The role of immune dysfunction in the pathophysiology of autism
Open accessAbstract
Autism spectrum disorders (ASD) are a complex group of neurodevelopmental disorders encompassing impairments in communication, social interactions and restricted stereotypical behaviors. Although a link between altered immune responses and ASD was first recognized nearly 40 years ago, only recently has new evidence started to shed light on the complex multifaceted relationship between immune dysfunction and behavior in ASD. Neurobiological research in ASD has highlighted pathways involved in neural development, synapse plasticity, structural brain abnormalities, cognition and behavior. At the same time, several lines of evidence point to altered immune dysfunction in ASD that directly impacts some or all these neurological processes. Extensive alterations in immune function have now been described in both children and adults with ASD, including ongoing inflammation in brain specimens, elevated pro-inflammatory cytokine profiles in the CSF and blood, increased presence of brain-specific auto-antibodies and altered immune cell function. Furthermore, these dysfunctional immune responses are associated with increased impairments in behaviors characteristic of core features of ASD, in particular, deficits in social interactions and communication. This accumulating evidence suggests that immune processes play a key role in the pathophysiology of ASD. This review will discuss the current state of our knowledge of immune dysfunction in ASD, how these findings may impact on underlying neuro-immune mechanisms and implicate potential areas where the manipulation of the immune response could have an impact on behavior and immunity in ASD.
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The literature exploring immune dysregulation in autism is broad, ranging from upregulated pro-inflammatory cytokine levels in cerebrospinal fluid and blood, brain-specific autoantibodies (both in patients and mothers), and changes to immune cell function (e.g., downregulated T regulatory cells).
“The literature exploring immune dysregulation in autism is broad, ranging from upregulated pro-inflammatory cytokine levels in cerebrospinal fluid and blood, brain-specific autoantibodies (both in patients and mothers), and changes to immune cell function (e.g., downregulated T regulatory cells) [124,125].”
From The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders (2020) · cites this paper as [124]
Individuals with ASD have an increased incidence of autoimmune disorders, allergy and asthma.
“individuals with ASD have an increased incidence of autoimmune disorders, allergy and asthma65,103.”
From Immune mediators in the brain and peripheral tissues in autism spectrum disorder (2015) · cites this paper as [103]
Immune dysfunction and gastrointestinal inflammation are common in individuals with ASD and contribute to severity of behaviors seen in the disorder.
“Immune dysfunction and gastrointestinal (GI) inflammation are also common in individuals with ASD and contribute to severity of behaviors seen in the disorder [6–8].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [6]
High levels of cytokines such as IL-1B, IL-6, IL-8, and IL-12p40 have been reported in ASD children associated with poor communication and impaired social communication.
“High levels of cytokines (e.g., IL-1B, IL-6, IL-8, and IL-12p40) have been reported in ASD children associated with poor communication and impaired social communication [32,152].”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [32]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461 · see citing works
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 5× · see citing works
“These findings include prominent microglia activation and, increased inflammatory cytokine and chemokine production, including interferon (IFN)-c, IL-1b, IL-6, IL-12p40, tumor necrosis factor (TNF)-a and chemokine C–C motif ligand (CCL)-2 in the brain tissue and cerebral spinal fluid (Li et al., 2009; Morgan et al., 2…”
InfluentialTranscriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology
Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · cited 3× · see citing works
“The recent finding of altered transciptome profiles in microglia in brain specimens from individuals with ASD (Voineagu et al., 2011) also suggests that environmental factors may play a role in the activation of these cells.”
Advances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866 · see citing works
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851 · see citing works
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
Common variants conferring risk of schizophrenia
†Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., et al. (2009) · Nature · doi:10.1038/nature08186 · Cited by 1,677 · see citing works
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works
Ziv, Y., Ron, N., Butovsky, O., Landa, G., Sudai, E., Greenberg, N., Cohen, H., Kipnis, J., & Schwartz, M. (2006) · Nature Neuroscience · doi:10.1038/nn1629 · Cited by 1,209 · see citing works
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154 · see citing works
Takahashi, K., Rochford, C. D. P., & Neumann, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041611 · Cited by 1,124 · see citing works
Acute phase reaction and acute phase proteins
Gruys, E., Toussaint, M. J. M., Niewold, T., & Koopmans, S. J. (2005) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.2005.b1045 · Cited by 1,084 · see citing works
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940 · see citing works
Self-citationMaternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders
Atladóttir, H. Ó., Thorsen, P., Østergaard, L., Schendel, D. E., Lemcke, S., Abdallah, M., & Parner, E. T. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1006-y · Cited by 916 · see citing works
Deverman, B. E., & Patterson, P. H. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.002 · Cited by 865 · see citing works
Regulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works
