TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

Calculation of substrate oxidation rates in vivo from gaseous exchange.

Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365

Obesity and the Environment: Where Do We Go from Here?

Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986

Antibiotics in early life alter the murine colonic microbiome and adiposity

Cho, I., Yamanishi, S., Cox, L., Methé, B. A., Zavadil, J., Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., et al. (2012) · Nature · doi:10.1038/nature11400 · Cited by 1,613

The theoretical bases of indirect calorimetry: A review

Ferrannini, E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90110-2 · Cited by 1,604

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S. M., Pryor, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11514 · Cited by 1,180

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099

The Hormonal Control of Food Intake

Coll, A. P., Farooqi, I. S., & O’Rahilly, S. (2007) · Cell · doi:10.1016/j.cell.2007.04.001 · Cited by 624

Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1

Johnen, H., Lin, S., Kuffner, T., Brown, D. A., Tsai, V. W.-W., Bauskin, A. R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., et al. (2007) · Nature Medicine · doi:10.1038/nm1677 · Cited by 612

Large-Scale Delineation of Secreted Protein Biomarkers Overexpressed in Cancer Tissue and Serum

Welsh, J. B., Sapinoso, L. M., Kern, S. G., Brown, D. A., Liu, T., Bauskin, A. R., Ward, R. L., Hawkins, N. J., Quinn, D. I., Russell, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530278100 · Cited by 503

Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Melvin, A., Lacerda, E., Dockrell, H., O’Rahilly, S., & Nacul, L. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02153-6 · Cited by 21

Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling

Feetham, C. H., Collabolletta, V., Worth, A. A., Shoop, R., Groom, S., Harding, C., Boutagouga Boudjadja, M., Coskun, T., Emmerson, P. J., D’Agostino, G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54367-y · Cited by 22

Weight Loss Correlates with Macrophage Inhibitory Cytokine-1 Expression and Might Influence Outcome in Patients with Advanced Esophageal Squamous Cell Carcinoma

Lu, Z., Li, Y., Yu, J., Lü, M., Li, J., Zhou, J., Wang, X., Gong, J., Gao, J., Zhang, X., et al. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.15.6047 · Cited by 23

The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15

Kincaid, J. W. R., Rimmington, D., Tadross, J. A., Cimino, I., Zvetkova, I., Kaser, A., Richards, P., Patel, S., O’Rahilly, S., & Coll, A. P. (2024) · Scientific Reports · doi:10.1038/s41598-024-51866-2 · Cited by 20

Central mechanisms of emesis: A role for GDF15

Borner, T., Pataro, A. M., & Jonghe, B. C. D. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14886 · Cited by 20

Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges

Zhang, J., Sun, J., Li, J., & Xia, H. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70251 · Cited by 21

Metabolic Messenger: growth differentiation factor 15

Breit, S. N., & Tsai, V. W.-W. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01353-3 · Cited by 23

First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15

Low, J. K., Ambikairajah, A., Shang, K., Brown, D. A., Tsai, V. W.-W., Breit, S. N., & Karl, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0168416 · Cited by 20

Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications

Changalidis, A. I., Maksiutenko, E. M., Barbitoff, Y. A., Tkachenko, A. A., Vashukova, E. S., Pachuliia, O. V., Nasykhova, Y. A., & Glotov, A. S. (2022) · Genes · doi:10.3390/genes13122255 · Cited by 20

Current advancements in pharmacotherapy for cancer cachexia

da Fonseca, G. W. P., Sato, R., Alves, M. J. D. N. N., & von Haehling, S. (2023) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2023.2194489 · Cited by 21

The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis

Paepe, B. D., Verhamme, F., & Bleecker, J. D. (2020) · Cytokine · doi:10.1016/j.cyto.2019.154966 · Cited by 20

An updated patent review of GLP-1 receptor agonists (2020-present)

Lu, W., Zhou, Z., Jiang, N., & Han, J. (2023) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2023.2274905 · Cited by 17

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

Hill, R. J., Bona, N., Smink, J., Webb, H. K., Crisp, A., Garaycoechea, J. I., & Crossan, G. P. (2024) · Nature Communications · doi:10.1038/s41467-024-46844-1 · Cited by 21

Presence of growth/differentiation factor-15 cytokine in human follicular fluid, granulosa cells, and oocytes

