Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

The blood-brain barrier

Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437 · see citing works

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,515 · see citing works

Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors

Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333 · see citing works

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Weksler, B. B., Subileau, E.-A., Perrière, N., Charneau, P., Holloway, K. E., Leveque, M., Tricoire-Leignel, H., Nicotra, A., Bourdoulous, S., Turowski, P., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3458fje · Cited by 1,325 · see citing works

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321 · see citing works

Functional morphology of the blood–brain barrier in health and disease

Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872 · see citing works

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630991 · Cited by 843 · see citing works

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J. W., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 831 · see citing works

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.

Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 807 · see citing works

The hCMEC/D3 cell line as a model of the human blood brain barrier

Weksler, B., Romero, I. A., & Couraud, P.-O. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-16 · Cited by 753 · see citing works

Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

Daneman, R., Agalliu, D., Zhou, L., Kuhnert, F., Kuo, C. J., & Barres, B. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805165106 · Cited by 753 · see citing works

The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

Vercauteren, D., Vandenbroucke, R. E., Jones, A. T., Rejman, J., Demeester, J., Smedt, S. C. D., Sanders, N. N., & Braeckmans, K. (2009) · Molecular Therapy · doi:10.1038/mt.2009.281 · Cited by 694 · see citing works

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014) · Genes & Development · doi:10.1101/gad.235473.113 · Cited by 656 · see citing works

Secreted and transmembrane wnt inhibitors and activators

Cruciat, C.-M., & Niehrs, C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a015081 · Cited by 646 · see citing works

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

Stenman, J. M., Rajagopal, J., Carroll, T. J., Ishibashi, M., McMahon, J., & McMahon, A. P. (2008) · Science · doi:10.1126/science.1164594 · Cited by 641 · see citing works

Emerging roles of Wnts in the adult nervous system

Inestrosa, N. C., & Arenas, E. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2755 · Cited by 611 · see citing works

Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K., & Woodgett, J. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.001 · Cited by 449 · see citing works

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

Wang, Y., Rattner, A., Zhou, Y., Williams, J., Smallwood, P. M., & Nathans, J. (2012) · Cell · doi:10.1016/j.cell.2012.10.042 · Cited by 406 · see citing works

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

Janda, C. Y., Dang, L. T., You, C., Chang, J., de Lau, W., Zhong, Z. A., Yan, K. S., Marecic, O., Siepe, D., Li, X., et al. (2017) · Nature · doi:10.1038/nature22306 · Cited by 403 · see citing works

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

Proffitt, K. D., Madan, B., Ke, Z., Pendharkar, V. V., Ding, L., Lee, M. A., Hannoush, R. N., & Virshup, D. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2258 · Cited by 383 · see citing works

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

Cecchelli, R., Aday, S., Sevin, E., Praça, C., Culot, M., Dehouck, L., Coisne, C., Engelhardt, B., Dehouck, M., & Ferreira, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099733 · Cited by 361 · see citing works

Wnts as ligands: processing, secretion and reception

Mikels, A. J., & Nusse, R. (2006) · Oncogene · doi:10.1038/sj.onc.1210053 · Cited by 353 · see citing works

Canonical WNT signaling components in vascular development and barrier formation

Zhou, Y., Wang, Y., Tischfield, M. A., Williams, J., Smallwood, P. M., Rattner, A., Taketo, M. M., & Nathans, J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76431 · Cited by 353 · see citing works

An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/ <i>wingless</i> signaling pathway

Gonsalves, F. C., Klein, K., Carson, B. B., Katz, S., Ekas, L. A., Evans, S., Nagourney, R., Cardozo, T., Brown, A. M. C., & DasGupta, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017496108 · Cited by 337 · see citing works

The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies

Poller, B., Gutmann, H., Krähenbühl, S., Weksler, B. B., Romero, I. A., Couraud, P., Tuffin, G., Drewe, J., & Huwyler, J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05730.x · Cited by 318 · see citing works

The R-spondin protein family

de Lau, W. B. M., Snel, ‎., & Clevers, H. C. (2012) · Genome biology · doi:10.1186/gb-2012-13-3-242 · Cited by 298 · see citing works

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298 · see citing works

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

Lim, R. G., Quan, C., Reyes-Ortiz, A. M., Lutz, S. E., Kedaigle, A. J., Gipson, T. A., Wu, J., Vatine, G. D., Stocksdale, J., Casale, M. S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.021 · Cited by 253 · see citing works

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood–Brain Barrier Integrity and Central Nervous System Homeostasis

Tran, K. A., Zhang, X., Predescu, D., Huang, X., Machado, R. F., Göthert, J. R., Malik, A. B., Valyi-Nagy, T., & Zhao, Y.-Y. (2016) · Circulation · doi:10.1161/circulationaha.115.015982 · Cited by 219 · see citing works

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca 2+ /NFAT Signaling

Scholz, B., Korn, C., Wojtarowicz, J., Mogler, C., Augustin, I., Boutros, M., Niehrs, C., & Augustin, H. G. (2016) · Developmental Cell · doi:10.1016/j.devcel.2015.12.015 · Cited by 182 · see citing works

