Dietary Oleic Acid Increases M2 Macrophages in the Mesenteric Adipose Tissue
Open accessAbstract
Several studies have implicated fatty-acids as inflammatory regulators, suggesting that there may be a direct role for common dietary fatty-acids in regulating innate immune cells. In humans, a single high-fat meal increases systemic cytokines and leukocytes. In mice, short term high-fat feeding increases adipose tissue (AT) leukocytes and alters the inflammatory profile of AT macrophages. We have seen that short term high fat feeding to C57BL/6J male mice increases palmitic and oleic acid within AT depots, but oleic acid increase is highest in the mesenteric AT (MAT). In vitro, oleic acid increases M2 macrophage markers (CD206, MGL1, and ARG1) in a murine macrophage cell line, while addition of palmitic acid is able to inhibit that increase. Three day supplementation of a chow diet, with oleic acid, induced an increase in M2 macrophage markers in the MAT, but not in the epididymal AT. We tested whether increases in M2 macrophages occur during short term ad lib feeding of a high fat diet, containing oleic acid. Experiments revealed two distinct populations of macrophages were altered by a three day high milk-fat diet. One population, phenotypically intermediate for F4/80, showed diet-induced increases in CD206, an anti-inflammatory marker characteristic of M2 macrophages intrinsic to the AT. Evidence for a second population, phenotypically F4/80(HI)CD11b(HI) macrophages, showed increased association with the MAT following short term feeding that is dependent on the adhesion molecule, ICAM-1. Collectively, we have shown that short term feeding of a high-fat diet changes two population of macrophages, and that dietary oleic acid is responsible for increases in M2 macrophage polarization.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Acute high-fat feeding induces antiinflammatory immune cell actions, cell repair signaling, and angiogenesis.
“that acute HFF induces antiinflammatory immune cell actions, cell repair signaling, and angiogenesis (1,17,18).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [18]
Acute high-fat-diet stress leads to activation of antiinflammatory macrophages in some reports.
“In contrast, others have reported that acute HFD stress leads to activation of antiinflammatory macrophages (17,18).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Mensink, R. P., Zock, P. L., Kester, A. D., & Katan, M. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1146 · Cited by 2,811 · see citing works
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164 · see citing works
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 3× · see citing works
“PPARc is abundantly expressed in macrophages, where its activity promotes M2 polarization by increasing oxidative metabolism, as opposed to the switch to glycolysis that is seen in LPS-stimulated M1 macrophages, by increasing the expression of anti-inflammatory genes and by inhibiting the activity of NFkB and transcri…”
BackgroundTriglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075 · see citing works
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956 · see citing works
Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works
Bone Marrow-Derived Macrophages (BMM): Isolation and ApplicationsPreprint
Weischenfeldt, J., & Porse, B. T. (2008) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5080 · Cited by 959 · see citing works
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
Diamond, M., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., García‐Aguilar, J., Hibbs, M. L., & Springer, T. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.3129 · Cited by 881 · see citing works
Alternative macrophage activation and metabolism
Odegaard, J. I., & Chawla, A. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130138 · Cited by 640 · see citing works
Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways
Huang, S., Rutkowsky, J. M., Snodgrass, R. G., Ono‐Moore, K. D., Schneider, D. A., Newman, J. W. I., Adams, S. H., & Hwang, D. H. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d029546 · Cited by 591 · see citing works
Karaskov, E., Scott, C. C., Zhang, L., Teodoro, T., Ravazzola, M., & Volchuk, A. (2006) · Endocrinology · doi:10.1210/en.2005-1494 · Cited by 573 · see citing works
Maedler, K., Oberholzer, J., Bucher, P., Spinas, G. A., & Donath, M. Y. (2003) · Diabetes · doi:10.2337/diabetes.52.3.726 · Cited by 552 · see citing works
Control of Macrophage Activation and Function by PPARs
Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531 · see citing works
Oleic acid content is responsible for the reduction in blood pressure induced by olive oil
Terés, S., Barceló‐Coblijn, G., Rodríguez, M. B., Álvarez, R., Bressani, R., Halver, J. E., & Escribá, P. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807500105 · Cited by 519 · see citing works
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
Elgazar-Carmon, V., Rudich, A., Hadad, N., & Lévy, R. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800132-jlr200 · Cited by 488 · see citing works
Morán‐Salvador, E., López‐Parra, M., García‐Alonso, V., Titos, E., Martínez‐Clemente, M., González‐Périz, A., López‐Vicario, C., Barak, Y., Arroyo, V., & Clària, J. (2011) · The FASEB Journal · doi:10.1096/fj.10-173716 · Cited by 388 · see citing works
Prieur, X., Mok, C. Y. L., Velagapudi, V. R., Núñez, V., Fuentes, L., Montaner, D., Ishikawa, K., Camacho, A., Barbarroja, N., O’Rahilly, S., et al. (2011) · Diabetes · doi:10.2337/db10-0705 · Cited by 381 · see citing works
Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351 · see citing works
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334 · see citing works
Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells.
