Circulating Exosomal microRNAs as Biomarkers of Colon Cancer

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

Global cancer statistics

Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 55,077

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

MicroRNA expression profiles classify human cancers

Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637

Oncomirs—MicroRNAs with a role in cancer

Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001

Causes and consequences of microRNA dysregulation in cancer

Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

Iorio, M. V., & Croce, C. M. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201100209 · Cited by 1,778

Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial

Atkin, W. S., Edwards, R., Kralj‐Hans, I., Wooldrage, K., Hart, A. R., Northover, J. M. A., Parkin, D. M., Wardle, J., Duffy, S. W., & Cuzick, J. M. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60551-x · Cited by 1,618

A Comprehensive Meta-Analysis of MicroRNAs for Predicting Colorectal Cancer

Lin, Y., Zhao, W., Yu, H., Wang, Y., Liu, Y., & Xie, C. L. (2016) · Medicine · doi:10.1097/md.0000000000002738 · Cited by 28

Clinical Applications of Liquid Biopsy in Colorectal Cancer Screening: Current Challenges and Future Perspectives

Galoș, D., Gorzo, A., Bălăcescu, O., & Sur, D. G. (2022) · Cells · doi:10.3390/cells11213493 · Cited by 28

Circulating Exosomal miRNAs as a Promising Diagnostic Biomarker in Cancer

Behulová, R., Bugalová, A., Bugala, J., Struhárňanská, E., Šafranek, M., & Juráš, I. (2023) · Physiological Research · doi:10.33549/physiolres.935153 · Cited by 31

Extracellular vesicles: biogenesis mechanism and impacts on tumor immune microenvironment

Yeat, N. Y., & Chen, R. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01182-2 · Cited by 32

An update on miRNAs as biological and clinical determinants in colorectal cancer: a bench-to-bedside approach

Weng, W., Feng, J., Qin, H., Ma, Y., & Goel, A. (2015) · Future Oncology · doi:10.2217/fon.15.83 · Cited by 28

SACMDA: MiRNA-Disease Association Prediction with Short Acyclic Connections in Heterogeneous Graph

Shao, B., Liu, B., & Yan, C. C. (2018) · Neuroinformatics · doi:10.1007/s12021-018-9373-1 · Cited by 27

Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases

Bongiovanni, L., Andriessen, A., Wauben, M. H. M., Hoen, E. N. M. N., & de Bruin, A. (2021) · Veterinary Pathology · doi:10.1177/0300985821999328 · Cited by 27

A systematic approach to RNA-associated motif discovery

Gao, T. X., Shu, J., & Cui, J. (2018) · BMC Genomics · doi:10.1186/s12864-018-4528-x · Cited by 26

Exosomal miR-1246 in Body Fluids is a Potential Biomarker for Gastrointestinal Cancer

Wei, C., Li, Y., Huang, K., Li, G., & He, M. (2018) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0440 · Cited by 27

MicroRNA-8073: Tumor suppressor and potential therapeutic treatment

Mizoguchi, A., Takayama, A., Arai, T., Kawauchi, J., & Sudo, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209750 · Cited by 28

Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140–3p/HIF-1α/VEGF signaling axis

Payervand, N., Pakravan, K., Razmara, E., Vinu, K. K., Ghodsi, S., Heshmati, M., & Babashah, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31584 · Cited by 26

Recent Technologies towards Diagnostic and Therapeutic Applications of Circulating Nucleic Acids in Colorectal Cancers

Chung, J., Xiao, S., Gao, Y., & Soung, Y. H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168703 · Cited by 26

Clinical value of microRNA-23a upregulation in non-small cell lung cancer.