Souček, K., Malenovská, A., Kahounová, Z., Remšík, J., Holubcová, Z., Soukup, T., Kurfürstová, D., Bouchal, J., Suchánková, T., Slabáková, E., et al. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1230-5 · Cited by 17

Weight Loss Induced by Bariatric Surgery Restricts Hepatic GDF15 Expression

Adolph, T. E., Grabherr, F., Mayr, L., Grander, C., Enrich, B., Moschen, A. R., & Tilg, H. (2018) · Journal of Obesity · doi:10.1155/2018/7108075 · Cited by 19

Regulation of diurnal energy balance by mitokines

Klaus, S., Gil, C. I., & Ost, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03748-9 · Cited by 19

GDF15 plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets

Mohammad, M. G., Saeed, R., Mohammed, A. K., Khalique, A., Hamad, M., El‐Huneidi, W., Hamad, M. A., & Taneera, J. (2023) · Experimental Biology and Medicine · doi:10.1177/15353702221146552 · Cited by 16

New Role for Growth/Differentiation Factor 15 in the Survival of Transplanted Brown Adipose Tissues in Cooperation with Interleukin-6

Oka, M., Kobayashi, N., Matsumura, K., Nishio, M., Nakano, K., Okamura, T., Okochi, H., Minamisawa, T., Shiba, K., & Saeki, K. (2020) · Cells · doi:10.3390/cells9061365 · Cited by 16

GDF15 and energy balance: homing in on a mechanism

Cimino, I., Coll, A. P., & Yeo, G. S. H. (2017) · Nature Medicine · doi:10.1038/nm.4414 · Cited by 15

Increased Growth Differentiation Factor 15 in Patients with Hypoleptinemia-Associated Lipodystrophy

Kralisch, S., Hoffmann, A., Estrada-Kunz, J., Stümvoll, M., Faßhauer, M., Tönjes, A., & Miehle, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197214 · Cited by 15

Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells

Asrih, M., Dusaulcy, R., Gosmain, Y., Philippé, J., Somm, E., Jornayvaz, F. R., Kang, B. E., Jo, Y., Choi, M. J., Yi, H., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111503 · Cited by 15

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues

Wiens, K. R., Wasti, N., Ulloa, O. O., & Klegeris, A. (2024) · Molecules · doi:10.3390/molecules29235525 · Cited by 16

Regulation of food intake after surgery and the gut brain axis

Tewari, N., Awad, S., & Lobo, D. N. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283638e97 · Cited by 14

Regulation of Satiety Quiescence by Neuropeptide Signaling in Caenorhabditis elegans

Makino, M., Ulzii, E., Shirasaki, R., Kim, J., & You, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.678590 · Cited by 15

Growth differentiation factor-15 is an IFN-γ regulated mediator of infection-induced weight loss and the hepatic FGF21 response

Reyes, J., Zhao, Y., Pandya, K., & Yap, G. S. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.029 · Cited by 13

Circulating Growth Differentiation Factor 15 Is Associated with Diabetic Neuropathy

Weng, S., Chen, W., Shen, F., Wang, P., Chen, J., & Liou, C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113033 · Cited by 13

Neurological & psychological aspects of Barth syndrome: Clinical manifestations and potential pathogenic mechanisms

Olivar‐Villanueva, M., Ren, M., & Phoon, C. K. L. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.011 · Cited by 13

Alteration of BDNF, SPARC, FGF-21, and GDF-15 circulating levels after 1 year of anti-obesity treatments and their association with 1-year weight loss

Chaiyasoot, K., Khumkhana, N., Deekum, W., Chaichana, C., Taweerutchana, V., Srisuworanan, N., & Pramyothin, P. (2023) · Endocrine · doi:10.1007/s12020-023-03435-2 · Cited by 12

Epilepsy and brain health: a large prospective cohort study

Zhang, D., Wang, Z., Zhang, Y.-R., Gao, P., Zhang, W., Fu, Y., Chi, H., Ma, L., Ge, Y., He, X., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-06006-9 · Cited by 13

GDF15 mediates renal cell plasticity in response to potassium depletion in mice

Lasaad, S., Walter, C., Rafael, C., Morla, L., Doucet, A., Picard, N., Blanchard, A., Fromes, Y., Matot, B., Crambert, G., et al. (2023) · Acta Physiologica · doi:10.1111/apha.14046 · Cited by 13