DeGiorgio, L. A., Konstantinov, K. N., Lee, S. C., Hardin, J., Volpe, B. T., & Diamond, B. (2001) · Nature Medicine · doi:10.1038/nm1101-1189 · Cited by 798 · see citing works
Elevated immune response in the brain of autistic patients
Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786 · see citing works
A Twin Study of Autism in Denmark, Finland, Iceland, Norway and Sweden
Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I. C., Jakobsson, G., & Bohman, M. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00254.x · Cited by 780 · see citing works
Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
Patterson, P. H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.016 · Cited by 766 · see citing works
Morgan, J. T., Chana, G., Pardo, C. A., Achim, C., Semendeferi, K., Buckwalter, J., Courchesne, E., & Everall, I. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.024 · Cited by 749 · see citing works
Contribution of SHANK3 Mutations to Autism Spectrum Disorder
Moessner, R., Marshall, C. R., Sutcliffe, J. S., Skaug, J., Pinto, D., Vincent, J., Zwaigenbaum, L., Fernandez, B., Roberts, W., Szatmari, P., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/522590 · Cited by 681 · see citing works
Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works
Microglia in health and disease
Kim, S. U., & de Vellis, J. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20562 · Cited by 663 · see citing works
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Regulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity
Corriveau, R. A., Huh, G. S., & Shatz, C. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80562-0 · Cited by 548 · see citing works
PI3K-mediated negative feedback regulation of IL-12 production in DCs
Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T., & Koyasu, S. (2002) · Nature Immunology · doi:10.1038/ni825 · Cited by 529 · see citing works
Smalley, S. L., Tanguay, P. E., Smith, M., & Gutierrez, G. (1992) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01048239 · Cited by 518 · see citing works
Kipnis, J., Cohen, H., Cardon, M., Ziv, Y., & Schwartz, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402268101 · Cited by 510 · see citing works
A neuromodulatory role of interleukin-1β in the hippocampus
Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7778 · Cited by 498 · see citing works
Microglia Biology in Health and Disease
Garden, G. A., & Möller, T. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9015-5 · Cited by 494 · see citing works
Microglial control of neuronal death and synaptic properties
Bessis, A., Béchade, C., Bernard, D., & Roumier, A. (2006) · Glia · doi:10.1002/glia.20459 · Cited by 454 · see citing works
Hematopoietic origin of pathological grooming in Hoxb8 mutant mice
Chen, S.-K., Tvrdik, P., Peden, E., Cho, S., Wu, S., Spangrude, G., & Capecchi, M. R. (2010) · Cell · doi:10.1016/j.cell.2010.03.055 · Cited by 450 · see citing works
Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders
Atladóttir, H. O., Pedersen, M. G., Thorsen, P., Mortensen, P. B., Deleuran, B., Eaton, W. W., & Parner, E. T. (2009) · Pediatrics · doi:10.1542/peds.2008-2445 · Cited by 404 · see citing works
Activation of the maternal immune system induces endocrine changes in the placenta via IL-6
Hsiao, E. Y., & Patterson, P. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.12.017 · Cited by 402 · see citing works
A genetic variant that disrupts <i>MET</i> transcription is associated with autism
Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401 · see citing works
Hoxb8 Is Required for Normal Grooming Behavior in Mice
Greer, J. M., & Capecchi, M. R. (2002) · Neuron · doi:10.1016/s0896-6273(01)00564-5 · Cited by 401 · see citing works
Interleukin-1 (IL-1): A central regulator of stress responses
Goshen, I., & Yirmiya, R. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.001 · Cited by 399 · see citing works
Immune transcriptome alterations in the temporal cortex of subjects with autism
Garbett, K., Ebert, P. J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K., & Persico, A. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.01.012 · Cited by 375 · cited 1× · see citing works
“Microglial cells are uniquely positioned to robustly respond to immune signals, and influence the CNS environment, through the production of inflammatory cytokines and the generation of reactive oxygen species (ROS) within the CNS (Garden and Moller, 2006; Hanisch and Kettenmann, 2007).”
MHC Class I: An Unexpected Role in Neuronal Plasticity
Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.044 · Cited by 369 · see citing works
Maternal Autoimmune Diseases, Asthma and Allergies, and Childhood Autism Spectrum Disorders
Croen, L., Grether, J. K., Yoshida, C. K., Odouli, R., & de Water, J. V. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.2.151 · Cited by 360 · see citing works
Fragile X syndrome and autism at the intersection of genetic and neural networks
Belmonte, M. K., & Bourgeron, T. (2006) · Nature Neuroscience · doi:10.1038/nn1765 · Cited by 345 · see citing works
Regulation of CNS synapses by neuronal MHC class I
Goddard, C. A., Butts, D. A., & Shatz, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702023104 · Cited by 322 · see citing works
Association between a GABRB3 polymorphism and autism
Buxbaum, J. D., Silverman, J. M., Smith, C. J. W., Greenberg, D. A., Kilifarski, M., Reichert, J. G., Cook, E. H., Fang, Y., Song, C.-Y., & Vitale, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001011 · Cited by 322 · see citing works
Differential monocyte responses to TLR ligands in children with autism spectrum disorders
Enstrom, A. M., Onore, C. E., Van de Water, J. A., & Ashwood, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.001 · Cited by 294 · see citing works
Self-citationAlternatively activated macrophages in infection and autoimmunity
Fairweather, D., & Cihakova, D. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.09.012 · Cited by 290 · see citing works
Samuelsson, A., Jennische, E., Hansson, H., & Holmäng, A. B. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00268.2005 · Cited by 283 · see citing works
Autism: maternally derived antibodies specific for fetal brain proteins.
Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R. L., Croen, L., Pessah, I., & van de Water, J. A. (2007) · Neurotoxicology · doi:10.1016/j.neuro.2007.10.010 · Cited by 281 · see citing works
Self-citationAltered T cell responses in children with autism
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.09.002 · Cited by 281 · see citing works
Self-citationAssociations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.10.025 · Cited by 279 · see citing works
Self-citationAntibodies to Myelin Basic Protein in Children with Autistic Behavior
Singh, V. K., Warren, R. P., Odell, J. D., Warren, W. L., & Cole, P. (1993) · Brain, Behavior, and Immunity · doi:10.1006/brbi.1993.1010 · Cited by 274 · see citing works
Ashwood, P., Enstrom, A., Krakowiak, P., Hertz-Picciotto, I., Hansen, R. L., Croen, L. A., Ozonoff, S., Pessah, I. N., & de Water, J. V. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.07.006 · Cited by 271 · see citing works
Self-citationEnstrom, A. M., Lit, L., Onore, C. E., Gregg, J. P., Hansen, R. L., Pessah, I. N., Hertz-Picciotto, I., Van de Water, J. A., Sharp, F. R., & Ashwood, P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.001 · Cited by 257 · see citing works
Self-citationTh1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism
Gupta, S., Aggarwal, S., Rashanravan, B., & Lee, T. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00021-6 · Cited by 250 · see citing works
Circulating autoantibodies to neuronal and glial filament proteins in autism
Singh, V. K., Warren, R., Averett, R., & Ghaziuddin, M. (1997) · Pediatric Neurology · doi:10.1016/s0887-8994(97)00045-3 · Cited by 234 · see citing works
Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism
Martin, L. A., Ashwood, P., Braunschweig, D., Cabanlit, M., Van de Water, J., & Amaral, D. G. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.007 · Cited by 231 · see citing works
Self-citationBehavioral consequences of congenital rubella
Chess, S., Fernandez, P., & Korn, S. (1978) · The Journal of Pediatrics · doi:10.1016/s0022-3476(78)80921-4 · Cited by 223 · see citing works
Open-label add-on treatment trial of minocycline in fragile X syndrome.
Paribello, C., Tao, L., Folino, A., Berry-Kravis, E., Tranfaglia, M., Ethell, I. M., & Ethell, D. W. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-91 · Cited by 223 · see citing works
Tumor necrosis factor α triggers proliferation of adult neural stem cells via IKK/NF-κB signaling
Widera, D., Mikenberg, I., Elvers, M., Kaltschmidt, C., & Kaltschmidt, B. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-64 · Cited by 216 · see citing works
Wiznitzer, M. (2004) · Journal of Child Neurology · doi:10.1177/08830738040190090701 · Cited by 214 · see citing works
ASHWOOD, P., ANTHONY, A., TORRENTE, F., & WAKEFIELD, A. J. (2004) · Journal of Clinical Immunology · doi:10.1007/s10875-004-6241-6 · Cited by 212 · see citing works
Self-citationGenetic Structure of Reciprocal Social Behavior
Constantino, J. N., & Todd, R. D. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.12.2043 · Cited by 210 · see citing works
CNS manifestations of Nasu–Hakola disease
Bm, J., Autti, T., Raininko, R., Partanen, J., Salonen, O., Puranen, M., Hakola, P., & Haltia, M. (2001) · Neurology · doi:10.1212/wnl.56.11.1552 · Cited by 205 · see citing works
Depressed lymphocyte responsiveness in autistic children
Stubbs, E. G., Crawford, M. L., Burger, D. R., & Vandenbark, A. A. (1977) · Journal of Autism and Childhood Schizophrenia · doi:10.1007/bf01531114 · Cited by 202 · see citing works
Ashwood, P., & Wakefield, A. J. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.12.007 · Cited by 202 · see citing works
Self-citationTorrente, F., Ashwood, P., Day, R. M., Machado, N., Furlano, R. I., Anthony, A., Davies, S. E., Wakefield, A. J., Thomson, M. A., Walker-Smith, J. A., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001077 · Cited by 201 · see citing works
Self-citationAnalysis of the RELN gene as a genetic risk factor for autism
Skaar, D. A., Shao, Y., Haines, J. L., Stenger, J. E., Jaworski, J. M., Martin, E. R., DeLong, G. R., Moore, J. H., McCauley, J. L., Sutcliffe, J. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001614 · Cited by 197 · see citing works
Corbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001943 · Cited by 197 · see citing works
Self-citationVojdani, A., Campbell, A. W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00180-7 · Cited by 197 · see citing works
Complex segregation analysis of autism.
