The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Effect of Antioxidant Vitamin Supplementation on Cardiovascular Outcomes: A Meta-Analysis of Randomized Controlled Trials
Open accessAbstract
BACKGROUND: Antioxidant vitamin (vitamin E, beta-carotene, and vitamin C) are widely used for preventing major cardiovascular outcomes. However, the effect of antioxidant vitamin on cardiovascular events remains unclear. METHODOLOGY AND PRINCIPAL FINDINGS: We searched PubMed, EmBase, the Cochrane Central Register of Controlled Trials, and the proceedings of major conferences for relevant literature. Eligible studies were randomized controlled trials that reported on the effects of antioxidant vitamin on cardiovascular outcomes as compared to placebo. Outcomes analyzed were major cardiovascular events, myocardial infarction, stroke, cardiac death, total death, and any possible adverse events. We used the I(2) statistic to measure heterogeneity between trials and calculated risk estimates for cardiovascular outcomes with random-effect meta-analysis. Independent extraction was performed by two reviewers and consensus was reached. Of 293 identified studies, we included 15 trials reporting data on 188209 participants. These studies reported 12749 major cardiovascular events, 6699 myocardial infarction, 3749 strokes, 14122 total death, and 5980 cardiac deaths. Overall, antioxidant vitamin supplementation as compared to placebo had no effect on major cardiovascular events (RR, 1.00; 95%CI, 0.96-1.03), myocardial infarction (RR, 0.98; 95%CI, 0.92-1.04), stroke (RR, 0.99; 95%CI, 0.93-1.05), total death (RR, 1.03; 95%CI, 0.98-1.07), cardiac death (RR, 1.02; 95%CI, 0.97-1.07), revascularization (RR, 1.00; 95%CI, 0.95-1.05), total CHD (RR, 0.96; 95%CI, 0.87-1.05), angina (RR, 0.98; 95%CI, 0.90-1.07), and congestive heart failure (RR, 1.07; 95%CI, 0.96 to 1.19). CONCLUSION/SIGNIFICANCE: Antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Several vitamins and nutrients associate with lower CVD risk in observational studies, but trials of supplements, including folate, B-vitamins, beta-carotene, vitamin C, vitamin E, and selenium, have shown no significant effects on atherosclerosis progression or CVD events.19, 331, 332”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [332]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609
Self-citation(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Dong, Y., Hao, L., Shi, Z., Wang, G., Zhang, Z., & Han, C. (2013) · Urologia Internationalis · doi:10.1159/000351405 · Cited by 4,557
Research works printed but not linked: 2
- MJ Stampfer, 1993, A review of the epidemiology of dietary antioxidants and risk of coronary heart disease, Can J Cardiol, l9, 14B
- D Steinberg, 1992, Antioxidants in the prevention of human atherosclerosis, Circulation, 85, 2337
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216
“Antioxidant Vitamins Several vitamins and nutrients are associated with lower CVD risk in observational studies, but trials of supplements, including folate, B vitamins, β-carotene, vitamin C, vitamin E, and selenium, have shown no significant effects on atherosclerosis progression or CVD events.(19,331,332) Most of t…”
Mitochondrial dysfunction and oxidative stress in heart disease
Peoples, J. N., Saraf, A., Ghazal, N., Pham, T. T., & Kwong, J. Q. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0355-7 · Cited by 950
Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019
Précoma, D. B., de Oliveira, G. M. M., Simão, A. F. L., Dutra, Ó. P., Coelho-Filho, O. R., Izar, M. C. D. O., Póvoa, R., Giuliano, I. D. C. B., Filho, A. C. D. A., Machado, C. A., et al. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190204 · Cited by 507
