The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Relationships between Body Composition and the Systemic Inflammatory Response in Patients with Primary Operable Colorectal Cancer
Open accessAbstract
BACKGROUND: Weight loss is recognised as a marker of poor prognosis in patients with cancer but the aetiology of cancer cachexia remains unclear. The aim of the present study was to examine the relationships between CT measured parameters of body composition and the systemic inflammatory response in patients with primary operable colorectal cancer. PATIENT AND METHODS: 174 patients with primary operable colorectal cancer who underwent resection with curative intent (2003-2010). Image analysis of CT scans was used to measure total fat index (cm(2)/m(2)), subcutaneous fat index (cm(2)/m(2)), visceral fat index (cm(2)/m(2)) and skeletal muscle index (cm(2)/m(2)). Systemic inflammatory response was measured by serum white cell count (WCC), neutrophil:lymphocyte ratio (NLR) and the Glasgow Prognostic Score (mGPS). RESULTS: There were no relationships between any parameter of body composition and serum WCC or NLR. There was a significant relationship between low skeletal muscle index and an elevated systemic inflammatory response, as measured by the mGPS (p = 0.001). This was confirmed by linear relationships between skeletal muscle index and both C-reactive protein (r = -0.21, p = 0.005) and albumin (r = 0.31, p<0.001). There was no association between skeletal muscle index and tumour stage. CONCLUSIONS: The present study highlights a direct relationship between low levels of skeletal muscle and the presence of a systemic inflammatory response in patients with primary operable colorectal cancer.
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Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
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Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210
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“Several previous studies investigating the clinical impact of cancer cachexia have focused specifically on the loss of lean tissue [4,29].”
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Cited by
Reisinger, K. W., van Vugt, J. L. A., Tegels, J. J. W., Snijders, C., Hulsewé, K. W. E., Hoofwijk, A. G. M., Stoot, J. H., Von Meyenfeldt, M. F., Beets, G. L., Derikx, J. P. M., et al. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000000628 · Cited by 507
Influence of body composition profile on outcomes following colorectal cancer surgery
Malietzis, G., Currie, A. C., Athanasiou, T., Johns, N., Anyamene, N., Glynne-Jones, R., Kennedy, R. H., Fearon, K. C. H., & Jenkins, J. T. (2016) · British Journal of Surgery · doi:10.1002/bjs.10075 · Cited by 299
van Vugt, J. L. A., Levolger, S., Gharbharan, A., Koek, M., Niessen, W. J., Burger, J. W. A., Willemsen, S. P., de Bruin, R. W. F., & IJzermans, J. N. M. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12158 · Cited by 217
Smith, S., & Madden, A. M. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12372 · Cited by 67
Dolan, R. D., Maclay, J. D., Abbass, T., Colville, D., Buali, F., MacLeod, N., McSorley, S. T., Horgan, P. G., & McMillan, D. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-77269-7 · Cited by 22
Self-citation
Metadata
- Authors
- Richards, C. H., Roxburgh, C. S. D., MacMillan, M. T., Isswiasi, S., Robertson, E. G., Guthrie, G. K., Horgan, P. G., & McMillan, D. C.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-08-03
- Volume
- 7
- Issue
- 8
- Pages
- e41883
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1988539555
- Cited by
- 161
- References
- 6
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Richards, C. H., Roxburgh, C. S. D., MacMillan, M. T., Isswiasi, S., Robertson, E. G., Guthrie, G. K., Horgan, P. G., & McMillan, D. C. (2012). The Relationships between Body Composition and the Systemic Inflammatory Response in Patients with Primary Operable Colorectal Cancer. PLoS ONE. https://doi.org/10.1371/journal.pone.0041883
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