The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Proneural genes and the specification of neural cell types
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789
Hematopoietic development: a balancing act
Cantor, A. B., & Orkin, S. H. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00226-4 · Cited by 191
Research works printed but not linked: 154
- Ghysen, A. & Dambly-Chaudiere, C. From DNA to form: the achaete-scute complex. Genes Dev. 2, 495–501 (1988). · DOI
- Garcia-Bellido, A. Genetic analysis of the achaete-scute system of Drosophila melanogaster. Genetics 91, 491–520 (1979). · DOI
- Gonzalez, F. et al. Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development. EMBO J. 8, 3553–3562 (1989). · DOI · Paper page
- Villares, R. & Cabrera, C. V. The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 50, 415–424 (1987).This paper was the first to report the molecular characterization of asc genes and to show that they share a domain that later became known as a bHLH domain. · DOI · Paper page
- Murre, C. et al. Interactions between heterologous helix–loop–helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537–544 (1989). · DOI · Paper page
- Murre, C., McCaw, P. S. & Baltimore, D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56, 777–783 (1989).The bHLH class of transcription factors was first defined in this article. The properties of DNA binding and heterodimerization of bHLH domains were also first characterized here and in reference 5. · DOI · Paper page
- Jarman, A. P. et al. atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell 73, 1307–1321 (1993).This paper reports the isolation of the first known Drosophila proneural gene outside the asc complex, ato , and shows that asc and ato encode neuronal-subtype information. · DOI · Paper page
- Goulding, S. E., White, N. M. & Jarman, A. P. cato encodes a basic helix–loop–helix transcription factor implicated in the correct differentiation of Drosophila sense organs. Dev. Biol. 221, 120–131 (2000). · DOI
- Goulding, S. E., zur Lage, P. & Jarman, A. P. amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. Neuron 25, 69–78 (2000). · DOI · Paper page
- Huang, M. L., Hsu, C. H. & Chien, C. T. The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Neuron 25, 57–67 (2000). · DOI
- Campuzano, S. & Modolell, J. Patterning of the Drosophila nervous system: the achaete-scute gene complex. Trends Genet. 8, 202–208 (1992). · doi:10.1016/0168-9525(92)90234-u · Paper page
- Jan, Y. N. & Jan, L. Y. Genetic control of cell fate specification in Drosophila peripheral nervous system. Annu. Rev. Genet. 28, 373–393 (1994). · DOI
- Jimenez, F. & Modolell, J. Neural fate specification in Drosophila. Curr. Opin. Genet. Dev. 3, 626–632 (1993). · DOI
- Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signaling: cell fate control and signal integration in development. Science 284, 770–776 (1999). · DOI · Paper page
- Jimenez, F. & Campos-Ortega, J. A. Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster. Neuron 5, 81–89 (1990). · DOI · Paper page
- Moore, A. W. et al. A genomewide survey of basic helix–loop–helix factors in Drosophila. Proc. Natl Acad. Sci. USA 97, 10436–10441 (2000). · DOI
- Peyrefitte, S., Kahn, D. & Haenlin, M. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix–loop–helix genes. Mech. Dev. 104, 99–104 (2001). · DOI
- Lee, J. E. Basic helix–loop–helix genes in neural development. Curr. Opin. Neurobiol. 7, 13–20 (1997). · DOI · Paper page
- Guillemot, F. Vertebrate bHLH genes and the determination of neuronal fates. Exp. Cell Res. 253, 357–364 (1999). · DOI
- Hassan, B. A. & Bellen, H. J. Doing the MATH: is the mouse a good model for fly development? Genes Dev. 14, 1852–1865 (2000). · DOI
- Cabrera, C. V. & Alonso, M. C. Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J. 10, 2965–2973 (1991). · DOI
- Johnson, J. E. et al. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc. Natl Acad. Sci. USA 89, 3596–3600 (1992). · DOI
- Massari, M. E. & Murre, C. Helix–loop–helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20, 429–440 (2000). · DOI · Paper page