Qu, W., Liu, L., & Yu, Z. (2015) · Europe PMC (PubMed Central) · Cited by 26

Dual Laplacian regularized matrix completion for microRNA-disease associations prediction

Tang, C., Zhou, H., Zheng, X., Zhang, Y., & Sha, X. (2019) · RNA Biology · doi:10.1080/15476286.2019.1570811 · Cited by 26

Serum microRNA‑125a‑5p as a potential biomarker of HCV‑associated hepatocellular carcinoma

Oura, K., Fujita, K., Morishita, A., Iwama, H., Nakahara, M., Tadokoro, T., Sakamoto, T., Nomura, T., Yoneyama, H., Mimura, S., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10385 · Cited by 26

The tumorigenic and therapeutic functions of exosomes in colorectal cancer: Opportunity and challenges

Ahmadi, M., Jafari, R., Mahmoodi, M., & Rezaie, J. (2021) · Cell Biochemistry and Function · doi:10.1002/cbf.3622 · Cited by 26

MiRNA-Disease association prediction via non-negative matrix factorization based matrix completion

Zheng, X., Zhang, C., & Cheng, W. (2021) · Signal Processing · doi:10.1016/j.sigpro.2021.108312 · Cited by 26

Emerging micro-nanotechnologies for extracellular vesicles in immuno-oncology: from target specific isolations to immunomodulation

Onukwugha, N., Kang, Y., & Nagrath, S. (2022) · Lab on a Chip · doi:10.1039/d2lc00232a · Cited by 24

The Rise of Extracellular Vesicles as New Age Biomarkers in Cancer Diagnosis: Promises and Pitfalls

Bamankar, S., & Londhe, V. Y. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338221149266 · Cited by 26

Fusion of Exosomes and Nanotechnology: Cutting-Edge Cancer Theranostics

Agnihotram, R., Dhar, R., Dhar, D., Purushothaman, K., Narasimhan, A. K., & Devi, A. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c01033 · Cited by 27

Deregulation of cancer-stem-cell-associated miRNAs in tissues and sera of colorectal cancer patients

Farace, C., Pisano, A., Griñán‐Lisón, C., Solinas, G., Jiménez, G., Serra, M., Carrillo, E., Scognamillo, F., Attene, F., Montella, A., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27411 · Cited by 26

Pathogenesis and biomarkers of colorectal cancer by epigenetic alteration

Oh, C. K., & Cho, Y. (2024) · Intestinal Research · doi:10.5217/ir.2023.00115 · Cited by 24

Advances in microRNAs as Emerging Biomarkers for Colorectal Cancer Early Detection and Diagnosis

Ždralević, M., Radović, A., Raonić, J., Popović, N., Klisic, A. N., & Vučković, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011060 · Cited by 28

Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory

García‐Casas, A., Garcı́a-Olmo, D. C., & García‐Olmo, D. (2017) · World Journal of Clinical Oncology · doi:10.5306/wjco.v8.i5.378 · Cited by 25

Lack of miR‐1246 in small extracellular vesicle blunts tumorigenesis of laryngeal carcinoma cells by regulating Cyclin G2

Huang, Q., Hsueh, C., Guo, Y., Wu, X., Li, J.-Y., & Zhou, L. F. (2020) · IUBMB Life · doi:10.1002/iub.2274 · Cited by 25

Predictive Efficacy of MiR-125b-5p, MiR-17-5p, and MiR-185-5p in Liver Metastasis and Chemotherapy Response Among Advanced Stage Colorectal Cancer Patients

Sur, D. G., Bălăcescu, L., Cainap, S. S., Vișan, S., Pop, L., Burz, C. C., Havasi, A. D., Buiga, R., Cainap, C. I., Irimie, A., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.651380 · Cited by 25

Heterogeneous Nuclear Ribonucleoprotein A1 Loads Batched Tumor-Promoting MicroRNAs Into Small Extracellular Vesicles With the Assist of Caveolin-1 in A549 Cells

Li, Y., Zhang, J., Li, S., Guo, C., Li, Q., Zhang, X., Li, M., & Mi, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.687912 · Cited by 26

Exosomal miRNAs as a Promising Source of Biomarkers in Colorectal Cancer Progression

Bakhsh, T., Alhazmi, S., Alburae, N. A., Farsi, A., Alzahrani, F. A., Choudhry, H., & Bahieldin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094855 · Cited by 26

Exosomes in Colorectal Cancer: From Physiology to Clinical Applications

Țîțu, Ș., Gâta, V., Decea, R., Mocan, T., Dina, C., Irimie, A., & Lisencu, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054382 · Cited by 24