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance

Wang, Y., Cho, C., Williams, J., Smallwood, P. M., Zhang, C., Junge, H. J., & Nathans, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813217115 · Cited by 168 · see citing works

Activation of β‐catenin signalling by GSK‐3 inhibition increases p‐glycoprotein expression in brain endothelial cells

Lim, J. C., Kania, K., Wijesuriya, H. C., Chawla, S., Sethi, J. K., Pułaski, Ł., Romero, I. A., Couraud, P. O., Weksler, B. B., Hladky, S. B., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05537.x · Cited by 165 · see citing works

ABC transporters at the blood–brain barrier

Mahringer, A., & Fricker, G. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2016.1168804 · Cited by 165 · see citing works

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis

Okamoto, M., Inoue, K., Iwamura, H., Terashima, K., Soya, H., Asashima, M., & Kuwabara, T. (2011) · The FASEB Journal · doi:10.1096/fj.11-184697 · Cited by 162 · see citing works

Wnts in adult brain: from synaptic plasticity to cognitive deficiencies

Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162 · see citing works

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

Franco, C. A., Jones, M. L., Bernabéu, M. O., Vion, A.-C., Barbacena, P., Fan, J., Mathivet, T., Fonseca, C. G., Ragab, A., Yamaguchi, T. P., et al. (2016) · eLife · doi:10.7554/elife.07727 · Cited by 154 · see citing works

Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis

Lengfeld, J. E., Lutz, S. E., Smith, J. R., Diaconu, C., Scott, C., Kofman, S. B., Choi, C., Walsh, C. M., Raine, C. S., Agalliu, I., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609905114 · Cited by 152 · see citing works

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

Valkenburg, K. C., Graveel, C. R., Diegel, C. R., Zhong, Z. A., & Williams, B. O. (2011) · Cancers · doi:10.3390/cancers3022050 · Cited by 141 · see citing works

Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers

Fontaine, M., Elmquist, W. F., & Miller, D. W. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00483-3 · Cited by 133 · see citing works

Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis

Korn, C., Scholz, B., Hu, J., Srivastava, K., Wojtarowicz, J., Arnsperger, T., Adams, R. H., Boutros, M., Augustin, H. G., & Augustin, I. (2014) · Development · doi:10.1242/dev.104422 · Cited by 131 · see citing works

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by <i>Cryptococcus neoformans</i>

Vu, K., Weksler, B., Romero, I., Couraud, P.-O., & Gelli, A. (2009) · Eukaryotic Cell · doi:10.1128/ec.00240-09 · Cited by 124 · see citing works

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

Bardelmeijer, H. A., Beijnen, J. H., Brouwer, K. R., Rosing, H., Nooijen, W. J., Schellens, J. H. M., & van Tellingen, O. (2000) · PubMed · Cited by 121 · see citing works

Mapping of Wnt‐Frizzled interactions by multiplex CRISPR targeting of receptor gene families

Voloshanenko, O., Gmach, P., Winter, J., Kranz, D., & Boutros, M. (2017) · The FASEB Journal · doi:10.1096/fj.201700144r · Cited by 118 · see citing works

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

Paolinelli, R., Corada, M., Ferrarini, L., Devraj, K., Artus, C., Czupalla, C. J., Rudini, N., Maddaluno, L., Papa, E., Engelhardt, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070233 · Cited by 115 · see citing works

Plasmalemma vesicle-associated protein: A crucial component of vascular homeostasis

Guo, L., Zhang, H., Hou, Y., Wei, T., & Liu, J. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3557 · Cited by 115 · see citing works

Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling

Goodwin, A. M., Sullivan, K., & D'Amore, P. A. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20939 · Cited by 111 · see citing works

Plasmalemmal Vesicle Associated Protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models

Shue, E. H., Carson-Walter, E. B., Liu, Y., Winans, B., Ali, Z. S., Chen, J., & Walter, K. A. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-29 · Cited by 109 · see citing works

Wnt2 acts as a cell type–specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway

Klein, D., Demory, A., Peyre, F., Krøll, J., Augustin, H. G., Helfrich, W., Kzhyshkowska, J. G., Schledzewski, K., Arnold, B., & Goerdt, S. (2008) · Hepatology · doi:10.1002/hep.22084 · Cited by 109 · see citing works

Dysfunctional Wnt/β-catenin signaling contributes to blood–brain barrier breakdown in Alzheimer’s disease

Liu, L., Wan, W., Xia, S., Kalionis, B., & Li, Y. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.05.004 · Cited by 94 · see citing works

Abcg2/Bcrp1 Mediates the Polarized Transport of Antiretroviral Nucleosides Abacavir and Zidovudine

Pan, G., Giri, N., & Elmquist, W. F. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.014274 · Cited by 90 · see citing works

The Blood-Brain Barrier

Dyrna, F. G. E., Hanske, S., Krueger, M. C., & Bechmann, I. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9473-5 · Cited by 79 · see citing works

Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice

Herrnberger, L., Seitz, R., Kuespert, S., Bösl, M. R., Fuchshofer, R., & Tamm, E. R. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0987-3 · Cited by 76 · see citing works

