HGF and Direct Mesenchymal Stem Cells Contact Synergize to Inhibit Hepatic Stellate Cells Activation through TLR4/NF-kB Pathway
Open accessAbstract
AIMS: Bone marrow-derived mesenchymal stem cells (BMSCs) can reduce liver fibrosis. Apart from the paracrine mechanism by which the antifibrotic effects of BMSCs inhibit activated hepatic stellate cells (HSCs), the effects of direct interplay and juxtacrine signaling between the two cell types are poorly understood. The purpose of this study was to explore the underlying mechanisms by which BMSCs modulate the function of activated HSCs. METHODS: We used BMSCs directly and indirectly co-culture system with HSCs to evaluate the anti-fibrosis effect of BMSCs. Cell proliferation and activation were examined in the presence of BMSCs and HGF. c-met was knockdown in HSCs to evaluate the effect of HGF secreted by BMSCs. The TLR4 and Myeloid differentiation primary response gene 88(MyD88) mRNA levels and the NF-kB pathway activation were determined by real-time PCR and western blotting analyses. The effect of BMSCs on HSCs activation was investigated in vitro in either MyD88 silencing or overexpression in HSCs. Liver fibrosis in rats fed CCl(4) with and without BMSCs supplementation was compared. Histopathological examinations and serum biochemical tests were compared between the two groups. RESULTS: BMSCs remarkably inhibited the proliferation and activation of HSCs by interfering with LPS-TLR4 pathway through a cell-cell contact mode that was partially mediated by HGF secretion. The NF-kB pathway is involved in HSCs activation inhibition by BMSCs. MyD88 over expression reduced the BMSC inhibition of NF-kB luciferase activation. BMSCs protected liver fibrosis in vivo. CONCLUSION: BMSCs modulate HSCs in vitro via TLR4/MyD88/NF-kB signaling pathway through cell-cell contact and secreting HGF. BMSCs have therapeutic effects on cirrhosis rats. Our results provide new insights into the treatment of hepatic fibrosis with BMSCs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HGF secreted by MSCs suppresses LPS-induced HSC activation by inhibiting the TLR4/MyD88/NF-κB pathway.
“HGF secreted by MSCs has also been shown to suppress LPS-induced HSC activation by inhibiting TLR4/MyD88/NF-κB pathway [180].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [180]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T. R., Lund, T. C., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,523 · see citing works
RetractedClassification of chronic hepatitis: Diagnosis, grading and staging
Desmet, V. J., Gerber, M. A., Hoofnagle, J. H., Manns, M. P., & Scheuer, P. J. (1994) · Hepatology · doi:10.1002/hep.1840190629 · Cited by 2,591 · see citing works
Molecular cloning and expression of human hepatocyte growth factor
Nakamura, T., Nishizawa, T., Hagiya, M., Seki, T., Shimonishi, M., Sugimura, A., Tashiro, K., & Shimizu, S. (1989) · Nature · doi:10.1038/342440a0 · Cited by 2,158 · see citing works
Chang, T., Liaw, Y., Wu, S., Schiff, E. R., Han, K., Lai, C., Safadi, R., Lee, S. S., Halota, W., Goodman, Z. D., et al. (2010) · Hepatology · doi:10.1002/hep.23785 · Cited by 970 · see citing works
Bacterial translocation (BT) in cirrhosis†
Wiest, R., & Garcia‐Tsao, G. (2005) · Hepatology · doi:10.1002/hep.20632 · Cited by 677 · see citing works
Haynesworth, S. E., Baber, M. A., & Caplan, A. I. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199603)166:3 · Cited by 658 · see citing works
Gohda, E., Tsubouchi, H., Nakayama, H., Hirono, S., Sakiyama, O., Takahashi, K., MIYAZAKI, H., Hashimoto, S., & Daikuhara, Y. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113334 · Cited by 656 · see citing works
Transplantation of Bone Marrow Cells Reduces Ccl4–Induced Liver Fibrosis in Mice
Sakaida, I., Terai, S., Yamamoto, N., Aoyama, K., Ishikawa, T., Nishina, H., & Okita, K. (2004) · Hepatology · doi:10.1002/hep.20452 · Cited by 524 · see citing works
Terai, S., Ishikawa, T., Ômori, K., Aoyama, K., Marumoto, Y., Urata, Y., Yokoyama, Y., Uchida, K., Yamasaki, T., Fujii, Y., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0542 · Cited by 491 · see citing works
