Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome
Open accessAbstract
Epstein-Barr virus (EBV) has long been discussed as a possible cause or trigger of Chronic Fatigue Syndrome (CFS). In a subset of patients the disease starts with infectious mononucleosis and both enhanced and diminished EBV-specific antibody titers have been reported. In this study, we comprehensively analyzed the EBV-specific memory B- and T-cell response in patients with CFS. While we observed no difference in viral capsid antigen (VCA)-IgG antibodies, EBV nuclear antigen (EBNA)-IgG titers were low or absent in 10% of CFS patients. Remarkably, when analyzing the EBV-specific memory B-cell reservoir in vitro a diminished or absent number of EBNA-1- and VCA-antibody secreting cells was found in up to 76% of patients. Moreover, the ex vivo EBV-induced secretion of TNF-α and IFN-γ was significantly lower in patients. Multicolor flow cytometry revealed that the frequencies of EBNA-1-specific triple TNF-α/IFN-γ/IL-2 producing CD4(+) and CD8(+) T-cell subsets were significantly diminished whereas no difference could be detected for HCMV-specific T-cell responses. When comparing EBV load in blood immune cells, we found more frequently EBER-DNA but not BZLF-1 RNA in CFS patients compared to healthy controls suggesting more frequent latent replication. Taken together, our findings give evidence for a deficient EBV-specific B- and T-cell memory response in CFS patients and suggest an impaired ability to control early steps of EBV reactivation. In addition the diminished EBV response might be suitable to develop diagnostic marker in CFS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Epstein-Barr and hepatitis viral infections have been implicated as potential causes of ME/CFS, with evidence that these viruses can persistently inhibit innate and adaptive immunity.
“Epstein-Barr and hepatitis viral infections have been implicated as potential causes14,67, with evidence that these viruses can persistently inhibit innate and adaptive immunity.”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [14]
The Introduction and Abstract (pages not supplied) describe EBV as a possible cause or trigger of CFS, and the Discussion reports deficient EBV-specific B- and T-cell responses. The Discussion mentions impaired T-cell responses in chronic hepatitis C infection, but does not implicate hepatitis as a cause of CFS or show that either virus persistently inhibits both innate and adaptive immunity. (LLM, conf=0.88)
Experimental — accuracy not yet measuredDeficient Epstein-Barr virus-specific B cell responses in ME/CFS patients suggest that dysregulated B cell function and persistent latent viral infection may be significant contributing factors to ME/CFS.
“Combined with observations of deficient Epstein-Barr virus-specific B cell responses in ME/CFS patients14, this suggests that dysregulated B cell function and persistent latent viral infection may be significant contributing factors to ME/CFS.”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [14]
Evidence of dysregulated B cell and NK cell function has been reported in ME/CFS.
“Since evidence of dysregulated B cell14 and NK cell function39 has been reported in ME/CFS, these cell populations were also included in the model.”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Lombardi, V. C., Ruscetti, F. W., Das Gupta, J., Pfost, M. A., Hagen, K. S., Peterson, D. L., Ruscetti, S. K., Bagni, R. K., Petrow-Sadowski, C., Gold, B., et al. (2009) · Science · doi:10.1126/science.1179052 · Cited by 538 · see citing works
RetractedThe Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., & and International Chronic Fatigue Syndrome Study Group. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-12-199412150-00009 · Cited by 4,969 · see citing works
Myalgic encephalomyelitis: International Consensus Criteria
Carruthers, B. M., van de Sande, M. I., Meirleir, K. L. D., Klimas, N. G., Broderick, G., Mitchell, T., Staines, D., Powles, A. C. P., Speight, N., Vallings, R., et al. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02428.x · Cited by 1,234 · see citing works
EBV Persistence in Memory B Cells In Vivo
Babcock, G. J., Decker, L. L., Volk, M. S., & Thorley‐Lawson, D. A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80622-6 · Cited by 829 · see citing works
Greenspan, J. S., Greenspan, D., Lennette, E. T., Abrams, D. I., Conant, M. A., Petersen, V., & Freese, U. K. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132502 · Cited by 797 · see citing works