Exosomes as Biomarker of Cancer

Sumrin, A., Moazzam, S., Khan, A. A., Ramzan, I., Batool, Z., Kaleem, S., Ali, M., Bashir, H., & Bilal, M. (2018) · Brazilian Archives of Biology and Technology · doi:10.1590/1678-4324-2018160730 · Cited by 27

MicroRNAs in diagnosis and therapeutics

Atri, C., Guerfali, F. Z., & Laouini, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815669-8.00006-3 · Cited by 25

Free-Energy-Driven Lock/Open Assembly-Based Optical DNA Sensor for Cancer-Related microRNA Detection with a Shortened Time-to-Result

Zhu, X., Wang, R., Zhou, X., & Shi, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06579 · Cited by 24

Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers

Karin‐Kujundžić, V., Šola, I. M., Predavec, N., Potkonjak, A., Somen, E., Mioč, P., Šerman, A., Vranić, S., & Šerman, L. (2019) · Cells · doi:10.3390/cells8111459 · Cited by 25

Beyond tumor mutational burden: potential and limitations in using exosomes to predict response to immunotherapy

Crow, J., Samuel, G., & Godwin, A. K. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1688144 · Cited by 24

EVs as Potential New Therapeutic Tool/Target in Gastrointestinal Cancer and HCC

Słomka, A., Mocan, T., Wang, B., Nenu, I., Urban, S., Gonzalez-Carmona, M. A., Schmidt‐Wolf, I. G. H., Kornek, M., Strassburg, C., Sparchez, Z. A., et al. (2020) · Cancers · doi:10.3390/cancers12103019 · Cited by 24

Exosomal Components and Modulators in Colorectal Cancer: Novel Diagnosis and Prognosis Biomarkers

Chang, Y., Chan, M., Li, C., Fang, C., Hsiao, M., & Chen, C. (2021) · Biomedicines · doi:10.3390/biomedicines9080931 · Cited by 25

The Role of Small Extracellular Vesicles in the Progression of Colorectal Cancer and Its Clinical Applications

Chang, L., Chiu, H., Wu, M., & Shen, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031379 · Cited by 24

Diagnostic Potential of Exosomal microRNAs in Colorectal Cancer

Dohmen, J., Semaan, A., Kobilay, M., Zaleski, M., Branchi, V., Schlierf, A., Hettwer, K., Uhlig, S., Hartmann, G., Kalff, J. C., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12061413 · Cited by 24

Liquid biopsy in colorectal cancer

Najafi, S., Majidpoor, J., & Mortezaee, K. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117674 · Cited by 27

Genome-wide miRNA response to anacardic acid in breast cancer cells

Schultz, D. J., Muluhngwi, P., Alizadeh‐Rad, N., Green, M. A., Rouchka, E. C., Waigel, S. J., & Klinge, C. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184471 · Cited by 24

microRNA-25 as a novel modulator of circadian Period2 gene oscillation

Park, I., Kim, D., Kim, J., Jang, S., Choi, M., Choe, H. K., Choe, Y., & Kim, K. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00496-5 · Cited by 25

Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4

Ono, R., Yoshioka, Y., Furukawa, Y., Naruse, M., Kuwagata, M., Ochiya, T., Kitajima, S., & Hirabayashi, Y. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.05.002 · Cited by 24

Diagnostic performance of various liquid biopsy methods in detecting colorectal cancer: A meta‐analysis

Zhu, Y., Yang, T., Wu, Q., Yang, X., Hao, J., Deng, X., Yang, S., Gu, C., & Wang, Z. (2020) · Cancer Medicine · doi:10.1002/cam4.3276 · Cited by 23

NormiRazor: tool applying GPU-accelerated computing for determination of internal references in microRNA transcription studies

Grabia, S., Smyczyńska, U., Pagacz, K., & Fendler, W. M. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03743-8 · Cited by 25

DF-MDA: An effective diffusion-based computational model for predicting miRNA-disease association

Li, H., You, Z., Wang, L., Yan, X., & Li, Z. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.003 · Cited by 23

MicroRNAs and ‘Sponging’ Competitive Endogenous RNAs Dysregulated in Colorectal Cancer: Potential as Noninvasive Biomarkers and Therapeutic Targets