Loss of growth differentiation factor 15 exacerbates lung injury in neonatal mice

Al‐Mudares, F., Gutierrez, M. E. C., Cantu, A., Jiang, W., Wang, L., Dong, X., Moorthy, B., Sajti, E., & Lingappan, K. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00086.2023 · Cited by 10

Hyperbaric Oxygen Exposure Attenuates Circulating Stress Biomarkers: A Pilot Interventional Study

Chang, J. S., Chang, E., Lee, Y., Sung, Y., Cha, S., Cho, W. G., Jeong, Y., Kim, H., & Park, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17217853 · Cited by 11

The Effect of Dextrose or Protein Ingestion on Circulating Growth Differentiation Factor 15 and Appetite in Older Compared to Younger Women

Herpich, C., Lehmann, S., Kochlik, B., Kleinert, M., Klaus, S., Müller‐Werdan, U., & Norman, K. (2022) · Nutrients · doi:10.3390/nu14194066 · Cited by 10

Immunomodulatory agents for the treatment of cachexia

Chasen, M. R., Bhargava, R., & Hirschman, S. Z. (2014) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000086 · Cited by 10

Gastric GDF15 levels are regulated by age, sex, and nutritional status in rodents and humans

Pena-León, V., Pérez-Lois, R., Villalón, M., Folgueira, C., Barja-Fernández, S., Prida, E., Baltar, J., Santos, F., Fernø, J., García‐Caballero, T., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02232-y · Cited by 9

Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease

Chang, E., Chang, J. S., Kong, I. D., Baik, S. K., Kim, M. Y., & Park, K. (2021) · Gut and Liver · doi:10.5009/gnl210106 · Cited by 9

Gdf15 deletion exacerbates acute lung injuries induced by intratracheal inoculation of aerosolized ricin in mice

Deng, M., Su, D., Xiao, N., Zhang, Z., Wang, Y., Zong, F., Li, S., Wang, J., Zhou, D., Zhao, Y., et al. (2022) · Toxicology · doi:10.1016/j.tox.2022.153135 · Cited by 9

Relevance of GDF15 as a biomarker for clinical outcomes after bariatric surgery

Urones, P., Juiz-Valiña, P., Outeiriño-Blanco, E., García-Brao, M. J., Barreiro, V. B., Cordido, F., & Sangiao‐Alvarellos, S. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0010 · Cited by 9

GDF15 in the tumor microenvironment: A central mediator of cancer immunometabolism and therapeutic resistance

Lu, L., Johnson, C. H., Khan, S. A., & Irwin, M. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.01.004 · Cited by 11

The role of GDF15 in food intake and appetitive behaviour

Cimino, I., & Coll, A. P. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.100299 · Cited by 8

Screening study of anti-emetics to improve GDF15-induced malaise and anorexia: Implications for emesis control

Borner, T., Doebley, S. A., Furst, C. D., Pataro, A. M., Halas, J. G., Gao, X., Choi, G. K., Ramadan, S. A., Chow, A., & Jonghe, B. C. D. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114229 · Cited by 8

A long‐acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model

Zheng, S., Polidori, D., Wang, Y., Geist, B. J., Lin‐Schmidt, X., Furman, J. L., Nelson, S., Nawrocki, A. R., & Hinke, S. A. (2023) · Clinical and Translational Science · doi:10.1111/cts.13543 · Cited by 7

Neither glucagon-like peptide 1 receptors nor GDNF family receptor α-like neurons are required for aversive or anorectic response to deoxynivalenol (vomitoxin)

Patel, A. R., Frikke‐Schmidt, H., Sabatini, P. V., Rupp, A. C., Sandoval, D. A., Myers, M. G., & Seeley, R. J. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00189.2022 · Cited by 9

Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation

Binder, A. K., Kosak, J. P., Janhardhan, K. S., Moser, G. J., Eling, T. E., & Korach, K. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146518 · Cited by 7

Serum growth differentiation factor-15 analysis as a malnutrition marker in hemodialysis patients

Turgut, D., Topçu, D. İ., Alperen, C. C., & Baskın, E. (2021) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-2103-62 · Cited by 7

