Cited by 167Gut microbiota and healthGastrointestinal motility and disordersInflammatory Bowel Disease

Role of gut microbiota in intestinal wound healing and barrier function

Open access
Alam, Ashfaqul, Neish, Andrew·2018·Tissue Barriers

Abstract

The mammalian intestine harbors a highly complex and abundant ensemble of bacteria that flourish in a nutrient-rich environment while profoundly influencing many aspects of host biology. The intestine coevolved with its resident microbes in a manner where the mucosa developed a barrier function to segregate the resident microbes from the rest of the body, and yet paradoxically, allowing integration of microbial signals for the host benefit. In this review, we provided a comprehensive overview of why the gut microbiota is key to the efficient development and maintenance of the intestinal barrier. We also highlighted how a destabilized equilibrium between gut microbiota and the host may eventuate in a wide range of intestinal diseases characterized by the disrupted intestinal barrier. Finally, the review delineated how microenvironmental changes in the injured mucosa result in an enrichment of a pro-regenerating consortium of bacteria, which augments mucosal wound repair and restoration of barrier functions.

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Crossref · 10.1080/21688370.2018.1539595

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  • Microbial metabolites have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.

    “Further, they have been shown to significantly influence the maintenance of gut barrier integrity itself and intestinal homeostasis.73,74”

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Authors
Alam, A., & Neish, A.
Affiliations
Emory University (US)
Corresponding author
Alam, Ashfaqul
Venue
Tissue Barriers
Published
2018-07-03
Volume
6
Issue
3
Pages
1539595
ISSN
  • 2168-8362 (ISSN-L)
  • 2168-8370
OpenAlex
W2899740161
Cited by
166
References
152
Citations by year
2026: 14 · 2025: 17 · 2024: 28 · 2023: 20 · 2022: 26 · 2021: 40 · 2020: 12 · 2019: 9
FWCI
1.49
Type
journal article
Language
en
Open access
Locations
  • Tissue Barriers (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (5R01CA179424)
  • National Institutes of Health (R01AI064462, K01DK114391)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords
gut microbiota, intestinal barrier function, intestinal wound healing, mucosal regeneration, dysbiosis, intestinal diseases, mucosal injury, host-microbe interactions
MeSH terms
Gastrointestinal Microbiome, Intestinal Mucosa, Wound Healing

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