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Cited by 109Muscle metabolism and nutritionNutrition and Health in AgingBiochemical effects in animals

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index, and 1 are not checked yet.

Creatine Supplementation Associated or Not with Strength Training upon Emotional and Cognitive Measures in Older Women: A Randomized Double-Blind Study

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Alves, Christiano Robles Rodrigues, Merege Filho, Carlos Alberto Abujabra, Benatti, Fabiana Braga, Brucki, Sonia, Pereira, Rosa Maria R., de Sá Pinto, Ana Lucia, Lima, Fernanda Rodrigues, Roschel, Hamilton, Gualano, Bruno·2013·PLoS ONE
DOI 10.1371/journal.pone.0076301PMC PMC3789718
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Abstract

PURPOSE: To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman. METHODS: This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups (n=14 each): 1) placebo, 2) creatine supplementation, 3) placebo associated with strength training or 4) creatine supplementation associated with strength training. According to their allocation, the participants were given creatine (4 x 5 g/d for 5 days followed by 5 g/d) or placebo (dextrose at the same dosage) and were strength trained or not. Cognitive function, assessed by a comprehensive battery of tests involving memory, selective attention, and inhibitory control, and emotional measures, assessed by the Geriatric Depression Scale, were evaluated at baseline, after 12 and 24 weeks of the intervention. Muscle strength and food intake were evaluated at baseline and after 24 weeks. RESULTS: After the 24-week intervention, both training groups (ingesting creatine supplementation and placebo) had significant reductions on the Geriatric Depression Scale scores when compared with the non-trained placebo group (p = 0.001 and p = 0.01, respectively) and the non-trained creatine group (p < 0.001 for both comparison). However, no significant differences were observed between the non-trained placebo and creatine (p = 0.60) groups, or between the trained placebo and creatine groups (p = 0.83). Both trained groups, irrespective of creatine supplementation, had better muscle strength performance than the non-trained groups. Neither strength training nor creatine supplementation altered any parameter of cognitive performance. Food intake remained unchanged. CONCLUSION: Creatine supplementation did not promote any significant change in cognitive function and emotional parameters in apparently healthy older individuals. In addition, strength training per se improved emotional state and muscle strength, but not cognition, with no additive effects of creatine supplementation. TRIAL REGISTRATION: Clinicaltrials.gov NCT01164020.

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Figure 1 Experimental design.
Figure 1 Experimental design.CC BY · PubMed Central
Figure 2 Fluxogram of subjects. PL = placebo supplementation, CR = creatine supplementation, PL + ST = placebo supplementation associated with strength training and PL+ST = creatine supplementation associated with strength training group.
Figure 2 Fluxogram of subjects. PL = placebo supplementation, CR = creatine supplementation, PL + ST = placebo supplementation associated with strength training and PL+ST = creatine supplementation associated with strength training group.CC BY · PubMed Central
Figure 3 Delta changes in Geriatric Depression Scale at baseline and after 12 and 24 weeks of intervention. * denotes statistically significant differences at 24 week in the comparisons between the trained versus non-trained groups (i.e., Placebo + Strength training and Creatine + Strength training versus Placebo and Creatine; p < 0.05).
Figure 3 Delta changes in Geriatric Depression Scale at baseline and after 12 and 24 weeks of intervention. * denotes statistically significant differences at 24 week in the comparisons between the trained versus non-trained groups (i.e., Placebo + Strength training and Creatine + Strength training versus Placebo and Creatine; p < 0.05).CC BY · PubMed Central

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Research works printed but not linked: 3

  1. P Heyn, 2004, The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis, Arch Phys Med Rehabil, 84, 1694
  2. OP Almeida, 2003, Reliability of the Brazilian version of the abbreviated form of Geriatric Depression Scale (GDS) short form, Arq Neuropsiquiat, 57, 421
  3. SM Brucki, 2003, Suggestions for utilization of the mini-mental state examination in Brazil, Arq Neuro Psiquiatr, 61, 777

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Metadata

Authors
Alves, C. R. R., Merege Filho, C. A. A., Benatti, F. B., Brucki, S., Pereira, R. M. R., de Sá Pinto, A. L., Lima, F. R., Roschel, H., & Gualano, B.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Gualano, Bruno
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-10-03
Volume
8
Issue
10
Pages
e76301
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0076301
PMC
PMC3789718
OpenAlex
W2072529815
Cited by
109
References
53
Citations by year
2026: 15 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 6 · 2021: 27 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 5 · 2014: 2
FWCI
2.90
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Keywords
creatine supplementation, resistance training, older women, cognitive function, emotional state, depression, muscle strength, dietary intake, memory, selective attention, inhibitory control
MeSH terms
Age Factors, Aged, Aged, 80 and over, Cognition, Creatine, Diet, Double-Blind Method, Emotions, Female, Humans, Middle Aged, Neuropsychological Tests, Treatment Outcome, Dietary Supplements, Muscle Strength, Resistance Training, Medication Adherence, Self Report

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