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Cited by 691Sports Performance and TrainingCardiovascular and exercise physiologyMuscle metabolism and nutrition

Contribution of phosphocreatine and aerobic metabolism to energy supply during repeated sprint exercise

Bogdanis, G. C., Nevill, M. E., Boobis, L. H., Lakomy, H. K.·1996·Journal of Applied Physiology
DOI 10.1152/jappl.1996.80.3.876
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Abstract

This study examined the contribution of phosphocreatine (PCr) and aerobic metabolism during repeated bouts of sprint exercise. Eight male subjects performed two cycle ergometer sprints separated by 4 min of recovery during two separate main trials. Sprint 1 lasted 30 s during both main trials, whereas sprint 2 lasted either 10 or 30 s. Muscle biopsies were obtained at rest, immediately after the first 30-s sprint, after 3.8 min of recovery, and after the second 10- and 30-s sprints. At the end of sprint 1, PCr was 16.9 +/- 1.4% of the resting value, and muscle pH dropped to 6.69 +/- 0.02. After 3.8 min of recovery, muscle pH remained unchanged (6.80 +/- 0.03), but PCr was resynthesized to 78.7 +/- 3.3% of the resting value. PCr during sprint 2 was almost completely utilized in the first 10 s and remained unchanged thereafter. High correlations were found between the percentage of PCr resynthesis and the percentage recovery of power output and pedaling speed during the initial 10 s of sprint 2 (r = 0.84, P < 0.05 and r = 0.91, P < 0.01). The anaerobic ATP turnover, as calculated from changes in ATP, PCr, and lactate, was 235 +/- 9 mmol/kg dry muscle during the first sprint but was decreased to 139 +/- 7 mmol/kg dry muscle during the second 30-s sprint, mainly as a result of a approximately 45% decrease in glycolysis. Despite this approximately 41% reduction in anaerobic energy, the total work done during the second 30-s sprint was reduced by only approximately 18%. This mismatch between anaerobic energy release and power output during sprint 2 was partly compensated for by an increased contribution of aerobic metabolism, as calculated from the increase in oxygen uptake during sprint 2 (2.68 +/- 0.10 vs. 3.17 +/- 0.13 l/min; sprint 1 vs. sprint 2; P < 0.01). These data suggest that aerobic metabolism provides a significant part (approximately 49%) of the energy during the second sprint, whereas PCr availability is important for high power output during the initial 10 s.

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Crossref · 10.1152/jappl.1996.80.3.876

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  • RSA protocols maximize anaerobic power by breaking down high-energy phosphates and enhancing glycolytic enzyme activity while also activating the oxidative system during recovery periods.

    “RSA protocols maximize anaerobic power by breaking down high-energy phosphates and enhancing glycolytic enzyme activity while also activating the oxidative system during recovery periods7,12,13.”

    From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [13]

  • Indirect evidence points to the role of anaerobic energy pathways in maintaining repeated sprint performance, but this comes at the cost of metabolite accumulation and energy store depletion.

    “Indirect evidence points to the role of anaerobic energy pathways in maintaining repeated sprint performance, but this comes at the cost of metabolite accumulation and energy store depletion13,16,18.”

    From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [13]

  • Muscle buffering capacity and changes in muscle and blood pH significantly influence performance.

    “Research has shown that muscle buffering capacity and changes in muscle and blood pH significantly influence performance6,8,13.”

    From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [13]

  • The recovery of muscle force during repeated bouts of high-intensity exercise is linked to muscle PCr resynthesis, which is largely an O2-dependent process.

    “The recovery of muscle force during repeated bouts of high-intensity exercise is linked to muscle PCr resynthesis [104,105,106], which is largely an O2-dependent process [107,108].”

    From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [105]

  • Dietary NO3− supplementation has also been shown to increase muscle blood flow, which might aid muscle PCr resynthesis between sets to failure and the recovery of force and performance.

    “Dietary NO3− supplementation has also been shown to increase muscle blood flow [109], which might aid muscle PCr resynthesis between sets to failure [107,108] and the recovery of force and performance [104,105,106].”

    From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [105]

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Authors
Bogdanis, G. C., Nevill, M. E., Boobis, L. H., & Lakomy, H. K.
Affiliations
Loughborough University (GB)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1996-03-01
Volume
80
Issue
3
Pages
876-884
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1996.80.3.876
OpenAlex
W2158705184
Cited by
691
References
26
Citations by year
2026: 32 · 2025: 28 · 2024: 26 · 2023: 21 · 2022: 31 · 2021: 33 · 2020: 38 · 2019: 34 · 2018: 33 · 2017: 30 · 2016: 30 · 2015: 31 · 2014: 35 · 2013: 39 · 2012: 35
FWCI
8.68
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
phosphocreatine, aerobic metabolism, repeated sprint exercise, energy supply, glycolysis, muscle pH, oxygen consumption, output power, muscle energy metabolism, lactate, ATP turnover, muscle fatigue, muscle fiber composition
MeSH terms
Adenosine Triphosphate, Adult, Energy Metabolism, Humans, Male, Muscles, Phosphocreatine, Time Factors, Exercise

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