Jorde, L. B., Hasstedt, S. J., RITVO, E. R., MASON-BROTHERS, A., Freeman, B. J., Pingree, C., McMahon, W. M., Petersen, B., Jenson, W. R., & Mo, A. (1991) · PubMed · Cited by 191 · see citing works
Reduced Natural Killer Cell Activity in Autism
WARREN, R. P., FOSTER, A., & MARGARETTEN, N. C. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198705000-00008 · Cited by 190 · see citing works
Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms
Heuer, L., Ashwood, P., Schauer, J., Goines, P., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., Croen, L. A., Pessah, I. N., & Van de Water, J. (2008) · Autism Research · doi:10.1002/aur.42 · Cited by 190 · see citing works
Self-citationCacci, E., Claasen, J.-H., & Kokaia, Z. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20531 · Cited by 188 · see citing works
Djukic, M. (2006) · Brain · doi:10.1093/brain/awl206 · Cited by 186 · see citing works
Maternal Mid-Pregnancy Autoantibodies to Fetal Brain Protein: The Early Markers for Autism Study
Croen, L., Braunschweig, D., Haapanen, L. A. D., Yoshida, C. K., FIREMAN, B. H., Grether, J. K., Kharrazi, M., Hansen, R. L., Ashwood, P., & de Water, J. V. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.006 · Cited by 171 · see citing works
Self-citationImmune dysfunction in autism: A pathway to treatment
Careaga, M., Water, J., & Ashwood, P. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.003 · Cited by 166 · see citing works
Self-citationSinger, H. S., Morris, C., Gause, C., Pollard, M., Zimmerman, A. W., & Pletnikov, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.03.011 · Cited by 164 · cited 5× · see citing works
“…absent in mothers of children who are typically developing or mothers of children with developmental delays, suggests a potential inflammatory process that leads to the production of antibodies directed to the developing brain (Braunschweig et al., 2008; Croen et al., 2008; Singer et al., 2009).”
InfluentialWills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D. G., & Van de Water, J. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.007 · Cited by 163 · see citing works
Self-citationCell biology of antigen presentation
Neefjes, J., & Momburg, F. (1993) · Current Opinion in Immunology · doi:10.1016/0952-7915(93)90077-6 · Cited by 163 · see citing works
Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus
Lee, J. Y., Huerta, P. T., Zhang, J., Kowal, C., Bertini, E., Volpe, B. T., & Diamond, B. (2009) · Nature Medicine · doi:10.1038/nm.1892 · Cited by 163 · see citing works
Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory
Moore, A. H., Wu, M., Shaftel, S. S., Graham, K. A., & O’Banion, M. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.073 · Cited by 160 · see citing works
Behaviors Associated With Fever in Children With Autism Spectrum Disorders
Curran, L. K., Newschaffer, C. J., Lee, L.-C., Crawford, S. O., Johnston, M. V., & Zimmerman, A. W. (2007) · Pediatrics · doi:10.1542/peds.2007-0360 · Cited by 158 · see citing works
Immune-based regulation of adult neurogenesis: Implications for learning and memory
Ziv, Y., & Schwartz, M. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.006 · Cited by 158 · see citing works
High blood monocyte counts and neopterin levels in children with autistic disorder.
Sweeten, T. L., Posey, D., & McDougle, C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1691 · Cited by 157 · see citing works
Brain‐Specific Autoantibodies in the Plasma of Subjects with Autistic Spectrum Disorder
CABANLIT, M., WILLS, S., GOINES, P., ASHWOOD, P., & VAN DE WATER, J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.010 · Cited by 157 · see citing works
Self-citationInterleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
Opp, M. R., & Krueger, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.2.r453 · Cited by 152 · see citing works
In Search of Cellular Immunophenotypes in the Blood of Children with Autism
Ashwood, P., Corbett, B. A., Kantor, A. B., Schulman, H., de Water, J. V., & Amaral, D. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019299 · Cited by 140 · see citing works
Self-citationUlvestad, E., Williams, K. C., Matre, R., Nyland, H., Olivier, A., & Antel, J. P. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199401000-00004 · Cited by 137 · see citing works
Neuroanatomic Variation in Monozygotic Twin Pairs Discordant for the Narrow Phenotype for Autism
Kates, W. R., Burnette, C. P., Eliez, S., Strunge, L. A., Kaplan, D., Landa, R., Reiss, A. L., & Pearlson, G. D. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.3.539 · Cited by 137 · see citing works
Autoantibodies to cerebellum in children with autism associate with behavior
Goines, P., Haapanen, L., Boyce, R., Duncanson, P., Braunschweig, D., Delwiche, L., Hansen, R., Hertz-Picciotto, I., Ashwood, P., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.11.017 · Cited by 134 · see citing works
Self-citationDecreased serum levels of transforming growth factor-β1 in patients with autism
Okada, K., Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., Suda, S., Suzuki, K., Sugihara, G.-I., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.08.020 · Cited by 132 · see citing works