- Ellenberger, T. et al. Crystal structure of transcription factor E47: E-box recognition by a basic region helix–loop–helix dimer. Genes Dev. 8, 970–980 (1994). · DOI · Paper page
- Ferre-D'Amare, A. R. et al. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature 363, 38–45 (1993). · DOI · Paper page
- Ma, P. C. et al. Crystal structure of MyoD bHLH domain–DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell 77, 451–459 (1994). · DOI · Paper page
- Campuzano, S. Emc, a negative HLH regulator with multiple functions in Drosophila development. Oncogene 20, 8299–8307 (2001). · DOI
- Yokota, Y. Id and development. Oncogene 20, 8290–8298 (2001). · DOI
- Davis, R. L. & Turner, D. L. Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20, 8342–8357 (2001). · DOI · Paper page
- Kageyama, R. & Nakanishi, S. Helix–loop–helix factors in growth and differentiation of the vertebrate nervous system. Curr. Opin. Genet. Dev. 7, 659–665 (1997). · DOI · Paper page
- Chen, H. et al. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl Acad. Sci. USA 94, 5355–5360 (1997). · DOI · Paper page
- Ohsako, S. et al. Hairy function as a DNA-binding helix–loop–helix repressor of Drosophila sensory organ formation. Genes Dev. 8, 2743–2755 (1994). · DOI · Paper page
- Van Doren, M. et al. Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8, 2729–2742 (1994). · DOI
- Chien, C. T. et al. Neuronal type information encoded in the basic-helix–loop–helix domain of proneural genes. Proc. Natl Acad. Sci. USA 93, 13239–13244 (1996).By analysing the properties of chimeric genes of ato and sc , this paper provided the first indication that the specificity of proneural gene function might depend on interactions with cofactors. · DOI
- Mizuguchi, R. et al. Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31, 757–771 (2001). · DOI · Paper page
- Novitch, B. G., Chen, A. I. & Jessell, T. M. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31, 773–789 (2001). · DOI · Paper page
- Koyano-Nakagawa, N., Wettstein, D. & Kintner, C. Activation of Xenopus genes required for lateral inhibition and neuronal differentiation during primary neurogenesis. Mol. Cell. Neurosci. 14, 327–339 (1999). · DOI
- Jarman, A. P. et al. The regulation and function of the helix–loop–helix gene, asense, in Drosophila neural precursors. Development 119, 19–29 (1993). · DOI · Paper page
- Dominguez, M. & Campuzano, S. asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene. EMBO J. 12, 2049–2060 (1993). · DOI
- Rodriguez, I. et al. Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia. EMBO J. 9, 3583–3592 (1990). · DOI · Paper page
- Jarman, A. P. et al. atonal is the proneural gene for Drosophila photoreceptors. Nature 369, 398–400 (1994). · DOI · Paper page
- Hassan, B. A. et al. atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25, 549–561 (2000). · DOI · Paper page
- Casarosa, S., Fode, C. & Guillemot, F. Mash1 regulates neurogenesis in the ventral telencephalon. Development 126, 525–534 (1999).References 43 and 46 first showed the importance of proneural gene activity for the development of the vertebrate CNS. · DOI · Paper page
- Cau, E., Casarosa, S. & Guillemot, F. Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development 129, 1871–1880 (2002). · DOI · Paper page
- Guillemot, F. et al. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75, 463–476 (1993).The first demonstration by gene knockout in the mouse of the role of a proneural gene in vertebrate neurogenesis. · DOI · Paper page
- Horton, S. et al. Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH1. Mol. Cell. Neurosci. 14, 355–369 (1999). · DOI · Paper page
- Fode, C. et al. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20, 483–494 (1998). · DOI · Paper page
- Ma, Q. et al. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20, 469–482 (1998). · DOI · Paper page
- Ma, Q. et al. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 13, 1717–1728 (1999). · DOI · Paper page
- Scardigli, R. et al. Crossregulation between neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31, 203–217 (2001). · DOI · Paper page