Real-time cell analysis – A new method for dynamic, quantitative measurement of infectious viruses and antiserum neutralizing activity

Teng, Z., Kuang, X., Wang, J., & Zhang, X. (2013) · Journal of Virological Methods · doi:10.1016/j.jviromet.2013.06.034 · Cited by 64 · see citing works

Development of a direct contact astrocyte-human cerebral microvessel endothelial cells blood–brain barrier coculture model

Kulczar, C. D., Lubin, K. E., Lefebvre, S., Miller, D. W., & Knipp, G. T. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12803 · Cited by 62 · see citing works

The Cross-Talk between Canonical and Non-Canonical Wnt-Dependent Pathways Regulates P-Glycoprotein Expression in Human Blood–Brain Barrier Cells

Pinzón‐Daza, M. L., Salaroglio, I. C., Kopecka, J., Garzón, R., Couraud, P., Ghigo, D., & Riganti, C. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.100 · Cited by 53 · see citing works

Transporter-Based Delivery of Anticancer Drugs to the Brain: Improving Brain Penetration by Minimizing Drug Efflux at the Blood-Brain Barrier

On, N. H., & Miller, D. W. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990458 · Cited by 47 · see citing works

P-Glycoprotein, Breast Cancer Resistance Protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during Blood–Brain Barrier Maturation: Involvement of Wnt/β-Catenin and Endothelin-1 Signaling

Harati, R., Bénech, H., Villégier, A., & Mabondzo, A. M. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300334r · Cited by 46 · see citing works

Morphogens and blood-brain barrier function in health and disease

Wevers, N. R., & de Vries, H. E. (2015) · Tissue Barriers · doi:10.1080/21688370.2015.1090524 · Cited by 42 · see citing works

Reduction in cardiolipin decreases mitochondrial spare respiratory capacity and increases glucose transport into and across human brain cerebral microvascular endothelial cells

Nguyen, H., Mejia, E. M., Chang, W., Wang, Y., Watson, E. J., On, N. H., Miller, D. W., & Hatch, G. M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13753 · Cited by 26 · see citing works

Vascular changes in the cerebellum of Norrin /Ndph knockout mice correlate with high expression of Norrin and Frizzled‐4

Luhmann, U. F. O., Neidhardt, J., Kloeckener‐Gruissem, B., Schäfer, N., Glaus, E., Feil, S., & Berger, W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06237.x · Cited by 21 · see citing works

Assessment of P-glycoprotein Activity in the Blood-Brain Barrier (BBB) Using Near Infrared Fluorescence (NIRF) Imaging Techniques

On, N. H., Chen, F., Hinton, M., & Miller, D. W. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0478-6 · Cited by 19 · see citing works

Differential internalization of brick shaped iron oxide nanoparticles by endothelial cells

Sun, Z., Worden, M., Wroczynskyj, Y., Manna, P. K., Thliveris, J. A., van Lierop, J., Hegmann, T., & Miller, D. W. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01480a · Cited by 11 · see citing works

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

Takata, F., Nakagawa, S., Matsumoto, J., & Dohgu, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.661838 · Cited by 651 · see citing works

Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases

Vojdani, A., Vojdani, E., & Kharrazian, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.617089 · Cited by 322 · see citing works

Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease

Wang, Q., Huang, X., Su, Y., Yin, G., Wang, S., Yu, B., Li, H., Qi, J., Chen, H., Zeng, W., et al. (2022) · Brain · doi:10.1093/brain/awac236 · Cited by 219 · see citing works

P-glycoprotein: new insights into structure, physiological function, regulation and alterations in disease

Juvale, I. I. A., Hamid, A. A. A., Halim, K. B. A., & Has, A. T. C. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09777 · Cited by 191 · see citing works

ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery

Schulz, J., Hartz, A. M. S., & Bauer, B. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000025 · Cited by 109 · see citing works

Regulation of P-Glycoprotein in the Brain

Chai, A. B., Callaghan, R., & Gelissen, I. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314667 · Cited by 97 · see citing works

Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges

Parrasia, S., Szabó, I., Zoratti, M., & Biasutto, L. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00523 · Cited by 90 · see citing works

A review on in vitro model of the blood-brain barrier (BBB) based on hCMEC/D3 cells

Qi, D., Lin, H., Hu, B., & Wei, Y. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.04.020 · Cited by 87 · see citing works

Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases

Otto, E., Knapstein, P., Jahn, D., Appelt, J., Frosch, K., Tsitsilonis, S., & Keller, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144946 · Cited by 87 · see citing works

Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

Gastfriend, B. D., Nishihara, H., Canfield, S. G., Foreman, K. L., Engelhardt, B., Palecek, S. P., & Shusta, E. V. (2021) · eLife · doi:10.7554/elife.70992 · Cited by 86 · see citing works

Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke

Var, S. R., Shetty, A. V., Grande, A. W., Low, W. C., & Cheeran, M. C. ‐. (2021) · Cells · doi:10.3390/cells10123555 · Cited by 86 · see citing works