Jorgensen, B. G., & Ro, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042166 · Cited by 24

Exosomes as a Source of Biomarkers for Gastrointestinal Cancers

Yu, J., Ostowari, A., Gonda, A., Mashayekhi, K., Dayyani, F., Hughes, C. C. W., & Senthil, M. (2023) · Cancers · doi:10.3390/cancers15041263 · Cited by 23

Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer

Li, T., Zhou, T., Wu, J., Lv, H., Zhou, H., Du, M., Zhang, X., Wu, N., Gong, S., Ren, Z., et al. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101652 · Cited by 23

The Diagnostic Power of Circulating miR-1246 in Screening Cancer: An Updated Meta-analysis

Khanh, H. Q., Le, A. T., Phan, T. T., Ho, T. T., Pho, S. P., Nguyen, H. T., Anh, L. T., Nguyen, T. T., & Nguyen, S. T. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/8379231 · Cited by 22

Methyl jasmonate induces the apoptosis of human colorectal cancer cells via downregulation of EZH2 expression by microRNA-101

Peng, Z., & Zhang, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6061 · Cited by 23

Development of novel predictive miRNA/target gene pathways for colorectal cancer distance metastasis to the liver using a bioinformatic approach

Makondi, P. T., Wei, P., Huang, C., & Chang, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211968 · Cited by 23

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Mehta, M. J., Shin, D., Park, H. S., An, J., Lim, S. I., Kim, H. J., Hong, S., & Bu, J. (2025) · Small Methods · doi:10.1002/smtd.202402058 · Cited by 25

Recent advances in extracellular vesicles enriched with non-coding RNAs related to cancers

Song, Y., & Li, X. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.12.001 · Cited by 23

Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma

Morita, T., Fujiwara, T., Yoshida, A., Uotani, K., Kiyono, M., Yokoo, S., Hasei, J., Kunisada, T., & Ozaki, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-66120-8 · Cited by 24

Amplification-free profiling of microRNA-122 biomarker in DILI patient serums, using the luminex MAGPIX system

Marín-Romero, A., Tabraue-Chávez, M., Dear, J. W., Sanchez-Martin, R. M., Ilyine, H., Guardia-Monteagudo, J. J., Fara, M. A., López‐Delgado, F. J., Díaz‐Mochon, J. J., & Pernagallo, S. (2020) · Talanta · doi:10.1016/j.talanta.2020.121265 · Cited by 23

Exosomal noncoding RNAs in colorectal cancer

Wu, Q., Liu, W., Wang, J., Zhu, L., Wang, Z., & Peng, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.08.037 · Cited by 22

Erratum: Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes.

Huang, Y., Huang, T., Yadav, V. K., Sumitra, M. R., Tzeng, D. T. W., Wei, P., Shih, J.-W., & Wu, A. T. H. (2020) · PubMed Central · Cited by 22

Thinking Quantitatively of RNA-Based Information Transfer via Extracellular Vesicles: Lessons to Learn for the Design of RNA-Loaded EVs

Piffoux, M., Volatron, J., Silva, A., & Gazeau, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111931 · Cited by 24

Machine-learning-based Analysis Identifies miRNA Expression Profile for Diagnosis and Prediction of Colorectal Cancer: A Preliminary Study

Pawełka, D., Łaczmańska, I., Karpiński, P., Supplitt, S., Witkiewicz, W., Knychalski, B., PELAK, J., Żebrowska-Różańska, P., & Łaczmański, Ł. (2022) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20336 · Cited by 22

The Exosome Journey: From Biogenesis to Regulation and Function in Cancers

Li, Y., Li, M., Li, B., Li, Y., Shen, T., & Zhao, B. (2022) · Journal of Oncology · doi:10.1155/2022/9356807 · Cited by 26

Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development

Kwok, Z. H., Zhang, B., Chew, X. H., Chan, J. J., Teh, V., Yang, H. H., Kappei, D., & Tay, Y. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-1406 · Cited by 22

Extracellular vesicles in cancer pros and cons: The importance of the evidence-based medicine

