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Cited by 88Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and DiseaseMetabolomics and Mass Spectrometry Studies

Identification of Differential Responses to an Oral Glucose Tolerance Test in Healthy Adults

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Morris, Ciara, O’Grada, Colm, Ryan, Miriam, Roche, Helen M., Gibney, Michael J., Gibney, Eileen R., Brennan, Lorraine·2013·PLoS ONE
DOI 10.1371/journal.pone.0072890PMC PMC3749984
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Abstract

BACKGROUND: In recent years an individual's ability to respond to an acute dietary challenge has emerged as a measure of their biological flexibility. Analysis of such responses has been proposed to be an indicator of health status. However, for this to be fully realised further work on differential responses to nutritional challenge is needed. This study examined whether metabolic phenotyping could identify differential responders to an oral glucose tolerance test (OGTT) and examined the phenotypic basis of the response. METHODS AND RESULTS: A total of 214 individuals were recruited and underwent challenge tests in the form of an OGTT and an oral lipid tolerance test (OLTT). Detailed biochemical parameters, body composition and fitness tests were recorded. Mixed model clustering was employed to define 4 metabotypes consisting of 4 different responses to an OGTT. Cluster 1 was of particular interest, with this metabotype having the highest BMI, triacylglycerol, hsCRP, c-peptide, insulin and HOMA- IR score and lowest VO2max. Cluster 1 had a reduced beta cell function and a differential response to insulin and c-peptide during an OGTT. Additionally, cluster 1 displayed a differential response to the OLTT. CONCLUSIONS: This work demonstrated that there were four distinct metabolic responses to the OGTT. Classification of subjects based on their response curves revealed an "at risk" metabolic phenotype.

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  • Different people respond differently to foods and nutrients, warranting personalized approaches to nutrition interventions and services.

    “It is now understood that different people respond differently to foods and nutrients, warranting personalized approaches to nutrition interventions and services [3,17-21].”

    From Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study (2020) · cites this paper as [19]

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Cited by

Sorted by citations

Authors
Morris, C., O’Grada, C., Ryan, M., Roche, H. M., Gibney, M. J., Gibney, E. R., & Brennan, L.
Affiliations
University College Dublin (IE)
Corresponding author
Brennan, Lorraine
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-08-22
Volume
8
Issue
8
Pages
e72890
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0072890
PMC
PMC3749984
OpenAlex
W2012808960
Cited by
88
References
2
Citations by year
2026: 1 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 11 · 2021: 5 · 2020: 13 · 2019: 15 · 2018: 6 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 3
FWCI
2.36
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Health Research Board
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords
oral glucose tolerance test, metabolic phenotyping, metabolic phenotypes, insulin sensitivity, beta-cell function, insulin resistance, HOMA-IR, C-peptide, triglycerides, high-sensitivity C-reactive protein, body composition, VO2max, healthy adults
MeSH terms
Adult, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Islets of Langerhans, Male, Healthy Volunteers

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