NXNL1 negatively regulates osteoblast differentiation via GDF15‐induced PP2A Cα dependent manner in MC3T3‐E1 cells

Kim, K., & Jang, W. (2021) · BioFactors · doi:10.1002/biof.1817 · Cited by 5

Daily GDF15 treatment has sex‐specific effects on body weight and food intake and does not enhance the effects of voluntary physical activity in mice

Jeromson, S., Akcan, M., Baranowski, B. J., Arbeau, M., Bellucci, A., & Wright, D. C. (2024) · The Journal of Physiology · doi:10.1113/jp287256 · Cited by 6

Growth differentiation factor 15 (GDF-15) is a novel orexigen in fish

Blanco, A. M., Bertucci, J. I., Velasco, C., & Unniappan, S. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110720 · Cited by 6

Establishment of GDF15 time-resolved fluorescence immunoassay and its clinical application in colorectal cancer

Chen, M., Fang, H., Gao, S., Zheng, T., Kao, S., Yuan, Q., Zhao, X., Zhou, X., Bao, Z., & Huang, B. (2025) · Analytical Biochemistry · doi:10.1016/j.ab.2025.115848 · Cited by 5

Deletion of GFRAL blunts weight lowering effects of FGF21 in female mice

Buch-Rasmussen, A. S., Andersen, H., Stage, C., Hansen, A. M. K., Paulsen, S. J., Gillum, M. P., Andersen, B., Secher, A., Latta, M. R., Clemmensen, C., et al. (2025) · Journal of Endocrinology · doi:10.1530/joe-25-0017 · Cited by 4

Association of Difference Between eGFR From Cystatin C and Creatinine and Serum GDF‐15 With Adverse Outcomes in Diabetes Mellitus

Gohda, T., Kamei, N., Tanaka, M., Furuhashi, M., Sato, T., Kubota, M., Sanuki, M., Koshida, T., Hagiwara, S., Suzuki, Y., et al. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70011 · Cited by 4

Growth Differentiation Factor 15 Induces Gastric Fundus Contraction Involving Cholinergic Excitation: Morphofunctional Evidence in Rodent Models

Garella, R., Palmieri, F., Tarchi, L., Tani, A., Chellini, F., Guarnieri, G., Morelli, A., Bernacchioni, C., Rovero, P., Ricca, V., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70629 · Cited by 4

Proteins extracted from placenta regulate osteogenic differentiation of human mesenchymal stem cells

Wei, B., Chen, Y., Zhang, S., Cui, L., Zhang, S., Zhuang, Z., Sun, C., Ren, N., & Liu, H. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103015 · Cited by 2

TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases

Breit, S. N., & Brown, D. A. (2016) · Compendium of Inflammatory Diseases · doi:10.1007/978-3-7643-8550-7_54 · Cited by 2

Prognostic value of circulating macrophage inhibitory cytokine 1-growth differentiation factor 15 (MIC-1/GDF15) in obesity: Relation with vascular endothelial growth factor (VEGF) and markers of oxidative stress

Parvaneh, R. R., Vajdi, M., Shiraz, A. N., Khani, M., Farshbaf, S. E., & Farhangi, M. A. (2022) · Nutrition and Health · doi:10.1177/02601060221099716 · Cited by 3

The biological mechanisms underpinning nutritional and health-related consequences of mucositis in head and neck cancer – A review

Morcom, C. R., Williams, C. M. D., Al-Qadami, G. H., Vieyra, C. P., Fabbro, E. D., Naito, T., Yokota, T., Le, H. V., Franzese, C., Bonomo, P., et al. (2025) · Oral Oncology · doi:10.1016/j.oraloncology.2025.107548 · Cited by 3

Regulation of Food Intake After Surgery and the Gut-Brain Axis

Tewari, N., & Lobo, D. N. (2019) · Springer eBooks · doi:10.1007/978-3-030-16554-3_1 · Cited by 2

GDF15 negatively regulates RGS16 to impair hepatic lipid metabolism in male mice offspring conceived by in vitro fertilization.

