Effect of dorsal and ventral hippocampal lesions on contextual fear conditioning and unconditioned defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray
Open accessAbstract
The dorsal (DH) and ventral (VH) subregions of the hippocampus are involved in contextual fear conditioning. However, it is still unknown whether these two brain areas also play a role in defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present study, rats were implanted with electrodes into the dPAG to determine freezing and escape response thresholds after sham or bilateral electrolytic lesions of the DH or VH. The duration of freezing behavior that outlasted electrical stimulation of the dPAG was also measured. The next day, these animals were subjected to contextual fear conditioning using footshock as an unconditioned stimulus. Electrolytic lesions of the DH and VH impaired contextual fear conditioning. Only VH lesions disrupted conditioned freezing immediately after footshock and increased the thresholds of aversive freezing and escape responses to dPAG electrical stimulation. Neither DH nor VH lesions disrupted post-dPAG stimulation freezing. These results indicate that the VH but not DH plays an important role in aversively defensive behavior induced by dPAG electrical stimulation. Interpretations of these findings should be made with caution because of the fact that a non-fiber-sparing lesion method was employed.
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The increased periaqueductal gray volume suggests differences in fear and panic responses between susceptible and resilient mice.
“pointing toward differences in fear and panic responses between susceptible and resilient mice (43,44,59).”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [43]
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- Authors
- Ballesteros, C. I., de Oliveira Galvão, B., Maisonette, S., & Landeira-Fernandez, J.
- Affiliations
- Pontifícia Universidade Católica do Rio de Janeiro (BR)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-01-03
- Volume
- 9
- Issue
- 1
- Pages
- e83342
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3880253
- OpenAlex
- W1974424286
- Cited by
- 39
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 9 · 2023: 4 · 2022: 3 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 7 · 2014: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- dorsal hippocampus, ventral hippocampus, contextual fear conditioning, dorsal periaqueductal gray, defensive behavior, freezing behavior, escape behavior, footshock, electrolytic lesions, aversive behavior, rats
- MeSH terms
- Animals, Behavior, Animal, Conditioning, Psychological, Electric Stimulation, Fear, Hippocampus, Male, Periaqueductal Gray, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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