Cited by 303Gut microbiota and healthPsoriasis: Treatment and PathogenesisAdipokines, Inflammation, and Metabolic Diseases

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

Open access
Garidou, Lucile, Pomié, Céline, Klopp, Pascale, Waget, Aurélie, Charpentier, Julie, Aloulou, Meryem, Giry, Anaïs, Serino, Matteo +15 more·2015·Cell Metabolism

Abstract

A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. Consistent with these data, the metabolic phenotype was mimicked in RORγt-deficient mice, which lack IL17 and IL22 function, and in the adoptive transfer experiment of T cells from RORγt-deficient mice into Rag1-deficient mice. We conclude that the microbiota of the ileum regulates Th17 cell homeostasis in the small intestine and determines the outcome of metabolic disease.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2015.06.001

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Insulin resistance caused by a high-fat diet correlates with fewer TH17 cells expressing IL-17 and RORγt.

    “Insulin resistance that is induced through a high-fat diet is associated with reduced levels of T helper 17 (TH17) cells that are positive for IL-17 and retinoic acid receptor-related orphan receptor γt (RORγt)112.”

Cites

Flagged first, then by citations

1 of the 49 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., Dray, C., Iacovoni, J. S., Courtney, M., Collet, X., Amar, J., Servant, F., Lelouvier, B., Valet, P., Eberl, G., Fazilleau, N., Douin-Echinard, V., Heymes, C., & Burcelin, R.
Affiliations
  • Université Toulouse III - Paul Sabatier (FR)
  • Centre National de la Recherche Scientifique (FR)
  • Inserm (FR)
  • Institut Pasteur (FR)
Corresponding author
  • Garidou, Lucile
  • Burcelin, Rémy
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2015-07
Volume
22
Issue
1
Pages
100-112
ISSN
1550-4131 (ISSN-L)
OpenAlex
W1483529702
Cited by
303
References
49
Citations by year
2026: 12 · 2025: 17 · 2024: 24 · 2023: 32 · 2022: 29 · 2021: 50 · 2020: 23 · 2019: 30 · 2018: 20 · 2017: 34 · 2016: 25 · 2015: 7
FWCI
12.43
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
gut microbiota, RORγt, Th17 cells, high-fat diet, metabolic disorders, metabolic inflammation, lamina propria, antigen-presenting cells, IL-17, IL-22, adoptive T cell therapy, Rag1-deficient mice
MeSH terms
Gastrointestinal Microbiome, Animals, Cells, Cultured, Diabetes Mellitus, Type 2, Gene Expression Regulation, Ileum, Immunity, Male, Obesity, CD4-Positive T-Lymphocytes, CD4 Antigens, Gene Deletion, Interleukin-17, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review