Cappello, F., & Fais, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.01.011 · Cited by 23

Tumor-Derived Extracellular Vesicles as Liquid Biopsy for Diagnosis and Prognosis of Solid Tumors: Their Clinical Utility and Reliability as Tumor Biomarkers

Dabral, P., Bhasin, N., Ranjan, M., Makhlouf, M. M., & Elmageed, Z. Y. A. (2024) · Cancers · doi:10.3390/cancers16132462 · Cited by 24

Circulating microRNAs: Next-generation Cancer Detection

Matsuzaki, J., & Ochiya, T. (2020) · The Keio Journal of Medicine · doi:10.2302/kjm.2019-0011-oa · Cited by 21

Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases

Diomaiuto, E., Principe, V., Luca, A. D., Laperuta, F., Alterisio, M. C., & Loria, A. D. (2021) · Pharmaceuticals · doi:10.3390/ph14080766 · Cited by 21

Alleviation of Spinal Cord Injury by MicroRNA 137-Overexpressing Bone Marrow Mesenchymal Stem Cell-Derived Exosomes

Shao, Y., Wang, Q., Liu, L., Wang, J., & Wu, M. (2022) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2022.j118 · Cited by 21

Hypoxia derived exosomes promote the proliferation and metastasis of colorectal cancer through the regulation of HIF-1α/miR-4299/ZBTB4

Wu, L., Xue, M., Lai, S., Chen, J., Lin, Y., Ding, N., Zhong, J., Chen, S., & Wang, L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121872 · Cited by 21

A brief review of exosomes and their roles in cancer

Mollaei, H., Safaralizadeh, R., & Pouladi, N. (2016) · Meta Gene · doi:10.1016/j.mgene.2016.11.010 · Cited by 23

Circulating miR-210 and miR-1246 as potential biomarkers for differentiating hepatocellular carcinoma from metastatic tumors in the liver

Ahmed, E. K., Fahmy, S. A., Effat, H., & Wahab, A. H. A. A. (2018) · Journal of Medical Biochemistry · doi:10.2478/jomb-2018-0010 · Cited by 21

Exosome-Derived microRNA: Efficacy in Cancer

Padda, J., Khalid, K., Khedr, A., Patel, V., Al-Ewaidat, O. A., Tasnim, F., Padda, S., Cooper, A. C., & Jean-Charles, G. (2021) · Cureus · doi:10.7759/cureus.17441 · Cited by 23

MiR-1246 is upregulated and regulates lung cell apoptosis during heat stress in feedlot cattle

Hu, Y. X., Cai, M., Wang, L., Zhang, T.-H., Luo, Z.-G., Zhang, G., & Zuo, F. (2018) · Cell Stress and Chaperones · doi:10.1007/s12192-018-0927-9 · Cited by 20

Extracellular Vesicles for the Diagnosis of Cancers

Xue, Y., Feng, X., Fan, X., Zhu, G., McLaughlan, J. R., Zhang, W., & Chen, X. (2021) · Small Structures · doi:10.1002/sstr.202100096 · Cited by 20

The Role of ncRNAs in the Immune Dysregulation of Preeclampsia

Mora-Palazuelos, C. E., Villegas‐Mercado, C. E., Avendaño-Félix, M. M., Lizárraga-Verdugo, E. R., Romero-Quintana, J. G., López-Gutiérrez, J., Beltrán-Ontiveros, S. A., & Bermúdez, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015215 · Cited by 20

The Uridylyl Transferase TUT7‐Mediated Accumulation of Exosomal miR‐1246 Reprograms TAMs to Support CRC Progression

Feng, Y., Jin, C., Wang, T., Chen, Z., Ji, D., Zhang, Y., Zhang, C., Zhang, D., Peng, W., & Sun, Y. (2024) · Advanced Science · doi:10.1002/advs.202304222 · Cited by 20

Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective

Manne, U., Jadhav, T., Putcha, B. K., Samuel, T., Soni, S., Shanmugam, C., & Suswam, E. A. (2016) · Current Colorectal Cancer Reports · doi:10.1007/s11888-016-0338-1 · Cited by 20

The immunomodulatory role of tumor‐derived extracellular vesicles in colorectal cancer

