Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
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Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity. Both under a normal chow diet and an obesogenic diet, the transgenic overexpression of MIC-1/GDF15 in mice leads to decreased body weight and fat mass. This lean phenotype was associated with decreased spontaneous but not fasting-induced food intake, on a background of unaltered energy expenditure and reduced physical activity. Importantly, the overexpression of MIC-1/GDF15 improved glucose tolerance, both under normal and high fat-fed conditions. Altogether, this work shows that the molecule MIC-1/GDF15 might be beneficial for the treatment of obesity as well as perturbations in glucose homeostasis.
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Overexpressing GDF-15 decreases body weight, fat mass and food intake, and improves glucose tolerance in mouse models.
“On the contrary, overexpressing GDF-15 led to decreased body weight, fat mass and food intake, improving the glucose tolerance in mouse models (83, 108–110).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [110]
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- Authors
- Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., & Sainsbury, A.
- Affiliations
- Garvan Institute of Medical Research (AU)
- UNSW Sydney (AU)
- The University of Sydney (AU)
- Corresponding author
- Sainsbury, Amanda
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-13
- Volume
- 7
- Issue
- 4
- Pages
- e34868
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3325923
- OpenAlex
- W2057219729
- Cited by
- 211
- References
- 26
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 20 · 2023: 21 · 2022: 21 · 2021: 18 · 2020: 32 · 2019: 19 · 2018: 12 · 2017: 11 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, cc-by)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (455291)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- MIC-1, GDF15, obesity, dietary intake, body weight, glucose tolerance, glucose homeostasis, high-fat diet, fat mass, energy expenditure, transgenic overexpression, anorectic effect
- MeSH terms
- Animals, Body Weight, Eating, Female, Glucose, Mice, Transgenic, Obesity, Mice, Growth Differentiation Factor 15
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