Management of NAFLD: a stage-based approach
Rinella, M. E., & Sanyal, A. J. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.3 · Cited by 393
Chronic kidney disease and premature ageing
Kooman, J. P., Kotanko, P., Schols, A. M. W. J., Shiels, P. G., & Stenvinkel, P. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.185 · Cited by 390
Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution
Niemann, B., Rohrbach, S., Miller, M. R., Newby, D. E., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.043 · Cited by 364
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 345
Ciccone, M. M., Cortese, F., Gesualdo, M., Carbonara, S., Zito, A., Ricci, G., Pascalis, F. D., Scicchitano, P., & Riccioni, G. (2013) · Mediators of Inflammation · doi:10.1155/2013/782137 · Cited by 298
Bohn, T., McDougall, G. J., Alegría, A., Alminger, M., Arrigoni, E., Aura, A., Brito, C., Cilla, A., El, S. N., Karakaya, S., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400745 · Cited by 278
Antioxidant supplements and mortality
Bjelakovic, G., Nikolova, D., & Gluud, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000009 · Cited by 234
The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging
Bruins, M. J., Dael, P. V., & Eggersdorfer, M. L. (2019) · Nutrients · doi:10.3390/nu11010085 · Cited by 244
Bjelakovic, G., Nikolova, D., & Gluud, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074558 · Cited by 183
I Diretriz Brasileira de Prevenção Cardiovascular
Simão, A., Précoma, D., Andrade, J., Filho, H. C., Saraiva, J., Oliveira, G., Murro, A., Campos, A., Alessi, A., Avezum, Á., et al. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.2013s012 · Cited by 186
Choe, G., Kim, S.-W., Park, J., Park, J., Kim, S., Kim, Y. S., Ahn, Y., Jung, D., Williams, D. R., & Lee, J. Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119513 · Cited by 166
Vitamin C and Cardiovascular Disease: An Update
Morelli, M. B., Gambardella, J., Castellanos, V., Trimarco, V., & Santulli, G. (2020) · Antioxidants · doi:10.3390/antiox9121227 · Cited by 178
Targeting inflammation to reduce cardiovascular disease risk: A realistic clinical prospect?
Welsh, P., Grassia, G., Botha, S., Sattar, N., & Maffia, P. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13818 · Cited by 164
Alberts, A., Moldoveanu, E.-T., Niculescu, A.-G., & Grumezescu, A. M. (2025) · Molecules · doi:10.3390/molecules30030748 · Cited by 161
Loria, P., Marchesini, G., Nascimbeni, F., Ballestri, S., Maurantonio, M., Carubbi, F., Ratziu, V., & Lonardo, A. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.030 · Cited by 136
Antioxidants and coronary artery disease
Leopold, J. A. (2014) · Coronary Artery Disease · doi:10.1097/mca.0000000000000187 · Cited by 130
Oxidative theory of atherosclerosis and antioxidants
Salvayre, R., Nègre‐Salvayre, A., & Camaré, C. (2015) · Biochimie · doi:10.1016/j.biochi.2015.12.014 · Cited by 129
Hamley, S. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0254-5 · Cited by 133
Particulate matter air pollutants and cardiovascular disease: Strategies for intervention
Aryal, A., Harmon, A. C., & Dugas, T. R. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107890 · Cited by 119
Kim, J.-E., Chang, J.-H., Jeong, M.-J., Choi, J., Park, J., Baek, C., Shin, A., Park, S. M., Kang, D., & Choi, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-77534-9 · Cited by 122
Impact of Particulate Air Pollution on Cardiovascular Health
An, Z., Jin, Y., Li, J., Li, W., & Wu, W. (2018) · Current Allergy and Asthma Reports · doi:10.1007/s11882-018-0768-8 · Cited by 114
Self-citationTargeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities
Bernardo, I., Bozinovski, S., & Vlahos, R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.08.005 · Cited by 108
Trepanowski, J. F., & Ioannidis, J. P. A. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy014 · Cited by 107
Varadharaj, S., Kelly, O. J., Khayat, R. N., Kumar, P. S., Ahmed, N., & Zweier, J. L. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00064 · Cited by 101
Clinical Advances in Immunonutrition and Atherosclerosis: A Review
Ruiz-León, A. M., Lapuente, M., Estruch, R., & Casas, R. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00837 · Cited by 104
Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients
Liao, S., Omage, S. O., Börmel, L., Kluge, S., Schubert, M., Wallert, M., & Lorkowski, S. (2022) · Antioxidants · doi:10.3390/antiox11091785 · Cited by 109
Addressing nutritional gaps with multivitamin and mineral supplements
Ward, E. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-72 · Cited by 96
Tong, H. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.05.014 · Cited by 87
Shanmugam, G., Challa, A. K., Litovsky, S. H., Devarajan, A., Wang, D., Jones, D. P., Darley-Usmar, V. M., & Rajasekaran, N. S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101212 · Cited by 82
Jayedi, A., Rashidy‐Pour, A., Parohan, M., Zargar, M. S., & Shab‐Bidar, S. (2019) · Public Health Nutrition · doi:10.1017/s1368980018003725 · Cited by 83
The Failure to Measure Dietary Intake Engendered a Fictional Discourse on Diet-Disease Relations
Archer, E., Lavie, C. J., & Hill, J. O. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00105 · Cited by 77
Montiel, V., Bella, R., Michel, L. Y. M., Esfahani, H., Mulder, D. D., Robinson, E. L., Deglasse, J.-P., Tiburcy, M., Chow, P. H., Jonas, J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay2176 · Cited by 77
The Role of Oxidative Stress in Acute Ischemic Stroke‐Related Thrombosis
Li, Z., Bi, R., Sun, S., Chen, S., Chen, J., Hu, B., & Jin, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8418820 · Cited by 76
The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review
Villagrán, M., Ferreira, J. L., Martorell, M., & Mardones, L. (2021) · Antioxidants · doi:10.3390/antiox10121894 · Cited by 73
The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors
Cammisotto, V., Nocella, C., Bartimoccia, S., Sanguigni, V., Francomano, D., Sciarretta, S., Pastori, D., Peruzzi, M., Cavarretta, E., D’Amico, A., et al. (2021) · Antioxidants · doi:10.3390/antiox10020146 · Cited by 77
Carrasco, R. A., Castillo, R. L., Gormaz, J. G., Carrillo, M., & Thavendiranathan, P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8863789 · Cited by 74
Novel therapeutic strategies for ischemic heart disease
Perricone, A. J., & Heide, R. S. V. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.08.004 · Cited by 66
Carbone, F., Teixeira, P. C., Braunersreuther, V., Mach, F., Vuilleumier, N., & Montecucco, F. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5778 · Cited by 68
Chen, S., Roffey, D. M., Dion, C.-A. B., Arab, A., & Wai, E. K. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000218 · Cited by 68
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
Inglés, D. P., Rodriguez, J. B. C., & García, H. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-1270-1 · Cited by 69
Mitochondrial Quality Control in Cardiac Diseases
Campos, J. C., Bozi, L. H. M., Bechara, L. R. G., Lima, V. M., & Ferreira, J. C. B. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00479 · Cited by 67
Antioxidant vitamins and their effect on immune system
Khadim, R. M., & Al-Fartusie, F. S. D. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1853/1/012065 · Cited by 75