Manning, S., & Danielson, K. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12038 · Cited by 20

The accuracy of circulating micro RNA ‐21 in the diagnosis of colorectal cancer: a systematic review and meta‐analysis

Xu, F., Xu, L., Wang, M., An, G., & Feng, G. (2015) · Colorectal Disease · doi:10.1111/codi.12917 · Cited by 20

Extracellular vesicle biomarkers in circulation for colorectal cancer detection: a systematic review and meta-analysis

Shi, X., Zhao, X., Xue, J., & Jia, E. (2024) · BMC Cancer · doi:10.1186/s12885-024-12312-8 · Cited by 23

miR clusters target cellular functional complexes by defining their degree of regulatory freedom

Haier, J., Ströse, A., Matuszcak, C., & Hummel, R. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9617-1 · Cited by 19

Emerging Role of Extracellular Vesicles in Biomarking the Gastrointestinal Diseases

Heydari, R., Abdollahpour‐Alitappeh, M., Shekari, F., & Meyfour, A. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1954909 · Cited by 21

Potential Values of Circulating microRNA-21 to Predict Early Recurrence in Patients with Colorectal Cancer after Treatments

Hao, Y.-J., Yang, C., Chen, M., Chang, L.-W., Lin, C., Lo, L., Huang, S., Lyu, Y.-Y., Jiang, J., & Tseng, F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092400 · Cited by 19

Extracellular Vesicles and Epidermal Growth Factor Receptor Activation: Interplay of Drivers in Cancer Progression

Ferlizza, E., Romaniello, D., Borrelli, F., Pagano, F., Girone, C., Gelfo, V., Kuhre, R. S., Morselli, A., Mazzeschi, M., Sgarzi, M., et al. (2023) · Cancers · doi:10.3390/cancers15112970 · Cited by 19

Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis

Arena, G. O., Forte, S., Abdouh, M., Vanier, C. H., Corbeil, D., & Lorico, A. (2023) · Cells · doi:10.3390/cells12121566 · Cited by 18

Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon Cancer Diagnosis

Marassi, V., Giordani, S., Placci, A., Punzo, A., Caliceti, C., Zattoni, A., Reschiglian, P., Roda, B., & Roda, A. (2023) · Sensors · doi:10.3390/s23239432 · Cited by 20

Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine

Dong, X., Lin, Y., Li, K., Liang, G., Huang, X., Pan, J., Wang, L., Zhang, D., Liu, T., Wang, T., et al. (2024) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2024-0188 · Cited by 20

Therapeutic and diagnostic applications of exosomes in colorectal cancer

Shakerian, N., Eslam, E. D., Afsharnoori, F., Bana, N., ghahroodi, F. N., Tarin, M., Mard‐Soltani, M., Khalesi, B., Hashemi, Z. S., & Khalili, S. (2024) · Medical Oncology · doi:10.1007/s12032-024-02440-3 · Cited by 21

Tumor-derived exosomes in cancer metastasis risk diagnosis and metastasis therapy

Jiang, S., Hu, C., Liu, P., & Lu, M. (2018) · Clinical & Translational Oncology · doi:10.1007/s12094-018-1918-0 · Cited by 19

Suppressive effect of an analog of the antimicrobial peptide of LL‑37 on colon cancer cells via exosome‑encapsulated miRNAs

Hayashi, M., Kuroda, K., Ihara, K., Iwaya, T., & Isogai, E. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3875 · Cited by 19

Prognostic Significance of Circulating Tumor Cells with Mesenchymal Phenotypes in Patients with Gastric Cancer: A Prospective Study

Ishiguro, Y., 崎浜, 秀., Yoshida, T., Ichikawa, N., Homma, S., Fukai, M., Kawamura, H., Takahashi, N., & Taketomi, A. (2020) · Annals of Surgical Oncology · doi:10.1245/s10434-020-08827-6 · Cited by 19

Diagnostic and prognostic biomarkers in colorectal cancer and the potential role of exosomes in drug delivery

Sattar, R. S. A., Verma, R., Nimisha, Kumar, A., Dar, G. M., Apurva, A., Sharma, A. K., Kumari, I., Ahmad, E., Ali, A., et al. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110413 · Cited by 18

