Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

Solinas, Marta; Massi, Paola; Cinquina, Valentina; Valenti, Marta; Bolognini, Daniele; Gariboldi, Marzia; Monti, Elena; Rubino, Tiziana; Parolaro, Daniela

doi:10.1371/journal.pone.0076918

Cited by 160Cannabis and Cannabinoid ResearchGlioma Diagnosis and TreatmentCancer, Stress, Anesthesia, and Immune Response

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

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Solinas, Marta, Massi, Paola, Cinquina, Valentina, Valenti, Marta, Bolognini, Daniele, Gariboldi, Marzia, Monti, Elena, Rubino, Tiziana +1 more·2013·PLoS ONE

DOI 10.1371/journal.pone.0076918PMC PMC3804588

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Abstract

In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and invasiveness in vitro and caused a decrease in the expression of a set of proteins specifically involved in growth, invasion and angiogenesis. In addition, CBD treatment caused a dose-related down-regulation of ERK and Akt prosurvival signaling pathways in U87-MG and T98G cells and decreased hypoxia inducible factor HIF-1α expression in U87-MG cells. Taken together, these results provide new insights into the antitumor action of CBD, showing that this cannabinoid affects multiple tumoral features and molecular pathways. As CBD is a non-psychoactive phytocannabinoid that appears to be devoid of side effects, our results support its exploitation as an effective anti-cancer drug in the management of gliomas.

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CBD can modulate intracellular pathways directly connected with synaptic remodeling, such as Erk1/2 and Akt, in distinct types of cancer cell lines.
“CBD can modulate intracellular pathways directly connected with synaptic remodeling, such as Erk1/2 and Akt, in distinct types of cancer cell lines (109, 110).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [109]

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Authors: Solinas, M., Massi, P., Cinquina, V., Valenti, M., Bolognini, D., Gariboldi, M., Monti, E., Rubino, T., & Parolaro, D.
Affiliations: University of Insubria (IT)
University of Milan (IT)
University of Toronto (CA)
Corresponding author: Parolaro, Daniela
ORCID: Cinquina, Valentina
Valenti, Marta
Bolognini, Daniele
Gariboldi, Marzia
Monti, Elena
Rubino, Tiziana
Parolaro, Daniela
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2013-10-21
Volume: 8
Issue: 10
Pages: e76918
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0076918
PMC: PMC3804588
OpenAlex: W2083034715
Cited by: 159
References: 47
Citations by year: 2026: 14 · 2025: 8 · 2024: 17 · 2023: 22 · 2022: 21 · 2021: 24 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 3
FWCI: 3.43
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
IrInSubria (University of Insubria) (submittedVersion)
Funders: Università degli Studi di Milano
GW Pharmaceuticals
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords: cannabidiol, glioma, U87 cells, T98G cells, cell proliferation, tumor invasion, angiogenesis, ERK signaling, Akt signaling, HIF-1α, anticancer activity, phytocannabinoids
MeSH terms: Antineoplastic Agents, Cannabidiol, Cell Movement, Cell Survival, Dose-Response Relationship, Drug, Glioma, Humans, Neoplasm Invasiveness, Blotting, Western, Signal Transduction, Proteome, Proteomics, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, Cell Proliferation, Proto-Oncogene Proteins c-akt, Hypoxia-Inducible Factor 1, alpha Subunit

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Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect

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