Dysregulated Wnt Signalling in the Alzheimer’s Brain

Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70 · see citing works

Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice

Ding, J., Lee, S., Vlahos, L. J., Yuki, K., Rada, C. C., van Unen, V., Vuppalapaty, M., Chen, H., Sura, A., McCormick, A. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37689-1 · Cited by 68 · see citing works

Endothelial β-Catenin Deficiency Causes Blood-Brain Barrier Breakdown via Enhancing the Paracellular and Transcellular Permeability

Hussain, B., Fang, C., Huang, X., Feng, Z., Yao, Y., Wang, Y., & Chang, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.895429 · Cited by 59 · see citing works

Blood–Brain Barrier Transporters: Opportunities for Therapeutic Development in Ischemic Stroke

Nilles, K. L., Williams, E. I., Betterton, R. D., Davis, T. P., & Ronaldson, P. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031898 · Cited by 56 · see citing works

Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood–Brain Barrier

Hashimoto, Y., Campbell, M., Tachibana, K., Okada, Y., & Kondoh, M. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00408 · Cited by 54 · see citing works

Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity

Chen, X., Momin, A., Wanggou, S., Wang, X., Min, H.-K., Dou, W., Gong, Z., Chan, J., Dong, W., Fan, J. J., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.007 · Cited by 53 · see citing works

A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance

Karve, A. S., Desai, J. M., Gadgil, S. N., Dave, N., Wise-Draper, T. M., Gudelsky, G. A., Phoenix, T. N., Dasgupta, B., Yogendran, L., Sengupta, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063217 · Cited by 49 · see citing works

Endothelial dysfunctions in blood-brain barrier breakdown in alzheimer's disease: from mechanisms to potential therapies

Yue, Q., Leng, X., Xie, N., Zhang, Z., Yang, D., & Hoi, M. P. M. (2024) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/cns.70079 · Cited by 48 · see citing works

miR-27a-3p regulates expression of intercellular junctions at the brain endothelium and controls the endothelial barrier permeability

Harati, R., Hammad, S., Tlili, A., Mahfood, M., Mabondzo, A. M., & Hamoudi, R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262152 · Cited by 47 · see citing works

Laminar Flow Protects Vascular Endothelial Tight Junctions and Barrier Function via Maintaining the Expression of Long Non-coding RNA MALAT1

Yang, F., Zhang, Y., Zhu, J., Wang, J., Jiang, Z., Zhao, C., Yang, Q., Huang, Y., Yao, W., Pang, W., et al. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00647 · Cited by 42 · see citing works

Dynamic modulation of the blood–brain barrier in the healthy brain

Friedman, A., Prager, O., Serlin, Y., & Kaufer, D. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00976-5 · Cited by 43 · see citing works

Multiplexed chemogenetics in astrocytes and motoneurons restore blood–spinal cord barrier in ALS

Alami, N. O., Tang, L., Wiesner, D., Commisso, B., Bayer, D., Weishaupt, J. H., Dupuis, L., Wong, P. C., Baumann, B., Wirth, T., et al. (2020) · Life Science Alliance · doi:10.26508/lsa.201900571 · Cited by 39 · see citing works

Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?

Behrooz, A. B., & Syahir, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.642719 · Cited by 38 · see citing works

Synergistic induction of blood–brain barrier properties

Porkoláb, G., Mészáros, M., Szecskó, A., Vigh, J. P., Walter, F. R., de Figueiredo, R. M., Kálomista, I., Hoyk, Z., Vizsnyiczai, G., Gróf, I., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2316006121 · Cited by 36 · see citing works

Aging of the Vascular System and Neural Diseases

Watanabe, C., Imaizumi, T., Kawai, H., Suda, K., Honma, Y., Ichihashi, M., Ema, M., & Mizutani, K. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.557384 · Cited by 34 · see citing works

Lab-on-a-chip models of the blood–brain barrier: evolution, problems, perspectives

Deli, M. A., Porkoláb, G., Kincses, A., Mészáros, M., Szecskó, A., Kocsis, A. E., Vigh, J. P., Valkai, S., Veszelka, S., Walter, F. R., et al. (2024) · Lab on a Chip · doi:10.1039/d3lc00996c · Cited by 35 · see citing works

Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway

Knotek, T., Janečková, L., Kriška, J., Kořínek, V., & Anděrová, M. (2020) · Genes · doi:10.3390/genes11070804 · Cited by 35 · see citing works

Study of BBB Dysregulation in Neuropathogenicity Using Integrative Human Model of Blood–Brain Barrier

Gama, C. S. D., & Morin‐Brureau, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.863836 · Cited by 35 · see citing works

Transporter-Mediated Delivery of Small Molecule Drugs to the Brain: A Critical Mechanism That Can Advance Therapeutic Development for Ischemic Stroke

Williams, E. I., Betterton, R. D., Davis, T. P., & Ronaldson, P. T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020154 · Cited by 33 · see citing works

On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer’s Disease

Kriška, J., Heřmanová, Z., Knotek, T., Turečková, J., & Anděrová, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189689 · Cited by 33 · see citing works

