The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Markers of Celiac Disease and Gluten Sensitivity in Children with Autism
Open accessAbstract
OBJECTIVE: Gastrointestinal symptoms are a common feature in children with autism, drawing attention to a potential association with celiac disease or gluten sensitivity. However, studies to date regarding the immune response to gluten in autism and its association with celiac disease have been inconsistent. The aim of this study was to assess immune reactivity to gluten in pediatric patients diagnosed with autism according to strict criteria and to evaluate the potential link between autism and celiac disease. METHODS: Study participants included children (with or without gastrointestinal symptoms) diagnosed with autism according to both the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview, Revised (ADI-R) (n = 37), their unaffected siblings (n = 27), and age-matched healthy controls (n = 76). Serum specimens were tested for antibodies to native gliadin, deamidated gliadin, and transglutaminase 2 (TG2). Affected children were genotyped for celiac disease associated HLA-DQ2 and -DQ8 alleles. RESULTS: Children with autism had significantly higher levels of IgG antibody to gliadin compared with unrelated healthy controls (p<0.01). The IgG levels were also higher compared to the unaffected siblings, but did not reach statistical significance. The IgG anti-gliadin antibody response was significantly greater in the autistic children with gastrointestinal symptoms in comparison to those without them (p<0.01). There was no difference in IgA response to gliadin across groups. The levels of celiac disease-specific serologic markers, i.e., antibodies to deamidated gliadin and TG2, did not differ between patients and controls. An association between increased anti-gliadin antibody and presence of HLA-DQ2 and/or -DQ8 was not observed. CONCLUSIONS: A subset of children with autism displays increased immune reactivity to gluten, the mechanism of which appears to be distinct from that in celiac disease. The increased anti-gliadin antibody response and its association with GI symptoms points to a potential mechanism involving immunologic and/or intestinal permeability abnormalities in affected children.
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“There is also one report showing that children with ASD have increased immune reactivity to gluten and this immune response is enhanced when GI symptoms are present, but this study, like the aforementioned one, has not been replicated 53.”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [53]
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The Oslo definitions for coeliac disease and related terms
Ludvigsson, J. F., Leffler, D. A., Bai, J. C., Biagi, F., Fasano, A., Green, P. H. R., Hadjivassiliou, M., Kaukinen, K., Kelly, C. P., Leonard, J. N., et al. (2013) · Gut · doi:10.1136/gutjnl-2011-301346 · Cited by 1,721
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The role of immune dysfunction in the pathophysiology of autism
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Abnormal intestinal permeability in children with autism
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Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder
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Cerebral folate receptor autoantibodies in autism spectrum disorder
Frye, R. E., Sequeira, J. M., Quadros, E. V., James, S. J., & Rossignol, D. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.175 · Cited by 257
RESPONSE OF INTESTINAL MUCOSA TO GLUTEN CHALLENGE IN AUTISTIC SUBJECTS
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Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder
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Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders
Catassi, C., Bai, J. C., Bonaz, B. L., Bouma, G., Calabrò, A., Carroccio, A., Castillejo, G., Ciacci, C., Cristofori, F., Dolinšek, J., et al. (2013) · Nutrients · doi:10.3390/nu5103839 · Cited by 493
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Metadata
- Authors
- Lau, N. M., Green, P. H. R., Taylor, A. K., Hellberg, D., Ajamian, M., Tan, C. Z., Kosofsky, B. E., Higgins, J. J., Rajadhyaksha, A. M., & Alaedini, A.
- Affiliations
- Columbia University (US)
- Uppsala University (SE)
- Weill Cornell Medicine (US)
- Corresponding author
- Alaedini, Armin
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-06-18
- Volume
- 8
- Issue
- 6
- Pages
- e66155
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3688832
- OpenAlex
- W1968001810
- Cited by
- 124
- References
- 32
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 14 · 2020: 17 · 2019: 12 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 8 · 2013: 3
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Columbia Academic Commons (Columbia University)
- Funders
- U.S. Department of Defense (W81XWH)
- Autism Speaks
- National Institutes of Health (UL1TR000457)
- National Institute of Mental Health (U24MH081810)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, celiac disease, gluten sensitivity, anti-gliadin antibodies, HLA-DQ2, HLA-DQ8, gastrointestinal symptoms, intestinal permeability, children
- MeSH terms
- Autistic Disorder, Celiac Disease, Child, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Gliadin, Histocompatibility Testing, Humans, Immunoglobulin G, Male, Biomarkers, Case-Control Studies, Gastrointestinal Tract
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