Epstein–Barr Virus Replication in Oropharyngeal Epithelial Cells
Sixbey, J. W., Nedrud, J. G., Raab‐Traub, N., Hanes, R. A., & Pagano, J. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405103101905 · Cited by 722 · see citing works
Almeida, J. R., Price, D. A., Papagno, L., Arkoub, Z. A., Sauce, D., Bornstein, E. R., Asher, T. E., Samri, A., Schnuriger, A., Theodorou, I. D., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070784 · Cited by 708 · see citing works
Yates, J., Warren, N., Reisman, D., & Sugden, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3806 · Cited by 670 · see citing works
Lerner, M. R., Andrews, N. C., Miller, G. G., & STEITZ, J. A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.805 · Cited by 576 · see citing works
Radziewicz, H., Ibegbu, C., Fernandez, M. L., Workowski, K., Obideen, K. M., Wehbi, M. A., Hanson, H. L., Steinberg, J. P., Masopust, D., Wherry, E. J., et al. (2006) · Journal of Virology · doi:10.1128/jvi.02021-06 · Cited by 482 · see citing works
Immunologic abnormalities in chronic fatigue syndrome
Klimas, N. G., Salvato, F., Morgan, R. O., & Fletcher, M. A. (1990) · Journal of Clinical Microbiology · doi:10.1128/jcm.28.6.1403-1410.1990 · Cited by 464 · see citing works
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
McClain, M. T., Heinlen, L. D., Dennis, G. J., Roebuck, J., Harley, J. B., & James, J. A. (2004) · Nature Medicine · doi:10.1038/nm1167 · Cited by 442 · see citing works
Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system
Crotty, S., Aubert, R. D., Glidewell, J., & Ahmed, R. (2004) · Journal of Immunological Methods · doi:10.1016/j.jim.2003.12.015 · Cited by 421 · see citing works
Nilsson, K., Klein, G., Henle, W., & Henle, G. (1971) · International Journal of Cancer · doi:10.1002/ijc.2910080312 · Cited by 357 · see citing works
Lünemann, J. D., Jelčić, I., Roberts, S., Lutterotti, A., Tackenberg, B., Martinꝉ, R., & Münz, C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072397 · Cited by 337 · see citing works
Epstein-Barr virus–associated lymphoproliferative disorders
Rezk, S. A., & Weiss, L. M. (2007) · Human Pathology · doi:10.1016/j.humpath.2007.05.020 · Cited by 298 · see citing works
Chronic Fatigue Syndrome Research
Schluederberg, A., Straus, S. E., Peterson, P. K., Blumenthal, S. J., Komaroff, A. L., Spring, S. B., LANDAY, A. L., & Buchwald, D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-325 · Cited by 288 · see citing works
Bansell, J. C., & Valtueña, J. P. (2020) · Nursing Management · doi:10.1097/01.numa.0000719220.85627.ef · Cited by 276 · see citing works
Brenu, E., van Driel, M., Staines, D., Ashton, K. J., Ramos, S. B., Keane, J., Klimas, N. G., & Marshall‐Gradisnik, S. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-81 · Cited by 252 · see citing works
Latent and lytic Epstein‐Barr virus replication strategies
Tsurumi, T., Fujita, M., & Kudoh, A. (2004) · Reviews in Medical Virology · doi:10.1002/rmv.441 · Cited by 242 · see citing works
Chronic fatigue syndrome, the immune system and viral infection
Bansal, A. S., Bradley, A. S., Bishop, K. N., Kiani‐Alikhan, S., & Ford, B. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.016 · Cited by 220 · see citing works
Henle, W., Henle, G., Andersson, J., Ernberg, I. T., Klein, G., Horwitz, C., Marklund, G., Rymo, L., Wellinder, C., & Straus, S. E. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.2.570 · Cited by 207 · see citing works
A formal analysis of cytokine networks in chronic fatigue syndrome
Broderick, G., Fuite, J., Kreitz, A., Vernon, S. D., Klimas, N., & Fletcher, M. A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.04.012 · Cited by 202 · see citing works
Niller, H. H., Wolf, H. J., & Minárovits, J. (2008) · Autoimmunity · doi:10.1080/08916930802024772 · Cited by 201 · see citing works
Frequent HHV-6 reactivation in multiple sclerosis (MS) and chronic fatigue syndrome (CFS) patients
Ablashi, D. V., Eastman, H., Owen, C. B., Roman, M. M., Friedman, J. E., Zabriskie, J. B., Peterson, D. L., Pearson, G. R., & Whitman, J. E. (2000) · Journal of Clinical Virology · doi:10.1016/s1386-6532(99)00079-7 · Cited by 198 · see citing works
Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis
Jilek, S., Schluep, M., Meylan, P. R., Vingerhoets, F. J. G., Guignard, L., Monney, A., Kleeberg, J., Goff, G. L., Pantaleo, G., & Pasquier, R. D. (2008) · Brain · doi:10.1093/brain/awn108 · Cited by 169 · see citing works
Cytokines and Chronic Fatigue Syndrome
