TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

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Growth Differentiation Factor-15 (GDF-15) Is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients

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Growth differentiation factor 15 increases following oral glucose ingestion: effect of meal composition and obesity

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Regulation of Energy Metabolism by Receptor Tyrosine Kinase Ligands

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GDF15 is still a mystery hormone

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Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum

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GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway

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NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice

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Change of Body Weight and Macrophage Inhibitory Cytokine-1 during Chemotherapy in Advanced Gastric Cancer: What Is Their Clinical Significance?

Lu, Z., Li, Y., Yu, J., Lü, M., Zhang, X., Li, J., Zhou, J., Wang, X., Gong, J., Gao, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088553 · Cited by 42

Mitochondrial stress and GDF15 in the pathophysiology of sepsis

Fujita, Y., Ito, M., & Ohsawa, I. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108668 · Cited by 42

GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin

Ouyang, J., Isnard, S., Lin, J., Fombuena, B., Peng, X., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.581839 · Cited by 39

Growth Differentiation Factor 15 (GDF-15), a New Biomarker in Heart Failure Management

Sawalha, K., Norgard, N. B., Drees, B. M., & López‐Candales, A. (2023) · Current Heart Failure Reports · doi:10.1007/s11897-023-00610-4 · Cited by 38

Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

Guo, X., Asthana, P., Zhai, L., Cheng, K. W., Gurung, S., Huang, J., Wu, J., Zhang, Y., Mahato, A. K., Saarma, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45452-3 · Cited by 44

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

Zhou, H., Lei, X., Benson, T. W., MINTZ, J. D., Xu, X., Harris, R. B. S., Weintraub, N. L., Wang, X., & Chen, W. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m060244 · Cited by 37

New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk

Townsend, L. K., MacPherson, R. E. K., & Wright, D. C. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab333 · Cited by 36

Circulating growth-and-differentiation factor-15 in early life: relation to prenatal and postnatal growth and adiposity measurements

Díaz, M., Campderrós, L., Guimarães, M. P., López‐Bermejo, A., de Zegher, F., Villarroya, F., & Ibáñez, L. (2019) · Pediatric Research · doi:10.1038/s41390-019-0633-z · Cited by 33

The Role of Growth Differentiation Factor 15 in Energy Metabolism

Chang, J. Y., Hong, H. J., Kang, S., Kim, J. T., Zhang, B. Y., & Shong, M. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0087 · Cited by 32

Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study

Kochlik, B., Herpich, C., Moreno‐Villanueva, M., Klaus, S., Müller‐Werdan, U., Weinberger, B., Fiegl, S., Toussaint, O., Debacq‐Chainiaux, F., Schön, C., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00902-6 · Cited by 31

MIC1/GDF15 as a Bone Metastatic Disease Biomarker

Windrichová, J., Fuchsová, R., Kučera, R., Topolčan, O., Fiala, O., Fínek, J., & Slipkova, D. (2017) · Anticancer Research · doi:10.21873/anticanres.11477 · Cited by 31

Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases

Tian, T., Liu, M., Little, P. J., Strijdom, H., Weng, J., & Xu, S. (2025) · Research · doi:10.34133/research.0832 · Cited by 34

Identification of genome‐wide selection signatures in the L imousin beef cattle breed

Gurgul, A., Szmatoła, T., Ropka‐Molik, K., Jasielczuk, I., Pawlina‐Tyszko, K., Semik, E., & Bugno‐Poniewierska, M. (2015) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12196 · Cited by 33

Elevated Serum Growth Differentiation Factor 15 Levels in Hyperthyroid Patients

Zhao, J., Li, M., Chen, Y., Zhang, S., Ying, H., Song, Z., Lü, Y., Li, X., Xiong, X., & Jiang, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00793 · Cited by 28

Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Gene Deletion Promotes Cancer Growth in TRAMP Prostate Cancer Prone Mice