- Fode, C. et al. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 14, 67–80 (2000).This paper and reference 59 showed that proneural genes are involved in the specification of neuronal identity in the forebrain and spinal cord, respectively, and that distinct neuroepithelial domains of proneural gene expression are established through cross-inhibition. · DOI · Paper page
- Morrow, E. M. et al. NeuroD regulates multiple functions in the developing neural retina in rodent. Development 126, 23–36 (1999). · DOI · Paper page
- Tomita, K. et al. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 19, 5460–5472 (2000).References 53 and 68 provide genetic evidence that neural bHLH genes act in a redundant manner to promote neurogenesis and inhibit gliogenesis in the CNS. · DOI · Paper page
- Blader, P. et al. The activity of neurogenin1 is controlled by local cues in the zebrafish embryo. Development 124, 4557–4569 (1997). · DOI
- Ma, Q., Kintner, C. & Anderson, D. J. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87, 43–52 (1996).The first evidence that Ngn genes can ectopically activate neuronal differentiation and interact with Notch signalling, and thus have the characteristics of proneural genes. · DOI · Paper page
- Ben-Arie, N. et al. Math1 is essential for genesis of cerebellar granule neurons. Nature 390, 169–172 (1997). · DOI · Paper page
- Bermingham, N. A. et al. Math1: an essential gene for the generation of inner ear hair cells. Science 284, 1837–1841 (1999). · DOI · Paper page
- Bermingham, N. A. et al. Proprioceptor pathway development is dependent on Math1. Neuron 30, 411–422 (2001). · DOI · Paper page
- Gowan, K. et al. Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron 31, 219–232 (2001). · DOI · Paper page
- Brown, N. L. et al. Math5 is required for retinal ganglion cell and optic nerve formation. Development 128, 2497–2508 (2001). · DOI · Paper page
- Kay, J. N. et al. Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog. Neuron 30, 725–736 (2001). · DOI · Paper page
- Wang, S. W. et al. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 15, 24–29 (2001). · DOI · Paper page
- Kanekar, S. et al. Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron 19, 981–994 (1997). · DOI · Paper page
- Matter-Sadzinski, L. et al. Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins. Development 128, 217–231 (2001). · DOI
- Kim, P. et al. XATH-1, a vertebrate homolog of Drosophila atonal, induces a neuronal differentiation within ectodermal progenitors. Dev. Biol. 187, 1–12 (1997). · DOI
- Ben-Arie, N. et al. Functional conservation of atonal and Math1 in the CNS and PNS. Development 127, 1039–1048 (2000). · DOI · Paper page
- Sommer, L. et al. The cellular function of MASH1 in autonomic neurogenesis. Neuron 15, 1245–1258 (1995). · DOI · Paper page
- Nieto, M. et al. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29, 401–413 (2001). · DOI · Paper page
- Ferreiro, B. et al. XASH genes promote neurogenesis in Xenopus embryos. Development 120, 3649–3655 (1994). · DOI
- Lo, L. et al. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Development 129, 1553–1567 (2002). · DOI
- Turner, D. L. & Weintraub, H. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 8, 1434–1447 (1994). · DOI · Paper page
- Chitnis, A. & Kintner, C. Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos. Development 122, 2295–2301 (1996). · DOI · Paper page
- Henrique, D. et al. cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system. Genes Dev. 11, 603–615 (1997). · DOI
- Lewis, J. Notch signalling and the control of cell fate choices in vertebrates. Semin. Cell Dev. Biol. 9, 583–589 (1998). · DOI · Paper page
- Perron, M. & Harris, W. A. Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix–loop–helix transcription factors. Cell. Mol. Life Sci. 57, 215–223 (2000). · DOI
- Heitzler, P. et al. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122, 161–171 (1996). · DOI · Paper page
- Hinz, U., Giebel, B. & Campos-Ortega, J. A. The basic-helix–loop–helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77–87 (1994). · DOI · Paper page
- Kunisch, M., Haenlin, M. & Campos-Ortega, J. A. Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins. Proc. Natl Acad. Sci. USA 91, 10139–10143 (1994). · DOI
