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Cited by 273

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Comparison of the Force Exerted by Hippocampal and DRG Growth Cones

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Amin, Ladan, Ercolini, Erika, Ban, Jelena, Torre, Vincent·2013·PLoS ONE
DOI 10.1371/journal.pone.0073025
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Abstract

Mechanical properties such as force generation are fundamental for neuronal motility, development and regeneration. We used optical tweezers to compare the force exerted by growth cones (GCs) of neurons from the Peripheral Nervous System (PNS), such as Dorsal Root Ganglia (DRG) neurons, and from the Central Nervous System (CNS) such as hippocampal neurons. Developing GCs from dissociated DRG and hippocampal neurons were obtained from P1-P2 and P10-P12 rats. Comparing their morphology, we observed that the area of GCs of hippocampal neurons was 8-10 µm(2) and did not vary between P1-P2 and P10-P12 rats, but GCs of DRG neurons were larger and their area increased from P1-P2 to P10-P12 by 2-4 times. The force exerted by DRG filopodia was in the order of 1-2 pN and never exceeded 5 pN, while hippocampal filopodia exerted a larger force, often in the order of 5 pN. Hippocampal and DRG lamellipodia exerted lateral forces up to 20 pN, but lamellipodia of DRG neurons could exert a vertical force larger than that of hippocampal neurons. Force-velocity relationships (Fv) in both types of neurons had the same qualitative behaviour, consistent with a common autocatalytic model of force generation. These results indicate that molecular mechanisms of force generation of GC from CNS and PNS neurons are similar but the amplitude of generated force is influenced by their cytoskeletal properties.

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Metadata

Authors
Amin, L., Ercolini, E., Ban, J., & Torre, V.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-08-21
Volume
8
Issue
8
Pages
e73025
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0073025
OpenAlex
W1967567549
Cited by
273
References
42
FWCI
10.78
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Comparison of the Force Exerted by Hippocampal and DRG Growth Cones. https://app.cochat.ai/papers/10.1371/journal.pone.0073025
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Amin, L., Ercolini, E., Ban, J., & Torre, V. (2013). Comparison of the Force Exerted by Hippocampal and DRG Growth Cones. PLoS ONE. https://doi.org/10.1371/journal.pone.0073025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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