Patarca, R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05824.x · Cited by 164 · see citing works
Exhausted Cytotoxic Control of Epstein-Barr Virus in Human Lupus
Larsen, M., Sauce, D., Deback, C., Arnaud, L., Mathian, A., Miyara, M., Boutolleau, D., Parizot, C., Dorgham, K., Papagno, L., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002328 · Cited by 150 · see citing works
Altmann, M., Pich, D., Ruiss, R., Wang, J.-D., Sugden, B., & Hammerschmidt, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605985103 · Cited by 146 · see citing works
Devanur, L. D., & Kerr, J. R. (2006) · Journal of Clinical Virology · doi:10.1016/j.jcv.2006.08.013 · Cited by 144 · see citing works
Betts, M. R., Exley, B., Price, D. A., Bansal, A., Camacho, Z. T., Teaberry, V. S., West, S. M., Ambrozak, D. R., Tomaras, G. D., Roederer, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408773102 · Cited by 137 · see citing works
FLETCHER, M. A., Zeng, X. R., Maher, K. J., Levis, S., Hurwitz, B. E., Antoni, M. H., Broderick, G., & Klimas, N. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010817 · Cited by 127 · see citing works
Glaser, R., Padgett, D. A., Litsky, M. L., Baiocchi, R. A., Yang, E. V., Chen, M., Yeh, P., Klimas, N. G., Marshall, G. D., Whiteside, T. L., et al. (2004) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2004.09.001 · Cited by 125 · see citing works
High levels of type 2 cytokine-producing cells in chronic fatigue syndrome
Skowera, A., Cleare, A. J., BLAIR, D., Bevis, L., Wessely, S. C., & Peakman, M. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02354.x · Cited by 122 · see citing works
Whelton, C., Salit, I. E., & Moldofsky, H. (1992) · PubMed · Cited by 117 · see citing works
Chronic fatigue syndrome is associated with diminished intracellular perforin
Maher, K. J., Klimas, N. G., & Fletcher, M. A. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02935.x · Cited by 116 · see citing works
Lymphocyte phenotype and function in the chronic fatigue syndrome
Straus, S. E., Fritz, S., Dale, J. K., Gould, B. R., & Strober, W. (1993) · Journal of Clinical Immunology · doi:10.1007/bf00920633 · Cited by 113 · see citing works
Role of EBERs in the Pathogenesis of EBV Infection
Iwakiri, D., & Takada, K. (2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)07004-1 · Cited by 112 · see citing works
Curriu, M., Carrillo, J., Massanella, M., Rigau, J., Alegre, J., Puig, J., Garcia-Quintana, A. M., Castro‐Marrero, J., Negredo, E., Clotet, B., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-68 · Cited by 105 · see citing works
Simmons, G., Glynn, S. A., Komaroff, A. L., Mikovits, J. A., Tobler, L. H., Hackett, J., Tang, N., Switzer, W. M., Heneine, W., HEWLETT, I. K., et al. (2011) · Science · doi:10.1126/science.1213841 · Cited by 103 · see citing works
Patnaik, M., Komaroff, A. L., Conley, E. J., Ojo-Amaize, E. A., & Peter, J. B. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.5.1364 · Cited by 98 · see citing works
Autoimmune disease: A role for new anti-viral therapies?
Dreyfus, D. H. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.08.005 · Cited by 89 · see citing works
Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes
Klein, G., Klein, E., & Kashuba, E. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.146 · Cited by 87 · see citing works
T-cell exhaustion in HIV infection
Far, M. E., Halwani, R., Said, E. A., Trautmann, L., Doroudchi, M., Janbazian, L., Fonseca, S. G., van Grevenynghe, J., Yassine‐Diab, B., Sékaly, R., et al. (2008) · Current HIV/AIDS Reports · doi:10.1007/s11904-008-0003-7 · Cited by 87 · see citing works
Gabibov, A. G., Belogurov, A. A., Lomakin, Y. A., Zakharova, M. Y., Avakyan, M. R., Dubrovskaya, V. V., Smirnov, I. V., Ivanov, A. S., Molnar, A. A., Gurtsevitch, V., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-190769 · Cited by 86 · see citing works
Piriou, E., van Dort, K. A., Nanlohy, N. M., van Oers, M. H. J., Miedema, F. F., & van Baarle, D. (2005) · Blood · doi:10.1182/blood-2005-01-0432 · Cited by 85 · see citing works
Quantitative PCR for human herpesviruses 6 and 7
Secchiero, P., Zella, D., Crowley, R. W., Gallo, R. C., & Lusso, P. (1995) · Journal of Clinical Microbiology · doi:10.1128/jcm.33.8.2124-2130.1995 · Cited by 84 · see citing works
Ling, P. D., Vilchez, R. A., Keitel, W., Poston, D., Peng, R., White, Z. S., Visnegarwala, F., Lewis, D. E., & Butel, J. S. (2003) · Clinical Infectious Diseases · doi:10.1086/378808 · Cited by 77 · see citing works
