The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Origin and Spread of Bos taurus: New Clues from Mitochondrial Genomes Belonging to Haplogroup T1
Open accessAbstract
BACKGROUND: Most genetic studies on modern cattle have established a common origin for all taurine breeds in the Near East, during the Neolithic transition about 10 thousand years (ka) ago. Yet, the possibility of independent and/or secondary domestication events is still debated and is fostered by the finding of rare mitochondrial DNA (mtDNA) haplogroups like P, Q and R. Haplogroup T1, because of its geographic distribution, has been the subject of several investigations pointing to a possible independent domestication event in Africa and suggesting a genetic contribution of African cattle to the formation of Iberian and Creole cattle. Whole mitochondrial genome sequence analysis, with its proven effectiveness in improving the resolution of phylogeographic studies, is the most appropriate tool to investigate the origin and structure of haplogroup T1. METHODOLOGY: A survey of >2200 bovine mtDNA control regions representing 28 breeds (15 European, 10 African, 3 American) identified 281 subjects belonging to haplogroup T1. Fifty-four were selected for whole mtDNA genome sequencing, and combined with ten T1 complete sequences from previous studies into the most detailed T1 phylogenetic tree available to date. CONCLUSIONS: Phylogenetic analysis of the 64 T1 mitochondrial complete genomes revealed six distinct sub-haplogroups (T1a-T1f). Our data support the overall scenario of a Near Eastern origin of the T1 sub-haplogroups from as much as eight founding T1 haplotypes. However, the possibility that one sub-haplogroup (T1d) arose in North Africa, in domesticated stocks, shortly after their arrival from the Near East, can not be ruled out. Finally, the previously identified "African-derived American" (AA) haplotype turned out to be a sub-clade of T1c (T1c1a1). This haplotype was found here for the first time in Africa (Egypt), indicating that it probably originated in North Africa, reached the Iberian Peninsula and sailed to America, with the first European settlers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Approximately 7000 years ago, taurine cattle were distributed in southern Egypt and across the African continent, established by the T1 mtDNA lineage, which is now characteristic of African cattle [26,37,38,45].”
From The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution (2026) · cites this paper as [38]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A study on mtDNA indicates that all African cattle breeds analyzed so far carried taurine mtDNA haplotypes which suggests that these waves of indicine arrival into Africa were male-mediated (Bradley et al., 1996; Bonfiglio et al., 2012).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Bonfiglio et al., 2012
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Evolution, consequences and future of plant and animal domestication
Diamond, J. M. (2002) · Nature · doi:10.1038/nature01019 · Cited by 1,772
Anderson, S., de Bruijn, M. H. L., Coulson, A. R., Eperon, I. C., Sanger, F., & Young, I. G. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90137-1 · Cited by 1,472
Genetic diversity in farm animals – a review
Groeneveld, L. F., Lenstra, J. A., Eding, H., Toro, M. Á., Scherf, B., Pilling, D., Negrini, R., Finlay, E. K., Jianlin, H., Groeneveld, E., et al. (2010) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02038.x · Cited by 680
Tablet-next generation sequence assembly visualization.
