue after burn
Barayan, D., Abdullahi, A., Knuth, C. M., Khalaf, F., Rehou, S., Screaton, R. A., & Jeschke, M. G. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00084.2023 · Cited by 18
Lactic Acid Chemical Peeling in Skin Disorders
Feng, X., Shang, J., Gu, Z., Luo, X., Chen, Y., & Liu, Y. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s455700 · Cited by 18
Yang, J., Chen, B., Pan, Y., Han, J., Chen, F., & Hu, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046511 · Cited by 18
Morera, E., Steinhäuser, S. S., Budková, Z., Ingþórsson, S., Kricker, J. A., Krueger, A., Traustadóttir, G. Á., & Guðjónsson, Þ. (2019) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-019-00403-x · Cited by 19
PFKFB3: A Potential Key to Ocular Angiogenesis
Zhou, Z., Wang, L., Wang, Y., & Dou, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628317 · Cited by 18
Cross-talk between signaling and metabolism in the vasculature
Uebelhoer, M., & Iruela‐Arispe, M. L. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.06.002 · Cited by 18
Jayaraman, A., Kumar, P., Marín, S., de Atauri, P., Mateo, F., Thomson, T. M., Centelles, J. J., Graham, S. F., & Cascante, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192175 · Cited by 18
The role of MCT1 in tumor progression and targeted therapy: a comprehensive review
Xu, Z., Wang, X., Cheng, H., Li, J., Zhang, X., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1610466 · Cited by 17
Zhang, Y., Wang, J., Li, C., Lei, Z., Zhao, X., Xuan, X., Sukocheva, O. A., Tse, E., & Liu, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.12.005 · Cited by 19
Xia, P., Köberle, M., & Ghashghaeinia, M. (2024) · Antioxidants · doi:10.3390/antiox13080968 · Cited by 17
Systemic Buffers in Cancer Therapy: The Example of Sodium Bicarbonate; Stupid Idea or Wise Remedy?
Faes, S., & Dormond, O. (2015) · Medicinal Chemistry · doi:10.4172/2161-0444.1000314 · Cited by 17
Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment
Langsten, K. L., Kim, J. H., Sarver, A. L., Dewhirst, M. W., & Modiano, J. F. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01185 · Cited by 18
Self-citationHBXIP accelerates glycolysis and promotes cancer angiogenesis via AKT/mTOR pathway in bladder cancer
Liu, X., Li, H., Che, N., Zheng, Y., Fan, W., Li, M., Li, X., & Xuan, Y. (2021) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2021.104665 · Cited by 17
Brain Endothelial Cells: Metabolic Flux and Energy Metabolism
McDonald, C., Blankenheim, Z. J., & Drewes, L. R. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_494 · Cited by 17
Yang, X., Zhang, W., & Zhu, W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14896 · Cited by 16
Zhang, F., Wang, B., Zhang, W., Xu, Y., Zhang, C., & Xue, X. (2024) · Current Cancer Drug Targets · doi:10.2174/0115680096265896231226062212 · Cited by 16
Comparing the Secretomes of Chemorefractory and Chemoresistant Ovarian Cancer Cell Populations
Lee, A. H., Peña, C. M., & Dawson, M. (2022) · Cancers · doi:10.3390/cancers14061418 · Cited by 17
In the eye of the storm: T cell behavior in the inflammatory microenvironment.
