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Distinct Contributions of the Dorsolateral Prefrontal and Orbitofrontal Cortex during Emotion Regulation
Open accessAbstract
The lateral prefrontal and orbitofrontal cortices have both been implicated in emotion regulation, but their distinct roles in regulation of negative emotion remain poorly understood. To address this issue we enrolled 58 participants in an fMRI study in which participants were instructed to reappraise both negative and neutral stimuli. This design allowed us to separately study activations reflecting cognitive processes associated with reappraisal in general and activations specifically related to reappraisal of negative emotion. Our results confirmed that both the dorsolateral prefrontal cortex (DLPFC) and the lateral orbitofrontal cortex (OFC) contribute to emotion regulation through reappraisal. However, activity in the DLPFC was related to reappraisal independently of whether negative or neutral stimuli were reappraised, whereas the lateral OFC was uniquely related to reappraisal of negative stimuli. We suggest that relative to the lateral OFC, the DLPFC serves a more general role in emotion regulation, perhaps by reflecting the cognitive demand that is inherent to the regulation task.
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“In another study (Golkar et al., 2012), a neutral control state was introduced which contained non-emotional aspects of the task, and the interaction revealed more specific activation also in the lOFC/vlPFC.”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Golkar et al., 2012
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“Given the role of the amygdala in emotional processing [35] and that this region has been shown to be modulated by reappraisal [3,36], we defined the amygdala as an a priori region of interest (ROI).”
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Metadata
- Authors
- Golkar, A., Lonsdorf, T. B., Olsson, A., Lindstrom, K. M., Berrebi, J., Fransson, P., Schalling, M., Ingvar, M., & Öhman, A.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Golkar, Armita
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-11-07
- Volume
- 7
- Issue
- 11
- Pages
- e48107
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3492343
- OpenAlex
- W2076380444
- Cited by
- 235
- References
- 47
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 19 · 2023: 18 · 2022: 20 · 2021: 26 · 2020: 14 · 2019: 20 · 2018: 16 · 2017: 15 · 2016: 7 · 2015: 16 · 2014: 14 · 2013: 9
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
- Funders
- Stiftelsen för Strategisk Forskning
- VINNOVA
- Vetenskapsrådet
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- emotion regulation, cognitive reappraisal, dorsolateral prefrontal cortex, orbitofrontal cortex, negative emotions, cognitive demand
- MeSH terms
- Adult, Amygdala, Brain Mapping, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Photic Stimulation, Prefrontal Cortex, Young Adult
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