Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
Open accessAbstract
BACKGROUND: As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS (PI-CFS) patients and recovered controls. We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis (IM). We found an incidence of CFS at 6, 12 and 24 months of 13%, 7% and 4% respectively. METHODS: Using chemiluminescent imaging we measured the concentrations of IL-1a, 1b, 2, 4, 5, 6, 8, 10, 12 (p70), 13, 15, 17 and 23, IFN-γ, TNF-α and TNF-β in duplicate plasma samples available in bio-bank from 9 PI-CFS subjects and 12 recovered controls at 24 months post-infection. RESULTS: Standard comparative analysis indicated significant differences in IL-8 and 23 across subject groups. In constructing a linear classification model IL-6, 8 and 23 were selected by two different statistical approaches as discriminating features, with IL-1a, IL-2 and IFN-γ also selected in one model or the other. This supported an assignment accuracy of better than 80% at a confidence level of 0.95 into PI-CFS versus recovered controls. CONCLUSION: These results suggest that co-expression patterns in as few as 5 cytokines associated with Th17 function may hold promise as a tool for the diagnosis of post-infectious CFS.
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ME/CFS has frequently been observed to follow infection by Epstein-Barr virus, in which context it tends to be associated with chronic dysregulation of inflammatory cytokine production.
“Indeed, ME/CFS has frequently been observed to follow infection by Epstein-Barr virus, in which context it tends to be associated with chronic dysregulation of inflammatory cytokine production3.”
From Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically-relevant Phenotyping of Women with Chronic Fatigue Syndrome (2019) · cites this paper as [3]
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- Authors
- Broderick, G., Katz, B. Z., Fernandes, H., Fletcher, M. A., Klimas, N., Smith, F. A., O’Gorman, M. R., Vernon, S. D., & Taylor, R.
- Affiliations
- University of Alberta (CA)
- Lurie Children's Hospital (US)
- University of Miami (US)
- Veterans Health Administration (US)
- Northwestern University (US)
- Solve ME/CFS Initiative (US)
- Corresponding author
- Broderick, Gordon
- Venue
- Journal of Translational Medicine
- Published
- 2012-09-13
- Volume
- 10
- Issue
- 1
- Pages
- 191-191
- ISSN
- 1479-5876 (ISSN-L)
- PMC
- PMC3480896
- OpenAlex
- W2126486587
- Cited by
- 72
- References
- 55
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Translational Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- U.S. Department of Veterans Affairs
- National Institute on Alcohol Abuse and Alcoholism (R21AA016635)
- National Institute of Allergy and Infectious Diseases (R01AI065723)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD043301)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- infectious mononucleosis, Epstein-Barr virus, cytokine profile, immune dysregulation, interleukin-6, interleukin-8, IL-23, Th17 cells, interferon-gamma, TNF-α, plasma cytokines, adolescents
- MeSH terms
- Adolescent, Fatigue, Humans, Infectious Mononucleosis, Cohort Studies, Cytokines, Gene Expression Profiling
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