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The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking
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Sortilin and APP bind to each other via luminal (head-to-head) and cytosolic (tail-to-tail) interaction domains.
“It was shown that sortilin and the amyloid precursor protein (APP) bind to each other via luminal (head-to-head) and cytosolic (tail-to-tail) interaction domains (55).”
Sortilin targets APP for lysosomal degradation.
“Interestingly, sortilin was shown to target APP for lysosomal degradation (55), whereas our data revealed that sortilin stabilizes APLP2 (Fig. 4B), suggesting a functional difference between the interaction of sortilin with APP or APLP2.”
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Cites
Linking lipids to Alzheimer's disease: cholesterol and beyond
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Cited by
Sorted by citations
Butkinaree, C., Canuel, M., Essalmani, R., Poirier, S., Benjannet, S., Asselin, M.-C., Roubtsova, A., Hamelin, J., Marcinkiewicz, J., Chamberland, A., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.647180 · Cited by 53
Eggert, S., Kins, S., Endres, K., & Brigadski, T. (2022) · Biological Chemistry · doi:10.1515/hsz-2021-0330 · Cited by 46
Metadata
- Authors
- Yang, M., Virassamy, B., Vijayaraj, S. L., Lim, Y., Saadipour, K., Wang, Y.-J., Han, Y.-C., Zhong, J.-H., Morales, C. R., & Zhou, X.-F.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-21
- Volume
- 8
- Issue
- 5
- Pages
- e63049
- ISSN
- 1932-6203
- PMC
- PMC3660575
- Cited by
- 30
- References
- 3
- Language
- en
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