Iacoviello, L., Bonaccio, M., Cairella, G., Catani, M. V., Costanzo, S., D’Elia, L., Giacco, R., Rendina, D., Sabino, P., Savini, I., et al. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.12.010 · Cited by 60
Impact of Nutrition on Pulmonary Arterial Hypertension
Callejo, M., Barberà, J. A., Duarte, J., & Pérez‐Vizcaíno, F. (2020) · Nutrients · doi:10.3390/nu12010169 · Cited by 61
Yang, J., Zhang, Y., Na, X., & Zhao, A. (2022) · Nutrients · doi:10.3390/nu14061284 · Cited by 54
Carotenoid consumption is related to lower lipid oxidation and DNA damage in middle-aged men
Cocate, P. G., Natali, A. J., Alfenas, R. D. C. G., de Oliveira, A., dos Santos, E. C., & Hermsdorff, H. H. M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001622 · Cited by 52
Antioxidant Polymers as Biomaterial
van Lith, R., & Ameer, G. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803269-5.00010-3 · Cited by 51
Chemisorbed palladium phthalocyanine for simultaneous determination of biomolecules
Nemakal, M., Aralekallu, S., Mohammed, I., Prabhu, C. P. K., & Sannegowda, L. K. (2018) · Microchemical Journal · doi:10.1016/j.microc.2018.07.039 · Cited by 49
Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations
Zafar, M. S., Quarta, A., Marradi, M., & Ragusa, A. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11100505 · Cited by 50
JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease
Fujiyoshi, A., Kohsaka, S., Hata, J., Hara, M., Kai, H., Masuda, D., Miyamatsu, N., Nishio, Y., Ogura, M., Sata, M., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0285 · Cited by 55
Kim, C., Sung, J., Lee, J. H., Kim, W., Lee, G. J., Jee, S., Jung, I., Rah, U. W., Kim, B. O., Choi, K. H., et al. (2019) · Korean Circulation Journal · doi:10.4070/kcj.2019.0194 · Cited by 48
Endothelial Dysfunction and Coronary Artery Disease
Veerasamy, M., Bagnall, A. J., Neely, D., Allen, J., Sinclair, H., & Kunadian, V. (2014) · Cardiology in Review · doi:10.1097/crd.0000000000000047 · Cited by 45
Liu, Y., Liu, Y., Liu, X., Chen, J., Zhang, K., Huang, F., Wang, J., Tang, W., & Huang, H. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001598 · Cited by 45
Gligorijević, N., Stanić-Vučinić, D., Radomirović, M., Stojadinović, M., Olgica, N., Khulal, U., & Veličković, T. Ć. (2021) · Molecules · doi:10.3390/molecules26102834 · Cited by 48
Lee, C., Chan, R., Wan, H. Y., Woo, Y. C., Cheung, C. Y. Y., Fong, C. H.-Y., Cheung, B. M. Y., Lam, T.-H., Janus, E. D., Woo, J., et al. (2018) · Nutrients · doi:10.3390/nu10111664 · Cited by 44
Engineer, A., Saiyin, T., Greco, E. R., & Feng, Q. (2019) · Antioxidants · doi:10.3390/antiox8100436 · Cited by 45
Sack, C. S., Jansen, K. L., Cosselman, K. E., Trenga, C. A., Stapleton, P. L., Allen, J., Peretz, A., Olives, C., & Kaufman, J. D. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1247oc · Cited by 42
X12N12 (X = Al, B) clusters for protection of vitamin C; molecular modeling investigation
Rad, A. S., Samipour, V., Movaghgharnezhad, S., Mirabi, A., Shahavi, M. H., & Moghadas, B. K. (2019) · Surfaces and Interfaces · doi:10.1016/j.surfin.2019.02.001 · Cited by 42
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis
Antonucci, S., Mulvey, J. F., Burger, N., Sante, M. D., Hall, A. R., Hinchy, E. C., Caldwell, S. T., Gruszczyk, A. V., Deshwal, S., Hartley, R. C., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.034 · Cited by 44
Association between intake of red and processed meat and the risk of heart failure: a meta-analysis
Cui, K., Liu, Y., Zhu, L., Mei, X., Jin, P., & Luo, Y. (2019) · BMC Public Health · doi:10.1186/s12889-019-6653-0 · Cited by 44
Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease
Thompson, J. A., Larion, S., MINTZ, J. D., de Chantemèle, E. J. B., Fulton, D. J., & Stepp, D. W. (2017) · Circulation Research · doi:10.1161/circresaha.116.309965 · Cited by 43
Binding of Plant Polyphenols to Serum Albumin and LDL: Healthy Implications for Heart Disease
Poloni, D., Dangles, O., & Vinson, J. A. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06674 · Cited by 41
The Impact of Natural Antioxidants on the Regenerative Potential of Vascular Cells
Shafi, S., Ansari, H. R., Bahitham, W., & Aouabdi, S. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00028 · Cited by 41
Astori, E., Garavaglia, M. L., Colombo, G., Landoni, L., Portinaro, N. M., Milzani, A., & Dalle‐Donne, I. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000093 · Cited by 43
Yang, C., Yang, C.-C., Hsiao, L., Yu, C., Tseng, H., Hsu, C., & Situmorang, J. H. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s313665 · Cited by 39
Sahebkar, A. (2014) · Vascular Medicine · doi:10.1177/1358863x13515766 · Cited by 41
Yin, T., Zhu, X., Xu, D. R., Lin, H., Lu, X., Tang, Y., Shi, M., Yao, W., Zhou, Y., Zhang, H., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.799095 · Cited by 38
Rodrigo, R., Hasson, D., Prieto, J. C., Dussaillant, G., Ramos, C., León, L., Gárate, J., Valls, N., & Gormaz, J. G. (2014) · Trials · doi:10.1186/1745-6215-15-192 · Cited by 38
Jiang, T., Zhang, L., Ding, M., & Li, M. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s220396 · Cited by 40
Chen, L., Sun, X., Wang, Z., Lu, Y., Chen, M., He, Y., Xu, H., & Zheng, L. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.08.020 · Cited by 41
Shanmugam, G., Challa, A. K., Devarajan, A., Athmanathan, B., Litovsky, S. H., Krishnamurthy, P., Davidson, C. J., & Rajasekaran, N. S. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00068 · Cited by 37
Vitamin C Intake and Ischemic Stroke
Tang, X., Liu, H., Xiao, Y., Wu, L., & Shu, P. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.935991 · Cited by 35
Potential of graphene-based nanomaterials for cardiac tissue engineering
Edrisi, F., Baheiraei, N., Razavi, M., Roshanbinfar, K., Imani, R., & Jalilinejad, N. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb00654a · Cited by 35
Valls, N., Gormaz, J. G., Aguayo, R., González, J., Brito, R., Hasson, D., Libuy, M., Ramos, C., Carrasco, R. A., Prieto, J. C., et al. (2015) · Redox Report · doi:10.1179/1351000215y.0000000018 · Cited by 32
Fernandes, R. O., Bonetto, J. H. P., Baregzay, B., de Castro, A. L., Puukila, S., Forsyth, H. L., Schenkel, P. C., Llesuy, S., Brum, I. S., Araújo, A. S. D. R., et al. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2292-z · Cited by 32
Pitkälä, K. H., Suominen, M. H., Bell, J. S., & Strandberg, T. E. (2016) · Annals of Medicine · doi:10.1080/07853890.2016.1197414 · Cited by 32
Somade, O. T., Adeyi, O. E., Ajayi, B. O., Asunde, O. O., Iloh, P. D., Adesanya, A. A., Babalola, O. I., Folorunsho, O. T., Olakunle, D. A., & Lawal, O. F. (2022) · Metabolism Open · doi:10.1016/j.metop.2022.100179 · Cited by 32
Meng, L., Liu, S., Luo, J., Tu, Y., Li, T., Li, P., Yu, J., & Shi, L. (2025) · Redox Report · doi:10.1080/13510002.2025.2458942 · Cited by 31
Bakhtiari, A., Hajian‐Tilaki, K., Omidvar, S., & Amiri, F. N. (2017) · Biomedical Reports · doi:10.3892/br.2017.964 · Cited by 30
Effects of Particulate Matter and Antioxidant Dietary Intake on Blood Pressure
Schulz, A. J., Mentz, G. B., Sampson, N., Dvonch, J. T., Reyes, A. G., & Izumi, B. T. (2014) · American Journal of Public Health · doi:10.2105/ajph.2014.302176 · Cited by 32
Clinical Practice Guideline for Cardiac Rehabilitation in Korea
Kim, C., Sung, J., Lee, J. H., Kim, W., Lee, G. J., Jee, S., Jung, I., Rah, U. W., Kim, B. O., Choi, K. H., et al. (2019) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2019.43.3.355 · Cited by 29
Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1
Padgett, C. A., Batori, R. K., Speese, A. C., Rosewater, C. L., Bush, W. B., Derella, C. C., Haigh, S. B., Sellers, H. G., Corley, Z. L., West, M. A., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319476 · Cited by 28
Nakamura, M., Sugiura, M., Ogawa, K., Ikoma, Y., & Yano, M. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.04.001 · Cited by 26
Oxidative stress and food as medicine
Carlson, D. A., True, C., & Wilson, C. G. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1394632 · Cited by 30
Targeting the redox system for cardiovascular regeneration in aging
Allemann, M., Lee, P., Beer, J. H., & Saravi, S. S. S. (2023) · Aging Cell · doi:10.1111/acel.14020 · Cited by 23
Ramos, C., Brito, R., González‐Montero, J., Valls, N., Gormaz, J. G., Prieto, J. C., Aguayo, R., Puentes, Á., Noriega, V., Pereira, G., et al. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.59713 · Cited by 24
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.269028 · Cited by 24
Blood pressure lowering effect of scopoletin on oxidative stress-associated hypertensive rats
Armenia, A., HIDAYAT, R., MEILIANI, M., & Yuliandra, Y. (2019) · Journal of Research in Pharmacy · doi:10.12991/jrp.2019.131 · Cited by 22
Mazidi, M., Kengne, A. P., Katsiki, N., Mikhailidis, D. P., & Banach, M. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518002581 · Cited by 21
Antioxidant Properties of Whole Body Periodic Acceleration (pGz)
Uryash, A., Bassuk, J. A., Kurlansky, P. A., Altamirano, F. J., Lopez, J. R., & Adams, J. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131392 · Cited by 21
Seth, I., Bulloch, G., Seth, N., Siu, A. H. Y., Clayton, S. B., Lower, K., Roshan, S., & Nara, N. (2021) · The Journal of Foot & Ankle Surgery · doi:10.1053/j.jfas.2021.11.008 · Cited by 20
Erve, T. J. V. ‘. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.003 · Cited by 23
Braga, K. M. D. S., de Araújo, E. G., Sellke, F. W., & Abid, M. R. (2022) · Antioxidants · doi:10.3390/antiox11030474 · Cited by 19
Fruits, Vegetables, and Health
van Berleere, M., & Dauchet, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803968-7.00013-7 · Cited by 19
Brecht, P., Dring, J. C., Yanez, F., Styczeń, A., Mertowska, P., Mertowski, S., & Grywalska, E. (2023) · Nutrients · doi:10.3390/nu15143264 · Cited by 18
Metadata
- Authors
- Ye, Y., Li, J., & Yuan, Z.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Children's Hospital of Fudan University (CN)
- Corresponding author
- Yuan, Zhongxiang
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-02-20
- Volume
- 8
- Issue
- 2
- Pages
- e56803
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3577664
- OpenAlex
- W1975083648
- Cited by
- 204
- References
- 59
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 15 · 2021: 22 · 2020: 11 · 2019: 28 · 2018: 19 · 2017: 11 · 2016: 20 · 2015: 17 · 2014: 14 · 2013: 9
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- antioxidant vitamins, vitamin E, beta-carotene, vitamin C, cardiovascular outcomes, myocardial infarction, stroke, cardiovascular mortality, all-cause mortality, coronary artery disease, congestive heart failure, angina pectoris, revascularization, adverse events, vitamin supplementation, cardiovascular disease prevention, selenium, nicotinic acid, omega-3 fatty acids, statins, blood pressure
- MeSH terms
- Antioxidants, Ascorbic Acid, Cardiovascular Diseases, Humans, Risk, Vitamin E, Vitamins, Odds Ratio, Randomized Controlled Trials as Topic, Publication Bias, beta Carotene, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