Jonjić, N., Peri, G., Bernasconi, S., Sciacca, F. L., Colotta, F., Pelicci, P., Lanfrancone, L., & Mantovani, A. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.4.1165 · Cited by 290 · see citing works
Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states
Morris, D. L., Singer, K., & Lumeng, C. N.-K. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328347970b · Cited by 260 · see citing works
Kupffer cell activation is a causal factor for hepatic insulin resistance
Lanthier, N., Molendi‐Coste, O., Horsmans, Y., van Rooijen, N., Cani, P. D., & Leclercq, I. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2009 · Cited by 258 · see citing works
Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages
Håversen, L., Danielsson, K. N., Fogelstrand, L., & Wiklund, O. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.033 · Cited by 240 · see citing works
PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle
Remels, A. H. V., LANGEN, R. C. J., Gosker, H. R., Russell, A. P., Spaapen, F., Voncken, J. W., Schrauwen, P., & Schols, A. M. W. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90632.2008 · Cited by 189 · see citing works
Oleic acid modulation of the immune response in wound healing: A new approach for skin repair
Cardoso, C. R. D. B., Favoreto, S., de Oliveira, L. L., Vancim, J. O., Barban, G. B., Ferraz, D. B., & Silva, J. S. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.06.007 · Cited by 169 · see citing works
Ji, Y., Sun, S., Xia, S., Yang, L., Li, X., & Qi, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371807 · Cited by 150 · see citing works
ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice
Brake, D. K., Smith, E. O., Mersmann, H. J., Smith, C. W., & Robker, R. L. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00008.2006 · Cited by 150 · see citing works
Self-citationBurdge, G. C., & Calder, P. C. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041282 · Cited by 136 · see citing works
Li, F. K., Davenport, A., Robson, R. L., Loetscher, P., Rothlein, R., Williams, J. D., & Topley, N. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00174.x · Cited by 125 · see citing works
Palmitic acid induces IP-10 expression in human macrophages via NF-κB activation
Laine, P. S., Schwartz, E. A., Wang, Y., Zhang, W.-Y., Karnik, S. K., Musi, N., & Reaven, P. D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.092 · Cited by 99 · see citing works
Macrophages and Mesothelial Cells in Bacterial Peritonitis
Topley, N., Mackenzie, R. K., & Williams, J. D. (1996) · Immunobiology · doi:10.1016/s0171-2985(96)80022-2 · Cited by 94 · see citing works
Oleic acid mitigates TNF-α-induced oxidative stress in rat cardiomyocytes
Al‐Shudiefat, A. A., Sharma, A. K., Bagchi, A. K., Dhingra, S., & Singal, P. K. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1447-z · Cited by 51 · see citing works
Müller, J., & Yoshida, T. (1995) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1995.1076 · Cited by 38 · see citing works
Reardon, M. A., Gobern, S., Martinez, K., Shen, W., Reid, T., & McIntosh, M. (2012) · Lipids · doi:10.1007/s11745-012-3711-0 · Cited by 26 · see citing works
Phenotypic and functional analysis of murine resident and induced peritoneal macrophages.
