The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture
Open accessAbstract
This paper describes the construction and characterization of a system of transcriptional reporter genes for monitoring the activity of signaling pathways and gene regulation mechanisms in intact Drosophila, dissected tissues or cultured cells. Transgenic integration of the reporters into the Drosophila germline was performed in a site-directed manner, using ΦC31 integrase. This strategy avoids variable position effects and assures low base level activity and high signal responsiveness. Defined integration sites furthermore enable the experimenter to compare the activity of different reporters in one organism. The reporter constructs have a modular design to facilitate the combination of promoter elements (synthetic transcription factor binding sites or natural regulatory sequences), reporter genes (eGFP, or DsRed.T4), and genomic integration sites. The system was used to analyze and compare the activity and signal response profiles of two stress inducible transcription factors, AP-1 and Nrf2. To complement the transgenic reporter fly lines, tissue culture assays were developed in which the same synthetic ARE and TRE elements control the expression of firefly luciferase.
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Cites
Oxidants, oxidative stress and the biology of ageing
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Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Nrf2–Keap1 defines a physiologically important stress response mechanism
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The JNK signal transduction pathway
Weston, C. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00258-1 · Cited by 1,528
AP-1 subunits: quarrel and harmony among siblings
Hess, J., Angel, P., & Schorpp-Kistner, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01589 · Cited by 1,302
Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102
The cytoprotective role of the Keap1–Nrf2 pathway
Baird, L., & Dinkova-Kostova, A. T. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0674-5 · Cited by 1,027
The JNK signal transduction pathway
Weston, C. R., & Davis, R. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.001 · Cited by 1,021
Stress-activated cap’n’collar transcription factors in aging and human disease
Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · cited 3×
“The Nrf2 signaling system is functionally and structurally conserved in Drosophila [21,24].”
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Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain
Pearce, M. M. P., Spartz, E. J., Hong, W., Luo, L., & Kopito, R. R. (2015) · Nature Communications · doi:10.1038/ncomms7768 · Cited by 159
Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100
Self-citationATF4-induced warburg metabolism drives over-proliferation in Drosophila
Sorge, S., Theelke, J., Yildirim, K., Hertenstein, H., McMullen, E., Müller, S., Altbürger, C., Schirmeier, S., & Lohmann, I. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107659 · Cited by 44
Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture
Donohoe, C. D., Csordás, G., Correia, A., Jindra, M., Klein, C., Habermann, B., & Uhlirova, M. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007241 · Cited by 32
Ji, T., Zhang, L., Deng, M., Huang, S., Wang, Y., Pham, T. T., Smith, A. A., Sridhar, V., Cabernard, C., Wang, J., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040147 · Cited by 25
Metadata
- Authors
- Chatterjee, N., & Bohmann, D.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-11
- Volume
- 7
- Issue
- 4
- Pages
- e34063
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2045204908
- Cited by
- 254
- References
- 46
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chatterjee, N., & Bohmann, D. (2012). A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture. PLoS ONE. https://doi.org/10.1371/journal.pone.0034063
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