The Role of MiR-181 Family Members in Endothelial Cell Dysfunction and Tumor Angiogenesis

Yang, C., Gibson, V. P., & Hardy, P. (2022) · Cells · doi:10.3390/cells11101670 · Cited by 30 · see citing works

Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

Taggi, V., Riera‐Romo, M., Piquette‐Miller, M., zu Schwabedissen, H. E. M., & Neuhoff, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071376 · Cited by 30 · see citing works

Molecular Insights to the Wnt Signaling During Alzheimer’s Disorder: a Potential Target for Therapeutic Interventions

Nagu, P., Sharma, V., Behl, T., Pathan, A. K., & Mehta, V. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01940-5 · Cited by 28 · see citing works

A guide for blood–brain barrier models

Soliman, Y., Al‐khodor, J., Koken, G. Y., & Mustafaoğlu, N. (2024) · FEBS Letters · doi:10.1002/1873-3468.15053 · Cited by 27 · see citing works

The Role of the Wnt Pathway in VEGF/Anti-VEGF-Dependent Control of the Endothelial Cell Barrier

Li, Y., Baccouche, B., Olayinka, O., Serikbaeva, A., & Kazlauskas, A. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.12.17 · Cited by 26 · see citing works

Influence of traumatic brain injury on extracellular tau elimination at the blood–brain barrier

Eisenbaum, M., Pearson, A., Gratkowski, A., Mouzon, B., MULLAN, M. J., Crawford, F., Ojo, J. O., & Bachmeier, C. J. (2021) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00283-y · Cited by 25 · see citing works

Prenatal intake of omega‐3 promotes Wnt/β‐catenin signaling pathway, and preserves integrity of the blood–brain barrier in preeclamptic rats

ShamsEldeen, A. M., Mehesen, M. N., Aboulhoda, B. E., Rashed, L. A., Elsebaie, M. M., Mohamed, E. A., & Gamal, M. (2021) · Physiological Reports · doi:10.14814/phy2.14925 · Cited by 25 · see citing works

Escherichia coli NF73‐1 disrupts the gut–vascular barrier and aggravates high‐fat diet‐induced fatty liver disease via inhibiting Wnt/β‐catenin signalling pathway

Ke, Z., Huang, Y., Xu, J., Liu, Y., Zhang, Y., Wang, Y., Zhang, Y. Y., & Liu, Y. (2024) · Liver International · doi:10.1111/liv.15823 · Cited by 22 · see citing works

Impact of Wnt/β‐catenin signaling on ethanol‐induced changes in brain endothelial cell permeability

Laksitorini, M. D., Yathindranath, V., Xiong, W., Parkinson, F. E., Thliveris, J. A., & Miller, D. W. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15203 · Cited by 24 · see citing works

Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood–Brain Barrier

Cogill, S. A., Lee, J.-H., Jeon, M., Kim, D.-G., & Chang, Y. (2024) · Cells · doi:10.3390/cells13100789 · Cited by 20 · see citing works

Blood–Brain Barrier Dynamic Device with Uniform Shear Stress Distribution for Microscopy and Permeability Measurements

Choublier, N., Müller, Y., Baisac, L. G., Laedermann, J., de Rham, C., Declèves, X., & Roux, A. (2021) · Applied Sciences · doi:10.3390/app11125584 · Cited by 20 · see citing works

Single nuclei transcriptomics in diabetic mice reveals altered brain hippocampal endothelial cell function, permeability, and behavior

Nuthikattu, S., Milenković, D., Norman, J., & Villablanca, A. C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166970 · Cited by 19 · see citing works

Gestational Fisetin Exerts Neuroprotection by Regulating Mitochondria-Directed Canonical Wnt Signaling, BBB Integrity, and Apoptosis in Prenatal VPA-Induced Rodent Model of Autism

Mehra, S., Ahsan, A. U., Sharma, M., Budhwar, M., & Chopra, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03826-6 · Cited by 18 · see citing works

Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

Tong, Y., An, P., Tang, P., Mu, R., Zeng, Y., Sun, H., Zhao, M., Lv, Z., Wang, P., Han, W., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.03.024 · Cited by 18 · see citing works

Cadmium modulates intestinal Wnt/β-catenin signaling ensuing intestinal barrier disruption and systemic inflammation

Verma, M., Garg, M., Khan, A. S., Yadav, P., Rahman, S. S., Ali, A., & Kamthan, M. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116337 · Cited by 19 · see citing works

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB, and Wnt/β-Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis and Chronic Fatigue Syndrome

Maes, M. H. J., Kubera, M., & Kotańska, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.822382 · Cited by 18 · see citing works

Dynamics of Endothelial Cell Diversity and Plasticity in Health and Disease

Larionov, A. A., Hammer, C. M., Fiedler, K., & Filgueira, L. (2024) · Cells · doi:10.3390/cells13151276 · Cited by 18 · see citing works

Non-alcoholic Fatty Liver Disease: Also a Disease of the Brain? A Systematic Review of the Preclinical Evidence

Mikkelsen, A. C. D., Kjærgaard, K., Mookerjee, R. P., Vilstrup, H., Wegener, G., Bay-Richter, C., & Thomsen, K. L. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03551-x · Cited by 16 · see citing works