Antibrain antibodies in children with autism and their unaffected siblings
Singer, H. S., Morris, C. M., Williams, P. N., Yoon, D. Y., Hong, J. J., & Zimmerman, A. W. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.05.025 · Cited by 132 · see citing works
Increased serum albumin, γ globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism
Croonenberghs, J., Wauters, A., Devreese, K. M. J., Verkerk, R. M., Scharpé, S., Bosmans, E., Egyed, B., Deboutte, D., & Maes, M. H. J. (2002) · Psychological Medicine · doi:10.1017/s0033291702006037 · Cited by 128 · see citing works
Torres, A., Maciulis, A., Stubbs, E. G., Cutler, A., & Odell, D. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00374-9 · Cited by 125 · see citing works
Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15
Vojdani, A., Mumper, E. A., Granpeesheh, D., Mielke, L., Traver, D., Bock, K., Hirani, K., Neubrander, J. A., Woeller, K. N., O’Hara, N., et al. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.005 · Cited by 121 · see citing works
Harden, L. M., Plessis, I. D., Poole, S., & Laburn, H. P. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.006 · Cited by 118 · see citing works
Macrophage migration inhibitory factor and autism spectrum disorders
Grigorenko, E. L., Han, S. S., Yrigollen, C. M., Leng, L., Mizue, Y., Anderson, G. M., Mulder, E. J., de Bildt, A., Minderaa, R. B., Volkmar, F. R., et al. (2008) · PEDIATRICS · doi:10.1542/peds.2007-3604 · Cited by 118 · see citing works
Confirmation of the association of the C4B null allelle in autism
Odell, D., Maciulis, A., Cutler, A., Warren, L., McMahon, W. M., Coon, H., Stubbs, G., Henley, K., & Torres, A. (2005) · Human Immunology · doi:10.1016/j.humimm.2004.11.002 · Cited by 110 · see citing works
MECP2 promoter methylation and X chromosome inactivation in autism
Nagarajan, R. P., Patzel, K. A., Martin, M. R., Yasui, D. H., Swanberg, S. E., Hertz‐Picciotto, I., Hansen, R. L., de Water, J. V., Pessah, I. N., Jiang, R., et al. (2008) · Autism Research · doi:10.1002/aur.24 · Cited by 110 · see citing works
Enstrom, A. M., de Water, J. V., & Ashwood, P. (2009) · PubMed · Cited by 107 · see citing works
Self-citationHLA-DR4 in Families With Autism
Lee, L.-C., Zachary, A. A., Leffell, M. S., Newschaffer, C. J., Matteson, K. J., Tyler, J. D., & Zimmerman, A. W. (2006) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2006.06.006 · Cited by 106 · see citing works
The Association and Linkage of the HLA-A2 Class I Allele with Autism
Torres, A. R., Sweeten, T. L., Cutler, A., Bedke, B. J., Fillmore, M., Stubbs, E. G., & Odell, D. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.01.001 · Cited by 104 · see citing works
Increased IgG4 levels in children with autism disorder
Enstrom, A., Krakowiak, P., Onore, C., Pessah, I. N., Hertz-Picciotto, I., Hansen, R. L., Van de Water, J. A., & Ashwood, P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.12.005 · Cited by 101 · see citing works
Self-citationSingh, V. K., Singh, E. A., & Warren, R. P. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00522-7 · Cited by 99 · see citing works
Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice
Derecki, N. C., Quinnies, K. M., & Kipnis, J. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.009 · Cited by 97 · see citing works
Intravenous Immunoglobulin Treatment of Children With Autism
Plioplys, A. V. (1998) · Journal of Child Neurology · doi:10.1177/088307389801300207 · Cited by 93 · see citing works
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Baier, P. C., May, U., Scheller, J., Rose-John, S., & Schiffelholz, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.013 · Cited by 84 · see citing works
Mandal, M., Marzouk, A. C., DONNELLY, R. J., & Ponzio, N. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.011 · Cited by 82 · see citing works
Month of conception and risk of autism
Zerbo, O., Iosif, A.-M., Delwiche, L., Walker, C., & Hertz-Picciotto, I. (2011) · Epidemiology · doi:10.1097/ede.0b013e31821d0b53 · Cited by 81 · see citing works
Antibrain antibodies in infantile autism
Todd, R. D., Hickok, J. M., Anderson, G. M., & Cohen, D. J. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90012-1 · Cited by 80 · see citing works
Torrente, F., Anthony, A., Heuschkel, R. B., Thomson, M., Ashwood, P., & MURCH, S. H. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04142.x · Cited by 77 · see citing works
Self-citationRoles of the Complement System in Human Neurodegenerative Disorders
Gasque, P., Neal, J. W., Singhrao, S. K., McGreal, E. P., Dean, Y. D., van Beek, J., & Morgan, B. P. (2002) · Molecular Neurobiology · doi:10.1385/mn:25:1:001 · Cited by 77 · see citing works
Autoantibody repertoires to brain tissue in autism nuclear families
Silva, S. C., Correia, C., Fesel, C., Barreto, M., Coutinho, A. M., Marques, C., Miguel, T. S., Ataide, A., Bento, C., Borges, L., et al. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.03.015 · Cited by 76 · see citing works
Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome.
