Comparing Cutaneous Research Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases with 2010 Global Burden of Disease Results
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IMPORTANCE: Disease burden data helps guide research prioritization. OBJECTIVE: To determine the extent to which grants issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) reflect disease burden, measured by disability-adjusted life years (DALYs) from Global Burden of Disease (GBD) 2010 project. DESIGN: Two investigators independently assessed 15 skin conditions studied by GBD 2010 in the NIAMS database for grants issued in 2013. The 15 skin diseases were matched to their respective DALYs from GBD 2010. SETTING: The United States NIAMS database and GBD 2010 skin condition disability data. MAIN OUTCOME(S) AND MEASURE(S): Relationship of NIAMS grant database topic funding with percent total GBD 2010 DALY and DALY rank for 15 skin conditions. RESULTS: During fiscal year 2013, 1,443 NIAMS grants were issued at a total value of $424 million. Of these grants, 17.7% covered skin topics. Of the total skin disease funding, 82% (91 grants) were categorized as "general cutaneous research." Psoriasis, leprosy, and "other skin and subcutaneous diseases" (ie; immunobullous disorders, vitiligo, and hidradenitis suppurativa) were over-represented when funding was compared with disability. Conversely, cellulitis, decubitus ulcer, urticaria, acne vulgaris, viral skin diseases, fungal skin diseases, scabies, and melanoma were under-represented. Conditions for which disability and funding appeared well-matched were dermatitis, squamous and basal cell carcinoma, pruritus, bacterial skin diseases, and alopecia areata. CONCLUSIONS AND RELEVANCE: Degree of representation in NIAMS is partly correlated with DALY metrics. Grant funding was well-matched with disability metrics for five of the 15 studied skin diseases, while two skin diseases were over-represented and seven were under-represented. Global burden estimates provide increasingly transparent and important information for investigating and prioritizing national research funding allocations.
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When NIH funding was compared with the relative disability burden of skin conditions, seven skin diseases (cellulitis, decubitus ulcer, urticaria, acne vulgaris, viral skin diseases, fungal skin diseases, scabies, and melanoma) were underrepresented.
“When the amount of NIH funding was compared with the relative disability burden of skin conditions, seven skin diseases (cellulitis, decubitus ulcer, urticaria, acne vulgaris, viral skin diseases, fungal skin diseases, scabies, and melanoma) were underrepresented”
From Global Burden of Skin Disease: Inequities and Innovations (2017) · cites this paper as [29]
There remains a mismatch between resource allocation and the skin diseases with the greatest disability burden, both in grant funding and systematic reviews.
“There remains a mismatch between resource allocation and the skin diseases with the greatest disability burden – both in grant funding and systematic reviews”
From Global Burden of Skin Disease: Inequities and Innovations (2017) · cites this paper as [29]
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- Authors
- Karimkhani, C., Boyers, L. N., Margolis, D. J., Naghavi, M., Hay, R. J., Williams, H. C., Naldi, L., Coffeng, L. E., Weinstock, M. A., Dunnick, C. A., Pederson, H., Vos, T., Murray, C. J. L., & Dellavalle, R. P.
- Affiliations
- Georgetown University (US)
- University of Pennsylvania (US)
- University of Washington (US)
- King's College Hospital (GB)
- University of Nottingham (GB)
- Ospedale Papa Giovanni XXIII (IT)
- Brown University (US)
- United States Department of Veterans Affairs (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Dellavalle, Robert P.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-07-08
- Volume
- 9
- Issue
- 7
- Pages
- e102122
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4086973
- OpenAlex
- W2121910794
- Cited by
- 32
- References
- 22
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 6 · 2012: 1
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Columbia Academic Commons (Columbia University)
- Funders
- U.S. Department of Veterans Affairs
- Bill and Melinda Gates Foundation
- National Institute for Health and Care Research (NF-SI-0611-10246)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › scientometrics and bibliometrics research
- Social Sciences › Decision Sciences › Information Systems and Management › Research, Science, and Academia
- Keywords
- skin diseases, research funding, disability-adjusted life years, global burden of disease, research prioritization, psoriasis, leprosy, vitiligo, hidradenitis suppurativa, melanoma, pressure ulcers, urticaria, acne, fungal skin infection, scabies, bacterial skin infections, skin inflammation, squamous cell carcinoma, basal cell carcinoma, alopecia areata, pruritus
- MeSH terms
- Female, Financing, Government, Persons with Disabilities, Disabled Persons, Humans, Male, Skin Diseases, United States, Global Health, Cost of Illness, Quality-Adjusted Life Years, Biomedical Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.)
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