The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases
Soares, J., Pimentel‐Nunes, P., Roncon‐Albuquerque, R., & Leite-Moreira, A. F. (2010) · Hepatology International · doi:10.1007/s12072-010-9219-x · Cited by 369 · see citing works
Peng, L., Xie, D., Lin, B., Liu, J., Zhu, H., Xie, C., Zheng, Y., & Gao, Z. (2011) · Hepatology · doi:10.1002/hep.24434 · Cited by 366 · see citing works
Self-citationLin, R.-S., Lee, F.-Y., Lee, S.-D., Tsai, Y.-T., Lin, H. C., Rei-Hwa, L., Wan-Ching, H., Cheng-Chun, H., Sun-Sang, W., & Kwang-Juei, L. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80424-2 · Cited by 355 · see citing works
Ishiki, Y., Ohnishi, H., Muto, Y., Matsumoto, K., & Nakamura, T. (1992) · Hepatology · doi:10.1002/hep.1840160520 · Cited by 344 · see citing works
Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
Oyagi, S., Hirose, M., Kojima, M., Okuyama, M., Kawase, M., Nakamura, T., Ohgushi, H., & Yagi, K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.026 · Cited by 299 · see citing works
Non-Invasive markers for hepatic fibrosis
Baranova, A. V., Lal, P., Birerdinc, A., & Younossi, Z. M. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-91 · Cited by 297 · see citing works
Chen, X., Katakowski, M., Li, Y., Lu, D., Wang, L., Zhang, L., Chen, J., Xu, Y., Gautam, S. C., Mahmood, A., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10334 · Cited by 293 · see citing works
Gordon, M. Y., Levičar, N., Pai, M., Bachellier, P., Dimarakis, I., Al-Allaf, F. A., M’Hamdi, H., Thalji, T., Welsh, J. P., Marley, S. B., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0629 · Cited by 275 · see citing works
Guo, J., Loke, J., Zheng, F., Hong, F., Yea, S., Fukata, M., Tarocchi, M., Abar, O. T., Huang, H., Sninsky, J. J., et al. (2009) · Hepatology · doi:10.1002/hep.22697 · Cited by 217 · see citing works
Schiff, E. R., Lee, S. S., Chao, Y., Yoon, S. K., Bessone, F., Wu, S., Kryczka, W., Lurie, Y., Gadano, A. C., Kitis, G. E., et al. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.11.040 · Cited by 184 · see citing works
Gaia, S., Smedile, A., Omedè, P., Olivero, A., Sanavio, F., Balzola, F. A., Ottobrelli, A., Abate, M. L., Marzano, A., Rizzetto, M., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.02.018 · Cited by 161 · see citing works
Schwabe, R. F., Schnabl, B., Kweon, Y. O., & Brenner, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6812 · Cited by 155 · see citing works
Brun, P., Castagliuolo, I., Pinzani, M., Palù, G., & Martines, D. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00537.2004 · Cited by 144 · see citing works
Nolan, J. P., & Leibowitz, A. I. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90848-x · Cited by 121 · see citing works
Fibrogenic Potential of Human Multipotent Mesenchymal Stromal Cells in Injured Liver
Baertschiger, R. M., Serre‐Beinier, V., Morel, P., Bosco, D., Peyrou, M., Clément, S., Sgroi, A., Kaelin, A., Bühler, L. H., & Gonelle‐Gispert, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006657 · Cited by 121 · see citing works
Wound Repair by Bone Marrow Stromal Cells through Growth Factor Production
Liu, Y., Dulchavsky, D. S., Gao, X., Kwon, D., Chopp, M., Dulchavsky, S. A., & Gautam, S. C. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.037 · Cited by 89 · see citing works
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
Cho, K., Lim, G.-W., Joo, S.-Y., Woo, S., Seoh, J., Cho, S. J., Han, H., & Ryu, K. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02364.x · Cited by 85 · see citing works
Grinko, I., Geerts, A. E., & Wisse, E. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80204-5 · Cited by 64 · see citing works
Erratum: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T. R., Lund, T. C., Blackstad, M., et al. (2007) · Nature · doi:10.1038/nature05812 · Cited by 63 · see citing works
Roos, F. D., Terrell, T. G., Godowski, P. J., Chamow, S. M., & SCHWALL, R. H. (1992) · Endocrinology · doi:10.1210/en.131.6.2540 · Cited by 54 · see citing works
Development of cell therapy using autologous bone marrow cells for liver cirrhosis