Liu, J., Zhu, Y., Zhu, D., Shi, Y., Lu, L., Li, W., Li, L., Zhou, X., Zhang, P., Yang, H., et al. (2022) · PubMed Central · Cited by 2

Expresión Génica del Factor de Crecimiento Transformante Beta en Niños con Fisura Labio Palatina no Sindrómica

Anaya, M. V. M., Martínez, F. D. G., Suarez, D. E. R., & Causado, A. S. (2016) · International journal of odontostomatology · doi:10.4067/s0718-381x2016000100013 · Cited by 2

Hematological Findings in Non-Treated and γ-Irradiated Mice Deficient for MIC-1/GDF15

HOFER, M., Hoferová, Z., Remšík, J., Nováková, M., Procházková, J., Fedr, R., Kohoutek, J., Dušek, L., Hampl, A., & Souček, K. (2018) · Physiological Research · doi:10.33549/physiolres.933810 · Cited by 2

Control of Body Weight

Makaronidis, J., & Batterham, R. L. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch11 · Cited by 2

Exploring shared genetic factors and prognostic biomarkers in pancreatic cancer and non-alcoholic fatty liver disease: Focus on hsa-miR-29c-3p and COL11A1 axis

Saha, A., Rahman, I., Roy, A., Azad, N., Biswas, P., Usha, A. T., Chowdhury, A. F. M. D. N., & Ferdoush, J. (2024) · Human Gene · doi:10.1016/j.humgen.2024.201371 · Cited by 1

Appetite control: why we fail to stop eating even when we are full?

Davis, K. C., & You, Y. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1309-z · Cited by 1

Gut-brain Axis Regulation of Food Intake and Visceral Illness

Patel, A. R. (2021) · Deep Blue (University of Michigan) · doi:10.7302/1469 · Cited by 1

TGF-b Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases

Breit, S. N., & Brown, D. A. (2014) · Encyclopedia of Inflammatory Diseases · doi:10.1007/978-3-0348-0620-6_54-1 · Cited by 1

CCT-217: A Landmark Gene Silencing Therapeutic for Weight Loss That Enhances Lean Mass Composition, Reduces Visceral, Subcutaneous Fat and Restores Metabolic Health in Obesity through BrowningPreprint

Reddy, R., & Singh, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.30.630715 · Cited by 1

The Role of the Central Nervous System in the Reduction of Food Intake during Infectious and Neoplastic Disease and in Eating Disorders: Experimental Approaches

Konsman, J. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-40007-5_36-1

Mechanisms By Which Glucose Lowering Therapies Reduce Obesity And Atherosclerosis

Day, E. A. (2020) · MacSphere (McMaster University) · doi:10.71548/25269

The Effects of Induced Polycystic Ovary Syndrome in NAG-1 Transgenic Mice

Werner, N. (2020) · ScholarWorks (Central Washington University)

GDF15 is elevated in conditions of glucocorticoid deficiency and is modulated by glucocorticoid replacement

Melvin, A., Chantzichristos, D., Kyle, C. J., Mackenzie, S. D., Br, W., Johannsson, G., Stimson, R. H., & O’Rahilly, S. (2020) · Yearbook of pediatric endocrinology · doi:10.1530/ey.17.8.16

Metabolic and Electrophysiological Effects of Fibroblast Growth Factor 19 in the Dorsal Vagal Complex

Wean, J. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.383

Faculty Opinions recommendation of Regulation of energy metabolism by receptor tyrosine kinase ligands.

Ladbury, J. E. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737907472.793574673

The Role of the Central Nervous System in the Reduction of Food Intake During Infectious and Neoplastic Disease and in Eating Disorders: Experimental Approaches

Konsman, J. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-55387-0_36

GDF15 mediates renal cell plasticity in response to potassium depletionPreprint

Lasaad, S., Walter, C., Rafael, C., Morla, L., Doucet, A., Picard, N., Blanchard, A., Fromes, Y., Matot, B., Crambert, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.27.521983

TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases

Breit, S. N., & Brown, D. A. (2016) · Encyclopedia of Inflammatory Diseases · doi:10.1007/978-3-0348-0620-6_54-2

GDF15 induz o metabolismo oxidativo por um mecanismo mediado pelo eixo PGC1alfa/PPAR em células musculares

Santos, B. C. F. (2022) · doi:10.47749/t/unicamp.2022.1263751

Additional file 1 of Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study

Yonezawa, Y., Takahashi, I., Ohseto, H., Ueno, F., Onuma, T., Noda, A., Murakami, K., Ishikuro, M., Obara, T., & Kuriyama, S. (2024) · Figshare · doi:10.6084/m9.figshare.25448982

