Role of gut microbiota in intestinal wound healing and barrier function
Open accessAbstract
The mammalian intestine harbors a highly complex and abundant ensemble of bacteria that flourish in a nutrient-rich environment while profoundly influencing many aspects of host biology. The intestine coevolved with its resident microbes in a manner where the mucosa developed a barrier function to segregate the resident microbes from the rest of the body, and yet paradoxically, allowing integration of microbial signals for the host benefit. In this review, we provided a comprehensive overview of why the gut microbiota is key to the efficient development and maintenance of the intestinal barrier. We also highlighted how a destabilized equilibrium between gut microbiota and the host may eventuate in a wide range of intestinal diseases characterized by the disrupted intestinal barrier. Finally, the review delineated how microenvironmental changes in the injured mucosa result in an enrichment of a pro-regenerating consortium of bacteria, which augments mucosal wound repair and restoration of barrier functions.
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Microbial metabolites have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.
“Further, they have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.73,74”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [73]
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The Role of the Microbiota in Regeneration-Associated Processes
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Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases
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Gut Microbiota and Inflammatory Disorders
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- Authors
- Alam, A., & Neish, A.
- Affiliations
- Emory University (US)
- Corresponding author
- Alam, Ashfaqul
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2018-07-03
- Volume
- 6
- Issue
- 3
- Pages
- 1539595
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- PMC
- PMC6389125
- OpenAlex
- W2899740161
- Cited by
- 166
- References
- 152
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 28 · 2023: 20 · 2022: 26 · 2021: 40 · 2020: 12 · 2019: 9
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Tissue Barriers (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (5R01CA179424)
- National Institutes of Health (R01AI064462, K01DK114391)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- gut microbiota, intestinal barrier function, intestinal wound healing, mucosal regeneration, dysbiosis, intestinal diseases, mucosal injury, host-microbe interactions
- MeSH terms
- Gastrointestinal Microbiome, Intestinal Mucosa, Wound Healing
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