Sakaida, I., Terai, S., Nishina, H., & Okita, K. (2005) · Medical Molecular Morphology · doi:10.1007/s00795-005-0298-z · Cited by 36 · see citing works
Xie, C., Zheng, Y., Zhu, H., Peng, L., & Gao, Z. (2009) · Cell Biology International · doi:10.1016/j.cellbi.2009.01.006 · Cited by 28 · see citing works
Self-citationPayne, C. M., Samuel, K., Pryde, A., Lee, P. J., Jeske, A., Forbes, S. J., Plevris, J. N., Iredale, J. P., & Newsome, P. N. (2007) · Hepatology · Cited by 2 · see citing works
Brun, P., Castagliuolo, I., Pinzani, M., PALU, G., & MARTINES, D. (2003) · Hepatology · doi:10.1016/s0270-9139(03)80736-x · Cited by 1 · see citing works
Xie, C. L., Gao, Z., Zheng, Y. B., Peng, L., & Zhu, H. (2009) · Journal of Hepatology · doi:10.1016/s0168-8278(09)60591-2 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [23]Sakaida I, Terai S, Nishina H, Okita K (2005) Developmentof cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol 38: 197– 202. 16378227
Cited by
Sorted by citations
An, S. Y., Jang, Y. J., Lim, H.-J., Han, J., Lee, J., Lee, G., Park, J. Y., Park, S.-Y., Kim, J. H., Do, B.-R., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.003 · Cited by 193 · see citing works
Chen, L., Zhang, C., Chen, L., Wang, X., Xiang, B., Wu, X., Guo, Y., Mou, X., Yuan, L., Chen, B., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0265 · Cited by 142 · see citing works
Use of mesenchymal stem cells to treat liver fibrosis: Current situation and future prospects
Berardis, S., Sattwika, P. D., Najimi, M., & Sokal, E. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i3.742 · Cited by 140 · see citing works
Bai, T., Yang, Y., Wu, Y., Jiang, S., Lee, J. J., Lian, L., & Nan, J. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.02.006 · Cited by 93 · see citing works
Re, O. L., Panebianco, C., Porto, S., Cervi, C., Rappa, F., Biase, S. D., Caraglia, M., Pazienza, V., & Vinciguerra, M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25987 · Cited by 59 · see citing works
Song, N., Gao, L., Qiu, H., Huang, C., Cheng, H., Zhou, H., Lv, S., Chen, L., & Wang, J. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2191 · Cited by 54 · see citing works
Fiore, E. J., Mazzolini, G. D., & Aquino, J. B. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9585-9 · Cited by 52 · see citing works
Zhang, Z., Wang, Y., Chen, L., & Li, Z. (2019) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12065 · Cited by 49 · see citing works
Lee, C., Kim, M.-J., Han, J., Yoon, M. H., & Jung, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9111598 · Cited by 46 · see citing works
Regenerative Potential of Mesenchymal Stem Cells’ (MSCs) Secretome for Liver Fibrosis Therapies
Ignat, S.-R., Gharbia, S., Hermenean, A. O., Dinescu, S., & Costache, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413292 · Cited by 46 · see citing works
Zhang, Y., Li, R., Rong, W., Mingzi, H., Cui, C., Feng, Z., Sun, X., & Jin, S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1239-9 · Cited by 45 · see citing works
Controversial Role of Toll-like Receptor 4 in Adult Stem Cells
Zeuner, M., Bieback, K., & Widera, D. (2015) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9589-5 · Cited by 44 · see citing works
Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma
Cheng, Y., Luo, R.-C., Zheng, H., Wang, B., Liu, Y., Liu, D., Chen, J., Xu, W., Li, A., & Zhu, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.15575 · Cited by 43 · see citing works
Chen, P., Huang, C., Meng, X., & Li, J. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.016 · Cited by 41 · see citing works
Zhao, M., CUI, J.-Z., Cui, Y., LI, R., Tian, Y., SONG, S.-X., Zhang, J., & Gao, J. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1580 · Cited by 39 · see citing works
Otsuka, T., Imura, T., Nakagawa, K., Shrestha, L., Takahashi, S., Kawahara, Y., Sueda, T., Kurisu, K., & Yuge, L. (2018) · Stem Cells and Development · doi:10.1089/scd.2017.0299 · Cited by 38 · see citing works
Fu, J., Zhang, H., Zhuang, Y., Liu, H., Shi, Q., Li, D., & Ju, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103355 · Cited by 37 · see citing works