Cameron, B., Flamand, L., Juwana, H., Middeldorp, J. M., Naing, Z., Rawlinson, W. D., Ablashi, D. V., & Lloyd, A. R. (2010) · Journal of Medical Virology · doi:10.1002/jmv.21873 · Cited by 76 · see citing works
Chapenko, S., Krūmiņa, A., Logina, I., Rasa, S., Čistjakovs, M., Sultanova, A., Vīksna, L., & Murovska, M. (2012) · Advances in Virology · doi:10.1155/2012/205085 · Cited by 75 · see citing works
HHV-6 reactivation in chronic fatigue syndrome
Josephs, S. F., Henry, B. E., Balachandran, N., Strayer, D. R., Peterson, D. L., Komaroff, A. L., & Ablashi, D. V. (1991) · The Lancet · doi:10.1016/0140-6736(91)93018-5 · Cited by 74 · see citing works
A review of the definitional criteria for chronic fatigue syndrome
Christley, Y., Duffy, T., & Martin, C. R. (2010) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2010.01512.x · Cited by 73 · see citing works
Epigenetic Dysregulation of Epstein-Barr Virus Latency and Development of Autoimmune Disease
Niller, H. H., Wolf, H. J., Áy, É., & Minárovits, J. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8216-2_7 · Cited by 72 · see citing works
Human Herpesviruses in Chronic Fatigue Syndrome
Wallace, H. L., Natelson, B. H., Gause, W. C., & Hay, J. (1999) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.6.2.216-223.1999 · Cited by 72 · see citing works
Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
Broderick, G., Katz, B. Z., Fernandes, H., Fletcher, M. A., Klimas, N., Smith, F. A., O’Gorman, M. R., Vernon, S. D., & Taylor, R. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-191 · Cited by 72 · see citing works
Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome
Chapenko, S., Krūmiņa, A., Kozireva, S., Nora-Krūkle, Z., Sultanova, A., Vīksna, L., & Murovska, M. (2006) · Journal of Clinical Virology · doi:10.1016/s1386-6532(06)70011-7 · Cited by 70 · see citing works
Lerner, A. M., BEQAJ, S. H., Deeter, R. G., & Fitzgerald, J. T. (2004) · PubMed · Cited by 66 · see citing works
Role of Infection and Neurologic Dysfunction in Chronic Fatigue Syndrome
Komaroff, A. L., & Cho, T. A. (2011) · Seminars in Neurology · doi:10.1055/s-0031-1287654 · Cited by 64 · see citing works
Sairenji, T., Yamanishi, K., Tachibana, Y., Bertoni, G., & Kurata, T. (1995) · Intervirology · doi:10.1159/000150450 · Cited by 64 · see citing works
Antibody Responses to Two Epstein-Barr Virus Nuclear Antigens Defined by Gene Transfer
Miller, G., Grogan, E. A., Fischer, D. K., Niederman, J. C., Schooley, R. T., Henle, W., Lenoir, G., & Liu, C.-R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198503213121204 · Cited by 63 · see citing works
The biology of Epstein-Barr virus: lessons learned from the virus and the host
Cohen, J. I. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80062-4 · Cited by 59 · see citing works
Rodrigue‐Gervais, I. G., Rigsby, H., Jouan, L., Sauvé, D., Sékaly, R., Willems, B. E., & Lamarre, D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902522 · Cited by 58 · see citing works
Chronic fatigue syndrome and subsequent risk of cancer among elderly US adults
Chang, C. M., Warren, J. L., & Engels, E. A. (2012) · Cancer · doi:10.1002/cncr.27612 · Cited by 57 · see citing works
Infection, Vaccination, and Autoantibodies in Chronic Fatigue Syndrome, Cause or Coincidence?
Ortega‐Hernandez, O., & Shoenfeld, Y. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04799.x · Cited by 56 · see citing works
Höhn, O., Strohschein, K., Brandt, A. U., Seeher, S., Klein, S. M., Kurth, R., Paul, F., Meisel, C., Scheibenbogen, C., & Bannert, N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015632 · Cited by 55 · see citing works
Draborg, A. H., Jørgensen, J., Müller, H., Nielsen, C. T., Jacobsen, S., Iversen, L. V., Theander, E., Nielsen, L., Houen, G., & Duus, K. (2012) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2012.665944 · Cited by 52 · see citing works
Lerner, A. M., Ariza, M. E., Williams, M. V., Jason, L. A., BEQAJ, S. H., Fitzgerald, J. T., Lemeshow, S. A., & Glaser, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047891 · Cited by 51 · see citing works
Frémont, M., Metzger, K., Rady, H. F., Hulstaert, J., & Meirleir, K. D. (2009) · PubMed · Cited by 48 · see citing works
Klatt, N. R., Vinton, C. L., Lynch, R. M., Canary, L., Ho, J., Darrah, P. A., Estes, J. D., Seder, R. A., Moir, S. L., & Brenchley, J. M. (2011) · Blood · doi:10.1182/blood-2011-07-365874 · Cited by 47 · see citing works
Chronic Fatigue Syndrome and Herpesviruses: the Fading Evidence.