Milne, I., Bayer, M., Cardle, L., Shaw, P., Stephen, G., Wright, F., & Marshall, D. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp666 · Cited by 666
Genetic Evidence for Near-Eastern Origins of European Cattle
Troy, C. S., MacHugh, D. E., Bailey, J. F., Magee, D. A., Loftus, R. T., Cunningham, P., Chamberlain, A. T., Sykes, B. C., & Bradley, D. G. (2001) · Nature · doi:10.1038/35074088 · Cited by 627
Mitochondrial diversity and the origins of African and European cattle
Bradley, D. G., MacHugh, D. E., Cunningham, P., & Loftus, R. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5131 · Cited by 584
Harvesting the fruit of the human mtDNA tree
Torroni, A., Achilli, A., Macaulay, V. A., Richards, M. B., & Bandelt, H. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.04.001 · Cited by 501
Self-citationThe Origin of European Cattle: Evidence from Modern and Ancient DNA
Beja-Pereira, A., Caramelli, D., Lalueza-Fox, C., Vernesi, C., Ferrand, N., Casoli, A., Goyache, F., Royo, L. J., Conti, S., Lari, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509210103 · Cited by 342
Mitochondrial Genomes of Extinct Aurochs Survive in Domestic Cattle
Achilli, A., Olivieri, A., Pellecchia, M., Uboldi, C., Colli, L., Al-Zahery, N., Accetturo, M., Pala, M., Kashani, B. H., Perego, U. A., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.01.019 · Cited by 290
Self-citationOn the Origin of Cattle: How Aurochs Became Cattle and Colonized the World
Ajmone‐Marsan, P., Garcia, J. F., & Lenstra, J. A. (2010) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.20267 · Cited by 287
Self-citation
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–106 of 106
Les zébus africains (Bos indicus africanus) : origines, diversité et performances zootechniques
Yamboue, A. T., & Hanzen, C. (2025) · Revue d’élevage et de médecine vétérinaire des pays tropicaux · doi:10.19182/remvt.37615 · Cited by 1
Kwon, T., Kim, K., Caetano-Anollés, K., Sung, S., Cho, S., Jeong, C., Hanotte, O., & 김희발 (2022) · Figshare · doi:10.6084/m9.figshare.18585750
Cardinali, I., Tommasi, A., Villani, G., Migliore, N. R., Partel, E., Somenzi, E., Morabito, S., Osorio, A. M. C., Gerlando, R. D., Olivieri, A., et al. (2026) · Genetics Selection Evolution · doi:10.1186/s12711-026-01063-8 · Cited by 1
Self-citationBrunson, K., Witt, K. E., MONGE, S., Williams, S. R., Singleton, R. R., Peede, D., Odsuren, D., Bukhchuluun, D., Cameron, A., Szpak, P., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117409
Démoulins, T., Yimthin, T., Tassera, L., Brodard, I., Eggerschwiler, L., Hemphill, A. F., Jores, J., & Kuhnert, P. (2026) · Veterinary Research · doi:10.1186/s13567-026-01848-1
Okwasiimire, R., Pokharel, K., Weldenegodguad, M., Makgahlela, M. L., Ghanem, N., Ginja, C., Gao, J., Uimari, P., Kantanen, J., Kugonza, D. R., et al. (2026) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkag287
Self-citation
Metadata
- Authors
- Bonfiglio, S., Ginja, C., De Gaetano, A., Achilli, A., Olivieri, A., Colli, L., Tesfaye, K., Agha, S. H., Gama, L. T., Cattonaro, F., Penedo, M. C. T., Ajmone-Marsan, P., Torroni, A., & Ferretti, L.
- Affiliations
- University of Pavia (IT)
- University of Lisbon (PT)
- University of Perugia (IT)
- Università Cattolica del Sacro Cuore (IT)
- Addis Ababa University (ET)
- Ain Shams University (EG)
- Universidade Técnica de Lisboa (PT)
- Istituto di Genomica Applicata (IT)
- University of California, Davis (US)
- Corresponding author
- Ferretti, Luca
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-06-07
- Volume
- 7
- Issue
- 6
- Pages
- e38601
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3369859
- OpenAlex
- W1995568032
- Cited by
- 106
- References
- 31
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 9 · 2013: 4
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, other-oa)
- Greater South Information System
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- cattle, cattle domestication, mitochondrial genome, phylogeography, African cattle, Iberian cattle, Creole cattle, Neolithic Near East
- MeSH terms
- Africa, Americas, Animals, Cattle, DNA, Mitochondrial, Europe, Haplotypes, Molecular Sequence Data, Phylogeny, Species Specificity, Time Factors, Genetic Variation, Sequence Analysis, DNA, Evolution, Molecular, Genome, Mitochondrial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