Shenoy, S., Arnold, S. T., & Chatila, T. (2000) · Jornal de Pediatria · doi:10.1067/mpd.2000.105355 · Cited by 69 · see citing works
Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders
Onore, C. E., Enstrom, A. M., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., de Water, J. V., & Ashwood, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.09.005 · Cited by 67 · see citing works
Self-citationZalcman, S. S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02740-3 · Cited by 64 · see citing works
Steup‐Beekman, G. M., Steens, S., van Buchem, M. A., & Huizinga, T. W. J. (2007) · Lupus · doi:10.1177/0961203307078224 · Cited by 63 · see citing works
Breaking Boundaries in Neural-Immune Interactions
McAllister, A. K., & de Water, J. V. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.038 · Cited by 59 · see citing works
Impairment of recognition memory in interleukin-6 knock-out mice
Hryniewicz, A., Bialuk, I., Kamiński, K. A., & Winnicka, M. M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.08.046 · Cited by 54 · see citing works
Wills, S., Rossi, C. C., Bennett, J., Martínez‐Cerdeño, V., Ashwood, P., Amaral, D. G., & de Water, J. V. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-5 · Cited by 53 · see citing works
Self-citationThe association of MHC genes with autism
Anthony, R. T. (2001) · Frontiers in bioscience · doi:10.2741/torres · Cited by 48 · see citing works
Kajizuka, M., Miyachi, T., Matsuzaki, H., Iwata, K., Shinmura, C., Suzuki, K., Suda, S., Tsuchiya, K. J., Matsumoto, K., Iwata, Y., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.10.017 · Cited by 43 · see citing works
Tsuchiya, K. J., Hashimoto, K., Iwata, Y., Tsujii, M., Sekine, Y., Sugihara, G., Matsuzaki, H., Suda, S., Kawai, M., Nakamura, K., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.018 · Cited by 41 · see citing works
Scifo, R., Cioni, M., Nicolosi, A., Batticane, N., Tirolo, C., Testa, N., Quattropani, M. C. A., Morale, M. C., Gallo, F., & Marchetti, B. (1996) · PubMed · Cited by 40 · see citing works
Heat shock protein 90 antibodies in autism
Evers, M. J. A. P., Cunningham‐Rundles, C., & Hollander, E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001171 · Cited by 29 · see citing works
Monteleone, I., Monteleone, G., Fina, D., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.021 · Cited by 28 · see citing works
Congenital Rubella and Autistic Behavior
Siegel, S. R., & Muggia, F. M. (1975) · New England Journal of Medicine · doi:10.1056/nejm197507242930414 · Cited by 18 · see citing works
Serum levels of P-selectin in men with high-functioning autism
Iwata, Y., Tsuchiya, K. J., Mikawa, S., Nakamura, K., Takai, Y., Suda, S., Sekine, Y., Suzuki, K., Kawai, M., Sugihara, G., et al. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.043497 · Cited by 18 · see citing works
Letter: Congenital rubella and autistic behavior.
Cn, S., & Swisher, L. (1975) · PubMed · Cited by 7 · see citing works
Korade, Ž., & Mirnics, K. (2011) · Nature · doi:10.1038/474294a · Cited by 7 · see citing works
Daws (2001) · doi:10.1002/1521-4141(200103)31:3
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Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371 · see citing works
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182 · see citing works
New evidences on the altered gut microbiota in autism spectrum disorders
Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., Jousson, O., Leoncini, S., Renzi, D., Calabrò, A., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0242-1 · Cited by 1,040 · see citing works
Immune mediators in the brain and peripheral tissues in autism spectrum disorder
Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works
Autism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484 · see citing works
The Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works
Association of Maternal Diabetes With Autism in Offspring
Xiang, A. H., Wang, X., Martinez, M. P., Walthall, J. C., Curry, E. S., Page, K., Buchanan, T. A., Coleman, K. J., & Getahun, D. (2015) · JAMA · doi:10.1001/jama.2015.2707 · Cited by 395 · see citing works
Rai, D., Lee, B. K., Dalman, C., Golding, J., Lewis, G., & Magnusson, C. (2013) · BMJ · doi:10.1136/bmj.f2059 · Cited by 365 · see citing works
Elevated maternal C-reactive protein and autism in a national birth cohort
Brown, A. S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I. W., Sundvall, J., & Surcel, H.-M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.197 · Cited by 343 · see citing works
Modeling an autism risk factor in mice leads to permanent immune dysregulation
Hsiao, E. Y., McBride, S. W., Chow, J., Mazmanian, S. K., & Patterson, P. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202556109 · Cited by 340 · see citing works
Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314 · see citing works
Self-citationXu, M., Xu, X., Li, J., & Li, F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00473 · Cited by 309 · see citing works
Gastrointestinal Conditions in Children With Autism Spectrum Disorder: Developing a Research Agenda
Coury, D. L., Ashwood, P., Fasano, A., Fuchs, G., Geraghty, M., Kaul, A., Mawe, G., Patterson, P., & Jones, N. E. (2012) · Pediatrics · doi:10.1542/peds.2012-0900n · Cited by 264 · see citing works
Self-citationThe many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
Morris, G., & Berk, M. (2015) · BMC Medicine · doi:10.1186/s12916-015-0310-y · Cited by 245 · see citing works
Allen, J. L., Oberdorster, G., Morris-Schaffer, K., Wong, C., Klocke, C., Sobolewski, M., Conrad, K., Mayer-Proschel, M., & Cory-Slechta, D. A. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2015.12.014 · Cited by 241 · see citing works