Macrophage-derived Wnt signaling increases endothelial permeability during skeletal muscle injury

Tusavitz, S., Keoonela, S., Kalkstein, M., McCormick, S., Gasser, B., Arrigale, M., Rafferty, P., & Carpenter, A. C. (2020) · Inflammation Research · doi:10.1007/s00011-020-01397-z · Cited by 15 · see citing works

SOMAmer reagents and the SomaScan platform: Chemically modified aptamers and their applications in therapeutics, diagnostics, and proteomics

Schneider, D. J., Lynch, S. A., Gelinas, A. D., Ostroff, R. M., Rohloff, J. C., Williams, P., Janjić, N., & Drolet, D. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821595-1.00007-5 · Cited by 14 · see citing works

Causal associations and genetic overlap between COVID-19 and intelligence

Cao, H., Baranova, A. V., Song, Y., Chen, J., & Zhang, F. (2023) · QJM · doi:10.1093/qjmed/hcad122 · Cited by 15 · see citing works

Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation

Manukjan, N., Chau, S., Caiment, F., van Herwijnen, M. H. M., Smeets, H. J. M., Fulton, D. J., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03872-0 · Cited by 15 · see citing works

Regulation of P-glycoprotein by miR-27a-3p at the Brain Endothelial Barrier

Hammad, S., Mabondzo, A. M., Hamoudi, R., & Harati, R. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.10.021 · Cited by 15 · see citing works

Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme

Senthilathiban, D. P., Kuduvalli, S. S., Purushothaman, M., Marimuthu, P., Muralidharan, A. R., & Anitha, T. S. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467214666210420115431 · Cited by 14 · see citing works

Blood‑brain barrier dysfunction in schizophrenia: Mechanisms and implications (Review)

Lv, S., & Luo, C. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5594 · Cited by 16 · see citing works

A Cell-Based Nasal Model for Screening the Deposition, Biocompatibility, and Transport of Aerosolized PLGA Nanoparticles

Maaz, A., Blagbrough, I. S., & Bank, P. D. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00639 · Cited by 13 · see citing works

Bradykinin/bradykinin 1 receptor promotes brain microvascular endothelial cell permeability and proinflammatory cytokine release by downregulating Wnt3a

Huang, L., Liu, M., Jiang, W., Ding, H., Han, Y., Wen, M., Li, Y., Liu, X., & Zeng, H. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23213 · Cited by 13 · see citing works

The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression

Zhang, H., Yamaguchi, T., & Kawabata, K. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00408-5 · Cited by 13 · see citing works

Simulated Microgravity Alters P-Glycoprotein Efflux Function and Expression via the Wnt/β-Catenin Signaling Pathway in Rat Intestine and Brain

Liu, H., Liang, M., Deng, Y., & Li, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065438 · Cited by 13 · see citing works

Mfsd2a regulates the blood-labyrinth-barrier formation and function through tight junctions and transcytosis

Xu, X., Xu, K., Chen, F., Yu, D., & Wang, X. (2024) · Hearing Research · doi:10.1016/j.heares.2024.109048 · Cited by 12 · see citing works

X-linked genetic risk factors that promote autoimmunity and dampen remyelination are associated with multiple sclerosis susceptibility

Borziak, K., & Finkelstein, J. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.104065 · Cited by 12 · see citing works

Molecular Heterogeneity of the Brain Endothelium

Alnaqbi, N., Mohammad, M. G., Hamoudi, R., Mabondzo, A. M., & Harati, R. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040227 · Cited by 12 · see citing works

Nano‑selenium alleviates cadmium-induced blood-brain barrier destruction by restoring the Wnt7A/β-catenin pathway

Li, C.-X., Talukder, M., Wang, Z., Zhu, S., Xu, Y., Li, X., & Li, J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173249 · Cited by 10 · see citing works

Mechanical factors influence β-catenin localization and barrier properties

Wu, X., Cesarovic, N., Falk, V., Mazza, E., & Giampietro, C. (2024) · Integrative Biology · doi:10.1093/intbio/zyae013 · Cited by 10 · see citing works

PLVAP is associated with glioma-associated malignant processes and immunosuppressive cell infiltration as a promising marker for prognosis

Ma, K., Chen, X., Zhao, X., Chen, S., & Yang, J. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10298 · Cited by 10 · see citing works

REMOVED: Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51

Sharma, H. S., Lafuente, J. V., Feng, L., Muresanu, D. F., Menon, P. K., Nozari, A., Sahib, S., Tian, Z. R., Buzoianu, A. D., Sjöquist, P.-O. B., et al. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.06.008 · Cited by 9 · see citing works

Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders

Bicker, J., Alves, G., Fonseca, C., Falcão, A. C., & Fortuna, A. C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105226 · Cited by 9 · see citing works

A Drug Screening Reveals Minocycline Hydrochloride as a Therapeutic Option to Prevent Breast Cancer Cells Extravasation across the Blood–Brain Barrier