Towards the realization of clinical extracellular vesicle diagnostics: challenges and opportunities

Yokoi, A., Yoshioka, Y., & Ochiya, T. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1104249 · Cited by 19

MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer

Jafri, M., Zaidi, S. K., Ansari, S. A., Al-Qahtani, M. H., & Shay, J. W. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1069816 · Cited by 18

Circulating serum oncologic miRNA in pediatric juvenile pilocytic astrocytoma patients predicts mural nodule volume

Bookland, M. J., Tang‐Schomer, M. D., Gillan, E., & Kolmakova, A. (2018) · Acta Neurochirurgica · doi:10.1007/s00701-018-3589-6 · Cited by 18

The diagnostic value of exosomal miRNAs in human bile of malignant biliary obstructions

Ge, X., Tang, L., Wang, Y., Wang, N., Zhou, J., Deng, X., Zhong, Y., Li, Q., Wang, F., Jiang, G., et al. (2020) · Digestive and Liver Disease · doi:10.1016/j.dld.2020.11.010 · Cited by 18

Development and Clinical Application of Tumor-derived Exosomes in Patients with Cancer

Verdi, J., Ketabchi, N., Noorbakhsh, N., Saleh, M., Ebrahimi‐Barough, S., Seyhoun, I., & Kavianpour, M. (2021) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x16666210622123942 · Cited by 17

Identification of the Minimum Combination of Serum microRNAs to Predict the Recurrence of Colorectal Cancer Cases

Yoshikawa, Y., Fukunaga, M., Takahashi, J., Shimizu, D., Masuda, T., Mizushima, T., Yamada, K., Mori, M., Eguchi, H., Doki, Y., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-12355-w · Cited by 17

Exosomal miRNAs as novel avenues for breast cancer treatment

Singh, T., Kaushik, M. C., Mishra, L. C., Behl, C., Singh, V. P., & Tuli, H. S. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1134779 · Cited by 17

The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics

Kim, J., Kim, M., Kang, J. Y., Bong, K. W., & Choi, N. (2023) · BioChip Journal · doi:10.1007/s13206-023-00108-0 · Cited by 17

Exosomes: The Indispensable Messenger in Tumor Pathogenesis and the Rising Star in Antitumor Applications

Wang, S., Wang, J., Wei, W., & Ma, G. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900008 · Cited by 17

Serum exosomal miRNA as biomarkers for Retinoblastoma

Ravishankar, H., Mangani, A. S., Moses, G. L. P., Mani, S. P., Parameswaran, S., Khetan, V., Ganesan, S., & Krishnakumar, S. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108184 · Cited by 17

Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One (2014

Ogata-kawata, H., Izumiya, M., Kurioka, D., Honma, Y., Yamada, Y., Furuta, K., Gunji, T., Ohta, H., Okamoto, H., Sonoda, H., et al. (2016)

Four circulating exosomal miRNAs as novel potential biomarkers for the early diagnosis of human colorectal cancer

Shi, Y., Zhuang, Y., Zhang, J., Chen, M., & Wu, S. (2021) · Tissue and Cell · doi:10.1016/j.tice.2021.101499 · Cited by 39

Circulating Exosomal miR-150-5p and miR-99b-5p as Diagnostic Biomarkers for Colorectal Cancer

Zhao, Y. J., Song, X., Niu, L., Tang, Y., Song, X., & Xie, L. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01129 · Cited by 100

Molecular detection of exosomal miRNAs of blood serum for prognosis of colorectal cancer

Bakhsh, T., Alhazmi, S., Farsi, A., Yusuf, A., Alharthi, A., Qahl, S. H., Alghamdi, M. A., Alzahrani, F. A., Elgaddar, O., Ibrahim, M. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-58536-3 · Cited by 28

A panel of six-circulating miRNA signature in serum and its potential diagnostic value in colorectal cancer

Maminezhad, H., Ghanadian, S., Pakravan, K., Razmara, E., Rouhollah, F., Mohammadi, M. M., & Babashah, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118226 · Cited by 53