The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Energy Metabolism during Repeated Sets of Leg Press Exercise Leading to Failure or Not
Open accessAbstract
This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34 ± 6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P<0.05) of the power output, muscle PCr and ATP content, and markedly higher (P<0.05) levels of muscle lactate and IMP. Significant correlations (P<0.01) were observed between changes in muscle PCr and muscle lactate (R(2) = 0.46), between changes in muscle PCr and IMP (R(2) = 0.44) as well as between changes in power output and changes in muscle ATP (R(2) = 0.59) and lactate (R(2) = 0.64) levels. Reducing the number of repetitions per set by 50% causes a lower disruption to the energy balance in the muscle. The correlations suggest that the changes in PCr and muscle lactate mainly occur simultaneously during exercise, whereas IMP only accumulates when PCr levels are low. The decrease in ATP stores may contribute to fatigue.
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“This implies that when the last repetitions of a set are being performed in the MaxV condition, only moderate levels of velocity loss and metabolic stress occur [ 12 , 32 ] .”
From Effect of Movement Velocity during Resistance Training on Neuromuscular Performance (2014) · cites this paper as [12]
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“Intra‐set VL is correlated with mechanical and metabolic fatigue markers, in addition to proximity to muscular failure (Gorostiaga et al., 2012).”
From Acute systemic and energy metabolism responses to velocity-based resistance training following an oral glucose load in individuals with excess body weight (2026) · cites this paper as Gorostiaga et al., 2012
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“The metabolic stress and degree of fatigue induced by the RT protocols used in this investigation are far from those typically associated with exhaustive resistance training [ 12 , 32 ] .”
From Effect of Movement Velocity during Resistance Training on Neuromuscular Performance (2014) · cites this paper as [12]
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Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290
Self-citationThe importance of muscular strength: Training considerations
Suchomel, T. J., Nimphius, S., Bellon, C. R., & Stone, M. H. (2018) · Sports Medicine · doi:10.1007/s40279-018-0862-z · Cited by 940
Pareja‐Blanco, F., Rodríguez‐Rosell, D., Sánchez‐Medina, L., Sanchis‐Moysi, J., Dorado, C., Mora‐Custodio, R., Yáñez‐García, J. M., Morales‐Alamo, D., Pérez‐Suárez, I., Calbet, J. A. L., et al. (2017) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12678 · Cited by 505
Self-citationEgan, B., & Sharples, A. P. (2023) · Physiological Reviews · doi:10.1152/physrev.00054.2021 · Cited by 278
González‐Badillo, J. J., Rodríguez‐Rosell, D., Sánchez‐Medina, L., Gorostiaga, E. M., & Pareja‐Blanco, F. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2014.905987 · Cited by 243
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Metadata
- Authors
- Gorostiaga, E. M., Navarro-Amézqueta, I., Calbet, J. A. L., Hellsten, Y., Cusso, R., Guerrero, M., Granados, C., González-Izal, M., Ibañez, J., & Izquierdo, M.
- Affiliations
- Gobierno de Navarra (ES)
- Universidad de Las Palmas de Gran Canaria (ES)
- University of Copenhagen (DK)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Corresponding author
- Gorostiaga, Esteban M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-07-13
- Volume
- 7
- Issue
- 7
- Pages
- e40621
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3396634
- OpenAlex
- W2022174440
- Cited by
- 178
- References
- 45
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 18 · 2020: 27 · 2019: 15 · 2018: 14 · 2017: 10 · 2016: 4 · 2015: 10 · 2014: 6 · 2013: 1
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Update notices
- correction (2013-01-17)
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- Academica-e (Universidad Pública de Navarra) (acceptedVersion, cc-by)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- leg press, muscle energy metabolism, muscle fatigue, phosphocreatine, ATP, muscle lactate, inosine monophosphate, output power, vastus lateralis
- MeSH terms
- Adult, Biomechanical Phenomena, Energy Metabolism, Humans, Leg, Male, Nucleotides, Phosphocreatine, Uric Acid, Exercise, Muscle, Skeletal, Lactic Acid, Metabolome
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