Haas, R., Marelli‐Berg, F. M., & Mauro, C. (2013) · Europe PMC (PubMed Central) · Cited by 16
Modulatory properties of Lactobacillus paracasei fermented milks on gastric inflammatory conditions
Bengoa, A. A., Errea, A. J., Rumbo, M., Abraham, A. G., & Garrote, G. L. (2020) · International Dairy Journal · doi:10.1016/j.idairyj.2020.104839 · Cited by 17
In situ Metabolic Profiling of Ovarian Cancer Tumor Xenografts: A Digital Pathology Approach
Piga, I., Verza, M., Montenegro, F., Nardo, G., Zulato, E., Zanin, T., Bianco, P. D., Esposito, G., & Indraccolo, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01277 · Cited by 16
van Brakel, F., Zhao, Y., & van der Eerden, B. C. J. (2024) · Bone Reports · doi:10.1016/j.bonr.2024.101757 · Cited by 16
Qian, C., Jiang, H., Peng, Z., Sun, X., & Zhang, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1435334 · Cited by 15
Peng, T., Shao, X., Song, W., Xu, W., Xiong, W., He, Y., Ding, Y., & Huang, Y. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.08.042 · Cited by 16
Zhu, L., Yang, F., Li, X., Li, Q., & Zhong, C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.743133 · Cited by 16
Tiemeier, G. L., de Koning, R., Wang, G., Kostidis, S., Rietjens, R. G. J., Sol, W. M. P. J., Dumas, S. J., Giera, M. A., van den Berg, C. W., Eikenboom, J. C. J., et al. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0392 · Cited by 15
Acevedo‐Acevedo, S., Millar, D. C., Simmons, A. D., Favreau, P. F., Cobra, P. F., Skala, M. C., & Palecek, S. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-76394-7 · Cited by 15
A translational review of hyperthermia biology
Dewhirst, M. W. (2025) · International Journal of Hyperthermia · doi:10.1080/02656736.2024.2447952 · Cited by 15
Self-citationAn explorative metabolomic analysis of the endothelium in pulmonary hypertension
Carlsen, J., Henriksen, H., de Mas, I. M., & Johansson, P. I. (2022) · Scientific Reports · doi:10.1038/s41598-022-17374-x · Cited by 14
Blastocyst-Derived Lactate as a Key Facilitator of Implantation
Gurner, K. H., & Gardner, D. K. (2025) · Biomolecules · doi:10.3390/biom15010100 · Cited by 14
Al-Husari, M., & Webb, S. D. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.01.007 · Cited by 14
Targeting Metabolism to Counteract Tumor Angiogenesis: A Review of Patent Literature
Petrillo, S., Tolosano, E., Munaron, L., & Genova, T. (2018) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892813666180528105023 · Cited by 14
Endothelial Cells (ECs) Metabolism: A Valuable Piece to Disentangle Cancer Biology
Lopes‐Coelho, F., Martins, F., & Serpa, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_8 · Cited by 14
Evidence of metabolic activity during low-temperature ovarian tissue preservation in different media
Vilela, J. D. M. V., Dolmans, M., Maruhashi, E., Blackman, M. C. N. M., Sonveaux, P., Miranda‐Vilela, A. L., & Amorim, C. A. (2020) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-020-01935-y · Cited by 14
Self-citationKang, H., Min, B.-K., Choi, W., Jeon, J., Kim, D. W., Park, S., Lee, Y.-K., Kim, H.-J., Byeon, J.-E., Go, Y., et al. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00672-1 · Cited by 14
Singh, L., Roy, S., Kumar, A., Rastogi, S., Kumar, D., Ansari, M. N., Saeedan, A. S., Singh, M., & Kaithwas, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.736910 · Cited by 14
Nanosystem-mediated lactate modulation in the tumor micro environment for enhanced cancer therapy
Gu, J., Sun, J., Liu, Y., Chong, G., Li, Y., & Dong, H. (2022) · Nano Research · doi:10.1007/s12274-022-4620-z · Cited by 14
Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy
Sertorio, M. G., Perentesis, J. P., Vatner, R. E., Mascia, A. E., Zheng, Y., & Wells, S. I. (2018) · International Journal of Particle Therapy · doi:10.14338/ijpt-18-00023.1 · Cited by 14
Venturoli, C., Piga, I., Curtarello, M., Verza, M., Esposito, G., Venuto, S., Navaglia, F., Grassi, A., & Indraccolo, S. (2021) · Cells · doi:10.3390/cells10020325 · Cited by 14
San-Millán, I., Martinez, J. L., Pickard, S. L., Yu, H., Hirsch, F. R., Rivard, C. J., & Brooks, G. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.23.533060 · Cited by 14
Zhi, Y., Cai, C., Xu, T., Sun, F., Wang, K., Ji, Z., Pei, Y., Shen, G., & Wang, H. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23399 · Cited by 13
Park, Y., Jeong, J., Seong, S., & Kim, W. (2021) · Cells · doi:10.3390/cells10102673 · Cited by 13
Xu, J., Qin, S., Wei, H., Chen, Y., Peng, Y., & Qi, L. (2023) · Clinical Science · doi:10.1042/cs20220661 · Cited by 13
