Cited by 95Gut microbiota and healthProbiotics and Fermented FoodsInflammatory Bowel Disease

Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms

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Konieczna, Patrycja, Ferstl, Ruth, Ziegler, Mario, Frei, Remo, Nehrbass, Dirk, Lauener, Roger P., Akdis, Cezmi A., O'Mahony, Liam·2013·PLoS ONE

Abstract

Appropriate dendritic cell processing of the microbiota promotes intestinal homeostasis and protects against aberrant inflammatory responses. Mucosal CD103(+) dendritic cells are able to produce retinoic acid from retinal, however their role in vivo and how they are influenced by specific microbial species has been poorly described. Bifidobacterium infantis 35624 (B. infantis) feeding to mice resulted in increased numbers of CD103(+)retinaldehyde dehydrogenase (RALDH)(+) dendritic cells within the lamina propria (LP). Foxp3(+) lymphocytes were also increased in the LP, while TH1 and TH17 subsets were decreased. 3,7-dimethyl-2,6-octadienal (citral) treatment of mice blocked the increase in CD103(+)RALDH(+) dendritic cells and the decrease in TH1 and TH17 lymphocytes, but not the increase in Foxp3(+) lymphocytes. B. infantis reduced the severity of DSS-induced colitis, associated with decreased TH1 and TH17 cells within the LP. Citral treatment confirmed that these effects were RALDH mediated. RALDH(+) dendritic cells decreased within the LP of control inflamed animals, while RALDH(+) dendritic cells numbers were maintained in the LP of B. infantis-fed mice. Thus, CD103(+)RALDH(+) LP dendritic cells are important cellular targets for microbiota-associated effects on mucosal immunoregulation.

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Authors
Konieczna, P., Ferstl, R., Ziegler, M., Frei, R., Nehrbass, D., Lauener, R. P., Akdis, C. A., & O'Mahony, L.
Affiliations
  • University of Zurich (CH)
  • AO Foundation (CH)
  • CK-CARE (CH)
Venue
PLoS ONE
Published
2013-05-21
Volume
8
Issue
5
Pages
e62617
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2079372195
Cited by
95
References
33
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 7 · 2014: 2 · 2013: 1
FWCI
3.13
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • European Commission
  • Christine Kühne – Center for Allergy Research and Education
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
retinoic acid, retinaldehyde dehydrogenase, CD103+ dendritic cells, lamina propria, gut microbiota, immunomodulation, Foxp3+ regulatory T cells, Th1 cells, Th17 cells, citral, DSS-induced colitis, intestinal homeostasis
MeSH terms
Aldehyde Dehydrogenase 1 Family, Animals, Bifidobacterium, Colitis, Dendritic Cells, Feeding Behavior, Intestinal Mucosa, Isoenzymes, Mice, Inbred C57BL, Peyer's Patches, Phenotype, Tretinoin, Antigens, CD, Dextran Sulfate, Integrin alpha Chains, Cell Proliferation, Retinal Dehydrogenase, Mice, Forkhead Transcription Factors, Immunomodulation, Th17 Cells

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