Additional file 1 of The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker)

Omar, M., Jensen, J., Kistorp, C., Højlund, K., Videbæk, L., Tuxen, C., Larsen, J. H., Andersen, C. F., Gustafsson, F., Køber, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19243420

Additional file 2 of Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study

Yonezawa, Y., Takahashi, I., Ohseto, H., Ueno, F., Onuma, T., Noda, A., Murakami, K., Ishikuro, M., Obara, T., & Kuriyama, S. (2024) · Figshare · doi:10.6084/m9.figshare.25449090

Additional file 1 of Whole genome sequencing of simmental cattle for SNP and CNV discovery

Sun, T., Pei, S., Liu, Y., Hanif, Q., Xu, H., Chen, N., Lei, C., & Yue, X. (2024) · Figshare · doi:10.6084/m9.figshare.26580683

Additional file 2 of Whole genome sequencing of simmental cattle for SNP and CNV discovery

Sun, T., Pei, S., Liu, Y., Hanif, Q., Xu, H., Chen, N., Lei, C., & Yue, X. (2024) · Figshare · doi:10.6084/m9.figshare.26580686

Identifying sex-specific biomarkers for intrinsic capacity decline in the aging population

Zeng, L.-T., Ma, Y., Liu, H., & Cai, J. (2025) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2025.2606411

Prioritizing Therapeutic Targets for Interstitial Lung Disease: A Causal Mediation AnalysisPreprint

Oldham, J., Molyneaux, P. L., Maddali, M. V., Newton, C. A., Kim, J. S., Konkol, S., Pugashetti, J. V., Liu, G. Y., Goobie, G. C., Adegunsoye, A., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-8714555/v1

Is GDF15 or PGC-1α involved in 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD)-induced wasting syndrome? Evidence from a TCDD-sensitive and a TCDD-resistant rat strain

Pohjanvirta, R., Hakanen, J., Aatsinki, S., Lensu, S., Lindén, J., Mahiout, S., Pettersson, L., & Hakkola, J. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2026.2640123

In silico identification and evaluation of a novel GDF15 inhibitor for coronary artery disease

Samra, M., & Arora, I. (2026) · Discover Chemistry. · doi:10.1007/s44371-026-00618-4

Etude des mécanismes moléculaires impliqués dans l'effet hépatique des œstrogènes dans la perspective de prévenir les hépatopathies métaboliques

Guillaume, M. (2016) · theses.fr (ABES) · doi:10.70675/b04ca6a8zf8dbz408azbb15z2c2df9872cde

Le Growth Differenciation Factor 15 (GDF15) : expression et rôle au cours de processus ischémiques cardiaques

Dogon, G. (2023) · theses.fr (ABES) · doi:10.70675/10819641z5a2az498fzbc43zf48619419a7c

Peptide hormone-based combinational pharmacotherapies for chronic metabolic diseases

Chui, Z. S. W., Xue, Y., Wu, X., & Xu, A. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100150

GDF15 modulates mitochondrial content and differentiation-associated metabolic remodeling in skeletal muscle cells

Favero‐Santos, B. C., Lázaro, C. M., Kim, J. T., Guimaraes, D., Barrios, N. M. F., Gomes, L. B., Raimundo, P., Teófilo, F. B. S., Gomes, M., Reia, T. A., et al. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00438.2025

The sentinel hormone growth and differentiation factor-15, glucocorticoid homeostasis, and adrenal disorders

Bonaventura, I., Weigand, I., Isidori, A. M., Kroiß, M., & Reincke, M. (2026) · Endocrine Reviews · doi:10.1210/endrev/bnag035

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

Tsai, V. W.-W., Macia, L., Feinle‐Bisset, C., Manandhar, R., Astrup, A. V., Raben, A., Lorenzen, J. K., Schmidt, P. T., Wiklund, F. E., Pedersen, N. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133362 · Cited by 96

Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15

Tsai, V. W.-W., Lin, S., Brown, D. A., Salis, A., & Breit, S. N. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.242 · Cited by 109

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

Tsai, V. W.-W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.018 · Cited by 424

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034868 · Cited by 211

Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes

Tsai, V. W.-W., Brown, D. A., & Breit, S. N. (2018) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000384 · Cited by 20