Gut microbiota and autism: key concepts and findings
Ding, H. T., Taur, Y., & Walkup, J. T. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2960-9 · Cited by 232 · see citing works
Rose, D. R., Yang, H., Serena, G., Sturgeon, C., Ma, B., Careaga, M., Hughes, H. K., Angkustsiri, K., Rose, M., Hertz-Picciotto, I., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.03.025 · Cited by 227 · see citing works
Self-citationThe Gut Microbiota and Dysbiosis in Autism Spectrum Disorders
Hughes, H. K., Rose, D., & Ashwood, P. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0887-6 · Cited by 225 · see citing works
Self-citationHigh intelligence: A risk factor for psychological and physiological overexcitabilities
Karpinski, R. I., Kinase Kolb, A. M., Tetreault, N. A., & Borowski, T. B. (2018) · Intelligence · doi:10.1016/j.intell.2017.09.001 · Cited by 217 · see citing works
Immunological and autoimmune considerations of Autism Spectrum Disorders
Gesundheit, B., Rosenzweig, J. P., Naor, D., Lerer, B., Zachor, D. A., Procházka, V., Melamed, M., Kristt, D. A., Steinberg, A., Shulman, C., et al. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.05.005 · Cited by 207 · see citing works
Self-citationMaternal high fat diet consumption during the perinatal period programs offspring behavior
Sullivan, E. L., Nousen, E. K., & Chamlou, K. A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.07.014 · Cited by 217 · see citing works
O'Donovan, A., Rush, G., Hoatam, G., Hughes, B. M., McCrohan, A., Kelleher, C., O'Farrelly, C., & Malone, K. M. (2013) · Depression and Anxiety · doi:10.1002/da.22087 · Cited by 210 · see citing works
Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions
Ristori, M. V., Quagliariello, A., Reddel, S., Ianiro, G., Vicari, S., Gasbarrini, A., & Putignani, L. (2019) · Nutrients · doi:10.3390/nu11112812 · Cited by 214 · see citing works
Chow, M. L., Pramparo, T., Winn, M. E., Barnes, C. C., Li, H.-R., Weiss, L., Fan, J.-B., Murray, S., April, C., Belinson, H., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002592 · Cited by 202 · see citing works
Gastrointestinal issues in autism spectrum disorder
Hsiao, E. Y. (2014) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000029 · Cited by 209 · see citing works
Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms
Kim, D. R., Bale, T. L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0546-9 · Cited by 203 · see citing works
Tye, C., Runicles, A. K., Whitehouse, A. J. O., & Alvares, G. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00751 · Cited by 177 · see citing works
Intestinal Dysbiosis and Yeast Isolation in Stool of Subjects with Autism Spectrum Disorders
Iovene, M. R., Bombace, F., Maresca, R., Sapone, A., Iardino, P., Picardi, A., Marotta, R., Schiraldi, C., Siniscalco, D., Serra, N., et al. (2017) · Mycopathologia · doi:10.1007/s11046-016-0068-6 · Cited by 184 · see citing works
Rose, S., Frye, R. E., Slattery, J., Wynne, R., Tippett, M., Pavliv, O., Melnyk, S., & James, S. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085436 · Cited by 168 · see citing works
Brain Transcriptional and Epigenetic Associations with Autism
Ginsberg, M. R., Rubin, R. A., Falcone, T., Ting, A. H., & Natowicz, M. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044736 · Cited by 164 · see citing works
Lv, Y.-T., Zhang, Y., Liu, M., Qiuwaxi, J.-N.-T., Ashwood, P., Cho, S. C., Huan, Y., Ge, R.-C., Chen, X.-W., Wang, Z.-J., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-196 · Cited by 174 · see citing works
Self-citationTipping the balance of autism risk: potential mechanisms linking pesticides and autism
Shelton, J. F., Hertz-Picciotto, I., & Pessah, I. N. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104553 · Cited by 164 · see citing works
Ahmad, S. F., Zoheir, K. M. A., Ansari, M. A., Nadeem, A., Bakheet, S. A., AL-Ayadhi, L. Y., Alzahrani, M. Z., Al-Shabanah, O. A., Al-Harbi, M. M., & Attia, S. M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9977-0 · Cited by 155 · see citing works
Association of Food Allergy and Other Allergic Conditions with Autism Spectrum Disorder in Children
Xu, G., Snetselaar, L. G., Jing, J., Liu, B., Strathearn, L., & Bao, W. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.0279 · Cited by 159 · see citing works
The Impact of Neuroimmune Alterations in Autism Spectrum Disorder
Gottfried, C., Bambini-Junior, V., Francis, F., Riesgo, R., & Savino, W. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00121 · Cited by 143 · see citing works
Targeting gut microbiome: a novel and potential therapy for autism
Yang, Y., Tian, J., & Yang, B. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.027 · Cited by 140 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Bresnahan, M., Hornig, M., Schultz, A. F., Gunnes, N., Hirtz, D., Lie, K. K., Magnus, P., Reichborn-Kjennerud, T., Roth, C., Schjølberg, S., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.3034 · Cited by 132 · see citing works
Epigenetics of Autism Spectrum Disorder
Siu, M. T., & Weksberg, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-53889-1_4 · Cited by 121 · see citing works
Connolly, N., Anixt, J., Manning, P., Ping‐I Lin, D., Marsolo, K. A., & Bowers, K. (2016) · Autism Research · doi:10.1002/aur.1586 · Cited by 125 · see citing works
Markers of celiac disease and gluten sensitivity in children with autism
Lau, N. M., Green, P. H. R., Taylor, A. K., Hellberg, D., Ajamian, M., Tan, C. Z., Kosofsky, B. E., Higgins, J. J., Rajadhyaksha, A. M., & Alaedini, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066155 · Cited by 124 · see citing works