Cell therapy in end-stage liver disease: replace and remodel
Hu, X.-H., Chen, L., Wu, H., Tang, Y., Zheng, Q.-M., Wei, X., Wei, Q., Huang, Q., Chen, J., & Xu, X. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03370-z · Cited by 36 · see citing works
Dong, D., Yin, L., Qi, Y., Xu, L., & Peng, J. (2015) · Nutrients · doi:10.3390/nu7064829 · Cited by 36 · see citing works
Lee, E. J., Hwang, I., Lee, J. Y., Park, J. N., Kim, K. C., Kim, I., Moon, D., Park, H., Lee, S.-Y., Kim, H. S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190402 · Cited by 30 · see citing works
Qiao, H., Zhou, Y., Qin, X., Cheng, J., He, Y., & Jiang, Y. (2018) · Stem Cells International · doi:10.1155/2018/1239143 · Cited by 28 · see citing works
Parys, M., Nelson, N. C., Koehl, K. L., Miller, R., Kaneene, J. B., Kruger, J. M., & Yuzbasiyan‐Gurkan, V. (2015) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13655 · Cited by 28 · see citing works
Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects
Huang, Y., Zhu, M., Liu, Z., Hu, R., Li, F., Song, Y., Geng, Y., Ma, W., Song, K., & Zhang, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.997808 · Cited by 27 · see citing works
Dong, S., & Su, S.-B. (2014) · Journal of Chinese Integrative Medicine · doi:10.1016/s2095-4964(14)60022-4 · Cited by 25 · see citing works
Liu, X., Liu, J., Wang, X., Zou, Y., Tao, X., Li, J., Ye, M., Xu, W., Deng, Y., Liu, L., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01112-w · Cited by 23 · see citing works
Zhang, X., Li, M., & Wang, H. (2019) · Medical Science Monitor · doi:10.12659/msm.916030 · Cited by 23 · see citing works
Gan, N., Yang, L., Omran, A. G., Peng, J., Wu, L., He, F. P., Zhang, C., Xiang, Q., Kong, H., Ma, Y., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8522-7 · Cited by 22 · see citing works
Multipotent mesenchymal stromal cells in liver cancer: Implications for tumor biology and therapy
Hernanda, P. Y., Pedroza‐González, A., Sprengers, D., Peppelenbosch, M. P., & Pan, Q. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.08.008 · Cited by 22 · see citing works
Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease
Yi, S., Cong, Q., Zhu, Y., & Xu, Q. (2023) · Stem Cells International · doi:10.1155/2023/3919002 · Cited by 15 · see citing works
Yang, T., Zhao, S., Sun, N., Zhao, Y., Wang, H., Zhang, Y., Hou, X., Tang, Y., Gao, X. Y., & Fan, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109898 · Cited by 14 · see citing works
Imura, T., Tomiyasu, M., Otsuru, N., Nakagawa, K., & Otsuka, T. (2017) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000375 · Cited by 14 · see citing works
Shi, X., Zhang, K., Qi, Q., Zhou, W., Yu, F., & Zhang, Y. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09664-6 · Cited by 13 · see citing works
Stem Cell-based Therapy Strategy for Hepatic Fibrosis by Targeting Intrahepatic Cells
Deng, Y., Xia, B., Chen, Z., Wang, F., Lv, Y., & Chen, G. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10286-9 · Cited by 12 · see citing works
Chen, L., Zhang, N., Huang, Y., Zhang, Q., Fang, Y., Fu, J., Yuan, Y., Chen, L., Chen, X., Xu, Z., et al. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10583-5 · Cited by 11 · see citing works
Brückner, S., Zipprich, A., Hempel, M., Thonig, A., Schwill, F., Roderfeld, M., Roeb, E., & Christ, B. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.09.006 · Cited by 11 · see citing works
Shi, Y., Li, B., Sun, S., Tian, W., Ma, Z., & Liu, W. (2023) · PubMed Central · doi:10.22038/ijbms.2022.67908.14848 · Cited by 10 · see citing works
Wang, Y., Wang, X., Zhou, X., Zhu, Z., Yang, J., & Liu, F. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3953 · Cited by 10 · see citing works
Wang, L., Bai, G., & Chen, F. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0127 · Cited by 9 · see citing works
The emerging role of hepatocyte growth factor in renal diseases
Mao, S., & Zhang, J. (2015) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2015.1080275 · Cited by 7 · see citing works
Effects of exosomes of mesenchymal stem cells on cholesterol-induced hepatic fibrogenesis.
