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Candida albicans-Epithelial Interactions: Dissecting the Roles of Active Penetration, Induced Endocytosis and Host Factors on the Infection Process
Open accessAbstract
Candida albicans frequently causes superficial infections by invading and damaging epithelial cells, but may also cause systemic infections by penetrating through epithelial barriers. C. albicans is a remarkable pathogen because it can invade epithelial cells via two distinct mechanisms: induced endocytosis, analogous to facultative intracellular enteropathogenic bacteria, and active penetration, similar to plant pathogenic fungi. Here we investigated the contributions of the two invasion routes of C. albicans to epithelial invasion. Using selective cellular inhibition approaches and differential fluorescence microscopy, we demonstrate that induced endocytosis contributes considerably to the early time points of invasion, while active penetration represents the dominant epithelial invasion route. Although induced endocytosis depends mainly on Als3-E-cadherin interactions, we observed E-cadherin independent induced endocytosis. Finally, we provide evidence of a protective role for serum factors in oral infection: human serum strongly inhibited C. albicans adhesion to, invasion and damage of oral epithelial cells.
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“This result is in contrast to what has been found for Als3, which is required for both induced endocytosis and active penetration [29], and provides a likely explanation for why Hyr1 is dispensable for induction of epithelial cell damage.”
From Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection (2023) · cites this paper as [29]
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Metadata
- Authors
- Wächtler, B., Citiulo, F., Jablonowski, N., Förster, S., Dalle, F., Schaller, M., Wilson, D., & Hube, B.
- Affiliations
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- University of Tübingen (DE)
- Corresponding author
- Hube, Bernhard
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-05-14
- Volume
- 7
- Issue
- 5
- Pages
- e36952
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3351431
- OpenAlex
- W1995203663
- Cited by
- 250
- References
- 45
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 19 · 2023: 29 · 2022: 23 · 2021: 25 · 2020: 21 · 2019: 15 · 2018: 19 · 2017: 17 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 10 · 2012: 4
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (Hu528/10, SPP1160)
- Bundesministerium für Bildung und Forschung (0315901B)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, epithelial invasion, ALS3, E-cadherin, oral epithelial cells, serum factors, fungal adhesion, host-pathogen interaction, oral candidiasis
- MeSH terms
- Blood Physiological Phenomena, Candida albicans, Candidiasis, Oral, Cell Adhesion, Cell Line, Endocytosis, Epithelial Cells, Fungal Proteins, Humans, Mouth Mucosa, Cadherins, Microscopy, Electron, Transmission, Host-Pathogen Interactions
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