Husaini, Y., Lockwood, G. P., Nguyen, T. V., Tsai, V. W.-W., Mohammad, M. G., Russell, P. J., Brown, D. A., & Breit, S. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115189 · Cited by 27

Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study

Yonezawa, Y., Takahashi, I., Ohseto, H., Ueno, F., Onuma, T., Noda, A., Murakami, K., Ishikuro, M., Obara, T., & Kuriyama, S. (2024) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-06376-4 · Cited by 26

Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation

Breen, D. M., Jagarlapudi, S., Patel, A. R., Zou, C. H., Joaquim, S., Li, X., Kang, L., Pang, J., Hales, K. J., Ziso-Qejvanaj, E., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102554 · Cited by 26

The contribution of the nervous system in the cancer progression

Park, H., & Lee, C. H. (2024) · BMB Reports · doi:10.5483/bmbrep.2024-0019 · Cited by 25

Expression of the Body-Weight Signaling Players: GDF15, GFRAL and RET and their clinical relevance in Gastric Cancer

Buchholz, K., Antosik, P., Grzanka, D., Gagat, M., Smolińska, M., Grzanka, A., Gzil, A., Kasperska, A., & Klimaszewska‐Wiśniewska, A. (2021) · Journal of Cancer · doi:10.7150/jca.55511 · Cited by 24

Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity

Valenzuela‐Vallejo, L., Chrysafi, P., Bello-Ramos, J. C., Bsata, S., & Mantzoros, C. S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155237 · Cited by 24

Identification and characterization of human GDF15 knockouts

Gurtan, A. M., Khalid, S., Koch, C., Khan, M. Z., Lamarche, L. B., Splawski, I., Dolan, E., Carrion, A. M., Zessis, R., Clement, M. E., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01135-3 · Cited by 24

Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies

Koh, K., Scott, R., Feliciano, E. M. C., Janowitz, T., Goncalves, M. D., White, E., Laird, B. J. A., Haase, K., & Jamal‐Hanjani, M. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0293 · Cited by 27

Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model

Albuquerque, B., Chen, X., Hirenallur-Shanthappa, D. K., Zhao, Y. W., Stansfield, J. C., Zhang, B. B., Sheikh, A. Q., & Wu, Z. (2022) · Cells · doi:10.3390/cells11071073 · Cited by 24

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells

Bellio, C., Emperador, M., Castellano‐Escuder, P., Gris‐Oliver, A., Canals, F., Sánchez‐Pla, Á., Zamora, E., Arribas, J., Saura, C., Serra, V., et al. (2022) · Cancers · doi:10.3390/cancers14102562 · Cited by 25

GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement

Melvin, A., Chantzichristos, D., Kyle, C. J., Mackenzie, S. D., Walker, B. R., Johannsson, G., Stimson, R. H., & O’Rahilly, S. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz277 · Cited by 24

Tumor cell anabolism and host tissue catabolism-energetic inefficiency during cancer cachexia

Hegde, M., Daimary, U. D., Girisa, S., Kumar, A., & Kunnumakkara, A. B. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221087962 · Cited by 24

Whole genome sequencing of simmental cattle for SNP and CNV discovery

Sun, T., Pei, S., Liu, Y., Hanif, Q., Xu, H., Chen, N., Lei, C., & Yue, X. (2023) · BMC Genomics · doi:10.1186/s12864-023-09248-x · Cited by 23

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI

Tsai, V. W.-W., Macia, L., Feinle‐Bisset, C., Manandhar, R., Astrup, A. V., Raben, A., Lorenzen, J. K., Schmidt, P. T., Wiklund, F. E., Pedersen, N. L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133362 · Cited by 96

Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15

Tsai, V. W.-W., Lin, S., Brown, D. A., Salis, A., & Breit, S. N. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.242 · Cited by 109

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

Tsai, V. W.-W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.018 · Cited by 424

Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets

Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034868 · Cited by 211

Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes

Tsai, V. W.-W., Brown, D. A., & Breit, S. N. (2018) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000384 · Cited by 20