Godinho-Pereira, J., Lopes, M. D., Garcia, A. R., Botelho, H. M., Malhó, R., Figueira, I., & Brito, M. A. (2022) · Biomedicines · doi:10.3390/biomedicines10081988 · Cited by 8 · see citing works

Protocadherin gamma C3: a new player in regulating vascular barrier function

Burek, M., Kaupp, V., Blecharz-Lang, K. G., Dilling, C., & Meybohm, P. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.343896 · Cited by 6 · see citing works

Breast Cancer Brain Metastasis: Bridging Biological Mechanisms to Therapeutic Innovations

Feng, J. Q., Tao, Y., Li, F., & Liu, S. (2025) · MedComm – Oncology · doi:10.1002/mog2.70043 · Cited by 6 · see citing works

A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia

Li, G., Ma, Y., Zhang, S., Lin, W., Yao, X. Y., Zhou, Y., Zhao, Y., Rao, Q., Qu, Y.-J., Gao, Y., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103415 · Cited by 6 · see citing works

Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions

de Jager, C., Soliman, E., & Theus, M. H. (2025) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2025.104003 · Cited by 6 · see citing works

Tight Junction Regulation in Blood–Brain Barrier Integrity and Neurological Diseases

Nguyen, T. H., Pham, T. K. A., Tran, T. T. T., Trinh, K. N., Dhananjayan, S. S., Bui, A. T. T., Kim, N. D. T., Ho, H. H. N., Rai, A., Lee, C.-W., et al. (2026) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-25-00078 · Cited by 5 · see citing works

Biochemical‐ and Biophysical‐Induced Barriergenesis in the Blood–Brain Barrier: A Review of Barriergenic Factors for Use in In Vitro Models

Schofield, C. L., Rodrigo‐Navarro, A., Dalby, M. J., Agtmael, T. V., & Salmerón‐Sánchez, M. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000068 · Cited by 5 · see citing works

NanoIEA: A Nanopatterned Interdigitated Electrode Array‐Based Impedance Assay for Real‐Time Measurement of Aligned Endothelial Cell Barrier Functions

Choi, J. S., Doo, H. M., Kim, B., Lee, S. H., Sung, S., Go, G., Suarez, A., Kim, Y., Weon, B. M., Choi, B., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301124 · Cited by 5 · see citing works

Slow release of oxygen from carbamide peroxide for promoting the proliferation of human brain microvascular endothelial cells under hypoxia

Meng, X., Sun, Y., Wang, L., Li, Y., Ouyang, R., Yuan, P., & Miao, Y. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-8137 · Cited by 5 · see citing works

Plasma extracellular vesicles from <i>APOE3</i> Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease

Pineda‐Lopez, L., Aguillon, D., Villar‐Vesga, J., Valderrama‐Carmona, P., Guerrero, A., Upreti, A., Arevalo‐Alquichire, S., Correa, L., Mendez‐Castellanos, K., Castaño, D., et al. (2026) · Alzheimer's &amp; Dementia · doi:10.1002/alz.71148 · Cited by 4 · see citing works

Interaction of major facilitator superfamily domain containing 2A with the blood–brain barrier

Ma, Y., Dong, T., Luan, F., Yang, J., Feng, M., & Wei, P. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00191 · Cited by 4 · see citing works

Valosin-containing protein (VCP), a component of tumor-derived extracellular vesicles, impairs the barrier integrity of brain microvascular endothelial cells

Teles, R. H. G., Villarinho, N. J., Yamagata, A. S., Hiroki, C. T., de Oliveira, M. C., Terçarioli, G. R., Jaeger, R. G., Meybohm, P., Burek, M., & Freitas, V. M. (2024) · BBA Advances · doi:10.1016/j.bbadva.2024.100130 · Cited by 4 · see citing works

The association of the Wnt/β-catenin signaling pathway with Alzheimer's disease

Ma, J., Liu, Y., Lu, D., & Sun, Q. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110754 · Cited by 4 · see citing works

The role of blood-brain barrier integrity in the pathophysiology and progression of psychiatric disorders

Konstantinou, G., & Warsh, J. J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106658 · Cited by 6 · see citing works

Laser interstitial thermal therapy enhances bidirectional blood-brain barrier permeability in glioblastoma

Cleary, R. T., Fu, Y., Giles, D., Yuan, J., Garcia, D. P. M., Palmer, D., Han, R. H., Woodiwiss, T. R., Yang, A. B., Mathios, D., et al. (2026) · Neuro-Oncology · doi:10.1093/neuonc/noag080 · Cited by 4 · see citing works

Transport pathways across the blood-brain barrier for waste clearance and drug delivery

Gröbner, L. S., & Pietrzik, C. U. (2026) · Fluids and Barriers of the CNS · doi:10.1186/s12987-026-00812-7 · Cited by 4 · see citing works

Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy

An, P., Tong, Y., Mu, R., & Han, L. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00537 · Cited by 4 · see citing works

Inactivation of the Wnt/β-catenin signaling contributes to the epithelial barrier dysfunction induced by sodium oxalate in canine renal epithelial cells