Rashidi, M., Matour, E., Monjezi, S., Zadeh, S. A., Shakerian, E., Sabahy, S., & Afarin, R. (2023) · PubMed Central · doi:10.22038/ijbms.2023.68858.15003 · Cited by 6 · see citing works
Ibrahim, M. A., Khalifa, A. M., El‐Fadeal, N. M. A., Abdel-Karim, R. I., Elsharawy, A. F., Ellawindy, A., Galal, H. M., Nadwa, E. H., Shafee, M. A., & Galhom, R. A. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102239 · Cited by 6 · see citing works
Blocking the Hormone Receptors Modulates NLRP3 in LPS-Primed Breast Cancer Cells
Hamza, S., Garanina, E. E., Al-Saadi, A., Khaiboullina, S. F., & Tezcan, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054846 · Cited by 5 · see citing works
miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration
Wang, F., Zhu, J., Zheng, J., Duan, W., & Zhou, Z. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11065 · Cited by 5 · see citing works
Lin, N., Yao, Z., Xu, L., Xu, M., Yuan, L., Zhuang, H., Lin, Y., & Xu, R. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0248 · Cited by 5 · see citing works
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
“HGF secreted by MSCs has also been shown to suppress LPS-induced HSC activation by inhibiting TLR4/MyD88/NF-κB pathway [180].”
Ahmed, A. F., Madi, M. A., Ali, A. H., & Mokhemer, S. A. (2024) · Cell and Tissue Research · doi:10.1007/s00441-024-03925-3 · Cited by 2 · see citing works
Recent Advances in Derivation of Functional Hepatocytes from Placental Stem Cells
Iacono, M. L. (2013) · The Open Tissue Engineering and Regenerative Medicine Journal · doi:10.2174/1875043501306010012 · Cited by 2 · see citing works
Kawamoto, D., Matsumoto, T., Fujioka, T., Shinoda, S., Fujisawa, K., Ishikawa, T., Yamamoto, N., & Takami, T. (2026) · Stem Cells · doi:10.1093/stmcls/sxag006 · Cited by 1 · see citing works
Payushina, O. V., Tsomartova, D. A., Васильевна, Ч. Е., Ivanova, M. Y., & Kuznetsov, S. L. (2021) · Biology Bulletin Reviews · doi:10.1134/s2079086421010059 · Cited by 1 · see citing works
Wang, X., Zhao, W., Wang, J., Shi, K., Qin, X., Kong, Q., Wang, G., Mu, L., Li, H., Sun, B., et al. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3423-9
The implications of multipotent mesenchymal stromal cells in tumor biology and therapy
Hernanda, P. Y., Peppelenbosch, M. P., & Pan, Q. (2016) · Wiley eBooks · doi:10.1002/9781118907474.ch28
Menstrual Blood Mesenchymal Stem Cells: Boon In Therapeutics
Pushkala, K., & Gupta, P. (2020) · Open Access Journal of Gynecology and Obstetrics · doi:10.22259/2638-5244.0302004
Goonetilleke, M., Correia, J., Chen, Y., McDonald, H., Chan, S. T., Inocencio, I. M., Cross, J., Greening, D. W., Simpson, I. A., Sievert, W., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5679779/v1
Gao, H., Lei, Z., Wang, L., Li, Y., Chen, Z., & Wang, G. (2026) · Discover Oncology · doi:10.1007/s12672-026-05436-9
Stem Cell and Exosome Treatment for Organ Health and Longevity
Prodromos, C. C., Villar, R. D., Striegel, A., Pena, G. R., Dixit, R., & Xu, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209174
- Authors
- Wang, P.-P., Xie, D.-Y., Liang, X.-J., Peng, L., Zhang, G.-L., Ye, Y.-N., Xie, C., & Gao, Z.-L.
- Affiliations
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Corresponding author
- Xie, Chan
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-08-23
- Volume
- 7
- Issue
- 8
- Pages
- e43408
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3426540
- OpenAlex
- W2004568092
- Cited by
- 55
- References
- 34
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 8 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 5 · 2013: 3
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (H1617, 81101864)
- Fundamental Research Funds for the Central Universities
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- bone marrow-derived mesenchymal stem cells, hepatic stellate cells, liver fibrosis, hepatocyte growth factor, c-Met, cell-cell contact, juxtacrine signaling, co-culture, MyD88, liver cirrhosis, CCl4-induced fibrosis
- MeSH terms
- Animals, Bone Marrow Cells, Cell Line, Dose-Response Relationship, Drug, Humans, Lipopolysaccharides, Liver Cirrhosis, Signal Transduction, Up-Regulation, NF-kappa B, Rats, Sprague-Dawley, Hepatocyte Growth Factor, Toll-Like Receptor 4, Rats, Myeloid Differentiation Factor 88, Hepatic Stellate Cells, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