Turchyn, L. R., Baginski, T. J., Renkiewicz, R. R., Lesch, C. A., & Mobley, J. L. (2007) · PubMed · Cited by 23 · see citing works
Flow Cytometry on the Stromal-Vascular Fraction of White Adipose Tissue
Brake, D. K., & Smith, C. W. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-245-8_16 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Cellular and molecular mechanisms of skin wound healing
Peña, O. A., & Martin, P. (2024) · Nature reviews. Molecular cell biology · doi:10.1038/s41580-024-00715-1 · Cited by 1,637 · see citing works
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus
Palomer, X., Pizarro‐Delgado, J., Barroso, E., & Vázquez‐Carrera, M. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.11.009 · Cited by 551 · see citing works
Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid
Santa‐María, C., López-Enríquez, S., la Paz, S. M., Geniz, I., Reyes-Quiróz, M. E., Santamaría, M. M., Palomares, F., Sobrino, F., & Álba, G. (2023) · Nutrients · doi:10.3390/nu15010224 · Cited by 324 · see citing works
Metaflammation in obesity and its therapeutic targeting
Schleh, M. W., Caslin, H. L., Garcia, J. N., Mashayekhi, M., Srivastava, G., Bradley, A. B., & Hasty, A. H. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf9382 · Cited by 191 · see citing works
Piccinin, E., Cariello, M., Santis, S. D., Ducheix, S., Sabbà, C., Ntambi, J. M., & Moschetta, A. (2019) · Nutrients · doi:10.3390/nu11102283 · Cited by 188 · see citing works
Macrophage-mediated inflammation in diabetic wound repair
Wolf, S., Melvin, W., & Gallagher, K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.06.013 · Cited by 165 · see citing works
Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Li, X., Ren, Y., Chang, K.-W., Wu, W., Griffiths, H. R., Lu, S., & Gao, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1153915 · Cited by 165 · see citing works
Hidalgo, M. A., Carretta, M. D., & Burgos, R. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.668330 · Cited by 157 · see citing works
Bogie, J. F. J., Grajchen, E., Wouters, E., Corrales, A. G., Dierckx, T., Vanherle, S., Mailleux, J., Gervois, P., Wolfs, E., Dehairs, J., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191660 · Cited by 151 · see citing works
Rehman, K., Haider, K., Jabeen, K., & Akash, M. S. H. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09549-6 · Cited by 115 · see citing works
Ohue‐Kitano, R., Watanabe‐Yasuoka, Y., Goto, T., Kitamura, N., Park, S., Kishino, S., Kimura, I., Kasubuchi, M., Takahashi, H., Li, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700273r · Cited by 103 · see citing works
The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective
Pereira, J. A. D. S., Corrêa‐da‐Silva, F., & Moraes‐Vieira, P. M. (2017) · Journal of Diabetes Research · doi:10.1155/2017/4527980 · Cited by 89 · see citing works
Omega-3, Omega-6 and Omega-9 Fatty Acids: Implications for Cardiovascular and Other Diseases
Johnson, M. (2014) · Journal of Glycomics & Lipidomics · doi:10.4172/2153-0637.1000123 · Cited by 70 · see citing works
Posicionamento sobre o Consumo de Gorduras e Saúde Cardiovascular – 2021
Izar, M. C. D. O., Lottenberg, A. M., Giraldez, V. Z. R., Santos, R. D., Machado, R. M., Bertolami, A., Assad, M. H. V., Saraiva, J. F. K., Faludi, A. Á., Moreira, A. S. B., et al. (2021) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20201340 · Cited by 65 · see citing works
Santamarina, A. B., Pisani, L. P., Baker, E. J., Marat, A. D., Valenzuela, C. A., Miles, E. A., & Calder, P. C. (2021) · Food & Function · doi:10.1039/d1fo01304a · Cited by 61 · see citing works
Pardo, V., González‐Rodríguez, Á., Guijas, C., Balsinde, J., & Valverde, Á. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.649483 · Cited by 60 · see citing works
Regulation of Nlrp3 inflammasome by dietary metabolites
Camell, C. D., Goldberg, E. L., & Dixit, V. D. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.004 · Cited by 58 · see citing works
Self-citationAdipose tissue plasticity and the pleiotropic roles of BMP signaling
Qian, S., Tang, Y., & Tang, Q. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100678 · Cited by 52 · see citing works
Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
Ducheix, S., Montagner, A., Polizzi, A., Lasserre, F., Régnier, M., Marmugi, A., Benhamed, F., Bertrand‐Michel, J., Mselli-Lakhal, L., Loiseau, N., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181393 · Cited by 48 · see citing works
Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells
Wu, H., Weidinger, C., Schmidt, F., Keye, J., Friedrich, M., Yerinde, C., Willimsky, G., Qin, Z., Siegmund, B., & Glauben, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-07685-9 · Cited by 48 · see citing works
Cheon, S. Y., & Cho, K. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02117-8 · Cited by 45 · see citing works
Hansen, I. R., Jansson, K. M., Cannon, B., & Nedergaard, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.003 · Cited by 43 · see citing works
Zamani, R., Pilehvar‐Soltanahmadi, Y., Alizadeh, E., & Zarghami, N. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1367689 · Cited by 41 · see citing works
Role of LpL (Lipoprotein Lipase) in Macrophage Polarization In Vitro and In Vivo
Chang, H. R., Josefs, T., Scerbo, D. A., Gumaste, N., Hu, Y., Huggins, L.-A., Barrett, T. J., Chiang, S. S., Grossman, J., Bagdasarov, S., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312389 · Cited by 42 · see citing works
Poledne, R., Malínská, H., Kubatova, H., Froněk, J., Thieme, F., Kauerová, S., & Lesná, I. K. (2019) · Nutrients · doi:10.3390/nu12010008 · Cited by 41 · see citing works
Wei, S., Nain, A., Lin, Y., Wu, R.-S., Srivastava, P., Chang, L., Huang, Y., Chang, H., Chuang, K., & Huang, C. (2022) · Carbon · doi:10.1016/j.carbon.2022.10.008 · Cited by 36 · see citing works
Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins
Balestrieri, B., Costanzo, D. D., & Dwyer, D. F. (2021) · Molecules · doi:10.3390/molecules27010152 · Cited by 31 · see citing works
Zhu, X., Tu, Y., Chen, H., Jackson, A. O., Patel, V. B., & Yin, K. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2993 · Cited by 31 · see citing works
Ghanavati, M., Hosseinabadi, S. M., Parsa, S. A., Safi, M., Emamat, H., & Nasrollahzadeh, J. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00819-9 · Cited by 26 · see citing works
The Effects of Simulated Microgravity on Macrophage Phenotype
Ludtka, C., Moore, E., & Allen, J. B. (2021) · Biomedicines · doi:10.3390/biomedicines9091205 · Cited by 26 · see citing works
Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism
Álba, G., Dakhaoui, H., Santa‐María, C., Palomares, F., Cejudo‐Guillén, M., Geniz, I., Sobrino, F., la Paz, S. M., & Lopez-Enriquez, S. (2023) · Nutrients · doi:10.3390/nu15020411 · Cited by 26 · see citing works
Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity
Hargrave, A. C., Courson, J. A., Pham, V., Landry, P. T., Magadi, S., Shankar, P., Hanlon, S., Das, A., Rumbaut, R. E., Smith, C. W., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238750 · Cited by 26 · see citing works
Self-citationAbou-Rjeileh, U., Neto, J. M. D. S., Chirivi, M., O'Boyle, N. J., Salcedo-Tacuma, D., Prom, C., Laguna, J. G., Parales-Girón, J., Lock, A. L., & Contreras, G. A. (2023) · Journal of Dairy Science · doi:10.3168/jds.2022-22402 · Cited by 25 · see citing works
Mitchelson, K. A. J., O’Connell, F., O'Sullivan, J. N., & Roche, H. M. (2024) · Metabolites · doi:10.3390/metabo14010042 · Cited by 25 · see citing works
Impact of Dietary Fatty Acids on Macrophage Lipid Metabolism, Signaling and Function
Davanso, M. R., Crisma, A. R., Murata, G. M., Newsholme, P., & Curi, R. (2020) · Immunometabolism · doi:10.20900/immunometab20200008 · Cited by 22 · see citing works
The oil from Moringa oleifera seeds accelerates chronic skin wound healing
Ventura, A. C. S. S. B., de Paula, T. C., Gonçalves, J. P., Soley, B. D. S., Cretella, A. B. M., Otuki, M. F., & Cabrini, D. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100099 · Cited by 22 · see citing works
Functional macrophages and gastrointestinal disorders
Liu, Y., Ding, Y., Gao, C., Li, L.-S., Wang, Y.-X., & Xu, J. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i11.1181 · Cited by 21 · see citing works
Macrophages: their role in immunity and their relationship with fatty acids in health and disease