- Culi, J. & Modolell, J. Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev. 12, 2036–2047 (1998). · doi:10.1101/gad.12.13.2036
- Kintner, C. Neurogenesis in embryos and in adult neural stem cells. J. Neurosci. 22, 639–643 (2002). · DOI
- Vaessin, H. et al. daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo. Development 120, 935–945 (1994). · DOI
- Nolo, R., Abbott, L. A. & Bellen, H. J. Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102, 349–362 (2000). · DOI · Paper page
- Dubois, L. et al. XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the specification of primary neurons in Xenopus. Curr. Biol. 8, 199–209 (1998). · DOI
- Bae, S. et al. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development 127, 2933–2943 (2000). · DOI · Paper page
- Koyano-Nakagawa, N. et al. Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation. Development 127, 4203–4216 (2000). · DOI
- Bellefroid, E. J. et al. X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Cell 87, 1191–1202 (1996). · DOI · Paper page
- Sun, Y., Jan, L. Y. & Jan, Y. N. Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system. Development 125, 3731–3740 (1998). · DOI
- Van Doren, M. et al. Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev. 6, 2592–2605 (1992). · DOI · Paper page
- Helms, A. W. et al. Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development 127, 1185–1196 (2000). · DOI · Paper page
- Culi, J., Martin-Blanco, E. & Modolell, J. The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning. Development 128, 299–308 (2001). · DOI
- Ben-Arie, N. et al. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Hum. Mol. Genet. 5, 1207–1216 (1996). · DOI
- Gradwohl, G., Fode, C. & Guillemot, F. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev. Biol. 180, 227–241 (1996). · DOI · Paper page
- Cubas, P. et al. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 5, 996–1008 (1991). · DOI · Paper page
- Skeath, J. B. & Carroll, S. B. Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 5, 984–995 (1991). · DOI · Paper page
- Jan, Y. N. & Jan, L. Y. HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell 75, 827–830 (1993). · DOI · Paper page
- Farah, M. H. et al. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127, 693–702 (2000). · DOI · Paper page
- Lee, J. E. et al. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix–loop–helix protein. Science 268, 836–844 (1995).This paper reported, for the first time, that ectopic expression in Xenopus embryos of a neural bHLH gene, NeuroD , is sufficient to drive the differentiation of ectoderm cells into neurons. · DOI · Paper page
- Liu, M. et al. Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc. Natl Acad. Sci. USA 97, 865–870 (2000). · DOI · Paper page
- Miyata, T., Maeda, T. & Lee, J. E. NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 13, 1647–1652 (1999). · DOI · Paper page
- Olson, J. M. et al. NeuroD2 is necessary for development and survival of central nervous system neurons. Dev. Biol. 234, 174–187 (2001). · DOI · Paper page
- Schwab, M. H. et al. Neuronal basic helix–loop–helix proteins (NEX and BETA2/NeuroD) regulate terminal granule cell differentiation in the hippocampus. J. Neurosci. 20, 3714–3724 (2000). · DOI · Paper page
- Perron, M. et al. X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina. Proc. Natl Acad. Sci. USA 96, 14996–15001 (1999). · DOI
- Huang, H. P. et al. Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol. Cell. Biol. 20, 3292–3307 (2000). · DOI · Paper page
- Gerber, A. N. et al. Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis. Genes Dev. 11, 436–450 (1997). · DOI · Paper page
- Temple, S. The development of neural stem cells. Nature 414, 112–117 (2001). · DOI · Paper page
- Vetter, M. A turn of the helix: preventing the glial fate. Neuron 29, 559–562 (2001). · DOI
- Cai, L., Morrow, E. M. & Cepko, C. L. Misexpression of basic helix–loop–helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development 127, 3021–3030 (2000). · DOI
- Inoue, T. et al. Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129, 831–842 (2002). · DOI · Paper page
- Kessaris, N., Pringle, N. & Richardson, W. D. Ventral neurogenesis and the neuron–glial switch. Neuron 31, 677–680 (2001). · DOI
