The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes
Open accessAbstract
Breast milk is the primary source of nutrition for newborns, and is rich in immunological components. MicroRNAs (miRNAs) are present in various body fluids and are selectively packaged inside the exosomes, a type of membrane vesicles, secreted by most cell types. These exosomal miRNAs could be actively delivered into recipient cells, and could regulate target gene expression and recipient cell function. Here, we analyzed the lactation-related miRNA expression profiles in porcine milk exosomes across the entire lactation period (newborn to 28 days after birth) by a deep sequencing. We found that immune-related miRNAs are present and enriched in breast milk exosomes (p<10(-16), χ(2) test) and are generally resistant to relatively harsh conditions. Notably, these exosomal miRNAs are present in higher numbers in the colostrums than in mature milk. It was higher in the serum of colostrum-only fed piglets compared with the mature milk-only fed piglets. These immune-related miRNA-loaded exosomes in breast milk may be transferred into the infant body via the digestive tract. These observations are a prelude to in-depth investigations of the essential roles of breast milk in the development of the infant's immune system.
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The clinical significance of platelet microparticle-associated microRNAs.
Provost, P. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0895 · Cited by 68
Therapeutic and Diagnostic Potential of Exosomes as Drug Delivery Systems in Brain Cancer
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Metadata
- Authors
- Gu, Y., Li, M., Wang, T., Liang, Y., Zhong, Z., Wang, X., Zhou, Q., Chen, L., Lang, Q., He, Z., Chen, X., Gong, J., Gao, X., Li, X., & Lv, X.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-08-24
- Volume
- 7
- Issue
- 8
- Pages
- e43691
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2016960054
- Cited by
- 261
- References
- 41
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gu, Y., Li, M., Wang, T., Liang, Y., Zhong, Z., Wang, X., Zhou, Q., Chen, L., Lang, Q., He, Z., Chen, X., Gong, J., Gao, X., Li, X., & Lv, X. (2012). Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes. PLoS ONE. https://doi.org/10.1371/journal.pone.0043691
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