Comparison of Helicobacter pylori positive and negative gastric cancer via multi-omics analysis
Shang, F., Cao, Y., Wan, L., Ren, Z., Wang, X., Huang, M., & Guo, Y. (2023) · mBio · doi:10.1128/mbio.01531-23 · Cited by 13
Recent advances in nanomedicine for metabolism-targeted cancer therapy
Da, J., Di, X., Xie, Y., Li, J., Zhang, L., & Liu, Y. (2024) · Chemical Communications · doi:10.1039/d3cc05858a · Cited by 12
Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortex
Lee, D., Wu, A., Yao, L., Satish, S., Mei, L., & Xiong, W. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01581-w · Cited by 13
Membrane transporters and the diseases corresponding to functional defects
Lai, Y. (2013) · Elsevier eBooks · doi:10.1533/9781908818287.1 · Cited by 13
Sun, Y., Liang, S., Li, T., Peng, C., Yang, Y., Lin, Y., Ma, Y., & Dong, C. (2022) · Translational Cancer Research · doi:10.21037/tcr-21-1951 · Cited by 12
Uhernik, A. L., Li, L., LaVoy, N., Velasquez, M. J., & Smith, J. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085957 · Cited by 12
Su, C., Tseng, P., Chiu, H.-T., del Vall, A., Huang, Y., & Sun, Y. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.11.060 · Cited by 12
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2021) · Biomedicines · doi:10.3390/biomedicines9060619 · Cited by 12
Faes, S., & Dormond, O. (2019) · Medicinal Chemistry · doi:10.4172/2161-0444 · Cited by 12
Hypoxic microenvironment in cancer: role in metabolic reprogramming
Sureka, N., Maheshwari, R., Agravat, A., Singhal, S., Zaman, S., Rishi, B., Siraj, F., Zaheer, S., & Misra, A. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1771365 · Cited by 11
How lactate affects immune strategies in lymphoma
Zhou, Y., Lou, J., Yuqin, T., Ding, J., Wang, X., & Tang, B. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1480884 · Cited by 11
Feng, J., Zhu, L., He, C., Xiang, R., Liu, J., Cai, J., & Wang, D. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01181-1 · Cited by 12
Lactylation and antitumor immunity
Yang, B., Li, W., Shi, D., Zhong, T., & Xiong, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1690068 · Cited by 13
Zhou, J., Guo, H., Yang, A., Liu, T., Li, P., Cui, H., Wang, Y., & Tang, T. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4063315 · Cited by 11
Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells
Mijit, M., Liu, S., Sishtla, K. L., Hartman, G. D., Wan, J., Corson, T. W., & Kelley, M. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021101 · Cited by 11
Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly
Chu, Y., Chen, C.-W. D., Lai, M., Lim, S., & Lin, W.-R. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i29.4499 · Cited by 12
Automatic fluorometric lactate determination in human plasma samples
Pereira, S. A. P., Mota, F. A. R., Çay, I., Passos, M. L. C., Araújo, A. R. T. S., & Saraiva, M. L. M. F. S. (2019) · New Journal of Chemistry · doi:10.1039/c9nj04831f · Cited by 11
Messeha, S. S., Zarmouh, N. O., Taka, E., Gendy, S., Shokry, G., Kolta, M. G., & Soliman, K. F. A. (2016) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2016/23992 · Cited by 11
Lactic acid: a narrative review of a promoter of the liver cancer microenvironment
Chen, J., He, G., Cai, D., Giovannetti, E., Inamura, K., Liu, S., & Ma, W. (2024) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-24-368 · Cited by 10
Zhang, N., Guan, T., Shafiq, K., Yuan, X., Sun, B., Huang, Q., & Kong, J. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00353 · Cited by 10
Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis
Dalal, K. K., Katari, V., Kondapalli, N. B., Paruchuri, S. M., & Thodeti, C. K. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00352.2025 · Cited by 9
Lactate metabolism and lactylation in ocular diseases
Zhou, Y., Zhu, W., Yin, X., Zeng, M., & Wang, J. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110674 · Cited by 9
Ocaña, M. C., Martı́nez-Poveda, B., Quesada, A. R., & Medina, M. Á. (2019) · Biomolecules · doi:10.3390/biom9080332 · Cited by 9
Hwang, E., Sim, S., Park, S. H., Song, K., Lee, H., Heo, T., Jun, H. S., & Kim, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.115 · Cited by 9
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect
Jiang, X. J., Yan, N., Deng, D., & Yan, C. (2022) · IUBMB Life · doi:10.1002/iub.2668 · Cited by 9
Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing
Bisht, V. S., Giri, K., Kumar, D., & Ambatipudi, K. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1992233 · Cited by 8