- Zhou, Q., Choi, G. & Anderson, D. J. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 31, 791–807 (2001). · DOI · Paper page
- Sun, Y. et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104, 365–376 (2001).Reported the unexpected finding that Ngn1 promotes neurogenesis and inhibits astrocytic differentiation by independent mechanisms: the activation of transcription and direct interference with gliogenic signalling pathways, respectively. · DOI · Paper page
- Nakashima, K. et al. Synergistic signaling in fetal brain by STAT3–Smad1 complex bridged by p300. Science 284, 479–482 (1999). · DOI · Paper page
- Kondo, T. & Raff, M. Basic helix–loop–helix proteins and the timing of oligodendrocyte differentiation. Development 127, 2989–2998 (2000). · DOI · Paper page
- Wang, S. et al. A role for the helix–loop–helix protein Id2 in the control of oligodendrocyte development. Neuron 29, 603–614 (2001). · DOI · Paper page
- Edlund, T. & Jessell, T. M. Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system. Cell 96, 211–224 (1999). · DOI · Paper page
- Ohnuma, S., Philpott, A. & Harris, W. A. Cell cycle and cell fate in the nervous system. Curr. Opin. Neurobiol. 11, 66–73 (2001). · DOI
- Mutoh, H. et al. The basic helix–loop–helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12, 820–830 (1998). · DOI
- Johnston, L. A. & Edgar, B. A. Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394, 82–84 (1998). · DOI · Paper page
- Wallace, K., Liu, T. H. & Vaessin, H. The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes. Genesis 26, 77–85 (2000). · doi:10.1002/(sici)1526-968x(200001)26:1<77::aid-gene10>3.0.co;2-r
- Jarman, A. P. & Ahmed, I. The specificity of proneural genes in determining Drosophila sense organ identity. Mech. Dev. 76, 117–125 (1998). · DOI
- Parras, C. et al. Control of neural precursor specification by proneural proteins in the CNS of Drosophila. EMBO J. 15, 6394–6399 (1996). · DOI
- Skeath, J. B. & Doe, C. Q. The achaete-scute complex proneural genes contribute to neural precursor specification in the Drosophila CNS. Curr. Biol. 6, 1146–1152 (1996). · DOI
- Blochlinger, K., Jan, L. Y. & Jan, Y. N. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 5, 1124–1135 (1991). · DOI
- Davis, R. L. & Weintraub, H. Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12. Science 256, 1027–1030 (1992). · DOI
- Jhaveri, D. et al. Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mech. Dev. 99, 101–111 (2000). · DOI
- Ramain, P. et al. Interactions between chip and the achaete/scute–daughterless heterodimers are required for pannier-driven proneural patterning. Mol. Cell 6, 781–790 (2000).Shows that the spatially restricted activation of an enhancer by Achaete-Scute proteins depends on interaction with a region-specific cofactor, Pannier. · DOI
- Goridis, C. & Brunet, J. F. Transcriptional control of neurotransmitter phenotype. Curr. Opin. Neurobiol. 9, 47–53 (1999). · DOI
- Hirsch, M. R. et al. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development 125, 599–608 (1998). · DOI · Paper page
- Lo, L., Tiveron, M. C. & Anderson, D. J. MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity. Development 125, 609–620 (1998).References 130 and 131 show by complementary LOF and GOF approaches that Mash1 is a determinant of noradrenergic neuron identity. · DOI · Paper page
- Pattyn, A. et al. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399, 366–370 (1999). · DOI · Paper page
- Goridis, C. & Rohrer, H. Specification of catecholaminergic and serotonergic neurons. Nature Rev. Neurosci. 3, 531–541 (2002). · DOI · Paper page
- Pattyn, A., Goridis, C. & Brunet, J. F. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b. Mol. Cell. Neurosci. 15, 235–243 (2000).This paper and reference 70 provide evidence that Mash1 and Ngns are involved in the specification of distinct neuronal subtypes, and that their specificity is dictated to different degrees by the cellular context. · DOI · Paper page
- Parras, C. M. et al. Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 16, 324–338 (2002). · DOI · Paper page
- Perez, S. E., Rebelo, S. & Anderson, D. J. Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. Development 126, 1715–1728 (1999). · DOI