Soto, N. E., & Straus, S. E. (2000) · PubMed · Cited by 45 · see citing works
BEQAJ, S. H., Lerner, A. M., & Fitzgerald, J. T. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.050633 · Cited by 40 · see citing works
Symptom occurrence in persons with chronic fatigue syndrome
Jason, L. A., Torres‐Harding, S., Carrico, A. W., & Taylor, R. R. (2002) · Biological Psychology · doi:10.1016/s0301-0511(01)00120-x · Cited by 38 · see citing works
van Baarle, D., Nanlohy, N. M., Otto, S. A., Plunkett, F. J., Fletcher, J. M., & Akbar, A. N. (2008) · The Journal of Infectious Diseases · doi:10.1086/592170 · Cited by 35 · see citing works
Guerreiro, M., Na, I., Letsch, A., Haase, D., Bauer, S., Meisel, C., Roemhild, A., Reinke, P., Volk, H., & Scheibenbogen, C. (2010) · European Journal of Immunology · doi:10.1002/eji.200940000 · Cited by 34 · see citing works
Colmenares, M., Constant, S. L., Kima, P. E., & McMahon‐Pratt, D. (2002) · Infection and Immunity · doi:10.1128/iai.70.12.6597-6605.2002 · Cited by 34 · see citing works
Manian, F. A. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.3.448 · Cited by 30 · see citing works
Lerner, A. M., BEQAJ, S. H., Deeter, R. G., & Fitzgerald, J. T. (2002) · PubMed · Cited by 27 · see citing works
Piriou, E., van Dort, K. A., Nanlohy, N. M., van Oers, M. H. J., Miedema, F. F., & van Baarle, D. (2005) · European Journal of Immunology · doi:10.1002/eji.200425792 · Cited by 25 · see citing works
Studies on the Relationship between Chronic Fatigue Syndrome and Epstein-Barr Virus in Japan.
KAWAI, K., & Kawai, A. (1992) · Internal Medicine · doi:10.2169/internalmedicine.31.313 · Cited by 24 · see citing works
Biomarkers of stress and fatigue
Tanaka, Y., & Wakida, S. (2011) · Folia Pharmacologica Japonica · doi:10.1254/fpj.137.185 · Cited by 23 · see citing works
XMRV and CFS—the sad end of a story
van Kuppeveld, F. J. M., & van der Meer, J. W. M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60899-4 · Cited by 17 · see citing works
No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome.
Burbelo, P. D., Bayat, A., Wagner, J. M., Nutman, T. B., Baraniuk, J. N., & Iadarola, M. J. (2012) · Europe PMC (PubMed Central) · Cited by 16 · see citing works
Predicting therapy duration from therapist experience and client psychopathology
Renk, K., Dinger, T. M., & Bjugstad, K. B. (2000) · Journal of Clinical Psychology · doi:10.1002/1097-4679(200012)56:12 · Cited by 14 · see citing works
Krueger, G. R. F., Koch, B., Hoffmann, A. M., Rojo, J. U., Brandt, M. E., Wang, G., & Buja, L. M. (2001) · PubMed · Cited by 12 · see citing works
Editorial on CFS was biased, inaccurate, and misleading
Shepherd, C. (2002) · BMJ · doi:10.1136/bmj.324.7342.914 · Cited by 4 · see citing works
[Biomarkers of stress and fatigue].
Tanaka, Y. (2012) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
the European Network on ME/CFS (EUROMENE), Rasa, S., Nora-Krūkle, Z., Henning, N., Eliassen, E., Shikova, E., Harrer, T., Scheibenbogen, C., Murovska, M., & Prusty, B. K. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1644-y · Cited by 311 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management
Bateman, L., Bested, A. C., Bonilla, H. F., Chheda, B., Chu, L., Curtin, J. M., Dempsey, T. T., Dimmock, M. E., Dowell, T. G., Felsenstein, D., et al. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.07.004 · Cited by 302 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease
Sotzny, F., Blanco, J., Capelli, E., Castro‐Marrero, J., Steiner, S., Murovska, M., & Scheibenbogen, C. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.01.009 · Cited by 272 · see citing works
Onset Patterns and Course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Chu, L., Valencia, I. J., Garvert, D. W., & Montoya, J. G. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00012 · Cited by 208 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview
Deumer, U.-S., Varesi, A., Floris, V., Savioli, G., Mantovani, E., López-Carrasco, P., Rosati, G. M., Prasad, S., & Ricevuti, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204786 · Cited by 153 · see citing works
Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
Bellon, M., & Nicot, C. (2017) · Viruses · doi:10.3390/v9100289 · Cited by 146 · see citing works
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
König, R. S., Albrich, W. C., Kahlert, C. R., Bahr, L. S., Löber, U., Vernazza, P., Scheibenbogen, C., & Forslund, S. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628741 · Cited by 123 · see citing works
Blomberg, J., Gottfries, C., Elfaitouri, A., Rizwan, M., & Rosén, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00229 · Cited by 119 · see citing works
Shikova, E., Reshkova, V., Kumanova, А., Raleva, S. H., Alexandrova, D., Čapo, N., Murovska, M., & on behalf of the European Network on ME CFS (2020) · Journal of Medical Virology · doi:10.1002/jmv.25744 · Cited by 104 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease
Arron, H. E., Marsh, B. D., Khan, M. A., Jaeger, B., Kell, D., & Pretorius, E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1386607 · Cited by 111 · see citing works
Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome
Ruiz-Pablos, M., Paiva, B., Montero-Mateo, R., Garcia, N., & Zabaleta, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656797 · Cited by 100 · see citing works
The clinical value of cytokines in chronic fatigue syndrome
Yang, T., Yang, Y., Wang, D., Li, C., Qu, Y., Guo, J., Shi, T., Wang, B., Sun, Z., & Asakawa, T. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1948-6 · Cited by 99 · see citing works
Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach
Bjørklund, G., Dadar, M., Pen, J. J., Chirumbolo, S., & Aaseth, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.076 · Cited by 93 · see citing works
Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Cliff, J. M., King, E. C., Lee, J., Sepúlveda, N., Wolf, A., Kingdon, C. C., Bowman, E. W., Dockrell, H. M., Nacul, L., Lacerda, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00796 · Cited by 87 · see citing works
Löbel, M., Eckey, M., Sotzny, F., Hahn, E. M., Bauer, S., Grabowski, P., Zerweck, J., Holenya, P., Hanitsch, L. G., Wittke, K., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179124 · Cited by 73 · see citing works
The role of Epstein–Barr virus infection in primary Sjögren's syndrome
Maślińska, M. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000622 · Cited by 72 · see citing works
Rivas, J. L., Palencia, T., Fernández, G., & García, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01028 · Cited by 70 · see citing works
Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
Morris, G., Maes, M. H. J., Berk, M., & Puri, B. K. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-0388-6 · Cited by 66 · see citing works
Navaneetharaja, N., Griffiths, V., Wileman, T., & Carding, S. R. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5060055 · Cited by 60 · see citing works
Nguyen, C. B., Alsøe, L., Lindvall, J. M., Sulheim, D., Fagermoen, E., Winger, A., Kaarbø, M., Nilsen, H., & Wyller, V. B. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1201-0 · Cited by 59 · see citing works
Chronic fatigue syndrome and the immune system: Where are we now?
Mensah, F., Bansal, A. S., Ford, B., & Cambridge, G. (2017) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2017.02.002 · Cited by 59 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!
Ariza, M. E. (2021) · Biomolecules · doi:10.3390/biom11020185 · Cited by 60 · see citing works
Ruiz-Núñez, B., Tarasse, R., Vogelaar, E. F., Dijck-Brouwer, J., & Muskiet, F. A. J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00097 · Cited by 56 · see citing works
Williams, M. V., Cox, B., Lafuse, W. P., & Ariza, M. E. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.04.009 · Cited by 53 · see citing works
Halpin, P., Williams, M. V., Klimas, N. G., FLETCHER, M. A., Barnes, Z. M., & Ariza, M. E. (2017) · Journal of Medical Virology · doi:10.1002/jmv.24810 · Cited by 51 · see citing works
Eguchi, A., Fukuda, S., Kuratsune, H., Nojima, J., Nakatomi, Y., Watanabe, Y., & Feldstein, A. E. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.11.015 · Cited by 50 · see citing works
The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE
Scheibenbogen, C., Freitag, H., Blanco, J., Capelli, E., Lacerda, E., Authier, F., Meeus, M., Castro‐Marrero, J., Nora-Krūkle, Z., Oltra, E., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1263-z · Cited by 44 · see citing works
O’Neal, A. J., & Hanson, M. R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.688486 · Cited by 42 · see citing works
A clinical primer for the expected and potential post-COVID-19 syndromes
Walitt, B. T., & Bartrum, E. A. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000887 · Cited by 40 · see citing works
Sepúlveda, N., Carneiro, J., Lacerda, E., & Nacul, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02684 · Cited by 40 · see citing works
Guenther, S., Löbel, M., Mooslechner, A. A., Knops, M., Hanitsch, L. G., Grabowski, P., Wittke, K., Meisel, C., Unterwalder, N., Volk, H., et al. (2015) · Human Immunology · doi:10.1016/j.humimm.2015.09.028 · Cited by 36 · see citing works
Cox, B., Alharshawi, K., Mena-Palomo, I., Lafuse, W. P., & Ariza, M. E. (2022) · JCI Insight · doi:10.1172/jci.insight.158193 · Cited by 36 · see citing works
Myalgic Encephalomyelitis: Symptoms and Biomarkers
Jason, L. A., Zinn, M. L., & Zinn, M. A. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150928105725 · Cited by 37 · see citing works
Roerink, M. E., Knoop, H., Bronkhorst, E. M., Mouthaan, H., Hawinkels, L. J. A. C., Joosten, L. A. B., & van der Meer, J. W. M. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1371-9 · Cited by 36 · see citing works