Rueda-Munguía, M., Luévano‐Martínez, L. A., García‐Rivas, G., Castillo, E. C., & Lozano, O. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1694892 · Cited by 17 · see citing works
Fatty acids secreted from head and neck cancer induce M2-like Macrophages
Albakri, M. M., Huang, S. C., Tashkandi, H., & Sieg, S. F. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.1a0521-251r · Cited by 17 · see citing works
Deconstructing metabolic inflammation using cellular systems
Chan, K. L., Boroumand, P., Milanski, M., Pillon, N. J., Bilan, P. J., & Klip, A. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2017 · Cited by 16 · see citing works
Willemsen, L., Neele, A. E., van der Velden, S., Prange, K. H. M., den Toom, M., van Roomen, C. P. A. A., Reiche, M. E., Griffith, G. R., Gijbels, M. J., Lutgens, E., et al. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000751 · Cited by 16 · see citing works
Krapić, M., Kavazović, I., Mikašinović, S., Mladenić, K., Krstanović, F., Seyhan, G., Helmrath, S., Camerini, E., Brizić, I., Peters, F. S., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01273-2 · Cited by 15 · see citing works
Skinny Fat Cells Stimulate Wound Healing
Merrick, D., & Seale, P. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.04.021 · Cited by 15 · see citing works
Li, Y., Wang, Z., Ma, X., Shao, B., Gao, X., Zhang, B., Xu, G., & Wei, Y. (2014) · Pathogens and Disease · doi:10.1111/2049-632x.12189 · Cited by 13 · see citing works
Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth
Ghosh, S., Bandyopadhyay, S., Smith, D. M., Adak, S., Semenkovich, C. F., Nagy, L., Wolfgang, M. J., & O’Connor, T. J. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1011996 · Cited by 12 · see citing works
Poleti, M., Regitano, L. C. D. A., Souza, G. H. M. F., César, A. S. M., Simas, R. C., Silva‐Vignato, B., Montenegro, H., Pértille, F., Balieiro, J. C. D. C., Cameron, L. C., et al. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103792 · Cited by 12 · see citing works
Sugiyama, T., Hobro, A. J., Pavillon, N., Umakoshi, T., Verma, P., & Smith, N. I. (2020) · The Analyst · doi:10.1039/d0an02077j · Cited by 12 · see citing works
Abou-Rjeileh, U., Gouveia, K. M., Lock, A. L., & Contreras, G. A. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-26922 · Cited by 11 · see citing works
Bai, H., Zhang, H., Wang, C., Lambo, M. T., Li, Y., & Zhang, Y. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01052-1 · Cited by 9 · see citing works
Phenotypic Characterization of Human Monocytes following Macronutrient Intake in Healthy Humans
Alshahrani, A. S., Khunayfir, A. K. B., Rayih, M. A., Sayed, H. A., Alsadoon, A. S., Dubayee, M. A., Zhra, M., Alrumayyan, Y., Alzayer, M., Nasr, A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01293 · Cited by 9 · see citing works
Hidden features: CD36/SR-B2, a master regulator of macrophage phenotype/function through metabolism
Chen, Y., Zhang, X., Huang, S., & Febbraio, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1468957 · Cited by 8 · see citing works
Ziemba, A. M., Gottipati, M. K., Totsingan, F., Hanes, C. M., Gross, R. A., Lennartz, M. R., & Gilbert, R. J. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00451 · Cited by 7 · see citing works
Lipid Peroxidation as a Link between Unhealthy Diets and the Metabolic Syndrome
Onyango, A. N. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98183 · Cited by 6 · see citing works
Unravelling the role of obesity and lipids during tumor progression
Zhao, J., Lee, K., Toh, H. C., Lam, K., & Neo, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1163160 · Cited by 4 · see citing works
Gil, A. M., Zegarra-Ruiz, D. F., Wu, W.-J. H., Norwood, K., Assié, A., Samuel, B. S., Major, A. M., Diehl, G. E., & Hill, A. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-12448-y · Cited by 2 · see citing works
Tian, M., He, Z., Yuan, S., Lin, T., Su, S., Chen, D., Zeng, X., Guan, W., & Zhang, S. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110062 · Cited by 2 · see citing works
Chen, Q.-J., Li, Z.-X., Wang, G.-C., Xie, T., Xiao, G.-D., Xu, H., Li, J., Luo, X., Li, Y.-F., Liang, L., et al. (2026) · Journal of Natural Medicines · doi:10.1007/s11418-025-01984-6 · Cited by 2 · see citing works
