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A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
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After 6 days of co-culture, ECs acquire tight junctions and transporters typically observed in brain endothelium and display most of the BBB's in vivo properties for at least 20 days.
“After 6 days of co-culture, the ECs acquire the tight junctions and transporters typically observed in brain endothelium and display most of the BBB's in vivo properties for at least 20 days [39].”
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Cites
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Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609
Self-citationNanomaterial-based blood-brain-barrier (BBB) crossing strategies
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Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells
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Human pluripotent stem cell–derived brain pericyte–like cells induce blood-brain barrier properties
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Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery
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Metadata
- Authors
- Cecchelli, R., Aday, S., Sevin, E., Almeida, C., Culot, M., Dehouck, L., Coisne, C., Engelhardt, B., Dehouck, M.-P., & Ferreira, L.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-06-17
- Volume
- 9
- Issue
- 6
- Pages
- e99733
- ISSN
- 1932-6203
- PMC
- PMC4061029
- Cited by
- 349
- References
- 4
- Language
- en
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