Shirmanova, M. V., Sinyushkina, S. D., & Komarova, A. D. (2023) · Molecular Biology · doi:10.31857/s0026898423060186 · Cited by 8
Huang, D., Xu, F., Xu, L., Tang, Z., Hu, Y., Li, J., & Yu, J. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167814 · Cited by 8
The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication
Craige, S. M. (2025) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000376 · Cited by 8
Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets
Wang, X., Liu, C., Chen, Y., Fang, Y., Li, J. N., Liu, Y., Pan, Y., Bao, S., Wang, X., Liu, Y., et al. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00472-x · Cited by 8
Lactate induces PD-L1 in HRASG12V-positive oropharyngeal squamous cell carcinoma
Verma, A. K., Messerli, S. M., & Miskimins, W. K. (2020) · Oncotarget · doi:10.18632/oncotarget.27348 · Cited by 8
Wang, S.-Y., Wang, Y., Shen, A., Jian, R., An, N., & Yuan, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16157 · Cited by 8
Heidary, M., Akrami, S., Madanipour, T., Shakib, N. H., Ari, M. M., Beig, M., Khoshnood, S., Ghanavati, R., & Bazdar, M. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2024.1495596 · Cited by 8
Kim, W., Park, A., Jang, H. H., Kim, S.-E., & Park, K. (2022) · Cancers · doi:10.3390/cancers14194711 · Cited by 8
Involvement of brain metabolism in neurodevelopmental disorders
Kotchetkov, P., Blakeley, N., & Lacoste, B. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.08.004 · Cited by 9
Wang, Q., Li, M., Li, C., Gu, X., Zheng, M., Chen, L.-X., & Li, H. (2020) · Current Medical Science · doi:10.1007/s11596-020-2165-5 · Cited by 8
Pérez-Regalado, S., León, J., & Feriche, B. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-03918-1 · Cited by 8
The role of glycolysis in inflammation
Dehantschutter, E. T., & Taylor, C. T. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00113.2026 · Cited by 7
Tong, Y., Gu, M., Luo, X., Qi, H., Jiang, W., Deng, Y., Wei, L., Liu, J., Ding, Y., Cai, J., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.005 · Cited by 7
Wilczyński, J. R., Paradowska, E., Wilczyńska, J., & Wilczyński, M. (2023) · Current Oncology · doi:10.3390/curroncol31010015 · Cited by 7
Henriksen, H., de Mas, I. M., Nielsen, L. K., Krocker, J. D., Stensballe, J., Karvelsson, S. T., Secher, N. H., Rolfsson, Ó., Wade, C. E., & Johansson, P. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032257 · Cited by 7
Takeda, R., Nojima, H., Nishikawa, T., Okudaira, M., Hirono, T., & Watanabe, K. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05291-4 · Cited by 7
Metadata
- Authors
- Sonveaux, P., Copetti, T., De Saedeleer, C. J., Végran, F., Verrax, J., Kennedy, K. M., Moon, E. J., Dhup, S., Danhier, P., Frérart, F., Gallez, B., Ribeiro, A., Michiels, C., Dewhirst, M. W., & Feron, O.
- Affiliations
- Duke Medical Center (US)
- UCLouvain (BE)
- Duke University (US)
- University of Namur (BE)
- Corresponding author
- Sonveaux, Pierre
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-03-13
- Volume
- 7
- Issue
- 3
- Pages
- e33418
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3302812
- OpenAlex
- W2003842905
- Cited by
- 536
- References
- 67
- Citations by year
- 2026: 34 · 2025: 38 · 2024: 25 · 2023: 50 · 2022: 58 · 2021: 46 · 2020: 62 · 2019: 34 · 2018: 36 · 2017: 36 · 2016: 30 · 2015: 32 · 2014: 26 · 2013: 22 · 2012: 6
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Repository of the University of Namur (submittedVersion, other-oa)
- Funders
- Belgian American Educational Foundation
- Fonds De La Recherche Scientifique - FNRS
- National Institutes of Health (FP7/2007-2013, 5p01ca042745-23)
- National Cancer Institute (CA40355, R01CA040355, CA40355-24, P01-CA042745, CA40355-25)
- FP7 Ideas: European Research Council (243188)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- MCT1, MCT1 inhibition, lactate transport, endothelial cells, tumor angiogenesis, tumor hypoxia, glycolytic metabolism, VEGFR2, basic fibroblast growth factor, anti-angiogenic therapy, tumor microenvironment
- MeSH terms
- Monocarboxylate Transport Protein 1, Analysis of Variance, Animals, Cell Movement, Enzyme-Linked Immunosorbent Assay, Fibroblast Growth Factors, Humans, Immunohistochemistry, Luciferases, Neoplasms, Neovascularization, Pathologic, Blotting, Western, Polymerase Chain Reaction, Lactic Acid, Nuclear Magnetic Resonance, Biomolecular, Monocarboxylic Acid Transporters, Symporters, RNA Interference, RNA, Small Interfering, Vascular Endothelial Growth Factor Receptor-2, Endothelial Cells, Mice, Hypoxia-Inducible Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