- Cepko, C. L. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr. Opin. Neurobiol. 9, 37–46 (1999). · DOI · Paper page
- Hatakeyama, J. et al. Roles of homeobox and bHLH genes in specification of a retinal cell type. Development 128, 1313–1322 (2001). · DOI · Paper page
- Lu, Q. R. et al. Sonic hedgehog — regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25, 317–329 (2000). · DOI · Paper page
- Takebayashi, H. et al. Dynamic expression of basic helix–loop–helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech. Dev. 99, 143–148 (2000). · DOI · Paper page
- Wang, J. et al. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Proc. Natl Acad. Sci. USA 97, 3497–3502 (2000). · DOI
- Sun, T. et al. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr. Biol. 11, 1413–1420 (2001). · DOI
- Lu, Q. R. et al. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109, 75–86 (2002). · DOI · Paper page
- Qian, X. et al. Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28, 69–80 (2000). · DOI · Paper page
- Lo, L., Sommer, L. & Anderson, D. J. MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. Curr. Biol. 7, 440–450 (1997). · DOI · Paper page
- Shingo, T. et al. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J. Neurosci. 21, 9733–9743 (2001). · DOI · Paper page
- Johe, K. K. et al. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev. 10, 3129–3140 (1996). · DOI · Paper page
- Nakashima, K. et al. BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc. Natl Acad. Sci. USA 98, 5868–5873 (2001). · DOI · Paper page
- Shou, J., Rim, P. C. & Calof, A. L. BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor. Nature Neurosci. 2, 339–345 (1999). · DOI · Paper page
- Morrison, S. J. Neuronal potential and lineage determination by neural stem cells. Curr. Opin. Cell Biol. 13, 666–672 (2001). · DOI
- Tanigaki, K. et al. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 29, 45–55 (2001). · DOI · Paper page
- Anderson, D. J. Stem cells and pattern formation in the nervous system: the possible versus the actual. Neuron 30, 19–35 (2001). · DOI · Paper page
- Singson, A., Leviten, M. W., Bang, A. G., Hua, X. H. & Posakony, J. W. Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8, 2058–2071 (1994). · DOI
- Roztocil, T., Matter-Sadzinski, L., Gomez, M., Ballivet, M. & Matter, J. M. Functional properties of the neuronal nicotinic acetylcholine receptor β3 promoter in the developing central nervous system. J. Biol. Chem. 273, 15131–15137 (1998). · DOI
- Poulin, G., Turgeon, B. & Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol. Cell. Biol. 17, 6673–6682 (1997). · DOI
- Naya, F. J., Stellrecht, C. M. & Tsai, M. J. Tissue-specific regulation of the insulin gene by a novel basic helix–loop–helix transcription factor. Genes Dev. 9, 1009–1019 (1995). · DOI · Paper page
Cited by
Adult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
The use of brain organoids to investigate neural development and disease
Di Lullo, E., & Kriegstein, A. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.107 · Cited by 788
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J. (2003) · Nature Neuroscience · doi:10.1038/nn1131 · Cited by 825
Lessard, J., Wu, J. I., Ranish, J. A., Wan, M., Winslow, M. M., Staahl, B. T., Wu, H., Aebersold, R., Graef, I. A., & Crabtree, G. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.019 · Cited by 735
Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4987-09.2010 · Cited by 716
Metadata
- Authors
- Bertrand, N., Castro, D. S., & Guillemot, F.
- Venue
- Nature Reviews Neuroscience
- Published
- 2002-07
- Volume
- 3
- Issue
- 7
- Pages
- 517-530
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2043655216
- Cited by
- 1,488
- References
- 4
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Proneural genes and the specification of neural cell types. https://app.cochat.ai/papers/10.1038/nrn874
- The paper
- Bertrand, N., Castro, D. S., & Guillemot, F. (2002). Proneural genes and the specification of neural cell types. Nature Reviews Neuroscience. https://doi.org/10.1038/nrn874
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.