The emerging role of microRNAs in schizophrenia and autism spectrum disorders
Mellios, N., & Sur, M. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00039 · Cited by 120 · see citing works
Microbiota, immunoregulatory old friends and psychiatric disorders
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Napoli, E., Wong, S., Hertz-Picciotto, I., & Giulivi, C. (2014) · Pediatrics · doi:10.1542/peds.2013-1545 · Cited by 117 · see citing works
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Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2015) · Brain Research · doi:10.1016/j.brainres.2014.04.004 · Cited by 109 · see citing works
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Casanova, E. L., Baeza-Velasco, C., Buchanan, C. B., & Casanova, M. F. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040260 · Cited by 109 · see citing works
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Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107 · see citing works
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Onore, C. E., Schwartzer, J. J., Careaga, M., Berman, R. F., & Ashwood, P. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.02.007 · Cited by 106 · see citing works
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Mazina, V., Gerdts, J., Trinh, S., Ankenman, K., Ward, T., Dennis, M. Y., Girirajan, S., Eichler, E. E., & Bernier, R. (2015) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000126 · Cited by 101 · see citing works
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Akintunde, M. E., Rose, M., Krakowiak, P., Heuer, L., Ashwood, P., Hansen, R., Hertz-Picciotto, I., & Van de Water, J. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.07.003 · Cited by 96 · see citing works
Self-citationAbdallah, M. W., Larsen, N., Mortensen, E. L., Atladóttir, H. Ó., Nørgaard-Pedersen, B., Bonefeld-Jørgensen, E. C., Grove, J., & Hougaard, D. M. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.07.013 · Cited by 94 · see citing works
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McDougle, C. J., Landino, S. M., Vahabzadeh, A., O’Rourke, J., Zurcher, N. R., Finger, B. C., Palumbo, M. L., Helt, J., Mullett, J. E., Hooker, J. M., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2014.09.048 · Cited by 95 · see citing works
Beversdorf, D. Q., & MISSOURI AUTISM SUMMIT CONSORTIUM* (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000351 · Cited by 74 · see citing works
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Napolioni, V., Ober-Reynolds, B., Szelinger, S., Corneveaux, J. J., Pawlowski, T., Ober-Reynolds, S., Kirwan, J., Persico, A. M., Melmed, R. D., Craig, D. W., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-38 · Cited by 76 · see citing works
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van Sadelhoff, J. H. J., Perez Pardo, P., Wu, J., Garssen, J., van Bergenhenegouwen, J., Hogenkamp, A., Hartog, A., & Kraneveld, A. D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00247 · Cited by 71 · see citing works
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Needleman, L. A., & McAllister, A. K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22046 · Cited by 66 · see citing works
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Churchward, M. A., Tchir, D. R., & Todd, K. G. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0422-9 · Cited by 63 · see citing works
Visser, J. C., Rommelse, N., Vink, L., Schrieken, M., Oosterling, I. J., van der Gaag, R. J., & Buitelaar, J. K. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1678-6 · Cited by 50 · see citing works
Ghaffari, M. A., Mousavinejad, E., Riahi, F., Mousavinejad, M., & Afsharmanesh, M. R. (2016) · Neurology Research International · doi:10.1155/2016/9060751 · Cited by 49 · see citing works
Camacho, J., Jones, K., Miller, E., Ariza, J., Noctor, S., Van de Water, J., & Martínez-Cerdeño, V. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.045 · Cited by 49 · see citing works
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Kraneveld, A. D., Szklany, K., de Theije, C. G. M., & Garssen, J. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.09.001 · Cited by 47 · see citing works
Ranieri, A., Mennitti, C., Falcone, N., La Monica, I., Di Iorio, M. R., Tripodi, L., Gentile, A., Vitale, M., Pero, R., Pastore, L., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1238797 · Cited by 32 · see citing works
- Authors
- Onore, C., Careaga, M., & Ashwood, P.
- Affiliations
- University of California Davis Medical Center (US)
- Corresponding author
- Ashwood, Paul
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 26
- Issue
- 3
- Pages
- 383-392
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3418145
- OpenAlex
- W1968659204
- Cited by
- 635
- References
- 137
- Citations by year
- 2026: 30 · 2025: 24 · 2024: 49 · 2023: 28 · 2022: 35 · 2021: 42 · 2020: 47 · 2019: 46 · 2018: 54 · 2017: 46 · 2016: 50 · 2015: 45 · 2014: 47 · 2013: 50 · 2012: 39
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks (AS7567, ASCN5014)
- National Institute of Mental Health (R01MH089626)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD065269)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, immune dysfunction, neuroinflammation, inflammatory cytokines, cerebrospinal fluid, autoantibodies, immune cell function, social interaction deficits, communication difficulties, pathophysiology, synaptic plasticity, brain abnormalities
- MeSH terms
- Autistic Disorder, Brain, Humans, Immunity, Innate, Inflammation, Inflammation Mediators, Adaptive Immunity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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