Mensah, F., Bansal, A., Berkovitz, S., Sharma, A., Reddy, V, Leandro, M. J., & Cambridge, G. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12749 · Cited by 34 · see citing works
Kerr, J. R. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00059 · Cited by 35 · see citing works
Maya, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511937 · Cited by 35 · see citing works
Williams, M. V., Cox, B., & Ariza, M. E. (2016) · Pathogens · doi:10.3390/pathogens6010002 · Cited by 33 · see citing works
Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary
Richman, S., Morris, M. C., Broderick, G., Craddock, T. J. A., Klimas, N. G., & FLETCHER, M. A. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.02.011 · Cited by 35 · see citing works
Molnár, T., Várnai, R., Schranz, D., Závori, L., Péterfi, Z., Sipos, D., Tökés‐Füzesi, M., Illés, Z., Büki, A., & Csécsei, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194337 · Cited by 30 · see citing works
de Vega, W. D., Erdman, L., Vernon, S., Goldenberg, A., & McGowan, P. (2018) · Epigenomics · doi:10.2217/epi-2017-0150 · Cited by 26 · see citing works
Venturini, L., Bacchi, S., Capelli, E., Lorusso, L., Ricevuti, G., & Cusa, C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1684198 · Cited by 27 · see citing works
James, L. M., & Georgopoulos, A. P. (2022) · Neuroscience Insights · doi:10.1177/26331055221114817 · Cited by 26 · see citing works
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome
Hanevik, K., Kristoffersen, E. K., Mørch, K., Rye, K. P., Sørnes, S., Svärd, S. G., Bruserud, Ø., & Langeland, N. (2017) · BMC Immunology · doi:10.1186/s12865-017-0190-3 · Cited by 24 · see citing works
Ruiz-Pablos, M., Paiva, B., & Zabaleta, A. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04515-7 · Cited by 22 · see citing works
Sepúlveda, N., Malato, J., Sotzny, F., Grabowska, A. D., Fonseca, A., Cordeiro, C., Graça, L., Biecek, P., Behrends, U., Mautner, J., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.921101 · Cited by 21 · see citing works
Tschopp, R., König, R. S., Rejmer, P., & Paris, D. H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15595 · Cited by 20 · see citing works
Apostolou, E., & Rosén, A. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13792 · Cited by 18 · see citing works
Therapeutic Implications of the Microbial Hypothesis of Mental Illness
Savitz, J. B., & Yolken, R. H. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_368 · Cited by 16 · see citing works
Pricoco, R., Meidel, P., Hofberger, T., Zietemann, H., Mueller, Y., Wiehler, K., Michel, K., Paulick, J., Leone, A., Haegele, M., et al. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1266738 · Cited by 16 · see citing works
Morris, M. C., Cooney, K. E., Sedghamiz, H., Abreu, M., Collado, F., Balbin, E. G., Craddock, T. J. A., Klimas, N. G., Broderick, G., & Fletcher, M. A. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.03.002 · Cited by 14 · see citing works
The biological challenge of myalgic encephalomyelitis/chronic fatigue syndrome: a solvable problem
Edwards, J., McGrath, S. J., Baldwin, A., Livingstone, M., & Kewley, A. J. (2016) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2016.1160598 · Cited by 14 · see citing works
Sapra, A., & Bhandari, P. (2021) · StatPearls · Cited by 13 · see citing works
Palacios, N., Molsberry, S. A., Fitzgerald, K. C., & Komaroff, A. L. (2023) · Scientific Reports · doi:10.1038/s41598-023-29329-x · Cited by 10 · see citing works
Malato, J., Sotzny, F., Bauer, S., Freitag, H., Fonseca, A., Grabowska, A. D., Graça, L., Cordeiro, C., Nacul, L., Lacerda, E., et al. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07665 · Cited by 11 · see citing works
Duan, L., Yang, J., Zhao, J., Chen, Z., Yang, H., & Cai, D. (2025) · Biomedicines · doi:10.3390/biomedicines13051200 · Cited by 7 · see citing works
Bourgonje, A. R., Andreu‐Sánchez, S., Gaćeša, R., Innocenti, G., Kalka, I. N., Klompus, S., Leviatan, S., Schlesinger, Y., Krongauz, D. L., Weinberger, A., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334362 · Cited by 7 · see citing works
Sung, A. P., Tang, J. J.-J., Guglielmo, M. J., Smith‐Gagen, J., Bateman, L., Navarrete-Galvan, L. T., Redelman, D. D., & Hudig, D. (2020) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2021.1876613 · Cited by 7 · see citing works
Serological Assessment of 18 Pathogens and Risk of AIDS-Associated Non-Hodgkin Lymphoma
Halec, G., Waterboer, T., Brenner, N., Butt, J., Hardy, W. D., DʼSouza, G., Wolinsky, S. M., Macatangay, B. J. C., Pawlita, M., Detels, R., et al. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001916 · Cited by 7 · see citing works
Jason, L. A., & Katz, B. Z. (2025) · Microorganisms · doi:10.3390/microorganisms13040702 · Cited by 6 · see citing works
Eriksen, W. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.02.011 · Cited by 6 · see citing works