Ji, Y. S., Fang, S., Yang, Y., & Wu, Z. (2021) · Journal of Animal Science · doi:10.1093/jas/skab268 · Cited by 4 · see citing works

Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cellsPreprint

Gastfriend, B. D., Nishihara, H., Canfield, S. G., Foreman, K. L., Engelhardt, B., Palecek, S. P., & Shusta, E. V. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.12.443828 · Cited by 4 · see citing works

SARS-CoV-2 Infection Influences Wnt/β-Catenin Pathway Components in Astrocytes

Robinson, K. F., Ahiya, A. I., Richner, J. M., & Lutz, S. E. (2025) · Pathogens · doi:10.3390/pathogens14100994 · Cited by 3 · see citing works

The Impact of Neurotoxin Proteins Trafficked by Primary Cilia and Extracellular Vesicles in Neurodegenerative Diseases

Danna, R., Kondle, S., Amar, O., Mabourakh, M., Chen, G., Fadol, W. B., & Mohieldin, A. M. (2025) · Biology · doi:10.3390/biology14121787 · Cited by 2 · see citing works

Dual ligand cooperation at the plasma membrane drives transport of engineered small extracellular vesicles across brain endothelial cells

Albino, I., Ambrosetti, E., Vaz, M., Teixeira, A. I., Sampaio, P., Lino, M. M., & Ferreira, L. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114974 · Cited by 2 · see citing works

An easy-to-perform method for microvessel isolation and primary brain endothelial cell culture to study Alzheimer's disease

Chen, Y., Huang, X., Chen, H., & Yi, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33077 · Cited by 2 · see citing works

Role of the WNT signalling pathway in physiological and pathological blood-brain barrier

Yang, F., Wang, F., Jiang, Y., Qian, D., & Chen, L. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2657638 · Cited by 1 · see citing works

Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.

Dong, X., Sun, H., Mao, J., Zhang, S., & Meng, C. (2021) · PubMed Central · doi:10.11817/j.issn.1672-7347.2021.200692 · Cited by 1 · see citing works

Blood brain barrier disruption following COVID-19 infection and neurological manifestations

Deshwal, S., Dhiman, N., & Sandhir, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15256-6.00005-2 · Cited by 1 · see citing works

Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD 4 -selective WNT surrogatePreprint

Ding, J., Lee, S., Vlahos, L. J., Yuki, K., Rada, C. C., van Unen, V., Vuppalapaty, M., Chen, H., Sura, A., McCormick, A. K., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.13.510564 · Cited by 1 · see citing works

Control of Neuroinflammation and Protecting the Integrity of the Blood-Brain Barrier

Rom, S., & Persidsky, Y. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_42

Mercury-Induced Cerebral Hemorrhage Through Impairing Blood-Brain Barrier Function Via Wnt Signaling InhibitionPreprint

Zhang, X., Wang, L., Li, Y., Liu, Z., Zhang, T., Yeqi, W. A. N. G., & Wang, G. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5149581

Meta-analysis of RNA-seq Data Identifies Involvement of Interferon-Induced Genes to Facilitate Blood–Brain Barrier Traversal of Neuroinvasive Pathogens

Kulkarni, A. D., Alagundagi, D. B., Bhide, M. R., & Patil, P. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02400-0

Additional file 1 of The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression

Zhang, H., Yamaguchi, T., & Kawabata, K. (2024) · Figshare · doi:10.6084/m9.figshare.26565687

Lef1 is dispensable for blood-brain barrier integrity despite its dominant role in endothelial Wnt signalingPreprint

Yeretz‐Peretz, Y., Anzi, S., Bell, B., & Ben‐Zvi, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.14.711770

Wnt/β-catenin signaling controls development of the blood–brain barrier

Liebner, S., Corada, M., Bangsow, T., Babbage, J. W., Taddei, A., Czupalla, C. J., Reis, M., Felici, A., Wolburg, H., Fruttiger, M., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200806024 · Cited by 831 · see citing works

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

Paolinelli, R., Corada, M., Ferrarini, L., Devraj, K., Artus, C., Czupalla, C. J., Rudini, N., Maddaluno, L., Papa, E., Engelhardt, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070233 · Cited by 115 · see citing works

Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier

Vitro, I., Paolinelli, R., Corada, M., Ferrarini, L., Devraj, K., Czupalla, C. J., Rudini, N., Maddaluno, L., Papa, E., Engelhardt, B., et al. (2016)

Wnt7a Decreases Brain Endothelial Barrier Function Via β-Catenin Activation

Manukjan, N., Chau, S., Caiment, F., van Herwijnen, M. H. M., Smeets, H. J. M., Fulton, D. J., Ahmed, Z., Blankesteijn, W. M., & Foulquier, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03872-0 · Cited by 15 · see citing works

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Pinto, H. N., Kok, N., Hauger, P. C., Diepen, M. K.-V., de Kok, M., Paauw, N. J., van der Pol, S. M. A., Nugteren‐Boogaard, J. P., Hordijk, P. L., Beekhuis-Hoekstra, S. D., et al. (2026) · Small Methods · doi:10.1002/smtd.202502114 · Cited by 4 · see citing works