The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Improvement of Pest Resistance in Transgenic Tobacco Plants Expressing dsRNA of an Insect-Associated Gene EcR
Open accessAbstract
The adoption of pest-resistant transgenic plants to reduce yield loss and pesticide utilization has been successful in the past three decades. Recently, transgenic plant expressing double-stranded RNA (dsRNA) targeting pest genes emerges as a promising strategy for improving pest resistance in crops. The steroid hormone, 20-hydroxyecdysone (20E), predominately controls insect molting via its nuclear receptor complex, EcR-USP. Here we report that pest resistance is improved in transgenic tobacco plants expressing dsRNA of EcR from the cotton bollworm, Helicoverpa armigera, a serious lepidopteran pest for a variety of crops. When H. armigera larvae were fed with the whole transgenic tobacco plants expressing EcR dsRNA, resistance to H. armigera was significantly improved in transgenic plants. Meanwhile, when H. armigera larvae were fed with leaves of transgenic tobacco plants expressing EcR dsRNA, its EcR mRNA level was dramatically decreased causing molting defects and larval lethality. In addition, the transgenic tobacco plants expressing H. armigera EcR dsRNA were also resistant to another lepidopteran pest, the beet armyworm, Spodoptera exigua, due to the high similarity in the nucleotide sequences of their EcR genes. This study provides additional evidence that transgenic plant expressing dsRNA targeting insect-associated genes is able to improve pest resistance.
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Mao, Y.-B., Cai, W.-J., Wang, J.-W., Hong, G.-J., Tao, X.-Y., Wang, L.-J., Huang, Y.-P., & Chen, X.-Y. (2007) · Nature Biotechnology · doi:10.1038/nbt1352 · Cited by 1,358 · cited 1×
“armigera [23,24], the western corn rootworm, Diabrotica virgifera [25], and the pea aphid, Acyrthosiphon pisum [26].”
BackgroundEcdysone receptors and their biological actions
Riddiford, L. M., Cherbas, P., & Truman, J. W. (2000) · Vitamins & Hormones · doi:10.1016/s0083-6729(00)60016-x · Cited by 605
Cited by
Joga, M. R., Zotti, M. J., Smagghe, G., & Christiaens, O. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00553 · Cited by 521
Bolognesi, R., Ramaseshadri, P., Anderson, J., Bachman, P., Clinton, W., Flannagan, R., Ilagan, O., Lawrence, C., Levine, S., Moar, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047534 · Cited by 473
Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids
Zhang, J., Khan, S. A., Hasse, C., Ruf, S., Heckel, D. G., & Bock, R. (2015) · Science · doi:10.1126/science.1261680 · Cited by 471
Self-citationRNA interference technology in crop protection against arthropod pests, pathogens and nematodes
Zotti, M., dos Santos, E. A., Cagliari, D., Christiaens, O., Taning, C. N. T., & Smagghe, G. (2018) · Pest Management Science · doi:10.1002/ps.4813 · Cited by 465
Next-generation insect-resistant plants: RNAi-mediated crop protection
Zhang, J., Khan, S. A., Heckel, D. G., & Bock, R. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2017.04.009 · Cited by 348
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Metadata
- Authors
- Zhu, J.-Q., Liu, S., Ma, Y., Zhang, J.-Q., Qi, H.-S., Wei, Z.-J., Yao, Q., Zhang, W.-Q., & Li, S.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-06-07
- Volume
- 7
- Issue
- 6
- Pages
- e38572
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2023177226
- Cited by
- 170
- References
- 2
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhu, J.-Q., Liu, S., Ma, Y., Zhang, J.-Q., Qi, H.-S., Wei, Z.-J., Yao, Q., Zhang, W.-Q., & Li, S. (2012). Improvement of Pest Resistance in Transgenic Tobacco Plants Expressing dsRNA of an Insect-Associated Gene EcR. PLoS ONE. https://doi.org/10.1371/journal.pone.0038572
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