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BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin
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Our data disagree with prior studies that argued for a direct role of sortilin in APP processing through regulation of β-secretase trafficking.
“While our data substantiate an important role for sortilin in amyloidogenic processes, they disagree with prior studies in cellular overexpression systems that argued for a direct role of this receptor in APP processing through regulation of β-secretase trafficking (Finan et al., 2011).”
From The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain (2013) · cites this paper as Finan et al., 2011
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Self-citationProteomic identification of sorting nexin 6 as a negative regulator of BACE1‐mediated APP processing
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BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease
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Metadata
- Authors
- Finan, G. M., Okada, H., & Kim, T.-W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 286
- Issue
- 14
- Pages
- 12602-12616
- ISSN
- 0021-9258
- Cited by
- 104
- References
- 7
- Language
- en
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