He, C., Liu, Y., Lv, K., An, Z., Xue, C., & Dong, N. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116876 · Cited by 2 · see citing works
Wei, S., Nain, A., Lin, Y., Wu, R.-S., Srivastva, P., Chang, L., Huang, Y., Chang, H., & Huang, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4092456 · Cited by 2 · see citing works
Dyer, A., Dudley, R., Ahuja, S., Alsinet, C., Poudel, P., Bowyer, G., Sahota, K., Songvilay, S., Jones, D. C., Glover, M. S., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-30224-w · Cited by 1 · see citing works
Mesenteric adipose tissue: from protective gatekeeper to driver of inflammatory bowel disease
Gliniak, C. M. (2026) · Immunometabolism · doi:10.1097/in9.0000000000000081 · Cited by 1 · see citing works
Nakanishi, K., Shinkawa, H., Takemura, S., Nakagawa, K., Minamiyama, Y., & Ishizawa, T. (2026) · Physiological Reports · doi:10.14814/phy2.71082 · Cited by 1 · see citing works
Park, J.-H., Cho, H., Nam, J., & Lee, W. (2026) · Macromol—A Journal of Macromolecular Research · doi:10.3390/macromol6020021 · Cited by 1 · see citing works
da Silva, S. M., de Sousa, M. F. T., Martins, B. S., Martins, L. F., Moraes, S. K., Zehuri, M. M. O. N., Pinto, C. M. F., Desidério, C. S., Rojas, M. O. A. I., Oliveira, C. J. F., et al. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109167 · Cited by 1 · see citing works
Updates on Fatty Acids in Mushrooms: Content, Characterization, and Biological Effects
Tel‐Çayan, G., Devecı, E., & Çayan, F. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839167522-00068 · Cited by 1 · see citing works
Immunomodulation as the main characteristic of vegetable oils: a review
Três, D. P., Nicolau, S. T., Ayala, T. S., & Menolli, R. A. (2024) · Grasas y Aceites · doi:10.3989/gya.1183231.2072 · Cited by 1 · see citing works
Wei, S., Nain, A., Lin, Y., Wu, R.-S., Srivastva, P., Chang, L., Huang, Y., Chang, H., & Huang, C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4021922 · Cited by 1 · see citing works
Choi, M.-W., Choi, J.-H., Kim, H., & Kim, J. (2015) · Korean Journal of Fisheries and Aquatic Sciences · doi:10.5657/kfas.2015.0439
Ajabnoor, S. M. (2018) · UEA Digital Repository (University of East Anglia)
Therapeutic Mechanisms of Persicae Semen towards Healing Processes
Zheng, G., Qiao, A., & Lv, C. (2019) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm47256.2019.9044450
The role of odd chain fatty acids on hepatocyte and monocyte function
Ikwuobe, J. (2019) · Aston Publications Explorer (Aston University) · doi:10.48780/publications.aston.ac.uk.00041187
Pereira, J. A. D. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2022.tde-06052022-145847
The Mechanism and Application of Sea Buckthorn Fatty Acids in Burn Wound Repair
王, 飞. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113063
- Authors
- Camell, C., & Smith, C. W.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Camell, Christina
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-30
- Volume
- 8
- Issue
- 9
- Pages
- e75147
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3787090
- OpenAlex
- W2066786103
- Cited by
- 76
- References
- 39
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 11 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 10 · 2015: 3 · 2014: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Agriculture (6250-51000-046, 6250‐51000)
- Vanderbilt University (DK59637)
- Agricultural Research Service (6250-51000-046, 6250-51000)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK59637, U24DK059637, F31DK084841)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- oleic acid, M2 macrophages, mesenteric adipose tissue, high-fat diet, dietary fatty acids, macrophage polarization, CD206, ICAM-1, adipose tissue inflammation, palmitic acid, F4/80, CD11b
- MeSH terms
- Adipose Tissue, Animals, Dietary Fats, Unsaturated, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Macrophages, Male, Mesentery, Mice, Inbred C57BL, Intercellular Adhesion Molecule-1, Oleic Acid, Cell Proliferation, Mice, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