Wunsch, M., Hohmann, C., Milles, B., Rostermund, C., Lehmann, P., Schroeter, M., Bayas, A., Ulzheimer, J. C., Mäurer, M., Ergün, S., et al. (2016) · Viruses · doi:10.3390/v8040105 · Cited by 6 · see citing works
Trammell, R. A., & Toth, L. A. (2016) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Aubrecht, T. G., Weil, Z. M., Salloum, B. A., Ariza, M. E., Williams, M. V., Reader, B. F., Glaser, R., Sheridan, J. F., & Nelson, R. J. (2015) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2015.511049 · Cited by 5 · see citing works
Twisk, F. (2015) · International Journal of Neurology Research · doi:10.17554/j.issn.2313-5611.2015.01.13 · Cited by 4 · see citing works
Eriksen, W. (2018) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2018.1503125 · Cited by 3 · see citing works
Cox, B., Goolkasian, P. A., Palomo, I. M., Williams, M. V., Maloney, S. R., & Ariza, M. E. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70400 · Cited by 3 · see citing works
Yang, B., Wang, T., Xiong, K., Ding, X., Zhang, M., Chen, H., Huang, M. X., & Wu, X. (2025) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000180 · Cited by 3 · see citing works
Mena-Palomo, I., Cox, B., Williams, M. V., & Ariza, M. E. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70769 · Cited by 3 · see citing works
Cutting-edge assessment techniques for B cell immune memory: an overview
Bozhkova, M., Gardzheva, P., Rangelova, V., Taskov, H. B., & Murdjeva, M. (2024) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2024.2345119 · Cited by 2 · see citing works
Tokunaga, K., Sung, A. P., Tang, J. J.-J., Guglielmo, M. J., Smith‐Gagen, J., Bateman, L., Redelman, D. D., & Hudig, D. (2020) · Work · doi:10.3233/wor-203177 · Cited by 2 · see citing works
Zinn, M. A., Zinn, M. L., & Jason, L. A. (2021) · NeuroRegulation · doi:10.15540/nr.8.2.73 · Cited by 2 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Rowe, P. C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-75608-2.00200-7 · Cited by 2 · see citing works
van der Meer, J. W. M., & Bleijenberg, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-7020-6285-8.00070-8 · Cited by 2 · see citing works
Ariza, M. E., Palomo, I. M., & Williams, M. V. (2025) · Viruses · doi:10.3390/v17121624 · Cited by 1 · see citing works
Ramos‐Niño, M. E. (2026) · Clinics and Practice · doi:10.3390/clinpract16040064 · Cited by 1 · see citing works
Gayer, M., Xu, Z. M., Hodel, F., Preisig, M., Strippoli, M. F., Vollenweider, P., Vaucher, J., Lutti, A., Kherif, F., Penner, I., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100896 · Cited by 1 · see citing works
Broken Connections: The Evidence for Neuroglial Failure in ME/CFSPreprint
Renz‐Polster, H. (2021) · doi:10.31219/osf.io/ef3n4 · Cited by 1 · see citing works
The Impact Of Persistent Herpesvirus Infection On Immunity And Vaccination Response
A.Yu., V., Kuchma, M. V., Yu, K. T., Tl, К., Yu, К. I., Еs, K., Смелянская, М. В., Перемот, С. Д., Кашпур, Н. В., & Мb, D. (2016) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.5281/zenodo.167428
Sung, A. P., Tang, J. J.-J., Guglielmo, M. J., Smith‐Gagen, J., Bateman, L., Redelman, D. D., & Hudig, D. (2019) · medRxiv · doi:10.1101/2019.12.20.19015438
Badenschier, F. (2016) · Cerveau & Psycho · doi:10.3917/cerpsy.074.0082
Immunological Related Status of Chronic Fatigue Syndrome
王, 婕. (2018) · Advances in Clinical Medicine · doi:10.12677/acm.2018.84068
Xu, H., Luo, Y., & Wu, X. X. (2026) · Comprehensive physiology · doi:10.1002/cph4.70098
Samaan, P., Budylowski, P., Russell, V. R., Srighanthan, J., Cheung, A. M., & Ostrowski, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.27.701989
Shevtsova, V. I., Pilyakina, M. V., Ostroverkhova, D. A., & Ostroverkhov, V. S. (2026) · Problems of Virology · doi:10.36233/0507-4088-401
- Authors
- Loebel, M., Strohschein, K., Giannini, C., Koelsch, U., Bauer, S., Doebis, C., Thomas, S., Unterwalder, N., von Baehr, V., Reinke, P., Knops, M., Hanitsch, L. G., Meisel, C., Volk, H.-D., & Scheibenbogen, C.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-01-15
- Volume
- 9
- Issue
- 1
- Pages
- e85387
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3893202
- OpenAlex
- W1965161753
- Cited by
- 86
- References
- 86
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 3 · 2019: 13 · 2018: 10 · 2017: 9 · 2016: 8 · 2015: 6
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Keywords
- chronic fatigue syndrome, Epstein-Barr virus, EBV-specific T cells, EBNA1, viral capsid antigen, TNF-α, interferon-gamma, interleukin-2, EBV reactivation, diagnostic biomarkers
- MeSH terms
- Adult, Aged, Antibodies, Viral, B-Lymphocytes, Base Sequence, Enzyme-Linked Immunosorbent Assay, Herpesvirus 4, Human, Female, Flow Cytometry, Humans, Immunologic Memory, Male, Middle Aged, T-Lymphocytes, Virus Replication, Fatigue Syndrome, Chronic, T-Lymphocyte Subsets, DNA Primers, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
