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Stability of p53 Homologs
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“The stability of the p53 DBD from another cold-blooded animal, rainbow trout, which is native to cold-water tributaries of the North Pacific, was even slightly lower (Tm = 37.5 °C) than that of the Xenopus p53 DBD, further supporting the idea that vertebrate p53 DBDs evolved to be intrinsically unstable [28, 29].”
From Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog (2022) · cites this paper as [29]
In the citing paper
“Consistent with published data [28, 29], the thermodynamic stability of other vertebrate p53 DBDs correlated with differences in organismal temperature or living conditions in the case of cold-blooded species.”
From Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog (2022) · cites this paper as [29]
In the citing paper
“Subsequent studies revealed that the thermostability of the p53 DBD correlates with the organismal temperature of endothermic animals and temperatures for optimal development of ectothermic vertebrates [28–30].”
From Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog (2022) · cites this paper as [29]
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Citations
Cites
Core domain interactions in full-length p53 in solution
Veprintsev, D. B., Freund, S. M. V., Andreeva, A., Rutledge, S. E., Tidow, H., Cañadillas, J. M. P., Blair, C. M., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511130103 · Cited by 95
Self-citation
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Cited by
Leu, J. I.-J., Murphy, M. E., & George, D. L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009943117 · Cited by 47
Zhang, Q., Balourdas, D.-I., Baron, B., Senitzki, A., Haran, T. E., Wiman, K. G., Soussi, T., & Joerger, A. C. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04653-8 · Cited by 14
Metadata
- Authors
- Brandt, T., Kaar, J. L., Fersht, A. R., & Veprintsev, D. B.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-10-24
- Volume
- 7
- Issue
- 10
- Pages
- e47889
- ISSN
- 1932-6203
- Cited by
- 35
- References
- 1
- Language
- en
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- Brandt, T., Kaar, J. L., Fersht, A. R., & Veprintsev, D. B. (2012). Stability of p53 Homologs. PLoS ONE. https://doi.org/10.1371/journal.pone.0047889
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